granisetron (BioDeep_00000405850)
Main id: BioDeep_00000002376
代谢物信息卡片
granisetron
化学式: C18H24N4O (312.195)
中文名称: 格拉司琼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
InChI: InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12?,13-,14+
描述信息
A - Alimentary tract and metabolism > A04 - Antiemetics and antinauseants > A04A - Antiemetics and antinauseants > A04AA - Serotonin (5ht3) antagonists
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist > C94726 - 5-HT3 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
同义名列表
3 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:94501
- ChEBI: CHEBI:5537
- KEGG: C07023
- KEGGdrug: D04370
- PubChem: 5284566
- DrugBank: DB00889
- ChEMBL: CHEMBL1290003
- ChEMBL: CHEMBL399538
- MeSH: Granisetron
- CAS: 124998-65-8
- CAS: 109889-09-0
- MoNA: FiehnHILIC001974
- MoNA: FiehnHILIC000403
- ChEBI: CHEBI:184693
- PubChem: 9235
- NIKKAJI: J258.427A
- medchemexpress: HY-B0071
- KNApSAcK: 184693
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Min Zeng, Junxiang Li, Tingting Zheng, Xi Yan, Feng Yuan, Bingbing Xiang. Electropress Needle Stimulation for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Prospective, Randomized Controlled Trial.
Obesity surgery.
2023 09; 33(9):2831-2840. doi:
10.1007/s11695-023-06752-7. [PMID: 37507634] - Fei Liu, Liu-Lin Xiong, Ting-Ting Li, Yan-Jun Chen, Wei Ma, Qi-Jun Li, Qian Li, Ting-Hua Wang. Analgesic Effects and Adverse Reactions of Lidocaine for Patient-Controlled Intravenous Analgesia on Patients Undergoing Open Hepatectomy: A Retrospective Analysis.
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses.
2023 Feb; 38(1):39-44. doi:
10.1016/j.jopan.2022.05.069. [PMID: 35989234] - Mitsuhiro Goda, Masaya Kanda, Toshihiko Yoshioka, Ami Yoshida, Yoichi Murai, Yoshito Zamami, Fuka Aizawa, Takahiro Niimura, Hirofumi Hamano, Naoto Okada, Kenta Yagi, Masayuki Chuma, Yuki Izawa-Ishizawa, Keisuke Ishizawa. Effects of 5-HT₃ receptor antagonists on cisplatin-induced kidney injury.
Clinical and translational science.
2021 09; 14(5):1906-1916. doi:
10.1111/cts.13045. [PMID: 33982438] - Ashkan Divanbeigi, Mohammad Nasehi, Salar Vaseghi, Sepideh Amiri, Mohammad-Reza Zarrindast. Tropisetron But Not Granisetron Ameliorates Spatial Memory Impairment Induced by Chronic Cerebral Hypoperfusion.
Neurochemical research.
2020 Nov; 45(11):2631-2640. doi:
10.1007/s11064-020-03110-2. [PMID: 32797381] - Mohammad Reza Zirak, Gholamreza Karimi, Reza Rahimian, Amir Hossein Jafarian, A Wallace Hayes, Soghra Mehri. Tropisetron ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats.
European journal of pharmacology.
2020 Sep; 883(?):173310. doi:
10.1016/j.ejphar.2020.173310. [PMID: 32619674] - Qinghua Wu, Kamil Kuca, Eugenie Nepovimova, Wenda Wu. Type A Trichothecene Diacetoxyscirpenol-Induced Emesis Corresponds to Secretion of Peptide YY and Serotonin in Mink.
Toxins.
2020 06; 12(6):. doi:
10.3390/toxins12060419. [PMID: 32630472] - N Konthapakdee, L Grundy, T O'Donnell, S Garcia-Caraballo, S M Brierley, D Grundy, D M Daly. Serotonin exerts a direct modulatory role on bladder afferent firing in mice.
The Journal of physiology.
2019 11; 597(21):5247-5264. doi:
10.1113/jp278751. [PMID: 31520534] - Mahmoud A Tantawy, Soheir Alweshahy, Dalia A Elshabasy, Nadia F Youssef. Simultaneous Determination of Co-administrated Deflazacort, Aprepitant and Granisetron in Dosage Forms and Spiked Human Plasma by RP-HPLC/PAD.
Journal of chromatographic science.
2019 Oct; 57(9):790-798. doi:
10.1093/chromsci/bmz062. [PMID: 31504281] - Y Yu, H Fan, Y Cheng, J L Sun. [Effect of intravenous granisetron combined and acupuncture point injection at PC6(Neiguan) with 0.9\% sodium chlorideon postoperative nausea and vomiting after gynecological laparoscopy].
Zhonghua yi xue za zhi.
2019 Sep; 99(33):2606-2610. doi:
10.3760/cma.j.issn.0376-2491.2019.33.010. [PMID: 31510721] - Shenhai Gong, Zhengzheng Yan, Zhanguo Liu, Mengwei Niu, Heng Fang, Na Li, Chenyang Huang, Lei Li, Guiming Chen, Haihua Luo, Xiaojiao Chen, Hongwei Zhou, Jingjuan Hu, Wei Yang, Qiaobing Huang, Bernd Schnabl, Ping Chang, Timothy R Billiar, Yong Jiang, Peng Chen. Intestinal Microbiota Mediates the Susceptibility to Polymicrobial Sepsis-Induced Liver Injury by Granisetron Generation in Mice.
Hepatology (Baltimore, Md.).
2019 04; 69(4):1751-1767. doi:
10.1002/hep.30361. [PMID: 30506577] - Rui Chen, Xia Chen, Hongyun Wang, Wen Zhong, Eun Sil Oh, Min Soo Park, Yuji Kumagai, Li Zhou, Fumiko Nagahama, Pei Hu. Pharmacokinetics and safety of transdermal and oral granisetron in healthy Chinese subjects: An open-label, randomized, crossover study
.
International journal of clinical pharmacology and therapeutics.
2019 Jan; 57(1):24-31. doi:
10.5414/cp203327. [PMID: 30336808] - Yukari Tsubata, Mika Nakao, Yoshihiro Amano, Takamasa Hotta, Megumi Hamaguchi, Tamio Okimoto, Kiyotaka Miura, Shunichi Hamaguchi, Takashige Kuraki, Masayuki Itakura, Takeshi Isobe. Translational and Randomized Study of 5-HT3 Receptor Antagonists for Evaluation of Chemotherapy-induced Nausea and Vomiting Related Biomarkers.
The journal of medical investigation : JMI.
2019; 66(3.4):269-274. doi:
10.2152/jmi.66.269. [PMID: 31656287] - Kun Sheng, Xi Lu, Jianming Yue, Wei Gu, Chao Gu, Haibin Zhang, Wenda Wu. Role of neurotransmitters 5-hydroxytryptamine and substance P in anorexia induction following oral exposure to the trichothecene T-2 toxin.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Jan; 123(?):1-8. doi:
10.1016/j.fct.2018.10.041. [PMID: 30336258] - Rehab Abdelmonem, Mohamed El Nabarawi, Alshaimaa Attia. Development of novel bioadhesive granisetron hydrochloride spanlastic gel and insert for brain targeting and study their effects on rats.
Drug delivery.
2018 Nov; 25(1):70-77. doi:
10.1080/10717544.2017.1413447. [PMID: 29228824] - Cunying Huang, Huihui Wan, Jing Zhang, Hongmin Zhong, Juan Li, YuMing Sun, Qing Wang, Hua Zhang. Quantification of ondansetron, granisetron and tropisetron in goat plasma using hydrophilic interaction liquid chromatography-solid phase extraction coupled with hydrophilic interaction liquid chromatography-triple quadrupole tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Sep; 1095(?):50-58. doi:
10.1016/j.jchromb.2018.07.009. [PMID: 30053687] - André Dallmann, Ibrahim Ince, Katrin Coboeken, Thomas Eissing, Georg Hempel. A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.
Clinical pharmacokinetics.
2018 06; 57(6):749-768. doi:
10.1007/s40262-017-0594-5. [PMID: 28924743] - Guozhong Yang, Meilin He, Suohui Zhang, Man Wu, Yunhua Gao. An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron.
Drug development and industrial pharmacy.
2018 May; 44(5):808-816. doi:
10.1080/03639045.2017.1414230. [PMID: 29216752] - Mihoko Morita, Shinji Kishi, Miyuki Ookura, Yasufumi Matsuda, Katsunori Tai, Takahiro Yamauchi, Takanori Ueda. Efficacy of aprepitant for CHOP chemotherapy-induced nausea, vomiting, and anorexia.
Current problems in cancer.
2017 Nov; 41(6):419-425. doi:
10.1016/j.currproblcancer.2017.09.001. [PMID: 29061362] - Sheila A Doggrell. Granisetron in the treatment of chemotherapy-induced nausea and vomiting (CINV) - is there still a role after comparison with palonosetron?.
Expert opinion on pharmacotherapy.
2017 Jul; 18(10):1019-1026. doi:
10.1080/14656566.2017.1342809. [PMID: 28612633] - Yasmin Moustafa Ahmed, Basim Anwar Shehata Messiha, Ali Ahmed Abo-Saif. Granisetron and carvedilol can protect experimental rats againstadjuvant-induced arthritis.
Immunopharmacology and immunotoxicology.
2017 Apr; 39(2):97-104. doi:
10.1080/08923973.2017.1286502. [PMID: 28211304] - Martha L Bustos, Yang Zhao, Huijun Chen, Steve N Caritis, Raman Venkataramanan. Polymorphisms in CYP1A1 and CYP3A5 Genes Contribute to the Variability in Granisetron Clearance and Exposure in Pregnant Women with Nausea and Vomiting.
Pharmacotherapy.
2016 12; 36(12):1238-1244. doi:
10.1002/phar.1860. [PMID: 27809336] - Katja Rezonja, Tomaz Mars, Ales Jerin, Gordana Kozelj, Neva Pozar-Lukanovic, Maja Sostaric. Dexamethasone does not diminish sugammadex reversal of neuromuscular block - clinical study in surgical patients undergoing general anesthesia.
BMC anesthesiology.
2016 10; 16(1):101. doi:
10.1186/s12871-016-0254-6. [PMID: 27765010] - Steve Caritis, Yang Zhao, Hui-Jun Chen, Raman Venkataramanan. Pharmacodynamics of transdermal granisetron in women with nausea and vomiting of pregnancy.
American journal of obstetrics and gynecology.
2016 07; 215(1):93.e1-4. doi:
10.1016/j.ajog.2016.01.163. [PMID: 26812081] - Qi Shi, Wen Li, Hongjia Li, Qiqi Le, Shanshan Liu, Shaoqi Zong, Leizhen Zheng, Fenggang Hou. Prevention of cisplatin-based chemotherapy-induced delayed nausea and vomiting using triple antiemetic regimens: a mixed treatment comparison.
Oncotarget.
2016 Apr; 7(17):24402-14. doi:
10.18632/oncotarget.8255. [PMID: 27015550] - Jennyfer Cázares-Delgadillo, Adriana Ganem-Rondero, Virginia Merino, Yogeshvar N Kalia. Controlled transdermal iontophoresis for poly-pharmacotherapy: Simultaneous delivery of granisetron, metoclopramide and dexamethasone sodium phosphate in vitro and in vivo.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Mar; 85(?):31-8. doi:
10.1016/j.ejps.2016.01.027. [PMID: 26826281] - Yang Zhao, Hui-Jun Chen, Steve Caritis, Raman Venkataramanan. Development and validation of a sensitive liquid chromatographic-tandem mass spectrometric method for the simultaneous analysis of granisetron and 7-hydroxy granisetron in human plasma and urine samples: application in a clinical pharmacokinetic study in pregnant subject.
Biomedical chromatography : BMC.
2016 Feb; 30(2):149-54. doi:
10.1002/bmc.3530. [PMID: 26053159] - Hiroshi Kitamura, Atsushi Takahashi, Hiroshi Hotta, Ryuichi Kato, Yasuharu Kunishima, Fumiyasu Takei, Hiroki Horita, Naoya Masumori. Palonosetron with aprepitant plus dexamethasone to prevent chemotherapy-induced nausea and vomiting during gemcitabine/cisplatin in urothelial cancer patients.
International journal of urology : official journal of the Japanese Urological Association.
2015 Oct; 22(10):911-4. doi:
10.1111/iju.12842. [PMID: 26087891] - Judith A Smith, Justin M Julius, Anjali Gaikwad, Pamela D Berens, Joseph Alcorn, Kenneth J Moise, Jerrie S Refuerzo. Evaluating the potential effect on fetal tissue after exposure to granisetron during pregnancy.
Reproductive toxicology (Elmsford, N.Y.).
2015 Jun; 53(?):92-8. doi:
10.1016/j.reprotox.2015.02.011. [PMID: 25813292] - Howida K Ibrahim, Nevine S Abdel Malak, Sally A Abdel Halim. Formulation of Convenient, Easily Scalable, and Efficient Granisetron HCl Intranasal Droppable Gels.
Molecular pharmaceutics.
2015 Jun; 12(6):2019-25. doi:
10.1021/mp500825n. [PMID: 25936630] - Anita Barzegar-Fallah, Houman Alimoradi, Firouzeh Asadi, Ahmad Reza Dehpour, Mojgan Asgari, Massoumeh Shafiei. Tropisetron ameliorates early diabetic nephropathy in streptozotocin-induced diabetic rats.
Clinical and experimental pharmacology & physiology.
2015 Apr; 42(4):361-8. doi:
10.1111/1440-1681.12373. [PMID: 25676798] - Hironori Nakamura, Haruko Yokoyama, Risa Takayanagi, Koichi Yoshimoto, Akihiro Nakajima, Kiyoshi Okuyama, Osamu Iwase, Yasuhiko Yamada. Theoretical evaluation of antiemetic effects of 5-HT3 receptor antagonists for prevention of vomiting induced by cisplatin.
European journal of drug metabolism and pharmacokinetics.
2015 Mar; 40(1):39-44. doi:
10.1007/s13318-014-0175-z. [PMID: 24470169] - Ying Zhou, Ji Jiang, Pei Hu, Hongyun Wang. A high-performance liquid chromatography-tandem mass spectrometry method coupled with protein precipitation for determination of granisetron in human plasma and its application to a comparative pharmacokinetic study.
Biomedical chromatography : BMC.
2014 Dec; 28(12):1597-600. doi:
10.1002/bmc.3233. [PMID: 24811001] - Justin M Julius, Andrew Tindall, Kenneth J Moise, Jerrie S Refuerzo, Pamela D Berens, Judith A Smith. Evaluation of the maternal-fetal transfer of granisetron in an ex vivo placenta perfusion model.
Reproductive toxicology (Elmsford, N.Y.).
2014 Nov; 49(?):43-7. doi:
10.1016/j.reprotox.2014.06.003. [PMID: 25019977] - Wenda Wu, Melissa A Bates, Steven J Bursian, Brenna Flannery, Hui-Ren Zhou, Jane E Link, Haibin Zhang, James J Pestka. Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin).
Toxicological sciences : an official journal of the Society of Toxicology.
2013 May; 133(1):186-95. doi:
10.1093/toxsci/kft033. [PMID: 23457120] - Hironori Nakamura, Haruko Yokoyama, Koichi Yoshimoto, Akihiro Nakajima, Kiyoshi Okuyama, Osamu Iwase, Yasuhiko Yamada. Method for individualized evaluation of antiemetic effect induced by 5-HT3 receptor antagonist.
Biological & pharmaceutical bulletin.
2013; 36(5):780-7. doi:
10.1248/bpb.b12-00946. [PMID: 23459393] - Hea-Jeong Doh, Yunjin Jung, Prabagar Balakrishnan, Hyun-Jong Cho, Dae-Duk Kim. A novel lipid nanoemulsion system for improved permeation of granisetron.
Colloids and surfaces. B, Biointerfaces.
2013 Jan; 101(?):475-80. doi:
10.1016/j.colsurfb.2012.07.019. [PMID: 23010057] - Junki Endo, Hirotoshi Iihara, Maya Yamada, Koumei Yanase, Fumihiko Kamiya, Fumitaka Ito, Norihiko Funaguchi, Yasushi Ohno, Shinya Minatoguchi, Yoshinori Itoh. A randomized controlled non-inferiority study comparing the antiemetic effect between intravenous granisetron and oral azasetron based on estimated 5-HT3 receptor occupancy.
Anticancer research.
2012 Sep; 32(9):3939-47. doi:
. [PMID: 22993341] - Zeng Wang, Jin Xiang, Qin Yu, Mao-Zhi Liang, Feng Nan, Yong-Ping Qin. [Determination of ubenimex in human plasma by HPLC-MS/MS].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2012 Jul; 43(4):609-11, 630. doi:
NULL. [PMID: 22997907] - A J Thompson, M H P Verheij, I J P de Esch, S C R Lummis. VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors.
The Journal of pharmacology and experimental therapeutics.
2012 May; 341(2):350-9. doi:
10.1124/jpet.111.190769. [PMID: 22306960] - Yukako Ito, Masahiro Yoshimura, Tsutomu Tanaka, Kanji Takada. Effect of lipophilicity on the bioavailability of drugs after percutaneous administration by dissolving microneedles.
Journal of pharmaceutical sciences.
2012 Mar; 101(3):1145-56. doi:
10.1002/jps.22814. [PMID: 22086760] - P A Boakye, C Stenkamp-Strahm, Y Bhattarai, M D Heckman, S M Brierley, S P Pasilis, O B Balemba. 5-HT(3) and 5-HT(4) receptors contribute to the anti-motility effects of Garcinia buchananii bark extract in the guinea-pig distal colon.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2012 Jan; 24(1):e27-40. doi:
10.1111/j.1365-2982.2011.01807.x. [PMID: 22074563] - Max Schlaak, Patrick Schmidt, Christopher Bangard, Peter Kurschat, Cornelia Mauch, Hinrich Abken. Regression of metastatic melanoma in a patient by antibody targeting of cancer stem cells.
Oncotarget.
2012 Jan; 3(1):22-30. doi:
10.18632/oncotarget.437. [PMID: 22289880] - S C R Lummis, A J Thompson, M Bencherif, H A Lester. Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor.
The Journal of pharmacology and experimental therapeutics.
2011 Oct; 339(1):125-31. doi:
10.1124/jpet.111.185306. [PMID: 21775477] - Toshiaki Takahashi, Yukiko Nakamura, Asuka Tsuya, Haruyasu Murakami, Masahiro Endo, Nobuyuki Yamamoto. Pharmacokinetics of aprepitant and dexamethasone after administration of chemotherapeutic agents and effects of plasma substance P concentration on chemotherapy-induced nausea and vomiting in Japanese cancer patients.
Cancer chemotherapy and pharmacology.
2011 Sep; 68(3):653-9. doi:
10.1007/s00280-010-1519-2. [PMID: 21125277] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Inge R H M Konings, Stefan Sleijfer, Ron H J Mathijssen, Peter de Bruijn, Inge M Ghobadi Moghaddam-Helmantel, Linda M van Dam, Erik A C Wiemer, Jaap Verweij, Walter J Loos. Increasing tumoral 5-fluorouracil concentrations during a 5-day continuous infusion: a microdialysis study.
Cancer chemotherapy and pharmacology.
2011 May; 67(5):1055-62. doi:
10.1007/s00280-010-1400-3. [PMID: 20652702] - Fredrik Lindstedt, Jonathan Berrebi, Erik Greayer, Tina B Lonsdorf, Martin Schalling, Martin Ingvar, Eva Kosek. Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene.
PloS one.
2011 Mar; 6(3):e18252. doi:
10.1371/journal.pone.0018252. [PMID: 21464942] - Andrew J Thompson, Gavin E Jarvis, Rujee K Duke, Graham A R Johnston, Sarah C R Lummis. Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site.
Neuropharmacology.
2011 Feb; 60(2-3):488-95. doi:
10.1016/j.neuropharm.2010.11.003. [PMID: 21059362] - Tetsuro Ohno, Mitsuhiro Yanai, Hiroyuki Ando, Yoshitaka Toyomasu, Atsushi Ogawa, Hiroki Morita, Kyoichi Ogata, Erito Mochiki, Takayuki Asao, Hiroyuki Kuwano. Rikkunshito, a traditional Japanese medicine, suppresses cisplatin-induced anorexia in humans.
Clinical and experimental gastroenterology.
2011; 4(?):291-6. doi:
10.2147/ceg.s26297. [PMID: 22235173] - Kine Gregersen, Jørgen Valeur, Kristine Lillestøl, Livar Frøyland, Pedro Araujo, Gülen Arslan Lied, Arnold Berstad. Subjective food hypersensitivity: assessment of enterochromaffin cell markers in blood and gut lavage fluid.
International journal of general medicine.
2011; 4(?):555-60. doi:
10.2147/ijgm.s18349. [PMID: 21887108] - Manish Yadav, Ajay Gupta, Puran Singhal, Pranav S Shrivastav. Development and validation of a selective and rapid LC-MS-MS method for the quantification of abacavir in human plasma.
Journal of chromatographic science.
2010 Sep; 48(8):654-62. doi:
10.1093/chromsci/48.8.654. [PMID: 20819295] - Christopher Keating, Vicente Martinez, Lorna Ewart, Stephen Gibbons, Luke Grundy, Jean-Pierre Valentin, David Grundy. The validation of an in vitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions.
Toxicology and applied pharmacology.
2010 Jun; 245(3):299-309. doi:
10.1016/j.taap.2010.03.014. [PMID: 20350559] - Koji Yakabi, Susumu Kurosawa, Mitsuo Tamai, Mitsutoshi Yuzurihara, Miwa Nahata, Shino Ohno, Shoki Ro, Shingo Kato, Toru Aoyama, Tomoya Sakurada, Hidehiko Takabayashi, Tomohisa Hattori. Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction.
Regulatory peptides.
2010 Apr; 161(1-3):97-105. doi:
10.1016/j.regpep.2010.02.003. [PMID: 20171995] - Jennyfer Cázares-Delgadillo, Adriana Ganem-Rondero, David Quintanar-Guerrero, Alicia C López-Castellano, Virginia Merino, Yogeshvar N Kalia. Using transdermal iontophoresis to increase granisetron delivery across skin in vitro and in vivo: effect of experimental conditions and a comparison with other enhancement strategies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2010 Mar; 39(5):387-93. doi:
10.1016/j.ejps.2010.01.008. [PMID: 20096354] - Albert Tuca. Use of granisetron transdermal system in the prevention of chemotherapy-induced nausea and vomiting: a review.
Cancer management and research.
2009 Dec; 2(?):1-12. doi:
10.2147/cmar.s4953. [PMID: 21188092] - C P Lee, G S Payne, A Oregioni, R Ruddle, S Tan, F I Raynaud, D Eaton, M J Campbell, K Cross, G Halbert, M Tracy, J McNamara, B Seddon, M O Leach, P Workman, I Judson. A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy.
British journal of cancer.
2009 Dec; 101(11):1860-8. doi:
10.1038/sj.bjc.6605425. [PMID: 19935799] - Julian Howell, Jean Smeets, Henk-Jan Drenth, David Gill. Pharmacokinetics of a granisetron transdermal system for the treatment of chemotherapy-induced nausea and vomiting.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2009 Dec; 15(4):223-31. doi:
10.1177/1078155209104063. [PMID: 19304880] - Marleen Melis, Magda Bijster, Monique de Visser, Mark W Konijnenberg, Jan de Swart, Edgar J Rolleman, Otto C Boerman, Eric P Krenning, Marion de Jong. Dose-response effect of Gelofusine on renal uptake and retention of radiolabelled octreotate in rats with CA20948 tumours.
European journal of nuclear medicine and molecular imaging.
2009 Dec; 36(12):1968-76. doi:
10.1007/s00259-009-1196-8. [PMID: 19585115] - Inge R H M Konings, Frederike K Engels, Stefan Sleijfer, Jaap Verweij, Erik A C Wiemer, Walter J Loos. Application of prolonged microdialysis sampling in carboplatin-treated cancer patients.
Cancer chemotherapy and pharmacology.
2009 Aug; 64(3):509-16. doi:
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Bioanalysis.
2009 Jun; 1(3):537-48. doi:
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The Lancet. Oncology.
2009 Feb; 10(2):115-24. doi:
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Neuropharmacology.
2009 Jan; 56(1):285-91. doi:
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Cancer chemotherapy and pharmacology.
2008 Dec; 63(1):75-83. doi:
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International journal of pharmaceutics.
2008 Oct; 362(1-2):20-8. doi:
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Therapeutics and clinical risk management.
2008 Apr; 4(2):501-6. doi:
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Rapid communications in mass spectrometry : RCM.
2008; 22(4):511-8. doi:
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The oncologist.
2007 Sep; 12(9):1151-5. doi:
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Pain.
2007 Aug; 130(3):235-248. doi:
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International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
2007 Jul; 17(4):739-63. doi:
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Indian journal of dermatology, venereology and leprology.
2007 Jul; 73(4):231-4. doi:
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Archives of pharmacal research.
2007 Jun; 30(6):778-84. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 May; 850(1-2):101-8. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Dec; 844(2):268-77. doi:
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Journal of pharmaceutical and biomedical analysis.
2006 Oct; 42(4):464-73. doi:
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British journal of cancer.
2006 Sep; 95(6):729-34. doi:
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Biomedical chromatography : BMC.
2006 Sep; 20(9):888-97. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 May; 836(1-2):79-82. doi:
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Cancer journal (Sudbury, Mass.).
2006 Jan; 12(1):69-72. doi:
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Arthritis research & therapy.
2006; 8(4):R99. doi:
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Mediators of inflammation.
2005 Aug; 2005(4):194-201. doi:
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The Journal of biological chemistry.
2005 May; 280(21):20476-82. doi:
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Current medical research and opinion.
2005 Apr; 21(4):595-601. doi:
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Pain.
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British journal of cancer.
2004 Aug; 91(5):844-9. doi:
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British journal of cancer.
2004 Aug; 91(3):476-81. doi:
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British journal of cancer.
2003 Nov; 89(10):1855-9. doi:
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British journal of cancer.
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Clinical therapeutics.
2003 May; 25(5):1407-19. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2003 Apr; 89(2):311-20. doi:
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British journal of cancer.
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American journal of physiology. Gastrointestinal and liver physiology.
2002 Aug; 283(2):G400-7. doi:
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British journal of cancer.
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BMC biochemistry.
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BMC biochemistry.
2002 Jun; 3(?):16. doi:
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British journal of cancer.
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Sheng li xue bao : [Acta physiologica Sinica].
2001 Oct; 53(5):349-54. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2001 Oct; 7(10):3056-64. doi:
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Biological & pharmaceutical bulletin.
2001 Apr; 24(4):432-5. doi:
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Japanese journal of cancer research : Gann.
2001 Feb; 92(2):220-30. doi:
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