diclofenac (BioDeep_00000405802)
Main id: BioDeep_00000001459
代谢物信息卡片
diclofenac
化学式: C14H11Cl2NO2 (295.01668060000003)
中文名称: 2-(2,6-二氯苯氨基)苯乙酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
InChI: InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
描述信息
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
D - Dermatologicals
同义名列表
1 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:47381
- KEGG: C01690
- KEGGdrug: D07816
- PubChem: 3033
- DrugBank: DB00586
- ChEMBL: CHEMBL139
- MeSH: Diclofenac
- CAS: 128402-48-2
- CAS: 15307-86-5
- MoNA: FiehnHILIC002664
- MoNA: FiehnHILIC001883
- MoNA: FiehnHILIC001149
- MoNA: FiehnHILIC000306
- PubChem: 4831
- PDB-CCD: DIF
- NIKKAJI: J8.557J
- RefMet: Diclofenac
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Karthikeyan Kandaswamy, Ajay Guru, Siva Prasad Panda, Anahas Perianaika Matharasi Antonyraj, Zulhisyam Abdul Kari, Jayant Giri, Bader O Almutairi, Selvaraj Arokiyaraj, Guilherme Malafaia, Jesu Arockiaraj. Polystyrene nanoplastics synergistically exacerbate diclofenac toxicity in embryonic development and the health of adult zebrafish.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2024 Jul; 281(?):109926. doi:
10.1016/j.cbpc.2024.109926. [PMID: 38641085] - Klaudia Kwidzińska, Martyna Zalewska, Anna Aksmann, Justyna Kobos, Hanna Mazur-Marzec, Magda Caban. Multi-biomarker response of cyanobacteria Synechocystis salina and Microcystis aeruginosa to diclofenac.
Journal of hazardous materials.
2024 Jun; 471(?):134373. doi:
10.1016/j.jhazmat.2024.134373. [PMID: 38678710] - Stephan Schmidt, Holger Hoffmann, Leif-Alexander Garbe, Andrea Harrer, Markus Steiner, Martin Himly, Rudolf J Schneider. Re-assessment of monoclonal antibodies against diclofenac for their application in the analysis of environmental waters.
Analytical methods : advancing methods and applications.
2024 May; 16(21):3349-3363. doi:
10.1039/d3ay01333b. [PMID: 38742423] - Georgios Paraskevopoulos, Ferdinand Fandrei, Ajit Kumar Pratihast, Anna Paraskevopoulou, Eleni Panoutsopoulou, Lukáš Opálka, Venus Singh Mithu, Daniel Huster, Kateřina Vávrová. Effects of imidazolium ionic liquids on skin barrier lipids - Perspectives for drug delivery.
Journal of colloid and interface science.
2024 Apr; 659(?):449-462. doi:
10.1016/j.jcis.2023.12.139. [PMID: 38183811] - Thaise Boeing, Alana Bittencourt F Lima, Maria Eduarda Busana, Luísa Nathália Bolda Mariano, Luisa Mota da Silva, Rita de Cássia Vilhena da Silva, Priscila de Souza. Characterization of Diclofenac-induced Renal Damage in Normotensive and Hypertensive Rats: A Comparative Analysis.
Drug research.
2024 Apr; 74(4):171-179. doi:
10.1055/a-2277-8458. [PMID: 38503307] - Xiao-Zhou Hou, Jing Yin, Hai-Yang Wang, Jin-Yu Gu, Tian-Hao Wan, Man-Hong Yang, Di Xia, Qing Zhang. [A multicenter clinical study on the treatment of lateral epicondylitis of humerus by manipulation].
Zhongguo gu shang = China journal of orthopaedics and traumatology.
2024 Mar; 37(3):251-7. doi:
10.12200/j.issn.1003-0034.20230252. [PMID: 38515411] - Elackiya Sithamparanathan, Katarzyna Kujawa-Roeleveld, Huub H M Rijnaarts, Nora B Sutton. Hydroponic materials improve organic micropollutant removal in vertical flow constructed wetlands treating wastewater.
Chemosphere.
2024 Mar; 352(?):141388. doi:
10.1016/j.chemosphere.2024.141388. [PMID: 38346507] - Ioana Boarescu, Paul-Mihai Boarescu, Raluca Maria Pop, Ioana Corina Bocșan, Dan Gheban, Adriana Elena Bulboacă, Anca Dana Buzoianu, Sorana D Bolboacă. Zingiber officinale Root Capsule Extract Synergistically Enhance the Anti-Inflammatory Effects of Diclofenac Sodium in Experimental Acute Inflammation.
International journal of molecular sciences.
2024 Feb; 25(3):. doi:
10.3390/ijms25031781. [PMID: 38339059] - Kristin H Cochran, Danielle C Westerman, Cassiana C Montagner, Scott Coffin, Lorivic Diaz, Benjamin Fryer, Gary Harraka, Elvis Genbo Xu, Ying Huang, Daniel Schlenk, Dionysios D Dionysiou, Susan D Richardson. Chlorination of Emerging Contaminants for Application in Potable Wastewater Reuse: Disinfection Byproduct Formation, Estrogen Activity, and Cytotoxicity.
Environmental science & technology.
2024 Jan; 58(1):704-716. doi:
10.1021/acs.est.3c05978. [PMID: 38109774] - Sushmita Negi, Nikunj Tandel, Neeraj K Garg, Prakriti Sharma, Rajinder Kumar, Praveen Sharma, Reetesh Kumar, Sheetal Saini, Aman Sharma, Rajeev K Tyagi. Co-Delivery of Aceclofenac and Methotrexate Nanoparticles Presents an Effective Treatment for Rheumatoid Arthritis.
International journal of nanomedicine.
2024; 19(?):2149-2177. doi:
10.2147/ijn.s439359. [PMID: 38482519] - Tuyen Van Nguyen, Adam Bořík, Jaylen L Sims, Antonín Kouba, Vladimír Žlábek, Anna Koubová. Toxicological effects of diclofenac on signal crayfish (Pacifastacus leniusculus) as related to weakly acidic and basic water pH.
Aquatic toxicology (Amsterdam, Netherlands).
2023 Dec; 265(?):106777. doi:
10.1016/j.aquatox.2023.106777. [PMID: 38035650] - Tiantian Chen, Hewei Jiang, Yaoji He, Yawei Shen, Jiajie Fang, Zequn Huang, Yubang Sheng, Xiaowu Chen. Histopathological, physiological, and multi-omics insights into the hepatotoxicity mechanism of nanopolystyrene and/or diclofenac in Mylopharyngodon piceus.
Environmental pollution (Barking, Essex : 1987).
2023 Nov; ?(?):122894. doi:
10.1016/j.envpol.2023.122894. [PMID: 37944890] - Anjali, Payal Kamboj, Ozair Alam, Harun Patel, Iqrar Ahmad, Syed Sufian Ahmad, Mohd Amir. Design, synthesis, biological evaluation, and in silico studies of quinoxaline derivatives as potent p38α MAPK inhibitors.
Archiv der Pharmazie.
2023 Oct; ?(?):e2300301. doi:
10.1002/ardp.202300301. [PMID: 37847883] - Amanda Teixeira de Rezende, Ann H Mounteer. Ecological risk assessment of pharmaceuticals and endocrine disrupting compounds in Brazilian surface waters.
Environmental pollution (Barking, Essex : 1987).
2023 Sep; 338(?):122628. doi:
10.1016/j.envpol.2023.122628. [PMID: 37783413] - Itzayana Pérez-Alvarez, Hariz Islas-Flores, Livier Mireya Sánchez-Aceves, Leobardo Manuel Gómez-Olivan, Germán Chamorro-Cevallos. Spirulina (Arthrospira maxima) mitigates the toxicity induced by a mixture of metal and NSAID in Xenopus laevis.
Reproductive toxicology (Elmsford, N.Y.).
2023 09; 120(?):108422. doi:
10.1016/j.reprotox.2023.108422. [PMID: 37330176] - Qi Liu, Wenchong Ouyang, Xusheng Yang, Yuanyuan He, Zhengwei Wu, Kostya Ken Ostrikov. Plasma-microbubble treatment and sustainable agriculture application of diclofenac-contaminated wastewater.
Chemosphere.
2023 Sep; 334(?):138998. doi:
10.1016/j.chemosphere.2023.138998. [PMID: 37211167] - Denis S Baranov, Anna S Kashnik, Anastasiya N Atnyukova, Sergei A Dzuba. Spin-Labeled Diclofenac: Synthesis and Interaction with Lipid Membranes.
Molecules (Basel, Switzerland).
2023 Aug; 28(16):. doi:
10.3390/molecules28165991. [PMID: 37630243] - Ivan Liakh, Darya Harshkova, Pavel Hrouzek, Kateřina Bišová, Anna Aksmann, Bartosz Wielgomas. Green alga Chlamydomonas reinhardtii can effectively remove diclofenac from the water environment - A new perspective on biotransformation.
Journal of hazardous materials.
2023 Aug; 455(?):131570. doi:
10.1016/j.jhazmat.2023.131570. [PMID: 37163898] - Iman H Hasan, Amirah Badr, Haneen Almalki, Alanoud Alhindi, Hesham S Mostafa. Podocin, mTOR, and CHOP dysregulation contributes to nephrotoxicity induced of lipopolysaccharide/diclofenac combination in rats: Curcumin and silymarin could afford protective effect.
Life sciences.
2023 Aug; 330(?):121996. doi:
10.1016/j.lfs.2023.121996. [PMID: 37536613] - Mahak Jain, Pilla Sai Kiran, Partha Sarathi Ghosal, Ashok Kumar Gupta. Development of microbial fuel cell integrated constructed wetland (CMFC) for removal of paracetamol and diclofenac in hospital wastewater.
Journal of environmental management.
2023 Aug; 344(?):118686. doi:
10.1016/j.jenvman.2023.118686. [PMID: 37536238] - Simone S Silva, Luísa C Rodrigues, Emanuel M Fernandes, Diana Soares da Costa, Denise G Villalva, Watson Loh, Rui L Reis. Chitosan/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach.
Marine drugs.
2023 Jul; 21(7):. doi:
10.3390/md21070394. [PMID: 37504925] - Nathalie Marte Ureña, Catiúscia Padilha de Oliveira, Silvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Oscar Tadeu Ferreira da Costa, Antonio Luiz Boechat. The Anti-Arthritic Activity of Diclofenac Lipid-Core Nanocapsules: Stereological Analysis Showing More Protection of Deep Joint Components.
Molecules (Basel, Switzerland).
2023 Jul; 28(13):. doi:
10.3390/molecules28135219. [PMID: 37446881] - João Vitor Raupp de Oliveira, Pedro Leardin Silveira, Gabriela Spingolon, Gabriel Antonio Lopes Alves, Flávia Pires Peña, Tanira Alessandra Silveira Aguirre. Polymeric nanoparticles containing babassu oil: A proposed drug delivery system for controlled release of hydrophilic compounds.
Chemistry and physics of lipids.
2023 07; 253(?):105304. doi:
10.1016/j.chemphyslip.2023.105304. [PMID: 37080377] - Sara S Marques, David J H Cant, Caterina Minelli, Marcela A Segundo. Combining orthogonal measurements to unveil diclofenac encapsulation into polymeric and lipid nanocarriers.
Analytica chimica acta.
2023 Jun; 1262(?):341234. doi:
10.1016/j.aca.2023.341234. [PMID: 37179055] - Benish Rauf, Sobia Alyasi, Naureen Zahra, Sohail Ahmad, Abid Sarwar, Tariq Aziz, Metab Alharbi, Abdulrahman Alshammari, Abdullah F Alasmari. Evaluating the influence of Aloe barbadensis extracts on edema induced changes in C-reactive protein and interleukin-6 in albino rats through in vivo and in silico approaches.
Acta biochimica Polonica.
2023 Jun; 70(2):425-433. doi:
10.18388/abp.2020_6705. [PMID: 37329564] - Taylan Dolu, Bilgehan Nas. Dissemination of nonsteroidal anti-inflammatory drugs (NSAIDs) and metabolites from wastewater treatment plant to soils and agricultural crops via real-scale different agronomic practices.
Environmental research.
2023 06; 227(?):115731. doi:
10.1016/j.envres.2023.115731. [PMID: 36958380] - Dimitrina Zheleva-Dimitrova, Rumyana Simeonova, Magdalena Kondeva-Burdina, Yonko Savov, Vessela Balabanova, Gokhan Zengin, Alexandra Petrova, Reneta Gevrenova. Antioxidant and Hepatoprotective Potential of Echinops ritro L. Extracts on Induced Oxidative Stress In Vitro/In Vivo.
International journal of molecular sciences.
2023 Jun; 24(12):. doi:
10.3390/ijms24129999. [PMID: 37373147] - Radhika Khanna, H R Chitme, Khushaboo Bhadoriya, Y C Tripathi, V K Varshney. In vitro and in vivo anti-inflammatory activity of Cupressus torulosa D.DON needles extract and its chemical characterization.
Journal of ethnopharmacology.
2023 May; 314(?):116578. doi:
10.1016/j.jep.2023.116578. [PMID: 37172917] - Durbek Usmanov, Aziz Azamatov, Temur Baykuziyev, Ugiloy Yusupova, Bakhtiyor Rasulev. Chemical constituents, anti-inflammatory and analgesic activities of iridoids preparation from Phlomoides labiosa bunge.
Natural product research.
2023 May; 37(10):1709-1713. doi:
10.1080/14786419.2022.2104274. [PMID: 35879860] - Kamran Jalil, Shabir Ahmad, Nazrul Islam, Rahim Ullah, Qudsia Jalil, Sulaiman Sulaiman, Anoosha Sajjad, Riaz Ullah, Ali S Alqahtani, Ahmed Bari, Hidayat Hussain, Essam A Ali. One Pot Synthesis, Biological Efficacy of AuNPs and Au-Amoxicillin Conjugates Functionalized with Crude Flavonoids Extract of Micromeria biflora.
Molecules (Basel, Switzerland).
2023 Apr; 28(8):. doi:
10.3390/molecules28083320. [PMID: 37110554] - Fabian Balk, Juliane Hollender, Kristin Schirmer. Investigating the bioaccumulation potential of anionic organic compounds using a permanent rainbow trout liver cell line.
Environment international.
2023 04; 174(?):107798. doi:
10.1016/j.envint.2023.107798. [PMID: 36965398] - Jyoti Sharma, Iqra Mariam, Mukul Suresh Kareya, Pannaga Pavan Jutur, Monika Joshi, Harish, Amit Bhatnagar, Akhilesh K Chaurasia, Subhasha Nigam. Metabolomic response of microalgae towards diclofenac sodium during its removal from water and concomitant recovery of pigments and lipids.
Bioresource technology.
2023 Mar; 371(?):128617. doi:
10.1016/j.biortech.2023.128617. [PMID: 36640815] - Sujatha M Hanumegowda, Chandramma Srinivasa, Ashwini Shivaiah, Manjula M Venkatappa, Sebestian Santhosh, Rajesh R, Sathisha J Gonchigar, Devaraja Sannaningaiah. Antioxidant and Antithrombotic Activities of Kenaf Seed (Hibiscus cannabinus) Coat Ethanol Extract in Sprague Dawley Rats.
Applied biochemistry and biotechnology.
2023 Feb; 195(2):772-800. doi:
10.1007/s12010-022-04144-8. [PMID: 36173546] - Márton Pápai, Tibor Benedek, András Táncsics, Till L V Bornemann, Julia Plewka, Alexander J Probst, Daood Hussein, Gergely Maróti, Ofir Menashe, Balázs Kriszt. Selective enrichment, identification, and isolation of diclofenac, ibuprofen, and carbamazepine degrading bacteria from a groundwater biofilm.
Environmental science and pollution research international.
2023 Jan; ?(?):. doi:
10.1007/s11356-022-24975-6. [PMID: 36690856] - Saravanakumar Selvaraj, Jung-Hwa Oh, Seokjoo Yoon, Jürgen Borlak. Diclofenac Disrupts the Circadian Clock and through Complex Cross-Talks Aggravates Immune-Mediated Liver Injury-A Repeated Dose Study in Minipigs for 28 Days.
International journal of molecular sciences.
2023 01; 24(2):. doi:
10.3390/ijms24021445. [PMID: 36674967] - Khalil Said, Muhammad Hamayun, Mamoona Rauf, Sumera Afzal Khan, Muhammad Arif, Abdulwahed Fahad Alrefaei, Mikhlid H Almutairi, Sajid Ali. Simultaneous Study of Analysis of Anti-inflammatory Potential of Dryopteris ramosa (C. Hope) C. Chr. using GC-Mass and Computational Modeling on the Xylene-induced Ear Oedema in Mouse Model.
Current pharmaceutical design.
2023; 29(41):3324-3339. doi:
10.2174/0113816128290636231129074039. [PMID: 38111115] - Sanjeeb Mohapatra, Daniel Snow, Patrick Shea, Andy Gálvez-Rodríguez, Manish Kumar, Lokesh P Padhye, Suparna Mukherji. Photodegradation of a mixture of five pharmaceuticals commonly found in wastewater: Experimental and computational analysis.
Environmental research.
2023 01; 216(Pt 3):114659. doi:
10.1016/j.envres.2022.114659. [PMID: 36328221] - Sana Zahoor, Sadia Sheraz, Dilawar Farhan Shams, Gauhar Rehman, Saira Nayab, Muhammad Ishaq Ali Shah, Muhammad Ateeq, Said Karim Shah, Tanveer Ahmad, Sulaiman Shams, Waliullah Khan. Biosynthesis and Anti-inflammatory Activity of Zinc Oxide Nanoparticles Using Leaf Extract of Senecio chrysanthemoides.
BioMed research international.
2023; 2023(?):3280708. doi:
10.1155/2023/3280708. [PMID: 37082193] - L Ponce-Robles, L Benelhadj, A J García-García, F Pedrero-Salcedo, P A Nortes-Tortosa, J Albacete, J J Alarcón. Risk assessment for uptake and accumulation of pharmaceuticals by baby leaf lettuce irrigated with reclaimed water under commercial agricultural activities.
Journal of environmental management.
2022 Dec; 324(?):116321. doi:
10.1016/j.jenvman.2022.116321. [PMID: 36179471] - Mai M Anwar, Ibrahim M Ibrahim Laila. Mitigative effect of caffeine against diclofenac-induced hepato-renal damage and chromosomal aberrations in male albino rats.
BMC complementary medicine and therapies.
2022 Dec; 22(1):327. doi:
10.1186/s12906-022-03802-y. [PMID: 36482339] - Bin Wu, Duo Xu, Hao Wang, Runyu Xu, Naibing Qin, Jinlong Han. Wetland plant-derived biochar enhances the diclofenac treatment performance in vertical subsurface flow constructed wetlands.
Environmental research.
2022 12; 215(Pt 1):114326. doi:
10.1016/j.envres.2022.114326. [PMID: 36113575] - Mariana N Miranda, Ana R Lado Ribeiro, Adrián M T Silva, M Fernando R Pereira. Can aged microplastics be transport vectors for organic micropollutants? - Sorption and phytotoxicity tests.
The Science of the total environment.
2022 Dec; 850(?):158073. doi:
10.1016/j.scitotenv.2022.158073. [PMID: 35981591] - Han Bi Ji, Jae Young Hong, Cho Rim Kim, Chang Hee Min, Jae Hoon Han, Min Ji Kim, Se-Na Kim, Cheol Lee, Young Bin Choy. Microchannel-embedded implantable device with fibrosis suppression for prolonged controlled drug delivery.
Drug delivery.
2022 Dec; 29(1):489-498. doi:
10.1080/10717544.2022.2032873. [PMID: 35147052] - Aneta Kalvodová, Jarmila Zbytovská. Lipid nanocapsules enhance the transdermal delivery of drugs regardless of their physico-chemical properties.
International journal of pharmaceutics.
2022 Nov; 628(?):122264. doi:
10.1016/j.ijpharm.2022.122264. [PMID: 36209979] - Chun Shu, Fang Yang, Fubing Zhu, Dongping Hua. Effect of external use of Qingluo San on clinical efficacy in patients with acute gouty arthritis.
European journal of medical research.
2022 Nov; 27(1):245. doi:
10.1186/s40001-022-00872-z. [PMID: 36369177] - Atchara Paemanee, Siriluk Rattanabunyong, Yanisa Ketngamkum, Jeeraprapa Siriwaseree, Ponkanok Pongpamorn, Kanokwan Romyanon, Sithichoke Tangphatsornruang, Buabarn Kuaprasert, Kiattawee Choowongkomon. Mass spectrometry and synchrotron-FTIR microspectroscopy reveal the anti-inflammatory activity of Bua Bok extracts.
Phytochemical analysis : PCA.
2022 Oct; 33(7):1086-1098. doi:
10.1002/pca.3161. [PMID: 35790045] - Eveen Al-Shalabi, Samah Abusulieh, Alaa M Hammad, Suhair Sunoqrot. Rhoifolin loaded in PLGA nanoparticles alleviates oxidative stress and inflammation in vitro and in vivo.
Biomaterials science.
2022 Sep; 10(19):5504-5519. doi:
10.1039/d2bm00309k. [PMID: 35920694] - Saeed Ali Alsareii, Abdulrahman Manaa Alamri, Mansour Yousef AlAsmari, Mohammed A Bawahab, Mater H Mahnashi, Ibrahim Ahmed Shaikh, Arun K Shettar, Joy H Hoskeri, Vijay Kumbar. Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity.
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196306. [PMID: 36234841] - Inés Aguilar-Romero, Pieter van Dillewijn, Joseph Nesme, Søren J Sørensen, Rogelio Nogales, Laura Delgado-Moreno, Esperanza Romero. A novel and affordable bioaugmentation strategy with microbial extracts to accelerate the biodegradation of emerging contaminants in different media.
The Science of the total environment.
2022 Aug; 834(?):155234. doi:
10.1016/j.scitotenv.2022.155234. [PMID: 35427621] - Manjula M Venkatappa, Chikkappa Udagani, Sujatha M Hanumegowda, Siddanakoppalu N Pramod, Shivakumar Venkataramaiah, Rajesh Rangappa, Rajeshwara Achur, Abed Alataway, Ahmed Z Dewidar, Mohamed Al-Yafrsi, Eman A Mahmoud, Hosam O Elansary, Devaraja Sannaningaiah. Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis.
Molecules (Basel, Switzerland).
2022 Aug; 27(16):. doi:
10.3390/molecules27165162. [PMID: 36014400] - Lulu Wang, Minjie Liu, Meifen Jiang, Li Wan, Weijian Li, Dang Cheng, Fener Chen. Six-Step Continuous Flow Synthesis of Diclofenac Sodium via Cascade Etherification/Smiles Rearrangement Strategy: Tackling the Issues of Batch Processing.
Chemistry (Weinheim an der Bergstrasse, Germany).
2022 Aug; 28(45):e202202097. doi:
10.1002/chem.202202097. [PMID: 35880653] - Mohammed Alorabi, Simona Cavalu, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Gomaa Mostafa-Hedeab, Walaa A Negm, Amal Youssef, Aya H El-Kadem, Hebatallah M Saad, Gaber El-Saber Batiha. Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Aug; 152(?):113225. doi:
10.1016/j.biopha.2022.113225. [PMID: 35671584] - Jian-Feng Tu, Ying Cao, Li-Qiong Wang, Guang-Xia Shi, Lian-Cheng Jia, Bao-Li Liu, Wei-Hai Yao, Xiao-Lu Pei, Yan Cao, He-Wen Li, Shi-Yan Yan, Jing-Wen Yang, Zhi-Cheng Qu, Cun-Zhi Liu. Effect of Adjunctive Acupuncture on Pain Relief Among Emergency Department Patients With Acute Renal Colic Due to Urolithiasis: A Randomized Clinical Trial.
JAMA network open.
2022 08; 5(8):e2225735. doi:
10.1001/jamanetworkopen.2022.25735. [PMID: 35943743] - Nina Mertz, Frederik Bock, Jesper Østergaard, Anan Yaghmur, Susan Weng Larsen. Investigation of diclofenac release and dynamic structural behavior of non-lamellar liquid crystal formulations during in situ formation by UV-Vis imaging and SAXS.
International journal of pharmaceutics.
2022 Jul; 623(?):121880. doi:
10.1016/j.ijpharm.2022.121880. [PMID: 35661744] - Wang Wen-Yue, Xu Ying-Peng, Ding Quan-Mao, Xie Li-Min, Wang De-Zhi, Bai Yang, Wang Li-Su, Li Yu-Bin, Niu Zhi-Jun, Ma Yan-Xu, Chen Wu-Zhong, Bai Li-Qun, Liu Yang, Jin Li-Kun. A randomized, parallel control and multicenter clinical trial of evidence-based traditional Chinese medicine massage treatment VS External Diclofenac Diethylamine Emulgel for the treatment of knee osteoarthritis.
Trials.
2022 Jul; 23(1):555. doi:
10.1186/s13063-022-06388-5. [PMID: 35804406] - Abdullah, Mir Azam Khan, Waqar Ahmad, Manzoor Ahmad, Achyut Adhikari, Muhammad Ibrar, Maqsood Ur Rehman, Muhammad Asif. Antioxidant, antinociceptive, anti-inflammatory, and hepatoprotective activities of pentacyclic triterpenes isolated from Ziziphus oxyphylla Edgew.
Drug and chemical toxicology.
2022 Jul; 45(4):1796-1807. doi:
10.1080/01480545.2021.1880427. [PMID: 33557649] - Temitayo Ajibade, Akinleye Akinrinde, Moses Adetona, Ademola Oyagbemi, Aduragbenro Adedapo, Christopher Larbie, Temidayo Omobowale, Olufunke Ola-Davies, Adebowale Saba, Adeolu Adedapo, Oluwafemi Oguntibeju, Momoh Yakubu. Luteolin normalizes blood pressure via its antioxidant activity and down-regulation of renal Angiotensin II receptor and Mineralocorticoid receptor expressions in rats co-exposed to Diclofenac and sodium fluoride.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2022 Jun; 37(1):35-42. doi:
10.54548/njps.v37i1.5. [PMID: 35947836] - David Banji, Otilia J F Banji, Shaik Rashida, Saeed Alshahrani, Saad S Alqahtani. Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model.
Journal of ethnopharmacology.
2022 Jun; 292(?):115200. doi:
10.1016/j.jep.2022.115200. [PMID: 35306043] - Mohammed M Mehanna, Kawthar K Abla, Souraya Domiati, Hoda Elmaradny. Superiority of microemulsion-based hydrogel for non-steroidal anti-inflammatory drug transdermal delivery: a comparative safety and anti-nociceptive efficacy study.
International journal of pharmaceutics.
2022 Jun; 622(?):121830. doi:
10.1016/j.ijpharm.2022.121830. [PMID: 35589005] - Qiuying Zhang, Hui Liu, Dongmei Wu, Hongyan Yu, Kun Wang, Weijie Jiao, Xu Zhao. Methysticin Acts as a Mechanism-Based Inactivator of Cytochrome P450 2C9.
Chemical research in toxicology.
2022 06; 35(6):1117-1124. doi:
10.1021/acs.chemrestox.2c00098. [PMID: 35583123] - Hassan Salhab, James Barker. Development and Validation of an HPLC-UV Method for the Quantification of 4'-Hydroxydiclofenac Using Salicylic Acid: Future Applications for Measurement of In Vitro Drug-Drug Interaction in Rat Liver Microsomes.
Molecules (Basel, Switzerland).
2022 Jun; 27(11):. doi:
10.3390/molecules27113587. [PMID: 35684519] - José Adson Andrade de Carvalho Filho, Hedmun Matias da Cruz, Bruna Soares Fernandes, Fabrício Motteran, Anderson Luiz Ribeiro de Paiva, Jaime Joaquim da Silva Pereira Cabral. Efficiency of the bank filtration technique for diclofenac removal: A review.
Environmental pollution (Barking, Essex : 1987).
2022 May; 300(?):118916. doi:
10.1016/j.envpol.2022.118916. [PMID: 35104558] - Fatma Abd El-Fattah Ragab, Yassin Mohammed Nissan, M Alaraby Salem, Mamdouh Moawad Ali, Ahmed Abbass Mohamed Abdelrahman Selim. Non-ulcerogenic pyrazolyl 2-hydroxychalcones and pyrazolylpyrazolines derived from naturally existing furochromone (khellin): semi-synthesis, docking study and anti-inflammatory activity.
Natural product research.
2022 May; 36(10):2486-2494. doi:
10.1080/14786419.2021.1907383. [PMID: 33813964] - Elisabeta Ioana Chera, Tiberia Ioana Pop, Raluca Maria Pop, Marcel Pârvu, Ana Uifălean, Florinela Adriana Cătoi, Andra Diana Cecan, Camelia Manuela Mîrza, Patriciu Achimaș-Cadariu, Alina Elena Pârvu. Flaxseed Ethanol Extract Effect in Acute Experimental Inflammation.
Medicina (Kaunas, Lithuania).
2022 Apr; 58(5):. doi:
10.3390/medicina58050582. [PMID: 35629999] - Walaa H El-Maadawy, Marwa Hassan, Rabab M Abdou, Riham S El-Dine, Tarek Aboushousha, Nebal D El-Tanbouly, Aly M El-Sayed. 6-Paradol alleviates Diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR and NLRP3 inflammasome pathways.
Environmental toxicology and pharmacology.
2022 Apr; 91(?):103817. doi:
10.1016/j.etap.2022.103817. [PMID: 35091105] - Ratana Leksomboon, Kamonrot Kumpangnil, Kanjana Pangjit, Latiporn Udomsuk. The Effects of Ibuprofen, Naproxen and Diclofenac on cell Apoptosis, Cell Proliferation and Histology Changes in Human Cholangiocarcinoma Cell Lines.
Asian Pacific journal of cancer prevention : APJCP.
2022 Apr; 23(4):1351-1358. doi:
10.31557/apjcp.2022.23.4.1351. [PMID: 35485696] - Marie Rhodin, Pia Haubro Andersen, Karin Holm Forsström, Carl Ekstrand. In vivo joint synovial fluid disposition of a novel sustained-release formulation of diclofenac and hyaluronic acid in horses.
Journal of veterinary pharmacology and therapeutics.
2022 Mar; 45(2):167-176. doi:
10.1111/jvp.13033. [PMID: 34862600] - Jie Wang, Wen Wen, Daoyin Gong, Qi Chen, Ping Li, Panwang Liu, Fushun Wang, Shijun Xu. SZAP exerts analgesic effects on rheumatalgia in CIA rats by suppressing pain hyperalgesia and inhibiting TRPV1 and P2X3.
Journal of ethnopharmacology.
2022 Feb; 284(?):114780. doi:
10.1016/j.jep.2021.114780. [PMID: 34728318] - Xiaokang Li, Jinwen Li, Yunyuan Huang, Qi Gong, Yan Fu, Yixiang Xu, Junyang Huang, Haolan You, Dong Zhang, Dan Zhang, Fei Mao, Jin Zhu, Huan Wang, Haiyan Zhang, Jian Li. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
European journal of medicinal chemistry.
2022 Feb; 229(?):114045. doi:
10.1016/j.ejmech.2021.114045. [PMID: 34922191] - Dhrisya Chenthamara, Sankar Ganesh Ramakrishnan, Ameer Khusro, Sadhasivam Subramaniam, Saad Alghamdi, Mazen Almehmadi, Ahmed Kabrah, Muhammad Umar Khayam Sahibzada, Aziz Eftekhari. Diclofenac biotransformation and toxicity assessment of laccase from Pleurotus floridanus.
Cellular and molecular biology (Noisy-le-Grand, France).
2022 Feb; 67(5):439-450. doi:
10.14715/cmb/2021.67.5.56. [PMID: 35818224] - Xiaoyi Xu, Zhimin He, Hui Tang, Yidong Sun, Shuyuan Zhang, Dezhi Shi, Fangying Ji. Removal of diclofenac and oxytetracycline from synthetic urine by furfuryl alcohol-derived mesoporous carbon.
Chemosphere.
2022 Feb; 288(Pt 1):132317. doi:
10.1016/j.chemosphere.2021.132317. [PMID: 34582931] - Shaimaa Mohamed Abdelfattah Hassan, Moutasem Salih Aboonq, Emad A Albadawi, Yasmeen Aljehani, Hytham Mahmoud Abdel-Latif, Reham A Mariah, Noha M Shafik, Tamer M Soliman, Abdelhady Ragab Abdel-Gawad, Faten M Omran, Wafaa A Abdellah, Ahmed Shehata, Husam Shahada, Hussam H Baghdadi, Hanan Yousef Aly, Alfarazdeg Saad, Manal Mohamed Helmy Nabo, Abdullah Almilaibary, Heba M Eltahir, Salah Mohamed El Sayed, Mustafa A M Abu-Elnaga, Yasser M Elbastawisy. The Preventive and Therapeutic Effects of Ajwa Date Fruit Extract Against Acute Diclofenac Toxicity-Induced Colopathy: An Experimental Study.
Drug design, development and therapy.
2022; 16(?):2601-2616. doi:
10.2147/dddt.s344247. [PMID: 35965961] - Wenxiao Jiang, Yijun Zhang, Ye Huang, Yunfeng Cheng. Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis.
Journal of healthcare engineering.
2022; 2022(?):1979892. doi:
10.1155/2022/1979892. [PMID: 35399859] - Shatha Hussein Kadhim, Amal Umran Mosa, Moayad Mijbil Ubaid. Hepatorenal protective activity of Artemisia against diclofenac toxicity in male rats.
The Pan African medical journal.
2022; 43(?):192. doi:
10.11604/pamj.2022.43.192.36160. [PMID: 36942132] - Narasamma Nippatlapalli, Kamaraj Ramakrishnan, Ligy Philip. Enhanced degradation of complex organic compounds in wastewater using different novel continuous flow non - Thermal pulsed corona plasma discharge reactors.
Environmental research.
2022 01; 203(?):111807. doi:
10.1016/j.envres.2021.111807. [PMID: 34400163] - Christopher A Jones, Fred K Hoehler, Valeria Frangione, Gilbert Ledesma, Paul P Wisman, Clarence Jones. Safety and Efficacy of the FLECTOR (Diclofenac Epolamine) Topical System in Children with Minor Soft Tissue Injuries: A Phase IV Non-randomized Clinical Trial.
Clinical drug investigation.
2022 Jan; 42(1):43-51. doi:
10.1007/s40261-021-01101-x. [PMID: 34826122] - Jafar Akbari, Majid Saeedi, Katayoun Morteza-Semnani, Seyyed Mohammad Hassan Hashemi, Amirhossein Babaei, Mohammad Eghbali, Mahsa Mohammadi, Seyyed Sohrab Rostamkalaei, Kofi Asare-Addo, Ali Nokhodchi. Innovative topical niosomal gel formulation containing diclofenac sodium (niofenac).
Journal of drug targeting.
2022 01; 30(1):108-117. doi:
10.1080/1061186x.2021.1941060. [PMID: 34116599] - Zarimah Mohd Hanafiah, Wan Hanna Melini Wan Mohtar, Teh Sabariah Binti Abd Manan, Nur Aina Bachi', Nor Azura Abdullah, Haris Hafizal Abd Hamid, Salmia Beddu, Nur Liyana Mohd Kamal, Amirrudin Ahmad, Nadiah Wan Rasdi. The occurrence of non-steroidal anti-inflammatory drugs (NSAIDs) in Malaysian urban domestic wastewater.
Chemosphere.
2022 Jan; 287(Pt 2):132134. doi:
10.1016/j.chemosphere.2021.132134. [PMID: 34517236] - Khaled Shalaby. Effect of Olive Oil Acidity on Skin Delivery of Diclofenac: In Vitro Evaluation and Ex Vivo Skin Permeability Studies.
Journal of biomedical nanotechnology.
2022 Jan; 18(1):234-242. doi:
10.1166/jbn.2022.3219. [PMID: 35180917] - Thanapon Chobpenthai, Patcharapol Arunwatthanangkul, Wiriya Mahikul. Efficacy of Cabbage Leaf versus Cooling Gel Pad or Diclofenac Gel for Patients with Knee Osteoarthritis: A Randomized Open-Labeled Controlled Clinical Trial.
Pain research & management.
2022; 2022(?):3122153. doi:
10.1155/2022/3122153. [PMID: 35719197] - Rofida Wahman, Catarina Cruzeiro, Johanna Graßmann, Peter Schröder, Thomas Letzel. The changes in Lemna minor metabolomic profile: A response to diclofenac incubation.
Chemosphere.
2022 Jan; 287(Pt 1):132078. doi:
10.1016/j.chemosphere.2021.132078. [PMID: 34523431] - Wonseok Lee, Hyun Young Kim, You-Jin Choi, Seung-Hwan Jung, Yoon Ah Nam, Yunfan Zhang, Sung Ho Yun, Tong-Shin Chang, Byung-Hoon Lee. SNX10-mediated degradation of LAMP2A by NSAIDs inhibits chaperone-mediated autophagy and induces hepatic lipid accumulation.
Theranostics.
2022; 12(5):2351-2369. doi:
10.7150/thno.70692. [PMID: 35265214] - Chinaka Nwaehujor. Ficus vogelii methanol leaf extract ameliorates inflammation and arthritis by modulating osmotic fragility in C57BL/6J mice.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2021 Dec; 36(2):221-226. doi:
10.54548/njps.v36i2.11. [PMID: 35947731] - Han Ju, N Arul Murugan, Lingxin Hou, Ping Li, Laura Guizzo, Ying Zhang, Chiara Bertagnin, Xiujie Kong, Dongwei Kang, Ruifang Jia, Xiuli Ma, Ruikun Du, Vasanthanathan Poongavanam, Arianna Loregian, Bing Huang, Xinyong Liu, Peng Zhan. Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Journal of medicinal chemistry.
2021 12; 64(24):17992-18009. doi:
10.1021/acs.jmedchem.1c01366. [PMID: 34735766] - Mohamed Aboubakr, Afaf Abdelkader, Ola A Habotta, Nisreen Adel, Mahmoud A Emam, Ehab Y Abdelhiee, Obeid Shanab, Khaled Shoghy, Heba Elnoury, Mohamed M Soliman, Samah F Ibrahim, Ahmed Abdeen. Cefepime and diclofenac sodium combined treatment-potentiated multiple organ injury: Role of oxidative damage and disrupted lipid metabolism.
Journal of biochemical and molecular toxicology.
2021 Dec; 35(12):e22929. doi:
10.1002/jbt.22929. [PMID: 34676623] - Keisuke Okamoto, Hinata Ueda, Yoshitaka Saito, Katsuya Narumi, Ayako Furugen, Masaki Kobayashi. Diclofenac potentiates the antitumor effect of cisplatin in a xenograft mouse model transplanted with cisplatin-resistant cells without enhancing cisplatin-induced nephrotoxicity.
Drug metabolism and pharmacokinetics.
2021 Dec; 41(?):100417. doi:
10.1016/j.dmpk.2021.100417. [PMID: 34619549] - Daniela Ailincai, Maricel Agop, Ioana Cristina Marinas, Andrei Zala, Stefan Andrei Irimiciuc, Lucian Dobreci, Tudor-Cristian Petrescu, Constantin Volovat. Theoretical model for the diclofenac release from PEGylated chitosan hydrogels.
Drug delivery.
2021 Dec; 28(1):261-271. doi:
10.1080/10717544.2021.1876181. [PMID: 33501878] - Efraím A Serna-Galvis, John F Guateque-Londoño, Javier Silva-Agredo, Jazmín Porras, Yenny Ávila-Torres, Ricardo A Torres-Palma. Superior selectivity of high-frequency ultrasound toward chorine containing-pharmaceuticals elimination in urine: A comparative study with other oxidation processes through the elucidation of the degradation pathways.
Ultrasonics sonochemistry.
2021 Dec; 80(?):105814. doi:
10.1016/j.ultsonch.2021.105814. [PMID: 34763213] - Agnieszka Najda, Aarti Bains, Prince Chawla, Anil Kumar, Sebastian Balant, Magdalena Walasek-Janusz, Dariusz Wach, Ravinder Kaushik. Assessment of Anti-Inflammatory and Antimicrobial Potential of Ethanolic Extract of Woodfordia fruticosa Flowers: GC-MS Analysis.
Molecules (Basel, Switzerland).
2021 Nov; 26(23):. doi:
10.3390/molecules26237193. [PMID: 34885782] - Georges St Laurent, Ian Toma, Bernd Seilheimer, Konstantin Cesnulevicius, Myron Schultz, Michael Tackett, Jianhua Zhou, Maxim Ri, Dmitry Shtokalo, Denis Antonets, Tisha Jepson, Timothy A McCaffrey. RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model.
BMC genomics.
2021 Nov; 22(1):854. doi:
10.1186/s12864-021-08083-2. [PMID: 34823472] - Burhan Fatih Kocyigit, Ahmet Akyol. Reactive arthritis after COVID-19: a case-based review.
Rheumatology international.
2021 Nov; 41(11):2031-2039. doi:
10.1007/s00296-021-04998-x. [PMID: 34550429] - Bruno Sousa, Jorge Lopes, André Leal, Maria Martins, Cristiano Soares, Manuel Azenha, Fernanda Fidalgo, Jorge Teixeira. Specific glutathione-S-transferases ensure an efficient detoxification of diclofenac in Solanum lycopersicum L. plants.
Plant physiology and biochemistry : PPB.
2021 Nov; 168(?):263-271. doi:
10.1016/j.plaphy.2021.10.019. [PMID: 34666279] - Barbara Pawłowska, Arkadiusz Telesiński, Robert Biczak. Effect of diclofenac and naproxen and their mixture on spring barley seedlings and Heterocypris incongruens.
Environmental toxicology and pharmacology.
2021 Nov; 88(?):103746. doi:
10.1016/j.etap.2021.103746. [PMID: 34536620] - Chuanxi Sun, Shuqian Lin, Zhen Li, Huazheng Liu, Yixin Liu, Keke Wang, Tianyi Zhu, Guiming Li, Bin Yin, Renzhong Wan. iTRAQ-based quantitative proteomic analysis reveals the toxic mechanism of diclofenac sodium on the kidney of broiler chicken.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2021 Nov; 249(?):109129. doi:
10.1016/j.cbpc.2021.109129. [PMID: 34229076] - Bo Hu, Shanshan Hu, Jan Vymazal, Zhongbing Chen. Arbuscular mycorrhizal symbiosis in constructed wetlands with different substrates: Effects on the phytoremediation of ibuprofen and diclofenac.
Journal of environmental management.
2021 Oct; 296(?):113217. doi:
10.1016/j.jenvman.2021.113217. [PMID: 34246029] - Sibonokuhle F Ncube, Lyndy J McGaw, Emmanuel Mfotie Njoya, Hilton G T Ndagurwa, Peter J Mundy, Samson Sibanda. In vitro antioxidant activity of crude extracts of Harpagophytum zeyheri and their anti-inflammatory and cytotoxicity activity compared with diclofenac.
BMC complementary medicine and therapies.
2021 Sep; 21(1):238. doi:
10.1186/s12906-021-03407-x. [PMID: 34556115] - Rosa Ventura-Martínez, Myrna Déciga-Campos, Araceli Bustamante-Marquina, Guadalupe Esther Ángeles-López, José Aviles-Herrera, Maria Eva González-Trujano, Gabriel Navarrete-Vázquez. Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats.
The Journal of pharmacy and pharmacology.
2021 Sep; 73(10):1310-1318. doi:
10.1093/jpp/rgab093. [PMID: 34223630] - Vivian Rodriguez-Cruz, Tianjing Ren, Marilyn E Morris. Drug-drug interaction between diclofenac and gamma-hydroxybutyric acid.
Biopharmaceutics & drug disposition.
2021 Sep; 42(8):351-358. doi:
10.1002/bdd.2296. [PMID: 34191301] - Jerine Peter Simon, Sabina Evan Prince. Ameliorative activity of aqueous leaf extract from Madhuca longifolia against diclofenac-administered toxicity on rat stomach and intestine.
Journal of histotechnology.
2021 09; 44(3):114-126. doi:
10.1080/01478885.2020.1861917. [PMID: 33656414]