Exact Mass: 295.0167
Exact Mass Matches: 295.0167
Found 203 metabolites which its exact mass value is equals to given mass value 295.0167,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Diclofenac
Diclofenac is only found in individuals that have used or taken this drug. It is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. [PubChem]The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation. CONFIDENCE standard compound; INTERNAL_ID 186; ORIGINAL_ACQUISITION_NO 4640; ORIGINAL_PRECURSOR_SCAN_NO 4636; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0 CONFIDENCE standard compound; INTERNAL_ID 186; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9659; ORIGINAL_PRECURSOR_SCAN_NO 9657 CONFIDENCE standard compound; INTERNAL_ID 186; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9639; ORIGINAL_PRECURSOR_SCAN_NO 9636 CONFIDENCE standard compound; INTERNAL_ID 186; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4656; ORIGINAL_PRECURSOR_SCAN_NO 4654 CONFIDENCE standard compound; INTERNAL_ID 186; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4640; ORIGINAL_PRECURSOR_SCAN_NO 4636 M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor CONFIDENCE standard compound; EAWAG_UCHEM_ID 201 CONFIDENCE standard compound; INTERNAL_ID 4093 CONFIDENCE standard compound; INTERNAL_ID 2346 CONFIDENCE standard compound; INTERNAL_ID 8569 CONFIDENCE standard compound; INTERNAL_ID 1147 D000893 - Anti-Inflammatory Agents KEIO_ID D128; [MS2] KO008928 D004791 - Enzyme Inhibitors D - Dermatologicals KEIO_ID D128
N4-Acetylsulfamethoxazole
N4-Acetylsulfamethoxazole is a metabolite of the sulfonamide bacteriostatic antibiotic sulfamethoxazole. Sulfamethoxazole is metabolized via acetylation catalyzed by liver extramitochondrial N-acetyl transferases. Acetylsulfamethoxazole is excreted in urine. Acetylsulfamethoxazole and sulfamethoxazole can be used as a probe for the molecular percentage enrichment of liver extramitochondrial acetyl-CoA. N4-Acetylsulfamethoxazole can be used as a reference for measuring sulfamethoxazole impurities and waste determination (PMID: 15307787). It is one of the critical aspects of urine and stone analysis (PMID: 3811034) and its quantitative determination in body fluids could be performed by reversed-phase high-performance liquid chromatography, a rapid, precise and simple procedure (PMID: 6668314). It is also reported the renal excretion rate of the metabolite N4-acetylsulfamethoxazole is not dependent on the urinary pH (PMID: 670346). N4-Acetylsulfamethoxazole is only found in individuals who have consumed the drug sulfamethoxazole. D000890 - Anti-Infective Agents > D013424 - Sulfanilamides CONFIDENCE standard compound; EAWAG_UCHEM_ID 299
Meclofenamic acid
Meclofenamic acid is only found in individuals that have used or taken this drug. It is a non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. [PubChem]The mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. Therapeutic action does not result from pituitary-adrenal stimulation. In animal studies, meclofenamic acid was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site. In vitro meclofenamic acid was found to be an inhibitor of human leukocyte 5-lipoxygenase activity. These properties may be responsible for the anti-inflammatory action of meclofenamic acid. There is no evidence that meclofenamic acid alters the course of the underlying disease. M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AG - Fenamates D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor CONFIDENCE standard compound; EAWAG_UCHEM_ID 3690 D000893 - Anti-Inflammatory Agents D004791 - Enzyme Inhibitors
5-Aminoimidazole ribonucleotide
5-aminoimidazole ribonucleotide (AIR), is an intermediate of purine nucleotide biosynthesis. It is also the precursor to 4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP), the first product of pyrimidine biosynthesis. This reaction is mediated by the enzyme HMP-P kinase (ThiD). HMP is a precursor of thiamine phosphate (TMP), and subsequently to thiamine pyrophosphate (TPP). TPP is an essential cofactor in all living systems that plays a central role in metabolism. (PMID: 15326535). 5-Aminoimidazole ribonucleotide is a substrate for a number of proteins including: Scaffold attachment factor B2, Multifunctional protein ADE2, Pulmonary surfactant-associated protein B, Tumor necrosis factor receptor superfamily member 25, Pulmonary surfactant-associated protein C, Serine/threonine-protein kinase Chk1, Vinexin, Trifunctional purine biosynthetic protein adenosine-3, Antileukoproteinase 1 and Scaffold attachment factor B. 5-aminoimidazole ribonucleotide (AIR), is an intermediate of purine nucleotide biosynthesis. It is also the precursor to 4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP), the first product of pyrimidine biosynthesis. This reaction is mediated by the enzyme HMP-P kinase (ThiD). HMP is a precursor of thiamine phosphate (TMP), and subsequently to thiamine pyrophosphate (TPP). TPP is an essential cofactor in all living systems that plays a central role in metabolism. (PMID: 15326535) COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
5-amino-1-(5-phosphonato-D-ribosyl)imidazol-3-ium
5-amino-1-(5-phosphonato-D-ribosyl)imidazol-3-ium is considered to be soluble (in water) and acidic
2-(4-Chlorophenyl)-1H-pyrazolo[4,3-c]quinolin-3-one
N(1)-Acetylsulfamethoxazole
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
3-(2-Chlorophenyl)-2-(1,3-dithian-2-yliden)-3-oxopropanenitrile
5-hydroxy-2-methyl-pyrano[2,3:5,6]chromeno[3,4-c]pyridine-4,8-dione|Schumanniophytin|Schumanniophytine
8-(2-aminoethyl)-1,1-dioxo-2,3,4,6-tetrahydropyrrolo[2,3-g][1,4]benzothiazine-5,9-dione
Acetylsulfamethoxazole
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides CONFIDENCE standard compound; INTERNAL_ID 2672 CONFIDENCE standard compound; INTERNAL_ID 8589 CONFIDENCE standard compound; INTERNAL_ID 4117 CONFIDENCE standard compound; INTERNAL_ID 2014
diclofenac
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor D000893 - Anti-Inflammatory Agents D004791 - Enzyme Inhibitors D - Dermatologicals
meclofenamic acid
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AG - Fenamates D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor D000893 - Anti-Inflammatory Agents D004791 - Enzyme Inhibitors
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-Quinoline-3-carboxylic acid
METHYL 2-[BENZENESULFONYLIMINO]-3,3,3-TRIFLUOROPROPIONATE
3-AMINO-4-(ISOPROPYLSULFONYL)-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLIC ACID
Ethyl 2-(2-bromo-1-methyl-1H-indol-3-yl)acetate
(BENZENESULFONYL-FURAN-2-YLMETHYL-AMINO)-ACETIC ACID
3-[5-(4-bromophenyl)-1,2-oxazol-3-yl]propanoic acid
ethyl 6-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylate
ethyl 1-(5-bromopyridin-2-yl)pyrazole-4-carboxylate
N-(2-NITROBENZENESULFONYL)-1,3-DIAMINOPROPANE HYDROCHLORIDE
7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE
3-[5-(4-bromophenyl)-1,3-oxazol-2-yl]propanoic acid
4-((4-Chlorophenyl)sulfonyl)piperidine hydrochloride
2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE
2-(3-BROMO-2,2-DIMETHYLPROPYL)ISOINDOLINE-1,3-DIONE
3-AMINO-3-[5-(3-CHLORO-4-METHOXYPHENYL)-FURAN-2-YL]-PROPIONIC ACID
methyl 5-chloro-7-(trifluoromethyl)thieno[3,2-b]pyridine-3-carboxylate
3-(2-BROMO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
(4-(N-(4-Fluorophenyl)sulfamoyl)phenyl)boronic acid
N,N-bis(2-chloroethyl)-3-phenylpropan-1-amine hydrochloride
N-[2-(3-BROMO-PHENYL)-ETHYL]-2,2,2-TRIFLUORO-ACETAMIDE
Methyl 5-bromo-8-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylate
3-(4-CHLOROPHENYL)-3-(2,2,2-TRIFLUOROACETAMIDO)PROPANOIC ACID
4-Diazo-3,4-dihydro-7-nitro-3-oxo-1-naphthalenesulfonic acid
4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine
3-(TRIFLUOROMETHYL)-1-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOL-5-AMINE
2-[2-(4-bromophenyl)propan-2-yl]-4,4-dimethyl-5H-1,3-oxazole
3-Quinolinecarboxylic acid, 7-bromo-3,4-dihydro-4-oxo-, ethyl ester
ETHYL5-CHLORO-1-(2-NITROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
ETHYL5-CHLORO-1-(4-NITROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
(5-OXO-5-PHENYL-PENTYL)-CARBAMICACIDTERT-BUTYLESTER
dimethyl 7-chloro-4-oxo-1H-quinoline-2,3-dicarboxylate
4-(N-Acetylacetamido)benzenesulfonate potassium salt
ETHYL5-BROMO-1-(PYRIDIN-2-YL)-1H-PYRAZOLE-4-CARBOXYLATE
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate
4-chloro-6,7-dimethoxy-quinoline-3-carboxylic acid ethyl ester
1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
4-(4,6-DICHLORO-5-(2-CHLOROETHYL)PYRIMIDIN-2-YL)MORPHOLINE
4-ALLYL-5-(4-BROMOPHENYL)-4H-1,2,4-TRIAZOLE-3-THIOL
1-(4-bromo-2-fluorophenyl)-2,5-dimethylpyrrole-3-carbaldehyde
Methyl 1-(5-chloro-3-fluoropyridin-2-yl)-5-cyclopropyl-1H-pyrazole-4-carboxylate
ETHYL 5-HYDROXY-8-METHYL-2-(METHYLTHIO)-7-OXO-7,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE-6-CARBOXYLATE
(S)-N-(1-(4-bromophenyl)ethyl)-2,2,2-trifluoroacetamide
ETHYL 6-BROMO-2-OXO-1,2-DIHYDROQUINOLINE-4-CARBOXYLATE
methyl (E)-3-(2-chloro-6-fluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)prop-2-enoate
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol
Methyl 4-chloro-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate
5-(5,6-dichloro-1H-indol-2-yl)furan-2-carboxylic acid
ETHYL 7-BROMO-2-OXO-1,2-DIHYDROQUINOLINE-4-CARBOXYLATE
6-bromospiro[1,3-dihydroquinazoline-2,4-piperidine]-4-one
2-BENZYL-7-BROMO-6-METHOXY-2-AZABICYCLO[2.2.1]HEPTANE
methyl 4-(4-pyridin-4-ylphenyl)thiophene-2-carboxylate
1-(4-BROMOBENZYL)-5-METHYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID
8-nitronaphth[1,2-d][1,2,3]oxadiazole-5-sulphonic acid
(R)-2-((2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL)AMINO)-3-METHYLBUTANOIC ACID
ethyl 3-(2-chloro-4-nitrophenylaMino)-2-cyanoacrylate
2,4-dichloro-N-(2,6-dimethylphenyl)pyrimidine-5-carboxamide
5-[(2-chlorophenyl)methyl]thieno[3,2-c]pyridin-5-ium,chloride
5-(3-BROMO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
2-AMINO-4-(3-CHLORO-PHENYL)-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
ETHYL 7-BROMO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
3,6-Diamino-10-methylacridinium chloride hydrochloride
4-amino-N-(4-methoxyphenyl)-2-(methylthio)-5-thiazolecarboxamide
N-[2-[(4-chlorophenyl)methylsulfanyl]ethyl]furan-2-carboxamide
aspulvinone E(1-)
An organic anion that is the conjugate base of aspulvinone E, arising from selective deprotonation of the butenolide OH group; major species at pH 7.3.
7-[(2S)-2-amino-2-carboxylatoethyl]-5-hydroxy-2H-1,4-benzothiazine-3-carboxylate
8-[(2S)-2-amino-2-carboxylatoethyl]-5-hydroxy-2H-1,4-benzothiazine-3-carboxylate
6-Chloro-7-hydroxy-4-(morpholin-4-ylmethyl)chromen-2-one
5-Cyclopropyl-4-[(3,4-dichlorophenyl)hydrazinylidene]-3-pyrazolamine
4-Tert-butyl-2-[(5-nitro-2-pyridinyl)thio]thiazole
N-[(4-chlorophenyl)-oxomethyl]-2-methyl-4-thiazolecarbohydrazide
5-[(3-nitro-2-pyridinyl)thio]-N-prop-2-enyl-1,3,4-thiadiazol-2-amine
N-[2-chloro-6-(trifluoromethoxy)phenyl]-2,2-dimethylpropanamide
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methyl-4-pyrazolesulfonamide
3-[1-(3,5-Dichlorophenyl)-5-tetrazolyl]-5-methylisoxazole
2-Phenyl-5-(trifluoromethyl)-1,2-benzothiazol-3-one
1-[3-(4-Chlorophenyl)-5-(methylthio)-1,2,4-triazol-1-yl]-1-butanone
1-(2,6-Dichlorophenyl)-3-(6-methyl-3-pyridinyl)urea
2-(2-methoxyethylthio)-N-(1,3,4-thiadiazol-2-yl)benzamide
4-(3,4-dimethoxybenzylidene)-2-(methylthio)-1,3-thiazol-5(4H)-one
5-Aminoimidazole ribonucleotide
COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
N-acetylsulfamethoxazole
A sulfonamide compound having a 4-acetamidophenyl group attached to the sulfur atom and a 1,2-oxazol-3-yl group attached to the nitrogen atom.
isoaspulvinone E(1-)
An organic anion that is the conjugate base of isoaspulvinone E, arising from selective deprotonation of the butenolide OH group; major species at pH 7.3.
5-Amino-1-(5-phospho-beta-D-ribosyl)imidazole
A 1-(phosphoribosyl)imidazole that is 5-aminoimidazole in which the proton at position 1 has been replaced by a 5-phospho-beta-D-ribofuranosyl group.
5-HT2B antagonist-1
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease[1][2].
