bupropion (BioDeep_00000405772)
Main id: BioDeep_00000001443
代谢物信息卡片
bupropion
化学式: C13H18ClNO (239.1077)
中文名称: 安非他酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C
InChI: InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3
描述信息
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065690 - Cytochrome P-450 CYP2D6 Inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators
D000077444 - Smoking Cessation Agents
Bupropion is a selective catecholamine (norepinephrine and dopamine) reuptake inhibitor. It has only a small effect on serotonin reuptake. It does not inhibit MAO. The antidepressant effect of bupropion is considered to be mediated by its dopaminergic and noradrenergic action. Bupropion has also been shown to act as a competitive alpha-3-beta-4- nicotinic antagonist, the alpha-3-beta-4-antagonism has been shown to interrupt addiction in studies of other drugs such as ibogaine. This alpha-3-beta-4-antagonism correlates quite well with the observed effect of interrupting addiction.; A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment; Bupropion is a selective catecholamine (norepinephrine and dopamine) reuptake inhibitor. It has only a small effect on serotonin reuptake. It does not inhibit MAO. The antidepressant effect of bupropion is considered to be mediated by its dopaminergic and noradrenergic action. Bupropion has also been shown to act as a competitive alpha-3-beta-4-nicotinic antagonist, the alpha-3-beta-4-antagonism has been shown to interrupt addiction in studies of other drugs such as ibogaine. This alpha-3-beta-4-antagonism correlates quite well with the observed effect of interrupting addiction. Bupropion (amfebutamone) (brand names Wellbutrin and Zyban) is an antidepressant of the aminoketone class, chemically unrelated to tricyclics or selective serotonin reuptake inhibitors (SSRIs). It is similar in structure to the stimulant cathinone, and to phenethylamines in general. It is a chemical derivative of diethylpropion, an amphetamine-like substance used as an anorectic. Bupropion is both a dopamine reuptake inhibitor and a norepinephrine reuptake inhibitor. It is often used as a smoking cessation aid. [HMDB]. Bupropion is found in many foods, some of which are cardoon, mung bean, salmonberry, and climbing bean.
同义名列表
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:3219
- KEGG: C06860
- KEGGdrug: D07591
- PubChem: 444
- DrugBank: DB01156
- ChEMBL: CHEMBL894
- MeSH: Bupropion
- foodb: FDB022664
- CAS: 34841-39-9
- CAS: 34911-55-2
- MoNA: MoNA037593
- MoNA: MoNA033314
- MoNA: MoNA033312
- MoNA: MoNA033311
- MoNA: WA001617
- MoNA: WA001616
- MoNA: WA001615
- MoNA: WA001614
- MoNA: WA001613
- MoNA: FiehnHILIC002622
- MoNA: FiehnHILIC001807
- MoNA: FiehnHILIC000233
- PubChem: 9078
- NIKKAJI: J32.840E
- RefMet: Bupropion
- KNApSAcK: 3219
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mengjia Ji, Junfei Feng, Guirong Liu. Efficacy and safety of aripiprazole or bupropion augmentation and switching in patients with treatment-resistant depression or major depressive disorder: A systematic review and meta-analysis of randomized controlled trials.
PloS one.
2024; 19(4):e0299020. doi:
10.1371/journal.pone.0299020. [PMID: 38669232] - Yi Hu, Periyannan Velu, Pejman Rohani, Mohammad Hassan Sohouli. Changes in lipid profile and glucose metabolism following administration of bupropion alone or in combination with naltrexone: A systematic review and meta-regression analysis.
European journal of clinical investigation.
2023 Nov; ?(?):e14122. doi:
10.1111/eci.14122. [PMID: 37929909] - Konstantinos Stefanakis, Alexander Kokkinos, Georgia Argyrakopoulou, Sofia K Konstantinidou, Stamatia Simati, Matina Kouvari, Ajay Kumar, Bhanu Kalra, Melina Kumar, Nikolaos Bontozoglou, Konstantina Kyriakopoulou, Christos S Mantzoros. Circulating levels of proglucagon-derived peptides are differentially regulated by the glucagon-like peptide-1 agonist liraglutide and the centrally acting naltrexone/bupropion and can predict future weight loss and metabolic improvements: A 6-month long interventional study.
Diabetes, obesity & metabolism.
2023 09; 25(9):2561-2574. doi:
10.1111/dom.15141. [PMID: 37246799] - Seenae Eum, Franklin Sayre, Adam M Lee, Julia C Stingl, Jeffrey R Bishop. Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis.
Pharmacotherapy.
2022 01; 42(1):34-44. doi:
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Journal of pharmacokinetics and pharmacodynamics.
2021 12; 48(6):893-908. doi:
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Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
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Pharmacology, biochemistry, and behavior.
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2020 10; 8(5):e00649. doi:
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The Journal of emergency medicine.
2020 07; 59(1):e33. doi:
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Reproductive biology.
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Clinical toxicology (Philadelphia, Pa.).
2018 Jan; 56(1):51-54. doi:
10.1080/15563650.2017.1337909. [PMID: 28644682] - Shuanghu Wang, Yanwen Dong, Ke Su, Jing Zhang, Linyi Wang, Anyue Han, Congcong Wen, Xianqin Wang, Yan He. Effect of codeine on CYP450 isoform activity of rats.
Pharmaceutical biology.
2017 Dec; 55(1):1223-1227. doi:
10.1080/13880209.2017.1297466. [PMID: 28253826] - Mark B Sobell, Alan L Peterson, Linda Carter Sobell, Antoinette Brundige, Christopher M Hunter, Christine M Hunter, Jeffrey L Goodie, Sangeeta Agrawal, Ann S Hrysko-Mullen, William C Isler. Reducing alcohol consumption to minimize weight gain and facilitate smoking cessation among military beneficiaries.
Addictive behaviors.
2017 12; 75(?):145-151. doi:
10.1016/j.addbeh.2017.06.018. [PMID: 28734154] - Manish K Jha, Abu Minhajuddin, Bharathi S Gadad, Tracy L Greer, Taryn L Mayes, Madhukar H Trivedi. Interleukin 17 selectively predicts better outcomes with bupropion-SSRI combination: Novel T cell biomarker for antidepressant medication selection.
Brain, behavior, and immunity.
2017 Nov; 66(?):103-110. doi:
10.1016/j.bbi.2017.07.005. [PMID: 28698115] - Manish K Jha, Abu Minhajuddin, Bharathi S Gadad, Madhukar H Trivedi. Platelet-Derived Growth Factor as an Antidepressant Treatment Selection Biomarker: Higher Levels Selectively Predict Better Outcomes with Bupropion-SSRI Combination.
The international journal of neuropsychopharmacology.
2017 11; 20(11):919-927. doi:
10.1093/ijnp/pyx060. [PMID: 29016822] - Gregory Schmit, Evy De Boosere, Jessica Vanhaebost, Arnaud Capron. Bupropion Overdose Resulted in a Pharmacobezoar in a Fatal Bupropion (Wellbutrin® ) Sustained-release Overdose: Postmortem Distribution of Bupropion and its Major Metabolites.
Journal of forensic sciences.
2017 Nov; 62(6):1674-1676. doi:
10.1111/1556-4029.13497. [PMID: 28631318] - Jamie N Connarn, Stephanie Flowers, Marisa Kelly, Ruijuan Luo, Kristen M Ward, Gloria Harrington, Ila Moncion, Masoud Kamali, Melivin McInnis, Meihua R Feng, Vicki Ellingrod, Andrew Babiskin, Xinyuan Zhang, Duxin Sun. Pharmacokinetics and Pharmacogenomics of Bupropion in Three Different Formulations with Different Release Kinetics in Healthy Human Volunteers.
The AAPS journal.
2017 09; 19(5):1513-1522. doi:
10.1208/s12248-017-0102-8. [PMID: 28685396] - Abdelrahman R Shalabi, Donna Walther, Michael H Baumann, Richard A Glennon. Deconstructed Analogues of Bupropion Reveal Structural Requirements for Transporter Inhibition versus Substrate-Induced Neurotransmitter Release.
ACS chemical neuroscience.
2017 06; 8(6):1397-1403. doi:
10.1021/acschemneuro.7b00055. [PMID: 28220701] - Nan Hu, Yanjuan Huang, Xuejiao Gao, Sai Li, Zhixiang Yan, Bin Wei, Ru Yan. Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine.
Chemico-biological interactions.
2017 Jun; 271(?):48-58. doi:
10.1016/j.cbi.2017.04.018. [PMID: 28438436] - Tatiana N Nanovskaya, Cheryl Oncken, Valentina M Fokina, Richard S Feinn, Shannon M Clark, Holly West, Sunil K Jain, Mahmoud S Ahmed, Gary D V Hankins. Bupropion sustained release for pregnant smokers: a randomized, placebo-controlled trial.
American journal of obstetrics and gynecology.
2017 Apr; 216(4):420.e1-420.e9. doi:
10.1016/j.ajog.2016.11.1036. [PMID: 27890648] - Manish K Jha, Abu Minhajuddin, Bharathi S Gadad, Tracy Greer, Bruce Grannemann, Abigail Soyombo, Taryn L Mayes, A John Rush, Madhukar H Trivedi. Can C-reactive protein inform antidepressant medication selection in depressed outpatients? Findings from the CO-MED trial.
Psychoneuroendocrinology.
2017 04; 78(?):105-113. doi:
10.1016/j.psyneuen.2017.01.023. [PMID: 28187400] - Elham Ahmadian, Hossein Babaei, Alireza Mohajjel Nayebi, Aziz Eftekhari, Mohammad Ali Eghbal. Mechanistic Approach for Toxic Effects of Bupropion in Primary Rat Hepatocytes.
Drug research.
2017 Apr; 67(4):217-222. doi:
10.1055/s-0042-123034. [PMID: 28118671] - Priyanka A Singh, Kerry P Cassel, Ronald M Moscati, David Eckersley. Acute Generalized Erythrodermic Pustular Psoriasis Associated with Bupropion/Naltrexone (Contrave®).
The Journal of emergency medicine.
2017 Apr; 52(4):e111-e113. doi:
10.1016/j.jemermed.2016.11.034. [PMID: 28130024] - Nejal M Bhatt, Vijay D Chavada, Mallika Sanyal, Pranav S Shrivastav. Design of experiment assisted concurrent enantioseparation of bupropion and hydroxybupropion by high-performance thin-layer chromatography.
Chirality.
2017 Feb; 29(2):80-88. doi:
10.1002/chir.22673. [PMID: 28028832] - Cuong V Nguyen, Daniel D Miller. Serum sickness-like drug reaction: two cases with a neutrophilic urticarial pattern.
Journal of cutaneous pathology.
2017 Feb; 44(2):177-182. doi:
10.1111/cup.12863. [PMID: 27862184] - Jing-Ya Chen, Xiang-Tao Huang, Jun-Jun Wang, Yong Chen. In vivo effect of borneol on rat hepatic CYP2B expression and activity.
Chemico-biological interactions.
2017 Jan; 261(?):96-102. doi:
10.1016/j.cbi.2016.11.024. [PMID: 27889497] - Maria Bianca Abrudan, Dana Maria Muntean, Ana Maria Gheldiu, Maria Adriana Neag, Laurian Vlase. The Pharmacokinetic Interaction Study between Carvedilol and Bupropion in Rats.
Pharmacology.
2017; 99(3-4):139-143. doi:
10.1159/000453619. [PMID: 28052289] - Jamie N Connarn, Ruijuan Luo, Jim Windak, Xinyuan Zhang, Andrew Babiskin, Marisa Kelly, Gloria Harrington, Vicki L Ellingrod, Masoud Kamali, Melvin McInnis, Duxin Sun. Identification of non-reported bupropion metabolites in human plasma.
Biopharmaceutics & drug disposition.
2016 Dec; 37(9):550-560. doi:
10.1002/bdd.2046. [PMID: 27723114] - Valentina M Fokina, Meixiang Xu, Erik Rytting, Sherif Z Abdel-Rahman, Holly West, Cheryl Oncken, Shannon M Clark, Mahmoud S Ahmed, Gary D V Hankins, Tatiana N Nanovskaya. Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy.
Drug metabolism and disposition: the biological fate of chemicals.
2016 11; 44(11):1832-1838. doi:
10.1124/dmd.116.071530. [PMID: 27528039] - Pieter Beerepoot, Vincent M Lam, Ali Salahpour. Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells.
The Journal of biological chemistry.
2016 Oct; 291(42):22053-22062. doi:
10.1074/jbc.m116.749119. [PMID: 27555326] - Valentina M Fokina, Holly West, Cheryl Oncken, Shannon M Clark, Mahmoud S Ahmed, Gary D V Hankins, Tatiana N Nanovskaya. Bupropion therapy during pregnancy: the drug and its major metabolites in umbilical cord plasma and amniotic fluid.
American journal of obstetrics and gynecology.
2016 10; 215(4):497.e1-7. doi:
10.1016/j.ajog.2016.05.016. [PMID: 27180885] - Pirkko Kriikku, Ilkka Ojanperä. The relationship between bupropion and suicide in post-mortem investigations.
Forensic science international.
2016 Sep; 266(?):343-348. doi:
10.1016/j.forsciint.2016.06.026. [PMID: 27372438] - Jennifer E Sager, John R Choiniere, Justine Chang, Alyssa Stephenson-Famy, Wendel L Nelson, Nina Isoherranen. Identification and Structural Characterization of Three New Metabolites of Bupropion in Humans.
ACS medicinal chemistry letters.
2016 Aug; 7(8):791-6. doi:
10.1021/acsmedchemlett.6b00189. [PMID: 27660681] - Andrea R Masters, Brandon T Gufford, Jessica Bo Li Lu, Ingrid F Metzger, David R Jones, Zeruesenay Desta. Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers.
The Journal of pharmacology and experimental therapeutics.
2016 08; 358(2):230-8. doi:
10.1124/jpet.116.232876. [PMID: 27255113] - Aaron M Teitelbaum, Alicia M Flaker, Evan D Kharasch. Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Aug; 1027(?):239-53. doi:
10.1016/j.jchromb.2016.05.036. [PMID: 27318149] - Sung-Joon Cho, Sang-Bum Kim, Hyun-Jong Cho, Saeho Chong, Suk-Jae Chung, Il-Mo Kang, Jangik Ike Lee, In-Soo Yoon, Dae-Duk Kim. Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet.
Journal of agricultural and food chemistry.
2016 Jul; 64(27):5598-606. doi:
10.1021/acs.jafc.6b01663. [PMID: 27321734] - B Jiang, Y He, F Zuo, L Wu, Q H Liu, L Zhang, C X Zhou, J J Cheng, Z S Chan Sc, D Q Lam. [Effectiveness of bupropion and counseling for smoking cessation].
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].
2016 Jul; 50(7):640-4. doi:
10.3760/cma.j.issn.0253-9624.2016.07.015. [PMID: 27412843] - Larissa J Mooney, Maureen P Hillhouse, Christie Thomas, Alfonso Ang, Gaurav Sharma, Garth Terry, Linda Chang, Robrina Walker, Madhukar Trivedi, David Croteau, Steven Sparenborg, Walter Ling. Utilizing a Two-stage Design to Investigate the Safety and Potential Efficacy of Monthly Naltrexone Plus Once-daily Bupropion as a Treatment for Methamphetamine Use Disorder.
Journal of addiction medicine.
2016 Jul; 10(4):236-43. doi:
10.1097/adm.0000000000000218. [PMID: 27379819] - Jaleh Varshosaz, Mohsen Minaiyan, Mohammad Reza Zaki, Milad Fathi, Hossein Jaleh. In vitro/in vivo evaluation of agar nanospheres for pulmonary delivery of bupropion HCl.
Drug delivery.
2016 Jul; 23(6):1948-54. doi:
10.3109/10717544.2015.1025314. [PMID: 25835223] - Sonika Batra, Ravi Bhushan. Resolution of enantiomers of bupropion and its metabolites by liquid chromatography.
Biomedical chromatography : BMC.
2016 May; 30(5):670-82. doi:
10.1002/bmc.3572. [PMID: 26230937] - Scott J Leischow, Myra L Muramoto, Eva Matthews, Lysbeth L Floden, Rachel A Grana. Adolescent Smoking Cessation With Bupropion: The Role of Adherence.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.
2016 May; 18(5):1202-5. doi:
10.1093/ntr/ntv179. [PMID: 26567274] - Stacey C Sigmon, Mollie E Miller, Andrew C Meyer, Kathryn Saulsgiver, Gary J Badger, Sarah H Heil, Stephen T Higgins. Financial incentives to promote extended smoking abstinence in opioid-maintained patients: a randomized trial.
Addiction (Abingdon, England).
2016 May; 111(5):903-12. doi:
10.1111/add.13264. [PMID: 26638126] - Lawrence V Fulton, Robert A Fabich, Jeevan Bhatta, Brandon Fletcher, Kirby Leininger, Kevin Lienesch, Thais A Rodriguez, Jennifer L Coyner, Arthur D Johnson, Joseph O'Sullivan. Comparison of Resuscitative Protocols for Bupropion Overdose Using Lipid Emulsion in a Swine Model.
Military medicine.
2016 05; 181(5):482-7. doi:
10.7205/milmed-d-15-00218. [PMID: 27136657] - Thomas I F H Cremers, Gunnar Flik, Joost H A Folgering, Hans Rollema, Robert E Stratford. Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations.
Drug metabolism and disposition: the biological fate of chemicals.
2016 May; 44(5):624-33. doi:
10.1124/dmd.115.068932. [PMID: 26916207] - Brandon T Gufford, Jessica Bo Li Lu, Ingrid F Metzger, David R Jones, Zeruesenay Desta. Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo.
Drug metabolism and disposition: the biological fate of chemicals.
2016 Apr; 44(4):544-53. doi:
10.1124/dmd.115.068908. [PMID: 26802129] - Aaron M Teitelbaum, Alicia M Flaker, Evan D Kharasch. Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Apr; 1017-1018(?):101-113. doi:
10.1016/j.jchromb.2016.02.032. [PMID: 26963497] - Ioana Todor, Adina Popa, Maria Neag, Dana Muntean, Corina Bocsan, Anca Buzoianu, Laurian Vlase, Ana-Maria Gheldiu, Corina Briciu. Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2016 Apr; 19(2):198-207. doi:
10.18433/j3h03r. [PMID: 27518170] - Andrea R Masters, Michael McCoy, David R Jones, Zeruesenay Desta. Stereoselective method to quantify bupropion and its three major metabolites, hydroxybupropion, erythro-dihydrobupropion, and threo-dihydrobupropion using HPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Mar; 1015-1016(?):201-208. doi:
10.1016/j.jchromb.2016.02.018. [PMID: 26946423] - Melissa A Little, Jon O Ebbert. The safety of treatments for tobacco use disorder.
Expert opinion on drug safety.
2016; 15(3):333-41. doi:
10.1517/14740338.2016.1131817. [PMID: 26715118] - Andrea E Steuer, Corina Schmidhauser, Eva H Tingelhoff, Yasmin Schmid, Anna Rickli, Thomas Kraemer, Matthias E Liechti. Impact of Cytochrome P450 2D6 Function on the Chiral Blood Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine (MDMA) and Its Phase I and II Metabolites in Humans.
PloS one.
2016; 11(3):e0150955. doi:
10.1371/journal.pone.0150955. [PMID: 26967321] - Ana-Maria Gheldiu, Adina Popa, Maria Neag, Dana Muntean, Corina Bocsan, Anca Buzoianu, Laurian Vlase, Ioan Tomuta, Corina Briciu. Assessment of a Potential Pharmacokinetic Interaction between Nebivolol and Bupropion in Healthy Volunteers.
Pharmacology.
2016; 98(3-4):190-8. doi:
10.1159/000447266. [PMID: 27300331] - S R Khan, R T Berendt, C D Ellison, A B Ciavarella, E Asafu-Adjaye, M A Khan, P J Faustino. Bupropion Hydrochloride.
Profiles of drug substances, excipients, and related methodology.
2016; 41(?):1-30. doi:
10.1016/bs.podrm.2015.12.001. [PMID: 26940167] - Eric L Singman, Brian Hocum, Jithin Yohannan, Virginia Pearson. Fluvoxamine-associated oscillopsia and a role for personalized medication dosing.
Drug metabolism and personalized therapy.
2015 Dec; 30(4):271-5. doi:
10.1515/dmpt-2015-0006. [PMID: 26351962] - Gudrun Høiseth, Tore Haslemo, Linda H Uthus, Espen Molden. Effect of CYP2B6*6 on Steady-State Serum Concentrations of Bupropion and Hydroxybupropion in Psychiatric Patients: A Study Based on Therapeutic Drug Monitoring Data.
Therapeutic drug monitoring.
2015 Oct; 37(5):589-93. doi:
10.1097/ftd.0000000000000183. [PMID: 25565674] - Marilia Martins Cavariani, Luiz Ricardo de Almeida Kiguti, Josiane de Lima Rosa, Gabriel Adan de Araújo Leite, Patrícia Villela E Silva, André Sampaio Pupo, Wilma De Grava Kempinas. Bupropion treatment increases epididymal contractility and impairs sperm quality with no effects on the epididymal sperm transit time of male rats.
Journal of applied toxicology : JAT.
2015 Sep; 35(9):1007-16. doi:
10.1002/jat.3089. [PMID: 25645087] - Ewa Poleszak, Aleksandra Szopa, Elżbieta Wyska, Sylwia Wośko, Anna Serefko, Aleksandra Wlaź, Mateusz Pieróg, Andrzej Wróbel, Piotr Wlaź. The influence of caffeine on the activity of moclobemide, venlafaxine, bupropion and milnacipran in the forced swim test in mice.
Life sciences.
2015 Sep; 136(?):13-8. doi:
10.1016/j.lfs.2015.06.008. [PMID: 26135623]
