Penicillin G (BioDeep_00000404044)
Main id: BioDeep_00000002209
natural product Chemicals and Drugs
代谢物信息卡片
Penicillin-G
化学式: C16H18N2O4S (334.0987228)
中文名称: 青霉素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c(c3)ccc(c3)CC(=O)NC(C(=O)1)C([H])(S2)N1C(C(O)=O)C(C)(C)2
InChI: InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CE - Beta-lactamase sensitive penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AA - Antibiotics
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
2 个代谢物同义名
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:18208
- KEGG: C05551
- KEGGdrug: D02336
- PubChem: 5904
- DrugBank: DB01053
- ChEMBL: CHEMBL29
- MeSH: Penicillin G
- CAS: 61-33-6
- MoNA: CCMSLIB00005724005
- MoNA: WA002375
- MoNA: WA002374
- MoNA: WA002373
- MoNA: WA002372
- MoNA: WA002371
- MoNA: CCMSLIB00003739952
- PubChem: 7885
- PDB-CCD: PNN
- 3DMET: B01871
- NIKKAJI: J2.342F
- RefMet: Penicillin G
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 1901 Streptomyces clavuligerus: 10.1128/JB.175.3.623-629.1993
- 5076 Penicillium chrysogenum:
- 5046 Sarocladium strictum: 10.1039/C39850001808
- 1901 Streptomyces clavuligerus: 10.1128/JB.175.3.623-629.1993
- 5076 Penicillium chrysogenum:
- 5046 Sarocladium strictum: 10.1039/C39850001808
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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The Pediatric infectious disease journal.
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Journal of biochemical and molecular toxicology.
2022 Apr; 36(4):e22983. doi:
10.1002/jbt.22983. [PMID: 35019195] - Sophie J Jansen, Enrico Lopriore, Robbert G M Bredius, Martha T van der Beek, Dirk J A R Moes, Vincent Bekker. Benzylpenicillin Serum Concentrations in Neonates With Group B Streptococci Sepsis or Meningitis: A Descriptive Cohort Study.
The Pediatric infectious disease journal.
2021 05; 40(5):434-439. doi:
10.1097/inf.0000000000002993. [PMID: 33181784] - Shengzhi Yang, Yan Huang, Caiwu Li, Lei Jin, Wenwen Deng, Siyue Zhao, Daifu Wu, Yongguo He, Bei Li, Zhongliang Yu, Ti Li, Zhizhong Zhang, Xin Pan, Hemin Zhang, Likou Zou. The Fecal and Serum Metabolomics of Giant Pandas Based on Untargeted Metabolomics.
Zoological science.
2021 Apr; 38(2):179-186. doi:
10.2108/zs200106. [PMID: 33812357] - Georges Azar, Benjamin Wolff, Stéphane Azam, Martine Mauget-Faÿsse. Acute syphilitic posterior placoid chorioretinopathy presenting as atypical multiple evanescent white dot syndrome.
European journal of ophthalmology.
2021 Mar; 31(2):NP141-NP144. doi:
10.1177/1120672120957589. [PMID: 32878455] - Tanya Duke-Novakovski, Carolina Palacios Jimenez, Masako Fujiyama, Shannon G Beazley. Plasma histamine concentrations in horses administered sodium penicillin, guaifenesin-xylazine-ketamine and isoflurane with morphine or butorphanol.
Veterinary anaesthesia and analgesia.
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Amyotrophic lateral sclerosis & frontotemporal degeneration.
2020 11; 21(7-8):584-592. doi:
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Ocular immunology and inflammation.
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2019 02; 30(2):194-197. doi:
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Chemotherapy.
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PloS one.
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Asian journal of pharmaceutical sciences.
2018 Nov; 13(6):555-565. doi:
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2018 Oct; 24(10):812-814. doi:
10.1016/j.jiac.2018.06.008. [PMID: 30006248] - Elke Abbeloos, Satu Pyörälä, Päivi Rajala-Schultz, Vesa Myllys. Determination of the intramammary dose of benzylpenicillin required to maintain an adequate concentration in the milk to inhibit Gram-positive bacteria in the clinically normal udder for 24 hr.
Journal of veterinary pharmacology and therapeutics.
2018 Oct; 41(5):691-698. doi:
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
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Antimicrobial agents and chemotherapy.
2018 01; 62(1):. doi:
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Medicinal chemistry (Shariqah (United Arab Emirates)).
2018; 14(4):372-386. doi:
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Bioorganic & medicinal chemistry letters.
2017 11; 27(22):4943-4951. doi:
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Pakistan journal of pharmaceutical sciences.
2017 Nov; 30(6(Supplementary)):2349-2354. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Sep; 107(Pt A):74-87. doi:
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Bioorganic & medicinal chemistry letters.
2017 08; 27(15):3370-3373. doi:
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Antimicrobial agents and chemotherapy.
2017 08; 61(8):. doi:
10.1128/aac.00252-17. [PMID: 28559267] - Lütfiye Öksüz, Nezahat Gürler. [Serotype distribution and antibiotic resistance of Streptococcus pneumoniae strains isolated from the adult patients in a Turkish üniversity hospital].
Mikrobiyoloji bulteni.
2017 Jul; 51(3):195-208. doi:
10.5578/mb.48638. [PMID: 28929957] - Yodit Ayele, Fanta Desissa Gutema, Bedaso Mamo Edao, Robel Girma, Takele Beyene Tufa, Tariku Jibat Beyene, Fanos Tadesse, Mesula Geloye, Ashenafi Feyisa Beyi. Assessment of Staphylococcus aureus along milk value chain and its public health importance in Sebeta, central Oromia, Ethiopia.
BMC microbiology.
2017 06; 17(1):141. doi:
10.1186/s12866-017-1048-9. [PMID: 28655298] - Sumathy Mathialagan, Mary A Piotrowski, David A Tess, Bo Feng, John Litchfield, Manthena V Varma. Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach.
Drug metabolism and disposition: the biological fate of chemicals.
2017 04; 45(4):409-417. doi:
10.1124/dmd.116.074294. [PMID: 28179375] - Weilin L Shelver, Shubhashis Chakrabarty, David J Smith. Comparison of Lateral Flow Assay, Kidney Inhibition Swab, and Liquid Chromatography-Tandem Mass Spectrometry for the Detection of Penicillin G Residues in Sow Urine.
Journal of agricultural and food chemistry.
2017 Mar; 65(8):1778-1783. doi:
10.1021/acs.jafc.6b05049. [PMID: 28205436] - Kristina Öbrink-Hansen, Henrik Wiggers, Bo Martin Bibby, Tore Forsingdal Hardlei, Kaare Jensen, Marianne Kragh Thomsen, Birgitte Brock, Eskild Petersen. Penicillin G Treatment in Infective Endocarditis Patients - Does Standard Dosing Result in Therapeutic Plasma Concentrations?.
Basic & clinical pharmacology & toxicology.
2017 Feb; 120(2):179-186. doi:
10.1111/bcpt.12661. [PMID: 27565458] - Kazuto Tsukita, Akihiro Shimotake, Mitsuyoshi Nakatani, Yukitoshi Takahashi, Akio Ikeda, Ryosuke Takahashi. A case of neurosyphilis presenting with limbic encephalitis.
Rinsho shinkeigaku = Clinical neurology.
2017 01; 57(1):37-40. doi:
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American journal of veterinary research.
2017 Jan; 78(1):17-26. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2016 12; 44(12):1925-1933. doi:
10.1124/dmd.116.071472. [PMID: 27638508] - Noémie Scornet, Sandrine Delarue-Cochin, Marie Eliane Azoury, Maxime Le Mignon, Julie-Anne Chemelle, Emmanuel Nony, Bernard Maillère, Raphaël Terreux, Marc Pallardy, Delphine Joseph. Bioinspired Design and Oriented Synthesis of Immunogenic Site-Specifically Penicilloylated Peptides.
Bioconjugate chemistry.
2016 Nov; 27(11):2629-2645. doi:
10.1021/acs.bioconjchem.6b00393. [PMID: 27552359] - Yuanxiang Jin, Yan Wu, Zhaoyang Zeng, Cuiyuan Jin, Sisheng Wu, Yueyi Wang, Zhengwei Fu. From the Cover: Exposure to Oral Antibiotics Induces Gut Microbiota Dysbiosis Associated with Lipid Metabolism Dysfunction and Low-Grade Inflammation in Mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2016 11; 154(1):140-152. doi:
10.1093/toxsci/kfw150. [PMID: 27503388] - Yongming Jia, Zhihao Liu, Changyuan Wang, Qiang Meng, Xiaokui Huo, Qi Liu, Huijun Sun, Pengyuan Sun, Xiaobo Yang, Xiaodong Ma, Kexin Liu. P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate.
Toxicology and applied pharmacology.
2016 09; 306(?):27-35. doi:
10.1016/j.taap.2016.06.030. [PMID: 27377006] - Fadi Aldeek, Daniele Canzani, Matthew Standland, Mark R Crosswhite, Walter Hammack, Ghislain Gerard, Jo-Marie Cook. Identification of Penicillin G Metabolites under Various Environmental Conditions Using UHPLC-MS/MS.
Journal of agricultural and food chemistry.
2016 Aug; 64(31):6100-7. doi:
10.1021/acs.jafc.5b06150. [PMID: 26906275] - Jing-Sheng Cheng, Yan Zhao, Bin Qiao, Hua Lu, Yao Chen, Ying-Jin Yuan. Comprehensive Profiling of Proteome Changes Provide Insights of Industrial Penicillium chrysogenum During Pilot and Industrial Penicillin G Fermentation.
Applied biochemistry and biotechnology.
2016 Jul; 179(5):788-804. doi:
10.1007/s12010-016-2031-x. [PMID: 26961188] - Tara V Nelson, Sonela Blaceri, Jason I Biederman. Rhabdomyolysis and acute renal failure with syphilitic myositis.
Kidney international.
2016 May; 89(5):1169. doi:
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Antimicrobial agents and chemotherapy.
2016 Apr; 60(4):2043-51. doi:
10.1128/aac.00149-15. [PMID: 26787702] - Xiaoxi Lu, Ting Chan, Chenghao Xu, Ling Zhu, Qi Tony Zhou, Kade D Roberts, Hak-Kim Chan, Jian Li, Fanfan Zhou. Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins.
The Journal of antimicrobial chemotherapy.
2016 Feb; 71(2):403-12. doi:
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PloS one.
2016; 11(6):e0157576. doi:
10.1371/journal.pone.0157576. [PMID: 27300692] - An Jin, Wen-Ming Wu, Heng-Yi Yu, Ming Zhou, Ye Liu, Tian Tian, Han-Li Ruan. Bisabolane-Type Sesquiterpenoids from the Whole Plant of Parasenecio rubescens.
Journal of natural products.
2015 Aug; 78(8):2057-66. doi:
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Journal of agricultural and food chemistry.
2015 Jul; 63(26):5993-6000. doi:
10.1021/acs.jafc.5b02030. [PMID: 26072945] - Han Li, Bing Xu, Danqi Wang, Yin Zhou, Hongling Zhang, Wei Xia, Shunqing Xu, Yuanyuan Li. Immunosensor for trace penicillin G detection in milk based on supported bilayer lipid membrane modified with gold nanoparticles.
Journal of biotechnology.
2015 Jun; 203(?):97-103. doi:
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Journal of pharmaceutical and biomedical analysis.
2015 Mar; 106(?):186-96. doi:
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BMJ case reports.
2015 Mar; 2015(?):. doi:
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Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2015 Mar; 21(3):218-23. doi:
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Neuroscience.
2015 Jan; 284(?):349-359. doi:
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Internal medicine (Tokyo, Japan).
2015; 54(21):2769-73. doi:
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Antimicrobial agents and chemotherapy.
2014 Aug; 58(8):4495-503. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Aug; 59(?):94-103. doi:
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BMJ case reports.
2014 Jul; 2014(?):. doi:
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Journal of immunological methods.
2014 Apr; 406(?):43-50. doi:
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Journal of pharmaceutical and biomedical analysis.
2014 Apr; 92(?):98-104. doi:
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Journal of natural products.
2014 Mar; 77(3):521-6. doi:
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European journal of medicinal chemistry.
2014 Mar; 75(?):438-47. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Feb; 52(?):41-7. doi:
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Medicina clinica.
2013 Oct; 141(7):e13. doi:
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