quinolinic acid (BioDeep_00000400045)

Main id: BioDeep_00000001638

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


2,3-Pyridinedicarboxylic acid

化学式: C7H5NO4 (167.0219)
中文名称: 吡啶-2,3-二羧酸, 2,3-吡啶二甲酸, 喹啉酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(N=C1)C(=O)O)C(=O)O
InChI: InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)

描述信息

A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
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SARS
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2].
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2].

同义名列表

5 个代谢物同义名

2,3-Pyridinedicarboxylic acid; quinolinic acid; "PYRIDINE-2,3-DICARBOXYLATE"; Quinolinate; Quinolinic acid



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ACMSD, BDNF, CNTF, GFAP, GRIN2B, HAAO, IDO1, KYNU, NFE2L2, PTGS2, PVALB, QPRT, RBFOX3
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 2 GRIN2B, PTGS2
Nucleus 2 NFE2L2, RBFOX3
cytosol 8 ACMSD, GFAP, HAAO, IDO1, KMO, KYNU, NFE2L2, QPRT
dendrite 2 ADORA2A, BDNF
centrosome 1 NFE2L2
nucleoplasm 2 KYNU, NFE2L2
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 4 ADORA2A, GRID1, GRIN2B, TNF
Multi-pass membrane protein 4 ADORA2A, GRID1, GRIN2B, KMO
Synapse 1 PVALB
cell surface 2 GRIN2B, TNF
glutamatergic synapse 2 ADORA2A, GRID1
Golgi apparatus 1 NFE2L2
Golgi membrane 1 INS
neuronal cell body 2 ADORA2A, TNF
presynaptic membrane 1 ADORA2A
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 4 HAAO, IDO1, KYNU, NFE2L2
Lysosome 1 GRIN2B
plasma membrane 6 ADORA2A, GRID1, GRIN2B, IFNLR1, NFE2L2, TNF
presynaptic active zone 1 ADORA2A
Membrane 6 ACMSD, ADORA2A, BDNF, GRIN2B, IFNLR1, KMO
axon 3 BDNF, CNTF, PVALB
caveola 1 PTGS2
extracellular exosome 2 GRID1, QPRT
endoplasmic reticulum 1 PTGS2
extracellular space 6 ARTN, BDNF, CNTF, INS, KMO, TNF
perinuclear region of cytoplasm 1 BDNF
mitochondrion 2 KMO, KYNU
protein-containing complex 1 PTGS2
Microsome membrane 1 PTGS2
postsynaptic density 1 GRIN2B
Single-pass type I membrane protein 1 IFNLR1
Secreted 3 ARTN, BDNF, INS
extracellular region 5 ARTN, BDNF, CNTF, INS, TNF
Mitochondrion outer membrane 1 KMO
mitochondrial outer membrane 1 KMO
astrocyte end-foot 1 GFAP
external side of plasma membrane 1 TNF
perikaryon 1 RBFOX3
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 3 ADORA2A, GRID1, GRIN2B
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 GRIN2B
axolemma 1 ADORA2A
GABA-ergic synapse 1 GRID1
intermediate filament 2 ADORA2A, GFAP
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 2 GRID1, GRIN2B
Late endosome 1 GRIN2B
neuron projection 2 GRIN2B, PTGS2
chromatin 1 NFE2L2
mediator complex 1 NFE2L2
stereocilium bundle 1 IDO1
cell projection 1 GFAP
phagocytic cup 1 TNF
cytoskeleton 1 GRIN2B
endosome lumen 1 INS
Cell projection, dendrite 1 GRIN2B
cell body 1 GFAP
intermediate filament cytoskeleton 1 GFAP
synaptic membrane 1 GRIN2B
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BDNF, INS, PTGS2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 2 GRID1, GRIN2B
protein-DNA complex 1 NFE2L2
NMDA selective glutamate receptor complex 1 GRIN2B
cytoplasmic side of lysosomal membrane 1 GFAP
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalytic complex 1 QPRT
asymmetric synapse 1 ADORA2A
smooth muscle contractile fiber 1 IDO1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Aurélie Hanin, Céline Chollet, Sophie Demeret, Lucas Di Meglio, Florence Castelli, Vincent Navarro. Metabolomic changes in adults with status epilepticus: A human case-control study. Epilepsia. 2024 Apr; 65(4):929-943. doi: 10.1111/epi.17899. [PMID: 38339978]
  • Roghayeh Rashidi, Maryam Akaberi, Aida Gholoobi, Hamed Ghazavi, Fatemeh Forouzanfar. Artemisia absinthium extract attenuates the quinolinic acid-induced cell injury in OLN-93 cells. Current drug discovery technologies. 2023 Mar; ?(?):. doi: 10.2174/1570163820666230330105331. [PMID: 36998142]
  • Xing Ge, Mingxuan Zheng, Minmin Hu, Xiaoli Fang, Deqin Geng, Sha Liu, Li Wang, Jun Zhang, Li Guan, Peng Zheng, Yuanyi Xie, Wei Pan, Menglu Zhou, Limian Zhou, Renxian Tang, Kuiyang Zheng, Yinghua Yu, Xu-Feng Huang. Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models. The Journal of clinical investigation. 2023 Feb; 133(4):. doi: 10.1172/jci154612. [PMID: 36787221]
  • Daniele Sanna, Angela Fadda. Role of the Hydroxyl Radical-Generating System in the Estimation of the Antioxidant Activity of Plant Extracts by Electron Paramagnetic Resonance (EPR). Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144560. [PMID: 35889433]
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  • Lihui Guo, Bernadette Schurink, Eva Roos, Esther J Nossent, Jan Willem Duitman, Alexander Pj Vlaar, Paul van der Valk, Frédéric M Vaz, Syun-Ru Yeh, Zachary Geeraerts, Annemiek Dijkhuis, Lonneke van Vught, Marianna Bugiani, René Lutter. Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19. The Journal of pathology. 2022 03; 256(3):256-261. doi: 10.1002/path.5842. [PMID: 34859884]
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  • Hirofumi Inoue, Takeshi Matsushige, Takashi Ichiyama, Alato Okuno, Osamu Takikawa, Shozo Tomonaga, Banu Anlar, Deniz Yüksel, Yasushi Otsuka, Fumitaka Kohno, Madoka Hoshide, Shouichi Ohga, Shunji Hasegawa. Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis. Journal of neuroimmunology. 2020 02; 339(?):577088. doi: 10.1016/j.jneuroim.2019.577088. [PMID: 31733567]
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  • Jana Vondroušová, Miloš Mikoška, Kamila Syslová, Adéla Böhmová, Hana Tejkalová, Lukáš Vacek, Petr Kodym, Daniel Krsek, Jiří Horáček. Monitoring of kynurenine pathway metabolites, neurotransmitters and their metabolites in blood plasma and brain tissue of individuals with latent toxoplasmosis. Journal of pharmaceutical and biomedical analysis. 2019 Jun; 170(?):139-152. doi: 10.1016/j.jpba.2019.03.039. [PMID: 30925271]
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