lipoamide (BioDeep_00000399999)
Main id: BioDeep_00000003137
natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds
代谢物信息卡片
化学式: C8H15NOS2 (205.05950199999998)
中文名称: 硫辛酰胺, DL-硫辛酰胺, (±)-α-硫辛酰胺
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 0.74%
分子结构信息
SMILES: C(CCC(=O)N)CC1CCSS1
InChI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10)
描述信息
A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of lipoic acid with ammonia.
同义名列表
数据库引用编号
38 个数据库交叉引用编号
- ChEBI: CHEBI:17460
- KEGG: C00248
- KEGGdrug: D92402
- KEGGdrug: D00048
- PubChem: 863
- ChEMBL: CHEMBL1403899
- LipidMAPS: LMFA08010006
- CAS: 3206-73-3
- CAS: 940-69-2
- MoNA: CCMSLIB00005464349
- MoNA: CCMSLIB00005720523
- MoNA: MoNA038646
- MoNA: MoNA038007
- MoNA: MoNA037277
- MoNA: MoNA036283
- MoNA: MoNA036282
- MoNA: MoNA036281
- MoNA: MoNA034422
- MoNA: MoNA034421
- MoNA: MoNA034420
- MoNA: MoNA032391
- MoNA: MoNA032389
- MoNA: MoNA032385
- MoNA: MoNA023887
- MoNA: MoNA023868
- MoNA: MoNA016893
- MoNA: FiehnHILIC002057
- MoNA: FiehnHILIC000485
- MoNA: HMDB0000962_ms_ms_1368
- MoNA: HMDB0000962_ms_ms_1366
- MoNA: HMDB0000962_ms_ms_1367
- MoNA: CCMSLIB00000578066
- MetaboLights: MTBLC17460
- PubChem: 3547
- NIKKAJI: J25.390A
- RefMet: Lipoamide
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-440
- KNApSAcK: 17460
分类词条
相关代谢途径
Reactome(7)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 - Homo sapiens:
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Jie Yang, Qingzheng Zhu, Feng Xu, Ming Yang, Hechao Du, Xiaoying Bian, Zhaoxin Lu, Yingjian Lu, Fengxia Lu. Genome Mining, Heterologous Expression, Antibacterial and Antioxidant Activities of Lipoamides and Amicoumacins from Compost-Associated Bacillus subtilis fmb60.
Molecules (Basel, Switzerland).
2021 Mar; 26(7):. doi:
10.3390/molecules26071892
. [PMID: 33810551] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
. [PMID: 31515284] - Can Peng, Xiaohan Jiang, Ying Xiao, Zhiping Yuan, Yanwen Mao, Yuanyuan Wang Wang, Yingying Zhang, Fan Zhang, Lei Tang, Bing Guo. [Alpha-lipoamide inhibits renal inflammation and collagen 4 production in diabetic rats and its mechanism].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2018 Jul; 34(7):617-622. doi:
. [PMID: 30381126]
- Gaia Novarino, Paul El-Fishawy, Hulya Kayserili, Nagwa A Meguid, Eric M Scott, Jana Schroth, Jennifer L Silhavy, Majdi Kara, Rehab O Khalil, Tawfeg Ben-Omran, A Gulhan Ercan-Sencicek, Adel F Hashish, Stephan J Sanders, Abha R Gupta, Hebatalla S Hashem, Dietrich Matern, Stacey Gabriel, Larry Sweetman, Yasmeen Rahimi, Robert A Harris, Matthew W State, Joseph G Gleeson. Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy.
Science (New York, N.Y.).
2012 Oct; 338(6105):394-7. doi:
10.1126/science.1224631
. [PMID: 22956686] - Alan K Lam, Pamuditha N Silva, Svetlana M Altamentova, Jonathan V Rocheleau. Quantitative imaging of electron transfer flavoprotein autofluorescence reveals the dynamics of lipid partitioning in living pancreatic islets.
Integrative biology : quantitative biosciences from nano to macro.
2012 Aug; 4(8):838-46. doi:
10.1039/c2ib20075a
. [PMID: 22733276] - Meiyi Zhou, Gang Lu, Chen Gao, Yibin Wang, Haipeng Sun. Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm).
The Journal of biological chemistry.
2012 Jul; 287(28):23397-406. doi:
10.1074/jbc.m112.351031
. [PMID: 22589535] - Philip J Saylor, Edward D Karoly, Matthew R Smith. Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2012 Jul; 18(13):3677-85. doi:
10.1158/1078-0432.ccr-11-3209
. [PMID: 22589396] - Ruchi Sharma, Mark J Sharrard, Daniel J Connolly, Santosh R Mordekar. Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency.
Developmental medicine and child neurology.
2012 May; 54(5):469-71. doi:
10.1111/j.1469-8749.2011.04108.x
. [PMID: 21895644] - Yue-Ping Wang, Man-Long Qi, Ting-Ting Li, Yun-Jing Zhao. Two novel mutations in the BCKDHB gene (R170H, Q346R) cause the classic form of maple syrup urine disease (MSUD).
Gene.
2012 Apr; 498(1):112-5. doi:
10.1016/j.gene.2012.01.082
. [PMID: 22326532] - Alessandra Folda, Anna Citta, Guido Scutari, Alberto Bindoli, Maria Pia Rigobello. Contrasting effects of selenite and tellurite on lipoamide dehydrogenase activity suggest a different biological behaviour of the two chalcogens.
Archives of biochemistry and biophysics.
2012 Jan; 517(1):30-6. doi:
10.1016/j.abb.2011.11.009
. [PMID: 22100759] - Patrick M Finnegan, Weihua Chen. Arsenic toxicity: the effects on plant metabolism.
Frontiers in physiology.
2012; 3(?):182. doi:
10.3389/fphys.2012.00182
. [PMID: 22685440] - Johannes A Mayr, Franz A Zimmermann, Christine Fauth, Christa Bergheim, David Meierhofer, Doris Radmayr, Johannes Zschocke, Johannes Koch, Wolfgang Sperl. Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation.
American journal of human genetics.
2011 Dec; 89(6):792-7. doi:
10.1016/j.ajhg.2011.11.011
. [PMID: 22152680] - Jill Casteel, Ján A Miernyk, Jay J Thelen. Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis.
Plant physiology and biochemistry : PPB.
2011 Nov; 49(11):1355-61. doi:
10.1016/j.plaphy.2011.07.001
. [PMID: 21798751] - Ekaterina A Savrasova, Aleksander D Kivero, Rustem S Shakulov, Nataliya V Stoynova. Use of the valine biosynthetic pathway to convert glucose into isobutanol.
Journal of industrial microbiology & biotechnology.
2011 Sep; 38(9):1287-94. doi:
10.1007/s10295-010-0907-2
. [PMID: 21161324] - Sanna Auer, Martin Nirschl, Matthias Schreiter, Inger Vikholm-Lundin. Detection of DNA hybridisation in a diluted serum matrix by surface plasmon resonance and film bulk acoustic resonators.
Analytical and bioanalytical chemistry.
2011 May; 400(5):1387-96. doi:
10.1007/s00216-011-4871-0
. [PMID: 21472364] - Vadim B Fedorov, Anna V Goropashnaya, Øivind Tøien, Nathan C Stewart, Celia Chang, Haifang Wang, Jun Yan, Louise C Showe, Michael K Showe, Brian M Barnes. Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus).
BMC genomics.
2011 03; 12(?):171. doi:
10.1186/1471-2164-12-171
. [PMID: 21453527] - Caroline Mescka, Tarsila Moraes, Andrea Rosa, Priscila Mazzola, Bruna Piccoli, Carlos Jacques, Giovana Dalazen, Juliana Coelho, Marcelo Cortes, Melaine Terra, Carmen Regla Vargas, Carlos S Dutra-Filho. In vivo neuroprotective effect of L-carnitine against oxidative stress in maple syrup urine disease.
Metabolic brain disease.
2011 Mar; 26(1):21-8. doi:
10.1007/s11011-011-9238-x
. [PMID: 21380499] - K E Boyle, J P Canham, L A Consitt, D Zheng, T R Koves, T P Gavin, D Holbert, P D Neufer, O Ilkayeva, D M Muoio, J A Houmard. A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.
The Journal of clinical endocrinology and metabolism.
2011 Mar; 96(3):775-81. doi:
10.1210/jc.2010-2253
. [PMID: 21190973] - Nicola Brunetti-Pierri, Brendan Lanpher, Ayelet Erez, Elitsa A Ananieva, Mohammad Islam, Juan C Marini, Qin Sun, Chunli Yu, Madhuri Hegde, Jun Li, R Max Wynn, David T Chuang, Susan Hutson, Brendan Lee. Phenylbutyrate therapy for maple syrup urine disease.
Human molecular genetics.
2011 Feb; 20(4):631-40. doi:
10.1093/hmg/ddq507
. [PMID: 21098507] - Matjaž Simončič, Tadeja Režen, Peter Juvan, Damjana Rozman, Gregor Fazarinc, Catherine Fievet, Bart Staels, Simon Horvat. Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle.
BMC genomics.
2011 Feb; 12(?):96. doi:
10.1186/1471-2164-12-96
. [PMID: 21291556] - Olav A Christophersen, Anna Haug. Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology.
Lipids in health and disease.
2011 Jan; 10(?):16. doi:
10.1186/1476-511x-10-16
. [PMID: 21247506] - Peng Chen, Qiu-Gang Ma, Cheng Ji, Jian-Yun Zhang, Li-Hong Zhao, Yong Zhang, Yong-Ze Jie. Dietary lipoic acid influences antioxidant capability and oxidative status of broilers.
International journal of molecular sciences.
2011; 12(12):8476-88. doi:
10.3390/ijms12128476
. [PMID: 22272085] - Hyung-Doo Park, Dong Hwan Lee, Yong Hee Hong, Dong Hee Kang, You Kyoung Lee, Junghan Song, Soo-Youn Lee, Jong-Won Kim, Chang-Seok Ki, Yong-Wha Lee. Three Korean patients with maple syrup urine disease: four novel mutations in the BCKDHA gene.
Annals of clinical and laboratory science.
2011; 41(2):167-73. doi:
. [PMID: 21844576]
- Jian Wang, Hongjing Liu, Guoqiang Chen, Sian Hsiang-Te Tsuei, Tingting Yu, Qihua Fu. Identification of two novel BCKDHA mutations in a Chinese patient with maple syrup urine disease.
Journal of pediatric endocrinology & metabolism : JPEM.
2011; 24(9-10):827-9. doi:
10.1515/jpem.2011.278
. [PMID: 22145486] - Wayne Chadwick, Randall Brenneman, Bronwen Martin, Stuart Maudsley. Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease.
International journal of Alzheimer's disease.
2010 Dec; 2010(?):604792. doi:
10.4061/2010/604792
. [PMID: 21151659] - Cheol Soo Choi, Pushpankur Ghoshal, Malathi Srinivasan, Sheene Kim, Gary Cline, Mulchand S Patel. Liver-specific pyruvate dehydrogenase complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin sensitivity.
Lipids.
2010 Nov; 45(11):987-95. doi:
10.1007/s11745-010-3470-8
. [PMID: 20835892] - Weihua Chen, Yingjun Chi, Nicolas L Taylor, Hans Lambers, Patrick M Finnegan. Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis.
Plant physiology.
2010 Jul; 153(3):1385-97. doi:
10.1104/pp.110.153452
. [PMID: 20488895] - Chiaki Kusumoto, Tomoyo Kinugawa, Hitoshi Morikawa, Mari Teraoka, Tadashi Nishida, Yoshikazu Murawaki, Kazuo Yamada, Tatsuya Matsura. Protection by Exogenously Added Coenzyme Q(9) against Free Radical-Induced Injuries in Human Liver Cells.
Journal of clinical biochemistry and nutrition.
2010 May; 46(3):244-51. doi:
10.3164/jcbn.09-128
. [PMID: 20490320] - Markus Karl Wiltafsky, Michael Walter Pfaffl, Franz Xaver Roth. The effects of branched-chain amino acid interactions on growth performance, blood metabolites, enzyme kinetics and transcriptomics in weaned pigs.
The British journal of nutrition.
2010 Apr; 103(7):964-76. doi:
10.1017/s0007114509992212
. [PMID: 20196890] - Hideki Matsumoto, Keiichi Akita, Ryosei Sakai, Yoshiharu Shimomura. Analysis of branched-chain alpha-keto acid dehydrogenase complex activity in rat tissues using alpha-keto[1-13C]isocaproate as substrate.
Analytical biochemistry.
2010 Apr; 399(1):1-6. doi:
10.1016/j.ab.2009.12.017
. [PMID: 20018161] - Stephanie M Carleton, Dawn S Peck, Julie Grasela, Kristin L Dietiker, Charlotte L Phillips. DNA carrier testing and newborn screening for maple syrup urine disease in Old Order Mennonite communities.
Genetic testing and molecular biomarkers.
2010 Apr; 14(2):205-8. doi:
10.1089/gtmb.2009.0107
. [PMID: 20136525] - Kornelia Edes, Pamela Cassidy, Paul J Shami, Philip J Moos. JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1.
PloS one.
2010 Jan; 5(1):e8786. doi:
10.1371/journal.pone.0008786
. [PMID: 20098717] - Sabrina Le Bouter, Marianne Rodriguez, Nolwen Guigal-Stephan, Sophie Courtade-Gaïani, Laura Xuereb, Catherine de Montrion, Vincent Croixmarie, Thierry Umbdenstock, Claire Boursier-Neyret, Michel Lonchampt, Manuel Brun, Catherine Dacquet, Alain Ktorza, Brian-Paul Lockhart, Jean-Pierre Galizzi. Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice.
PPAR research.
2010; 2010(?):. doi:
10.1155/2010/679184
. [PMID: 20953342] - Theodoros Georgiou, Jacinta L Chuang, R Max Wynn, Goula Stylianidou, Mark Korson, David T Chuang, Anthi Drousiotou. Maple syrup urine disease in Cypriot families: identification of three novel mutations and biochemical characterization of the p.Thr211Met mutation in the E1alpha subunit.
Genetic testing and molecular biomarkers.
2009 Oct; 13(5):657-64. doi:
10.1089/gtmb.2009.0065
. [PMID: 19715473] - Gustavo Bajotto, Taro Murakami, Masaru Nagasaki, Yuzo Sato, Yoshiharu Shimomura. Decreased enzyme activity and contents of hepatic branched-chain alpha-keto acid dehydrogenase complex subunits in a rat model for type 2 diabetes mellitus.
Metabolism: clinical and experimental.
2009 Oct; 58(10):1489-95. doi:
10.1016/j.metabol.2009.04.029
. [PMID: 19586643] - Tadeja Rezen, Viola Tamasi, Anita Lövgren-Sandblom, Ingemar Björkhem, Urs A Meyer, Damjana Rozman. Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers.
BMC genomics.
2009 Aug; 10(?):384. doi:
10.1186/1471-2164-10-384
. [PMID: 19691840] - Kristen J Skvorak, Harbhajan S Paul, Kenneth Dorko, Fabio Marongiu, Ewa Ellis, Donald Chace, Carolyn Ferguson, K Michael Gibson, Gregg E Homanics, Stephen C Strom. Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease.
Molecular therapy : the journal of the American Society of Gene Therapy.
2009 Jul; 17(7):1266-73. doi:
10.1038/mt.2009.99
. [PMID: 19436271] - Gang Lu, Haipeng Sun, Pengxiang She, Ji-Youn Youn, Sarah Warburton, Peipei Ping, Thomas M Vondriska, Hua Cai, Christopher J Lynch, Yibin Wang. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells.
The Journal of clinical investigation.
2009 Jun; 119(6):1678-87. doi:
10.1172/jci38151
. [PMID: 19411760] - Sofia Quental, Alfredo Gusmão, Pilar Rodríguez-Pombo, Magdalena Ugarte, Laura Vilarinho, António Amorim, Maria J Prata. Revisiting MSUD in Portuguese Gypsies: evidence for a founder mutation and for a mutational hotspot within the BCKDHA gene.
Annals of human genetics.
2009 May; 73(Pt 3):298-303. doi:
10.1111/j.1469-1809.2009.00518.x
. [PMID: 19456321] - K J Skvorak. Animal models of maple syrup urine disease.
Journal of inherited metabolic disease.
2009 Apr; 32(2):229-46. doi:
10.1007/s10545-009-1086-z
. [PMID: 19263237] - Viacheslav V Dolgikh, Elena V Seliverstova, Anton M Naumov, Igor V Senderskiy, Olga A Pavlova, Galina V Beznoussenko. Heterologous expression of pyruvate dehydrogenase E1 subunits of the microsporidium Paranosema (Antonospora) locustae and immunolocalization of the mitochondrial protein in amitochondrial cells.
FEMS microbiology letters.
2009 Apr; 293(2):285-91. doi:
10.1111/j.1574-6968.2009.01545.x
. [PMID: 19260967] - Keri A Barksdale, Gautam N Bijur. The basal flux of Akt in the mitochondria is mediated by heat shock protein 90.
Journal of neurochemistry.
2009 Mar; 108(5):1289-99. doi:
10.1111/j.1471-4159.2009.05878.x
. [PMID: 19187436] - Kerstin Gorzelany, Ali Dursun, Turgay Coşkun, Serap H Kalkanoğlu-Sivri, Gülden Fatma Gökçay, Mübeccel Demirkol, Oliver Feyen, Udo Wendel. Molecular genetics of maple syrup urine disease in the Turkish population.
The Turkish journal of pediatrics.
2009 Mar; 51(2):97-102. doi:
NULL
. [PMID: 19480318] - G Y Liu. Isolation, sequence identification, and tissue expression profile of 3 novel porcine genes: NCF2, BCKDHB and BCKDHA.
Journal of applied genetics.
2009; 50(1):47-50. doi:
10.1007/bf03195651
. [PMID: 19193982] - G Y Liu, S Z Gao. Molecular cloning, sequence identification and tissue expression profile of three novel sheep (Ovis aries) genes - BCKDHA, NAGA and HEXA.
Biological research.
2009; 42(1):69-77. doi:
/s0716-97602009000100007
. [PMID: 19621134] - S Quental, E Martins, L Vilarinho, A Amorim, M João Prata. Maple syrup urine disease due to a new large deletion at BCKDHA caused by non-homologous recombination.
Journal of inherited metabolic disease.
2008 Dec; 31 Suppl 2(?):S457-60. doi:
10.1007/s10545-008-1046-z
. [PMID: 19085071] - Pawel Durek, Dirk Walther. The integrated analysis of metabolic and protein interaction networks reveals novel molecular organizing principles.
BMC systems biology.
2008 Nov; 2(?):100. doi:
10.1186/1752-0509-2-100
. [PMID: 19032748] - Suthipong Pangkanon, Wiyada Charoensiriwatana, Varaporn Sangtawesin. Maple syrup urine disease in Thai infants.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2008 Oct; 91 Suppl 3(?):S41-4. doi:
NULL
. [PMID: 19255991] - Intawat Nookaew, Michael C Jewett, Asawin Meechai, Chinae Thammarongtham, Kobkul Laoteng, Supapon Cheevadhanarak, Jens Nielsen, Sakarindr Bhumiratana. The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.
BMC systems biology.
2008 Aug; 2(?):71. doi:
10.1186/1752-0509-2-71
. [PMID: 18687109] - Wieslawa I Mentzen, Jianling Peng, Nick Ransom, Basil J Nikolau, Eve Syrkin Wurtele. Articulation of three core metabolic processes in Arabidopsis: fatty acid biosynthesis, leucine catabolism and starch metabolism.
BMC plant biology.
2008 Jul; 8(?):76. doi:
10.1186/1471-2229-8-76
. [PMID: 18616834] - Sofia Quental, Sandra Macedo-Ribeiro, Raquel Matos, Laura Vilarinho, Esmeralda Martins, Elisa Leão Teles, Esmeralda Rodrigues, Luísa Diogo, Paula Garcia, Filomena Eusébio, Ana Gaspar, Sílvia Sequeira, Fátima Furtado, Isabel Lança, António Amorim, Maria João Prata. Molecular and structural analyses of maple syrup urine disease and identification of a founder mutation in a Portuguese Gypsy community.
Molecular genetics and metabolism.
2008 Jun; 94(2):148-56. doi:
10.1016/j.ymgme.2008.02.008
. [PMID: 18378174] - Frances M Dupont. Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics.
BMC plant biology.
2008 Apr; 8(?):39. doi:
10.1186/1471-2229-8-39
. [PMID: 18419817] - Xuesen Li, Zhongbo Liu, Cheng Luo, Haiqun Jia, Lijuan Sun, Bei Hou, Weili Shen, Lester Packer, Carl W Cotman, Jiankang Liu. Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction.
Free radical biology & medicine.
2008 Apr; 44(7):1465-74. doi:
10.1016/j.freeradbiomed.2008.01.004
. [PMID: 18258206] - Nicolette S Bradley, George J F Heigenhauser, Brian D Roy, Elizabeth M Staples, J Greig Inglis, Paul J LeBlanc, Sandra J Peters. The acute effects of differential dietary fatty acids on human skeletal muscle pyruvate dehydrogenase activity.
Journal of applied physiology (Bethesda, Md. : 1985).
2008 Jan; 104(1):1-9. doi:
10.1152/japplphysiol.00636.2007
. [PMID: 17947500] - Gilli Barel, Idit Ginzberg. Potato skin proteome is enriched with plant defence components.
Journal of experimental botany.
2008; 59(12):3347-57. doi:
10.1093/jxb/ern184
. [PMID: 18653692] - Pengxiang She, Cynthia Van Horn, Tanya Reid, Susan M Hutson, Robert N Cooney, Christopher J Lynch. Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism.
American journal of physiology. Endocrinology and metabolism.
2007 Dec; 293(6):E1552-63. doi:
10.1152/ajpendo.00134.2007
. [PMID: 17925455] - N Flaschker, O Feyen, S Fend, E Simon, P Schadewaldt, U Wendel. Description of the mutations in 15 subjects with variant forms of maple syrup urine disease.
Journal of inherited metabolic disease.
2007 Nov; 30(6):903-9. doi:
10.1007/s10545-007-0579-x
. [PMID: 17922217] - David Schachter. L-glutamine in vitro regulates rat aortic glutamate content and modulates nitric oxide formation and contractility responses.
American journal of physiology. Cell physiology.
2007 Jul; 293(1):C142-51. doi:
10.1152/ajpcell.00589.2006
. [PMID: 17329397] - Xiaonan Wang, Junping Hu, S Russ Price. Inhibition of PI3-kinase signaling by glucocorticoids results in increased branched-chain amino acid degradation in renal epithelial cells.
American journal of physiology. Cell physiology.
2007 May; 292(5):C1874-9. doi:
10.1152/ajpcell.00617.2006
. [PMID: 17229808] - R A Power, M W Hulver, J Y Zhang, J Dubois, R M Marchand, O Ilkayeva, D M Muoio, R L Mynatt. Carnitine revisited: potential use as adjunctive treatment in diabetes.
Diabetologia.
2007 Apr; 50(4):824-32. doi:
10.1007/s00125-007-0605-4
. [PMID: 17310372] - Malcolm Watford. Lowered concentrations of branched-chain amino acids result in impaired growth and neurological problems: insights from a branched-chain alpha-keto acid dehydrogenase complex kinase-deficient mouse model.
Nutrition reviews.
2007 Apr; 65(4):167-72. doi:
10.1111/j.1753-4887.2007.tb00296.x
. [PMID: 17503711] - P Wang, J Renes, F Bouwman, A Bunschoten, E Mariman, J Keijer. Absence of an adipogenic effect of rosiglitazone on mature 3T3-L1 adipocytes: increase of lipid catabolism and reduction of adipokine expression.
Diabetologia.
2007 Mar; 50(3):654-65. doi:
10.1007/s00125-006-0565-0
. [PMID: 17245590] - Lina Holmquist, Grant Stuchbury, Katrin Berbaum, Sonja Muscat, Simon Young, Klaus Hager, Jürgen Engel, Gerald Münch. Lipoic acid as a novel treatment for Alzheimer's disease and related dementias.
Pharmacology & therapeutics.
2007 Jan; 113(1):154-64. doi:
10.1016/j.pharmthera.2006.07.001
. [PMID: 16989905] - Mandar A Joshi, Nam Ho Jeoung, Mariko Obayashi, Eyas M Hattab, Eric G Brocken, Edward A Liechty, Michael J Kubek, Krishna M Vattem, Ronald C Wek, Robert A Harris. Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice.
The Biochemical journal.
2006 Nov; 400(1):153-62. doi:
10.1042/bj20060869
. [PMID: 16875466] - Henrikas Nivinskas, Ausra Nemeikaite-Ceniene, Audrone Maroziene, Terese Normantiene, Narimantas Cenas. Prooxidant cytotoxicity of chromate in mammalian cells: the opposite roles of DT-diaphorase and glutathione reductase.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2006 Nov; 61(11-12):889-95. doi:
. [PMID: 17294702]
- Henriette Pilegaard, Jesper B Birk, Massimo Sacchetti, Marina Mourtzakis, D Graham Hardie, Greg Stewart, P Darrell Neufer, Bengt Saltin, Gerrit van Hall, Jorgen F P Wojtaszewski. PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion.
Diabetes.
2006 Nov; 55(11):3020-7. doi:
10.2337/db06-0152
. [PMID: 17065338] - H S Seol, Kan Sato, Hitoshi Murakami, Masaaki Toyomizu, Yukio Akiba. Changes in gene expression involved in energy utilization during chicken follicle development.
Animal reproduction science.
2006 Oct; 95(3-4):283-94. doi:
10.1016/j.anireprosci.2005.09.016
. [PMID: 16253445] - Eun-Ha Lee, Mi-Sun Ahn, Jin-Soon Hwang, Kyung-Hwa Ryu, Sun-Jun Kim, Sung-Hwan Kim. A Korean female patient with thiamine-responsive pyruvate dehydrogenase complex deficiency due to a novel point mutation (Y161C)in the PDHA1 gene.
Journal of Korean medical science.
2006 Oct; 21(5):800-4. doi:
10.3346/jkms.2006.21.5.800
. [PMID: 17043409] - Ozlem Onder, Heeyong Yoon, Bianca Naumann, Michael Hippler, Andrew Dancis, Fevzi Daldal. Modifications of the lipoamide-containing mitochondrial subproteome in a yeast mutant defective in cysteine desulfurase.
Molecular & cellular proteomics : MCP.
2006 Aug; 5(8):1426-36. doi:
10.1074/mcp.m600099-mcp200
. [PMID: 16684766] - Hiroki Ishiguro, Yoshiaki Katano, Isao Nakano, Masatoshi Ishigami, Kazuhiko Hayashi, Takashi Honda, Hidemi Goto, Gustavo Bajotto, Ken Maeda, Yoshiharu Shimomura. Clofibrate treatment promotes branched-chain amino acid catabolism and decreases the phosphorylation state of mTOR, eIF4E-BP1, and S6K1 in rat liver.
Life sciences.
2006 Jul; 79(8):737-43. doi:
10.1016/j.lfs.2006.02.037
. [PMID: 16616211] - Pilar Rodríguez-Pombo, Rosa Navarrete, Begoña Merinero, Paulino Gómez-Puertas, Magdalena Ugarte. Mutational spectrum of maple syrup urine disease in Spain.
Human mutation.
2006 Jul; 27(7):715. doi:
10.1002/humu.9428
. [PMID: 16786533] - Gregg E Homanics, Kristen Skvorak, Carolyn Ferguson, Simon Watkins, Harbhajan S Paul. Production and characterization of murine models of classic and intermediate maple syrup urine disease.
BMC medical genetics.
2006 Mar; 7(?):33. doi:
10.1186/1471-2350-7-33
. [PMID: 16579849] - Li Wen, Gai Liu, Zai-Jun Zhang, Jun Tao, Cui-Xiang Wan, Ying-Guo Zhu. [Preliminary proteomics analysis of the total proteins of HL Type cytoplasmic male sterility rice anther].
Yi chuan = Hereditas.
2006 Mar; 28(3):311-6. doi:
. [PMID: 16551598]
- Katsuhisa Omagari, Yoshiko Kadokawa, Minoru Nakamura, Shiho Akazawa, Kazuo Ohba, Ken Ohnita, Yohei Mizuta, Manabu Daikoku, Hiroshi Yatsuhashi, Hiromi Ishibashi, Shigeru Kohno. IgA class antibodies to 2-oxo-acid dehydrogenase complex are not predictive markers of histopathological progression in primary biliary cirrhosis.
Autoimmunity.
2006 Mar; 39(2):107-12. doi:
10.1080/08916930600633006
. [PMID: 16698666] - C Sansaricq, S Pardo, M Balwani, M Grace, K Raymond. Biochemical and molecular diagnosis of lipoamide dehydrogenase deficiency in a North American Ashkenazi Jewish family.
Journal of inherited metabolic disease.
2006 Feb; 29(1):203-4. doi:
10.1007/s10545-006-0175-5
. [PMID: 16601893] - Helga David, Gerald Hofmann, Ana Paula Oliveira, Hanne Jarmer, Jens Nielsen. Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans.
Genome biology.
2006; 7(11):R108. doi:
10.1186/gb-2006-7-11-r108
. [PMID: 17107606] - Nathalie Gass, Tatiana Glagotskaia, Stefan Mellema, Jeroen Stuurman, Mario Barone, Therese Mandel, Ute Roessner-Tunali, Cris Kuhlemeier. Pyruvate decarboxylase provides growing pollen tubes with a competitive advantage in petunia.
The Plant cell.
2005 Aug; 17(8):2355-68. doi:
10.1105/tpc.105.033290
. [PMID: 15994907] - Marie-Hélène Odièvre, Dominique Chretien, Arnold Munnich, Brian H Robinson, Renée Dumoulin, Sahben Masmoudi, Noman Kadhom, Agnès Rötig, Pierre Rustin, Jean-Paul Bonnefont. A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency.
Human mutation.
2005 Mar; 25(3):323-4. doi:
10.1002/humu.9319
. [PMID: 15712224] - Marina V Kovina, Aart De Kok, Irina A Sevostyanova, Ludmila S Khailova, Natalya V Belkina, German A Kochetov. The molecular origin of the thiamine diphosphate-induced spectral bands of ThDP-dependent enzymes.
Proteins.
2004 Aug; 56(2):338-45. doi:
10.1002/prot.20115
. [PMID: 15211516] - Abir U Igamberdiev, Natalia V Bykova, Werner Ens, Robert D Hill. Dihydrolipoamide dehydrogenase from porcine heart catalyzes NADH-dependent scavenging of nitric oxide.
FEBS letters.
2004 Jun; 568(1-3):146-50. doi:
10.1016/j.febslet.2004.05.024
. [PMID: 15196936] - Sherry LeClere, Rebekah A Rampey, Bonnie Bartel. IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog.
Plant physiology.
2004 Jun; 135(2):989-99. doi:
10.1104/pp.104.040519
. [PMID: 15173569] - Georgina Meneses-Lorente, Paul C Guest, Jeffrey Lawrence, Nagaraja Muniappa, Michael R Knowles, Heather A Skynner, Kamran Salim, Ileana Cristea, Russell Mortishire-Smith, Simon J Gaskell, Alan Watt. A proteomic investigation of drug-induced steatosis in rat liver.
Chemical research in toxicology.
2004 May; 17(5):605-12. doi:
10.1021/tx034203n
. [PMID: 15144217] - Jon T Self, Thomas E Spencer, Greg A Johnson, Jianbo Hu, Fuller W Bazer, Guoyao Wu. Glutamine synthesis in the developing porcine placenta.
Biology of reproduction.
2004 May; 70(5):1444-51. doi:
10.1095/biolreprod.103.025486
. [PMID: 14736817] - Andrea Kasinski, Christopher B Doering, Dean J Danner. Leucine toxicity in a neuronal cell model with inhibited branched chain amino acid catabolism.
Brain research. Molecular brain research.
2004 Mar; 122(2):180-7. doi:
10.1016/j.molbrainres.2003.08.023
. [PMID: 15010210] - Takashi Honda, Yoshihide Fukuda, Isao Nakano, Yoshiaki Katano, Hidemi Goto, Masaru Nagasaki, Yuzo Sato, Taro Murakami, Yoshiharu Shimomura. Effects of liver failure on branched-chain alpha-keto acid dehydrogenase complex in rat liver and muscle: comparison between acute and chronic liver failure.
Journal of hepatology.
2004 Mar; 40(3):439-45. doi:
10.1016/j.jhep.2003.11.003
. [PMID: 15123358] - Yoshiharu Shimomura, Takashi Honda, Hidemi Goto, Toshiaki Nonami, Tsuyoshi Kurokawa, Masaru Nagasaki, Taro Murakami. Effects of liver failure on the enzymes in the branched-chain amino acid catabolic pathway.
Biochemical and biophysical research communications.
2004 Jan; 313(2):381-5. doi:
10.1016/j.bbrc.2003.07.022
. [PMID: 14684172] - Robert A Harris, Mandar Joshi, Nam Ho Jeoung. Mechanisms responsible for regulation of branched-chain amino acid catabolism.
Biochemical and biophysical research communications.
2004 Jan; 313(2):391-6. doi:
10.1016/j.bbrc.2003.11.007
. [PMID: 14684174] - G Tajima, H Yofune, A D Bahagia Febriani, Y Nishimura, H Ono, N Sakura. A simple and rapid enzymatic assay for the branched-chain alpha-ketoacid dehydrogenase complex using high-performance liquid chromatography.
Journal of inherited metabolic disease.
2004; 27(5):633-9. doi:
10.1023/b:boli.0000042988.31581.ed
. [PMID: 15669679] - Maria Szpetnar, Kazimierz Pasternak, Anna Boguszewska. Branched chain amino acids (BCAAs) in heart diseases (ischaemic heart disease and myocardial infarction).
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina.
2004; 59(2):91-5. doi:
NULL
. [PMID: 16146056] - Andrew J Sweatt, Mac Wood, Agus Suryawan, Reidar Wallin, Mark C Willingham, Susan M Hutson. Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves.
American journal of physiology. Endocrinology and metabolism.
2004 Jan; 286(1):E64-76. doi:
10.1152/ajpendo.00276.2003
. [PMID: 12965870] - Dominic S C Raj, Hemangini Shah, Vallabh O Shah, Arny Ferrando, Arthur Bankhurst, Robert Wolfe, Philip G Zager. Markers of inflammation, proteolysis, and apoptosis in ESRD.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2003 Dec; 42(6):1212-20. doi:
10.1053/j.ajkd.2003.08.022
. [PMID: 14655193] - Marco Henneke, Nadine Flaschker, Christoph Helbling, Martina Müller, Peter Schadewaldt, Jutta Gärtner, Udo Wendel. Identification of twelve novel mutations in patients with classic and variant forms of maple syrup urine disease.
Human mutation.
2003 Nov; 22(5):417. doi:
10.1002/humu.9187
. [PMID: 14517957] - Natalia V Bykova, Allan Stensballe, Helge Egsgaard, Ole N Jensen, Ian M Moller. Phosphorylation of formate dehydrogenase in potato tuber mitochondria.
The Journal of biological chemistry.
2003 Jul; 278(28):26021-30. doi:
10.1074/jbc.m300245200
. [PMID: 12714601] - Wajanat Jan, Robert A Zimmerman, Zhiyue J Wang, Gerard T Berry, Paige B Kaplan, Edward M Kaye. MR diffusion imaging and MR spectroscopy of maple syrup urine disease during acute metabolic decompensation.
Neuroradiology.
2003 Jun; 45(6):393-9. doi:
10.1007/s00234-003-0955-7
. [PMID: 12736767] - V A Samokhvalov, N Iu Museĭkina, G V Mel'nikov, V V Ignatov. [Arsenite-induced lipid peroxidation in Saccharomyces cerevisiae].
Mikrobiologiia.
2003 May; 72(3):308-11. doi:
"
. [PMID: 12901003] - Rika Yui, Satoru Iketani, Tetsuo Mikami, Tomohiko Kubo. Antisense inhibition of mitochondrial pyruvate dehydrogenase E1alpha subunit in anther tapetum causes male sterility.
The Plant journal : for cell and molecular biology.
2003 Apr; 34(1):57-66. doi:
10.1046/j.1365-313x.2003.01704.x
. [PMID: 12662309] - Victoria I Bunik. 2-Oxo acid dehydrogenase complexes of multicellular organisms.
European journal of biochemistry.
2003 Mar; 270(6):1035. doi:
10.1046/j.1432-1033.2003.03467.x
. [PMID: 12631262] - Yasuko Noda, Kazumi Ogata, Akitane Mori. Antioxidant activities of novel alpha-lipoic acid derivatives: N-(6, 8-dimercaptooctanoyl)-2-aminoethanesulfonate- and N-(6, 8-dimercaptooctanoyl)-L-aspartate-zinc complex.
Research communications in molecular pathology and pharmacology.
2003; 113-114(?):133-47. doi:
"
. [PMID: 15686113]