Theophylline (BioDeep_00000399894)

Main id: BioDeep_00000000451

Secondary id: BioDeep_00000229644

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Theophylline

化学式: C7H8N4O2 (180.0647228)
中文名称: 茶碱
谱图信息: 最多检出来源 Homo sapiens(blood) 0.47%

分子结构信息

SMILES: CN1C2=C(C(=O)N(C1=O)C)NC=N2
InChI: InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

描述信息

R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DA - Xanthines
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; ZFXYFBGIUFBOJW-UHFFFAOYSA-N_STSL_0031_Theophylline_0500fmol_180416_S2_LC02_MS02_19; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].

同义名列表

3 个代谢物同义名

Theophylline; 1,3-Dimethylxanthine; Theo-24



数据库引用编号

107 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

44 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Georgios Paraskevopoulos, Ferdinand Fandrei, Ajit Kumar Pratihast, Anna Paraskevopoulou, Eleni Panoutsopoulou, Lukáš Opálka, Venus Singh Mithu, Daniel Huster, Kateřina Vávrová. Effects of imidazolium ionic liquids on skin barrier lipids - Perspectives for drug delivery. Journal of colloid and interface science. 2024 Apr; 659(?):449-462. doi: 10.1016/j.jcis.2023.12.139. [PMID: 38183811]
  • Ashutosh Pareek, Rupal Kothari, Aaushi Pareek, Yashumati Ratan, Pushpa Kashania, Vivek Jain, Philippe Jeandet, Parveen Kumar, Azmat Ali Khan, Amer M Alanazi, Madan Mohan Gupta. Development of a new inhaled swellable microsphere system for the dual delivery of naringenin-loaded solid lipid nanoparticles and doxofylline for the treatment of asthma. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Feb; 193(?):106642. doi: 10.1016/j.ejps.2023.106642. [PMID: 37977235]
  • Waqar Ahmed Siddiqui, Muniza Qayyum, Aamina Quddus Qureshi, Momina Khalid, Sehrish Zaffar, Rabiea Bilal. The Bronchodilator Potential of Astragalus sarcocolla: An in vitro Experiment. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2024 Jan; 34(1):58-62. doi: 10.29271/jcpsp.2024.01.58. [PMID: 38185962]
  • Liguo Liu, Dongmei Xu, Fengxin Chen, Shengnan Cai, Jin Wei, Jiaheng Deng, Jianhua Zheng, Qi Jin, Wenhui Lun. Identification of potential biomarkers for diagnosis of syphilis from the cerebrospinal fluid based on untargeted metabolomic analysis. Molecular omics. 2023 Apr; ?(?):. doi: 10.1039/d3mo00026e. [PMID: 37185577]
  • Magdalena Kotańska, Anna Dziubina, Małgorzata Szafarz, Kamil Mika, Marek Bednarski, Noemi Nicosia, Ahmed Temirak, Christa E Müller, Katarzyna Kieć-Kononowicz. Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice. International journal of molecular sciences. 2022 Nov; 23(21):. doi: 10.3390/ijms232113439. [PMID: 36362227]
  • Kenchi Miyasaka, Yoshiaki Manse, Akari Yoneda, Shogo Takeda, Norihito Shimizu, Wakana Yamada, Toshio Morikawa, Hiroshi Shimoda. Anti-melanogenic effects of glucosylceramides and elasticamide derived from rice oil by-products in melanoma cells, melanocytes, and human skin. Journal of food biochemistry. 2022 10; 46(10):e14353. doi: 10.1111/jfbc.14353. [PMID: 35986572]
  • Shuoyuan Huang, Huan Chen, Jianwen Teng, Zhengmei Wu, Li Huang, Baoyao Wei, Ning Xia. Antihyperlipidemic effect and increased antioxidant enzyme levels of aqueous extracts from Liupao tea and green tea in vivo. Journal of food science. 2022 Sep; 87(9):4203-4220. doi: 10.1111/1750-3841.16274. [PMID: 35982642]
  • Ken Wada, Akiko Kurata, Takashi Iwamoto, Junji Gon, Hiroma Shimizu. Oral theophylline augmentation for patients with missed or inadequate seizures with electroconvulsive therapy. Asian journal of psychiatry. 2022 Jul; 73(?):103148. doi: 10.1016/j.ajp.2022.103148. [PMID: 35597185]
  • Gaëlle Magliocco, Jules Desmeules, Caroline Flora Samer, Aurélien Thomas, Youssef Daali. Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots. Clinical and translational science. 2022 06; 15(6):1482-1491. doi: 10.1111/cts.13263. [PMID: 35338582]
  • Miyoko Matsushima, Souma Tanihata, Junpei Kusakabe, Momoha Okahira, Hiroshi Ito, Atsushi Yamamoto, Masanori Yamamoto, Ryohei Yamamoto, Tsutomu Kawabe. Correlation of theophylline levels in rat exhaled breath and lung tissue after its intravenous injection. Journal of breath research. 2022 05; 16(3):. doi: 10.1088/1752-7163/ac6b4b. [PMID: 35483336]
  • Luis M Montaño, Bettina Sommer, Juan C Gomez-Verjan, Genaro S Morales-Paoli, Gema Lizbeth Ramírez-Salinas, Héctor Solís-Chagoyán, Zuly A Sanchez-Florentino, Eduardo Calixto, Gloria E Pérez-Figueroa, Rohan Carter, Ruth Jaimez-Melgoza, Bianca S Romero-Martínez, Edgar Flores-Soto. Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies. International journal of molecular sciences. 2022 Apr; 23(8):. doi: 10.3390/ijms23084167. [PMID: 35456985]
  • Jake J Lee, Andrew M Peterson, Dorina Kallogjeri, Pawina Jiramongkolchai, Sara Kukuljan, John S Schneider, Cristine N Klatt-Cromwell, Andrew J Drescher, Joseph D Brunworth, Jay F Piccirillo. Smell Changes and Efficacy of Nasal Theophylline (SCENT) irrigation: A randomized controlled trial for treatment of post-viral olfactory dysfunction. American journal of otolaryngology. 2022 Mar; 43(2):103299. doi: 10.1016/j.amjoto.2021.103299. [PMID: 34894449]
  • Ralf Jäger, Martin Purpura, Shawn D Wells, Kylin Liao, Ashok Godavarthi. Paraxanthine Supplementation Increases Muscle Mass, Strength, and Endurance in Mice. Nutrients. 2022 Feb; 14(4):. doi: 10.3390/nu14040893. [PMID: 35215543]
  • Daniel Janitschke, Anna Andrea Lauer, Cornel Manuel Bachmann, Jakob Winkler, Lea Victoria Griebsch, Sabrina Melanie Pilz, Elena Leoni Theiss, Heike Sabine Grimm, Tobias Hartmann, Marcus Otto Walter Grimm. Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042295. [PMID: 35216410]
  • Kristen J Polinski, Alexandra Purdue-Smithe, Sonia L Robinson, Sifang Kathy Zhao, Karen C Schliep, Robert M Silver, Weihua Guan, Enrique F Schisterman, Sunni L Mumford, Edwina H Yeung. Maternal caffeine intake and DNA methylation in newborn cord blood. The American journal of clinical nutrition. 2022 02; 115(2):482-491. doi: 10.1093/ajcn/nqab348. [PMID: 34669932]
  • Jennifer M Reinhart, Gabriela A R de Oliveira, Lauren Forsythe, Zhong Li. Pharmacokinetics of a 503B outsourcing facility-produced theophylline in dogs. PloS one. 2022; 17(1):e0262336. doi: 10.1371/journal.pone.0262336. [PMID: 34990472]
  • Weiyi Qu, Ze Chen, Xing Hu, Toujun Zou, Yongping Huang, Yanyan Zhang, Yufeng Hu, Song Tian, Juan Wan, Rufang Liao, Lan Bai, Jinhua Xue, Yi Ding, Manli Hu, Xiao-Jing Zhang, Xin Zhang, Jingjing Zhao, Xu Cheng, Zhi-Gang She, Hongliang Li. Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model. Frontiers in endocrinology. 2022; 13(?):849060. doi: 10.3389/fendo.2022.849060. [PMID: 35620391]
  • Archit Dahiya, Rajeev Sharma, Abhimanyu Singh, Piyush Joshi, Harsh Wardhan. Role of Etophylline and Theophylline Prolonged Release Tablet in COVID-19 Associated Sinus Node Dysfunction. The Journal of the Association of Physicians of India. 2022 Jan; 70(1):11-12. doi: . [PMID: 35062804]
  • Martin Kertys, Nela Žideková, Kristián Pršo, Katarína Maráková, Katarína Kmeťová, Juraj Mokrý. Simultaneous determination of caffeine and its metabolites in rat plasma by UHPLC-MS/MS. Journal of separation science. 2021 Dec; 44(23):4274-4283. doi: 10.1002/jssc.202100604. [PMID: 34626085]
  • Dusan Petrovic, Menno Pruijm, Belén Ponte, Nasser A Dhayat, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Bruno Vogt, Pierre-Yves Martin, Silvia Stringhini, Sandrine Estoppey-Younès, Lutgarde Thijs, Zhenyu Zhang, Jesus D Melgarejo, Chin B Eap, Jan A Staessen, Murielle Bochud, Idris Guessous. Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies. Mayo Clinic proceedings. 2021 12; 96(12):3071-3085. doi: 10.1016/j.mayocp.2021.05.030. [PMID: 34579945]
  • Ching Thai, Bola Tayo, David Critchley. A Phase 1 Open-Label, Fixed-Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects. Clinical pharmacology in drug development. 2021 11; 10(11):1279-1289. doi: 10.1002/cpdd.950. [PMID: 33951339]
  • Mostafa Boskabady, Azam Alavinezhad, Mohammad Hossein Boskabady. Zataria multiflora induced bronchodilatoion comparable to theophylline syrup in asthmatic patients. Explore (New York, N.Y.). 2021 Nov; 17(6):578-583. doi: 10.1016/j.explore.2020.07.002. [PMID: 32709586]
  • Bassam Lajin, Natascha Schweighofer, Walter Goessler, Barbara Obermayer-Pietsch. The determination of the Paraxanthine/Caffeine ratio as a metabolic biomarker for CYP1A2 activity in various human matrices by UHPLC-ESIMS/MS. Talanta. 2021 Nov; 234(?):122658. doi: 10.1016/j.talanta.2021.122658. [PMID: 34364467]
  • Michelle C Starr, Jennifer R Charlton, Ronnie Guillet, Kimberly Reidy, Trent E Tipple, Jennifer G Jetton, Alison L Kent, Carolyn L Abitbol, Namasivayam Ambalavanan, Maroun J Mhanna, David J Askenazi, David T Selewski, Matthew W Harer. Advances in Neonatal Acute Kidney Injury. Pediatrics. 2021 11; 148(5):. doi: 10.1542/peds.2021-051220. [PMID: 34599008]
  • Kana N Miyata, Chao-Sheng Lo, Shuiling Zhao, Xin-Ping Zhao, Isabelle Chenier, Michifumi Yamashita, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Chan. Deletion of heterogeneous nuclear ribonucleoprotein F in renal tubules downregulates SGLT2 expression and attenuates hyperfiltration and kidney injury in a mouse model of diabetes. Diabetologia. 2021 11; 64(11):2589-2601. doi: 10.1007/s00125-021-05538-9. [PMID: 34370045]
  • Jennifer M Reinhart, Claudia Perkowski, Courtney Lester, Valeria Campos, Saki Kadotani, Zhong Li, Brendan C McKiernan, Ryan Fries. Multidose pharmacokinetics and safety of a modified, compounded theophylline product in dogs. Journal of veterinary pharmacology and therapeutics. 2021 Nov; 44(6):902-909. doi: 10.1111/jvp.12997. [PMID: 34173985]
  • Julia Brunmair, Mathias Gotsmy, Laura Niederstaetter, Benjamin Neuditschko, Andrea Bileck, Astrid Slany, Max Lennart Feuerstein, Clemens Langbauer, Lukas Janker, Jürgen Zanghellini, Samuel M Meier-Menches, Christopher Gerner. Finger sweat analysis enables short interval metabolic biomonitoring in humans. Nature communications. 2021 10; 12(1):5993. doi: 10.1038/s41467-021-26245-4. [PMID: 34645808]
  • Meghan Matheny, Noble Maleque, Natalie Channell, A Robin Eisch, Sara C Auld, Aleena Banerji, Kirk M Druey. Severe Exacerbations of Systemic Capillary Leak Syndrome After COVID-19 Vaccination: A Case Series. Annals of internal medicine. 2021 10; 174(10):1476-1478. doi: 10.7326/l21-0250. [PMID: 34125573]
  • Jader B Ruchel, Viviane M Bernardes, Josiane B S Braun, Alessandra G Manzoni, Daniela F Passos, Lívia G Castilhos, Fátima H Abdalla, Juliana S de Oliveira, Cinthia M de Andrade, Emerson A Casali, Ivana B M da Cruz, Daniela B R Leal. Lipotoxicity-associated inflammation is prevented by guarana (Paullinia cupana) in a model of hyperlipidemia. Drug and chemical toxicology. 2021 Sep; 44(5):524-532. doi: 10.1080/01480545.2019.1624767. [PMID: 31195840]
  • Ioannis Bellos, Aakash Pandita, Monika Yachha. Effectiveness of theophylline administration in neonates with perinatal asphyxia: a meta-analysis. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2021 Sep; 34(18):3080-3088. doi: 10.1080/14767058.2019.1673722. [PMID: 31558088]
  • Kamilla Nunes Machado, Antony de Paula Barbosa, Aline Alves de Freitas, Luana Farah Alvarenga, Rodrigo Maia de Pádua, André Augusto Gomes Faraco, Fernão Castro Braga, Cristina Duarte Vianna-Soares, Rachel Oliveira Castilho. TNF-α inhibition, antioxidant effects and chemical analysis of extracts and fraction from Brazilian guaraná seed powder. Food chemistry. 2021 Sep; 355(?):129563. doi: 10.1016/j.foodchem.2021.129563. [PMID: 33799249]
  • Xianrong Du, Hongju Bao, Daguo Zhao. Efficacy and safety of combined doxofylline and salbutamol in treatment of acute exacerbation of chronic obstructive pulmonary disease. Revista da Associacao Medica Brasileira (1992). 2021 Sep; 67(9):1256-1260. doi: 10.1590/1806-9282.20210429. [PMID: 34816917]
  • Yoshimitsu Ouchi, Miko Yamato, Vishwajit S Chowdhury, Takashi Bungo. Adenosine 5'-monophosphate induces hypothermia and alters gene expressions in the brain and liver of chicks. Brain research bulletin. 2021 07; 172(?):14-21. doi: 10.1016/j.brainresbull.2021.04.008. [PMID: 33862124]
  • Soo Hee Lee, Ju-Tae Sohn. Potential mechanisms underlying the effects of lipid emulsion against theophylline-induced toxicity. The American journal of emergency medicine. 2021 07; 45(?):629-630. doi: 10.1016/j.ajem.2020.11.042. [PMID: 33261948]
  • Geoffrey C Wall, Hayden L Smith, Matthew W Trump, Jason D Mohr, Samuel P DuMontier, Becca L Sabates, Iaswarya Ganapathiraju, Tim J Kable. Pentoxifylline or theophylline use in hospitalized COVID-19 patients requiring oxygen support. The clinical respiratory journal. 2021 Jul; 15(7):843-846. doi: 10.1111/crj.13363. [PMID: 33735520]
  • V P Chandrasekaran, Anand Parthasarathy, Balaji Muruga, Senthamil, Tharanesh. Lipid emulsion in theophylline and salbutamol overdose: Lipid sink theory (MS 25092). The American journal of emergency medicine. 2021 07; 45(?):632. doi: 10.1016/j.ajem.2020.11.040. [PMID: 33323277]
  • Xiaomei I Liu, John N van den Anker, Gilbert J Burckart, André Dallmann. Evaluation of Physiologically Based Pharmacokinetic Models to Predict the Absorption of BCS Class I Drugs in Different Pediatric Age Groups. Journal of clinical pharmacology. 2021 06; 61 Suppl 1(?):S94-S107. doi: 10.1002/jcph.1845. [PMID: 34185902]
  • Ramya R, Thivya P, Nathiya D, Wilson J. Polypyrrole and enzyme free cholesterol flakes based composite: Selective determination of theophylline. Journal of pharmaceutical and biomedical analysis. 2021 May; 199(?):114065. doi: 10.1016/j.jpba.2021.114065. [PMID: 33848914]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Trishul Siddharthan, Suzanne L Pollard, Peter Jackson, Nicole M Robertson, Adaeze C Wosu, Nihaal Rahman, Roma Padalkar, Isaac Sekitoleko, Esther Namazzi, Patricia Alupo, John R Hurst, Robert Kalyesubula, David Dowdy, Robert Wise, Peter J Barnes, William Checkley, Bruce Kirenga. Effectiveness of low-dose theophylline for the management of biomass-associated COPD (LODOT-BCOPD): study protocol for a randomized controlled trial. Trials. 2021 Mar; 22(1):213. doi: 10.1186/s13063-021-05163-2. [PMID: 33726828]
  • Deepa Thomas, Neethu Mathew, Megha S Nath. Starch modified alginate nanoparticles for drug delivery application. International journal of biological macromolecules. 2021 Mar; 173(?):277-284. doi: 10.1016/j.ijbiomac.2020.12.227. [PMID: 33453259]
  • Sharmin Siddiqui, Faisal Ameen, Tasneem Kausar, Shahid M Nayeem, Sayeed Ur Rehman, Mohammad Tabish. Biophysical insight into the binding mechanism of doxofylline to bovine serum albumin: An in vitro and in silico approach. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Mar; 249(?):119296. doi: 10.1016/j.saa.2020.119296. [PMID: 33338935]
  • Zhipeng Zhang, Jie Guo, Maojun Cheng, Weixin Zhou, Yang Wan, Rikang Wang, Yuanying Fang, Yi Jin, Jing Liu, Sai-Sai Xie. Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2021 Mar; 213(?):113154. doi: 10.1016/j.ejmech.2021.113154. [PMID: 33476932]
  • Mengsuo Cui, Hao Pan, Dongyang Fang, Haowei Sun, Sen Qiao, Weisan Pan. Exploration and evaluation of dynamic dose-control platform for pediatric medicine based on Drop-on-Powder 3D printing technology. International journal of pharmaceutics. 2021 Mar; 596(?):120201. doi: 10.1016/j.ijpharm.2021.120201. [PMID: 33539997]
  • Jessica L Gleason, Fasil Tekola-Ayele, Rajeshwari Sundaram, Stefanie N Hinkle, Yassaman Vafai, Germaine M Buck Louis, Nicole Gerlanc, Melissa Amyx, Alaina M Bever, Melissa M Smarr, Morgan Robinson, Kurunthachalam Kannan, Katherine L Grantz. Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry: A Secondary Analysis of the NICHD Fetal Growth Studies-Singletons. JAMA network open. 2021 03; 4(3):e213238. doi: 10.1001/jamanetworkopen.2021.3238. [PMID: 33764424]
  • Valerie Y Chock, Seo-Ho Cho, Adam Frymoyer. Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia. Pediatric research. 2021 03; 89(4):974-980. doi: 10.1038/s41390-020-0999-y. [PMID: 32503030]
  • Daniel Janitschke, Anna A Lauer, Cornel M Bachmann, Heike S Grimm, Tobias Hartmann, Marcus O W Grimm. Methylxanthines and Neurodegenerative Diseases: An Update. Nutrients. 2021 Feb; 13(3):. doi: 10.3390/nu13030803. [PMID: 33671099]
  • Li Qian, Yajuan Fan, Fengjie Gao, Binbin Zhao, Bin Yan, Wei Wang, Jian Yang, Xiancang Ma. Genetically Determined Levels of Serum Metabolites and Risk of Neuroticism: A Mendelian Randomization Study. The international journal of neuropsychopharmacology. 2021 01; 24(1):32-39. doi: 10.1093/ijnp/pyaa062. [PMID: 32808022]
  • Tomonori Miura, Shotaro Uehara, Makiko Shimizu, Norie Murayama, Hiroshi Suemizu, Hiroshi Yamazaki. Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice. The Journal of toxicological sciences. 2021; 46(11):525-530. doi: 10.2131/jts.46.525. [PMID: 34719555]
  • Grace F Crotty, Romeo Maciuca, Eric A Macklin, Junhua Wang, Manuel Montalban, Sonnet S Davis, Jamal I Alkabsh, Rachit Bakshi, Xiqun Chen, Alberto Ascherio, Giuseppe Astarita, Sarah Huntwork-Rodriguez, Michael A Schwarzschild. Association of caffeine and related analytes with resistance to Parkinson disease among LRRK2 mutation carriers: A metabolomic study. Neurology. 2020 12; 95(24):e3428-e3437. doi: 10.1212/wnl.0000000000010863. [PMID: 32999056]
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