chromomycin a3 (BioDeep_00000399856)

   

natural product Chemicals and Drugs Antibiotics


代谢物信息卡片


[(2R,3R,4R,6S)-6-[[(6S,7S)-6-[(2S,4R,5R,6R)-4-[(4R,5S,6R)-4-[(2S,4S,5R,6R)-5-acetyloxy-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-7-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-4,10-dihydroxy-3-methyl-5-oxo-7,8-dihydro-6H-anthracen-2-yl]oxy]-4-[(2S,4R,5S,6R)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-2-methyloxan-3-yl] acetate

化学式: C57H82O26 (1182.5094)
中文名称: 色霉素A3
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O
InChI: InChI=1S/C57H82O26/c1-21-34(79-40-19-37(53(26(6)75-40)77-28(8)59)82-38-16-33(61)52(70-11)25(5)74-38)15-31-13-30-14-32(54(71-12)51(68)46(63)22(2)58)55(50(67)44(30)49(66)43(31)45(21)62)83-41-18-35(47(64)24(4)73-41)80-39-17-36(48(65)23(3)72-39)81-42-20-57(10,69)56(27(7)76-42)78-29(9)60/h13,15,22-27,32-33,35-42,46-48,52-56,58,61-66,69H,14,16-20H2,1-12H3/t22-,23-,24-,25-,26-,27+,32+,33-,35-,36-,37-,38-,39+,40+,41+,42+,46+,47-,48-,52+,53+,54+,55+,56+,57+/m1/s1

描述信息

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
D000970 - Antineoplastic Agents > D000903 - Antibiotics, Antineoplastic > D002865 - Chromomycins
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D004396 - Coloring Agents > D005456 - Fluorescent Dyes
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent

同义名列表

3 个代谢物同义名

[(2R,3R,4R,6S)-6-[[(6S,7S)-6-[(2S,4R,5R,6R)-4-[(4R,5S,6R)-4-[(2S,4S,5R,6R)-5-acetyloxy-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-7-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-4,10-dihydroxy-3-methyl-5-oxo-7,8-dihydro-6H-anthracen-2-yl]oxy]-4-[(2S,4R,5S,6R)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-2-methyloxan-3-yl] acetate; chromomycin a3; Chromomycin A3



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ANXA5, AP5Z1, BIRC5, PCNT, SP1, SRF, TBP
Peripheral membrane protein 1 ANXA5
Endoplasmic reticulum membrane 1 GUCY2D
Nucleus 13 AP5Z1, BIRC5, DNASE1, H1-1, H1-5, H2BW1, PRM1, PRM2, SP1, SRF, TBP, TNP1, TNP2
cytosol 6 ANXA5, BIRC5, HBB, LIPE, PCNT, PRM1
centrosome 1 PCNT
nucleoplasm 9 AP5Z1, BIRC5, H1-1, H1-5, PRM1, PRM2, SP1, SRF, TBP
Cell membrane 1 LIPE
Multi-pass membrane protein 1 MT-CYB
cell surface 1 H1-1
mitochondrial inner membrane 1 MT-CYB
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 LIPE
Lysosome 1 AP5Z1
plasma membrane 2 GUCY2D, MUC7
Membrane 5 ANXA5, HBB, LIPE, MT-CYB, PCNT
caveola 1 LIPE
extracellular exosome 4 ANXA5, DNASE1, HBB, MUC7
extracellular space 2 HBB, SP1
mitochondrion 1 MT-CYB
protein-containing complex 2 BIRC5, TBP
Single-pass type I membrane protein 1 GUCY2D
Secreted 3 DNASE1, MUC7, SP1
extracellular region 4 ANXA5, DNASE1, HBB, SP1
centriolar satellite 1 PCNT
photoreceptor outer segment 1 GUCY2D
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PCNT
Nucleus membrane 1 H2BW1
nuclear membrane 1 H2BW1
external side of plasma membrane 1 ANXA5
microtubule cytoskeleton 1 BIRC5
nucleolus 2 H1-5, TNP2
midbody 1 BIRC5
vesicle 1 H1-1
Mitochondrion inner membrane 1 MT-CYB
heterochromatin 1 H1-5
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 1 ANXA5
microtubule 2 BIRC5, PCNT
spindle 1 BIRC5
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 1 AP5Z1
interphase microtubule organizing center 1 BIRC5
nuclear outer membrane 1 GUCY2D
Late endosome 1 AP5Z1
Zymogen granule membrane 1 ANXA5
chromatin 5 H1-1, H1-5, SP1, SRF, TBP
Chromosome 8 BIRC5, H1-1, H1-5, H2BW1, PRM1, PRM2, TNP1, TNP2
centriole 2 BIRC5, PCNT
Nucleus, nucleolus 1 TNP2
Chromosome, telomere 1 H2BW1
chromosome, telomeric region 1 H2BW1
nuclear chromosome 1 BIRC5
blood microparticle 1 HBB
nuclear envelope 1 DNASE1
Nucleus envelope 1 DNASE1
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
female germ cell nucleus 1 TBP
euchromatin 4 H1-1, H1-5, SP1, TBP
ficolin-1-rich granule lumen 1 HBB
Golgi lumen 1 MUC7
transcription repressor complex 1 SP1
male germ cell nucleus 3 PRM2, TBP, TNP1
transcription factor TFIID complex 1 TBP
tertiary granule lumen 1 HBB
kinetochore 1 BIRC5
chromosome, centromeric region 1 BIRC5
vesicle membrane 1 ANXA5
respiratory chain complex III 1 MT-CYB
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
protein-DNA complex 1 SP1
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
female pronucleus 1 TBP
male pronucleus 1 TBP
nucleosome 7 H1-1, H1-5, H2BW1, PRM1, PRM2, TNP1, TNP2
AP-5 adaptor complex 1 AP5Z1
AP-type membrane coat adaptor complex 1 AP5Z1
photoreceptor outer segment membrane 1 GUCY2D
zymogen granule 1 DNASE1
photoreceptor disc membrane 1 GUCY2D
hemoglobin complex 1 HBB
endocytic vesicle lumen 1 HBB
haptoglobin-hemoglobin complex 1 HBB
endothelial microparticle 1 ANXA5
RNA polymerase transcription factor SL1 complex 1 TBP
transcription factor TFIIA complex 1 TBP


文献列表

  • Yu-Wen Chen, Roshan Satange, Pei-Ching Wu, Cyong-Ru Jhan, Chung-Ke Chang, Kuang-Ren Chung, Michael J Waring, Sheng-Wei Lin, Li-Ching Hsieh, Ming-Hon Hou. CoII(Chromomycin)₂ Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex. International journal of molecular sciences. 2018 Sep; 19(9):. doi: 10.3390/ijms19092796. [PMID: 30227633]
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