Eplerenone (BioDeep_00000398950)

   

natural product


代谢物信息卡片


Eplerenone

化学式: C24H30O6 (414.204228)
中文名称: 依普利酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C=C2[C@](C1)([C@@]34[C@@]([C@@H](C2)C(OC)=O)([C@]5([C@](C[C@@H]3O4)([C@]6(CC5)CCC(O6)=O)C)[H])[H])C)=O
InChI: InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D000451 - Mineralocorticoid Receptor Antagonists
C - Cardiovascular system > C03 - Diuretics > C03D - Aldosterone antagonists and other potassium-sparing agents > C03DA - Aldosterone antagonists
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics

同义名列表

1 个代谢物同义名

Eplerenone



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Juan Hao, Panpan Qiang, Lili Fan, Yunzhao Xiong, Yi Chang, Fan Yang, Xiangting Wang, Tatsuo Shimosawa, Shengyu Mu, Qingyou Xu. Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats. Scientific reports. 2024 05; 14(1):9976. doi: 10.1038/s41598-024-60636-z. [PMID: 38693148]
  • Ran Sun, Yali Li, Lei Lv, Weiliang Zhang, Xiaoxia Guo. Efficacy and safety of esaxerenone (CS-3150) in primary hypertension: a meta-analysis. Journal of human hypertension. 2024 Feb; 38(2):102-109. doi: 10.1038/s41371-023-00889-9. [PMID: 38177694]
  • Thi Minh Phuong Nikrýnová Nguyen, Branislav Štrauch, Ondřej Petrák, Zuzana Krátká, Robert Holaj, Ivana Kurcová, Věra Marešová, Alena Pilková, Jan Hartinger, Petr Waldauf, Tomáš Zelinka, Jiří Widimský. Adherence and blood pressure control in patients with primary aldosteronism. Blood pressure. 2022 12; 31(1):58-63. doi: 10.1080/08037051.2022.2061416. [PMID: 35438025]
  • Zhen He, Mengjuan Zhang, Hepeng Xu, Wenping Zhou, Chang Xu, Zheng Wang, Ming He, Xiangting Wang. Yiqi Huoxue Tongluo recipe regulates NR4A1 to improve renal mitochondrial function in unilateral ureteral obstruction (UUO) rats. Pharmaceutical biology. 2022 Dec; 60(1):2308-2318. doi: 10.1080/13880209.2022.2148168. [PMID: 36428248]
  • Gege Chen, Yi Chang, Yunzhao Xiong, Juan Hao, Lingjin Liu, Ziqian Liu, Hui Li, Panpan Qiang, Yutong Han, Yunqian Xian, Tatsuo Shimosawa, Xiangting Wang, Fan Yang, Qingyou Xu. Eplerenone inhibits UUO-induced lymphangiogenesis and cardiac fibrosis by attenuating inflammatory injury. International immunopharmacology. 2022 Jul; 108(?):108759. doi: 10.1016/j.intimp.2022.108759. [PMID: 35428023]
  • Fathalla Belal, Mokhtar Mabrouk, Sherin Hammad, Aya Barseem, Hytham Ahmed. Multi-spectroscopic, thermodynamic and molecular docking studies to investigate the interaction of eplerenone with human serum albumin. Luminescence : the journal of biological and chemical luminescence. 2022 Jul; 37(7):1162-1173. doi: 10.1002/bio.4270. [PMID: 35489089]
  • Toru Iijima, Makoto Katoh, Kei Takedomi, Yasuo Yamamoto, Hidenori Akatsuka, Naritoshi Shirata, Akito Nishi, Misae Takakuwa, Yoshinori Watanabe, Hitomi Munakata, Naomi Koyama, Tomoko Ikeda, Taku Iguchi, Harutoshi Kato, Kohei Kikkawa, Takayuki Kawaguchi. Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist. Journal of medicinal chemistry. 2022 06; 65(12):8127-8143. doi: 10.1021/acs.jmedchem.2c00402. [PMID: 35652647]
  • Toshifumi Nakamura, Benjamin Bonnard, Roberto Palacios-Ramirez, Amaya Fernández-Celis, Frédéric Jaisser, Natalia López-Andrés. Biglycan Is a Novel Mineralocorticoid Receptor Target Involved in Aldosterone/Salt-Induced Glomerular Injury. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126680. [PMID: 35743123]
  • Pieter Martens, João Pedro Ferreira, John Vincent, Paula Abreu, Martijn Busselen, Wilfried Mullens, Wilson W H Tang, Michael Böhm, Bertram Pitt, Faiez Zannad, Patrick Rossignol. Serum sodium and eplerenone use in patients with a myocardial infarction and left ventricular dysfunction or heart failure: insights from the EPHESUS trial. Clinical research in cardiology : official journal of the German Cardiac Society. 2022 Apr; 111(4):380-392. doi: 10.1007/s00392-021-01853-8. [PMID: 33893561]
  • Namrata G Jain, Justin K Chen, Ruchi Mahajan, Jacqueline Kehoe, Pamela Singer, Dilys Whyte, Andrew S Bomback. Use of ofatumumab and eplerenone in post-transplant recurrence of FSGS. Pediatric transplantation. 2022 Mar; 26(2):e14191. doi: 10.1111/petr.14191. [PMID: 34806263]
  • Honglei Hu, Xiaodong Zhao, Xingqian Jin, Shujuan Wang, Wenlong Liang, Xiangguo Cong. Efficacy and safety of eplerenone treatment for patients with diabetic nephropathy: A meta-analysis. PloS one. 2022; 17(3):e0265642. doi: 10.1371/journal.pone.0265642. [PMID: 35324976]
  • Eman Abd-Elhakeem, Mohamed El-Nabarawi, Rehab Shamma. Lipid-based nano-formulation platform for eplerenone oral delivery as a potential treatment of chronic central serous chorioretinopathy: in-vitro optimization and ex-vivo assessment. Drug delivery. 2021 Dec; 28(1):642-654. doi: 10.1080/10717544.2021.1902023. [PMID: 33787445]
  • Jaejin An, Fang Niu, John J Sim. Cardiovascular and kidney outcomes of spironolactone or eplerenone in combination with ACEI/ARBs in patients with diabetic kidney disease. Pharmacotherapy. 2021 12; 41(12):998-1008. doi: 10.1002/phar.2633. [PMID: 34655484]
  • Masayo Koide, Osama F Harraz, Fabrice Dabertrand, Thomas A Longden, Hannah R Ferris, George C Wellman, David C Hill-Eubanks, Adam S Greenstein, Mark T Nelson. Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease. The Journal of clinical investigation. 2021 09; 131(18):. doi: 10.1172/jci149029. [PMID: 34351870]
  • Niels H Brandt-Jacobsen, Per Lav Madsen, Marie Louise Johansen, Jon J Rasmussen, Julie L Forman, Maria R Holm, Niklas Rye Jørgensen, Jens Faber, Patrick Rossignol, Morten Schou, Caroline Kistorp. Mineralocorticoid Receptor Antagonist Improves Cardiac Structure in Type 2 Diabetes: Data From the MIRAD Trial. JACC. Heart failure. 2021 08; 9(8):550-558. doi: 10.1016/j.jchf.2021.02.016. [PMID: 34325885]
  • Stine H Finsen, Mie R Hansen, Joachim Hoffmann-Petersen, Henrik F Højgaard, Stefan P Mortensen. Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes. Physiological reports. 2021 08; 9(15):e14971. doi: 10.14814/phy2.14971. [PMID: 34350730]
  • Jumpei Saito, Asako Mito, Naho Yakuwa, Kayoko Kaneko, Hiroyo Kawasaki, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Eplerenone levels in maternal serum, cord blood, and breast milk during pregnancy and lactation. Hypertension research : official journal of the Japanese Society of Hypertension. 2021 07; 44(7):879-881. doi: 10.1038/s41440-021-00621-5. [PMID: 33564177]
  • Niels H Brandt-Jacobsen, Marie Louise Johansen, Jon Rasmussen, Julie L Forman, Maria Refsgaard Holm, Jens Faber, Patrick Rossignol, Morten Schou, Caroline Kistorp. Effect of high-dose mineralocorticoid receptor antagonist eplerenone on urinary albumin excretion in patients with type 2 diabetes and high cardiovascular risk: Data from the MIRAD trial. Diabetes & metabolism. 2021 07; 47(4):101190. doi: 10.1016/j.diabet.2020.08.005. [PMID: 32919068]
  • Ezequiel Cordova, Franco Garibaldi, Leandro Bono, Claudia Rodriguez. Severe hyperkalaemia due to a potential drug-drug interaction between eplerenone and antiretrovirals in a HIV-positive patient after a myocardial infarction. International journal of STD & AIDS. 2021 07; 32(8):771-773. doi: 10.1177/0956462420987422. [PMID: 33629924]
  • João Pedro Ferreira, Zohra Lamiral, John J V McMurray, Karl Swedberg, Dirk J van Veldhuisen, John Vincent, Patrick Rossignol, Stuart J Pocock, Bertram Pitt, Faiez Zannad. Impact of Insulin Treatment on the Effect of Eplerenone: Insights From the EMPHASIS-HF Trial. Circulation. Heart failure. 2021 06; 14(6):e008075. doi: 10.1161/circheartfailure.120.008075. [PMID: 34129365]
  • Susan Stienen, João Pedro Ferreira, Christian Bär, Thomas Thum, António Barros, Bertram Pitt, Nicolas Girerd, Patrick Rossignol, Faiez Zannad. Serum microRNAs and antifibrotic response to eplerenone in acute myocardial infarction complicated by systolic dysfunction. International journal of cardiology. 2021 06; 332(?):35-37. doi: 10.1016/j.ijcard.2021.02.088. [PMID: 33676945]
  • Fan Yang, Yi Chang, Cuijuan Zhang, Yunzhao Xiong, Xiangting Wang, Xuelian Ma, Zheng Wang, Hui Li, Tatsuo Shimosawa, Lin Pei, Qingyou Xu. UUO induces lung fibrosis with macrophage-myofibroblast transition in rats. International immunopharmacology. 2021 Apr; 93(?):107396. doi: 10.1016/j.intimp.2021.107396. [PMID: 33540244]
  • Christopher Edwards. New Horizons: Does Mineralocorticoid Receptor Activation by Cortisol Cause ATP Release and COVID-19 Complications?. The Journal of clinical endocrinology and metabolism. 2021 03; 106(3):622-635. doi: 10.1210/clinem/dgaa874. [PMID: 33249452]
  • Takeshi Hasegawa, Hiroki Nishiwaki, Erika Ota, William Mm Levack, Hisashi Noma. Aldosterone antagonists for people with chronic kidney disease requiring dialysis. The Cochrane database of systematic reviews. 2021 02; 2(?):CD013109. doi: 10.1002/14651858.cd013109.pub2. [PMID: 33586138]
  • Ryo Nakamaru, Koichi Yamamoto, Hiroshi Akasaka, Hiromi Rakugi, Isao Kurihara, Takashi Yoneda, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Megumi Fujita, Kenji Oki, Kohei Kamemura, Akiyo Tanabe, Mitsuhide Naruse. Sex Differences in Renal Outcomes After Medical Treatment for Bilateral Primary Aldosteronism. Hypertension (Dallas, Tex. : 1979). 2021 02; 77(2):537-545. doi: 10.1161/hypertensionaha.120.16449. [PMID: 33356395]
  • Fathalla Belal, Mokhtar Mabrouk, Sherin Hammad, Aya Barseem, Hytham Ahmed. A Novel Eplerenone Ecofriendly Fluorescent Nanosensor Based on Nitrogen and Sulfur-Carbon Quantum Dots. Journal of fluorescence. 2021 Jan; 31(1):85-90. doi: 10.1007/s10895-020-02638-4. [PMID: 33074428]
  • Eman Abdelhakeem, Mohamed El-Nabarawi, Rehab Shamma. Effective Ocular Delivery of Eplerenone Using Nanoengineered Lipid Carriers in Rabbit Model. International journal of nanomedicine. 2021; 16(?):4985-5002. doi: 10.2147/ijn.s319814. [PMID: 34335024]
  • Akira Kurozumi, Yosuke Okada, Yoshiya Tanaka. Eplerenone Improves Vascular Endothelial Function in Patients with Primary Aldosteronism: A Pilot Study. Journal of UOEH. 2021; 43(4):379-384. doi: 10.7888/juoeh.43.379. [PMID: 34897166]
  • Viren H Makhijani, Preethi Irukulapati, Kalynn Van Voorhies, Brayden Fortino, Joyce Besheer. Central amygdala mineralocorticoid receptors modulate alcohol self-administration. Neuropharmacology. 2020 12; 181(?):108337. doi: 10.1016/j.neuropharm.2020.108337. [PMID: 33007359]
  • Shinji Kishimoto, Kenji Oki, Tatsuya Maruhashi, Masato Kajikawa, Haruki Hashimoto, Yuji Takaeko, Takahiro Harada, Takayuki Yamaji, Yiming Han, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Farina Mohamad Yusoff, Ayumu Nakashima, Yukihito Higashi. A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma. The Journal of clinical endocrinology and metabolism. 2020 11; 105(11):. doi: 10.1210/clinem/dgaa561. [PMID: 32818224]
  • Edmund Ym Chung, Marinella Ruospo, Patrizia Natale, Davide Bolignano, Sankar D Navaneethan, Suetonia C Palmer, Giovanni Fm Strippoli. Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease. The Cochrane database of systematic reviews. 2020 10; 10(?):CD007004. doi: 10.1002/14651858.cd007004.pub4. [PMID: 33107592]
  • Hitoshi Minakuchi, Shu Wakino, Hidenori Urai, Arata Kurokochi, Kazuhiro Hasegawa, Takeshi Kanda, Hirobumi Tokuyama, Hiroshi Itoh. The effect of aldosterone and aldosterone blockade on the progression of chronic kidney disease: a randomized placebo-controlled clinical trial. Scientific reports. 2020 10; 10(1):16626. doi: 10.1038/s41598-020-73638-4. [PMID: 33024237]
  • Atsushi Hashimoto, Yoshimichi Takeda, Shigehiro Karashima, Mitsuhiro Kometani, Daisuke Aono, Masashi Demura, Takuya Higashitani, Seigo Konishi, Takashi Yoneda, Yoshiyu Takeda. Impact of mineralocorticoid receptor blockade with direct renin inhibition in angiotensin II-dependent hypertensive mice. Hypertension research : official journal of the Japanese Society of Hypertension. 2020 10; 43(10):1099-1104. doi: 10.1038/s41440-020-0458-5. [PMID: 32398797]
  • Danli Hu, Ruolan Dong, Yanjun Zhang, Yan Yang, Zhihui Chen, Ying Tang, Menglu Fu, Xizhen Xu, Ling Tu. Age‑related changes in mineralocorticoid receptors in rat hearts. Molecular medicine reports. 2020 09; 22(3):1859-1867. doi: 10.3892/mmr.2020.11260. [PMID: 32582979]
  • Xue Wang, Yuhai Zhu, Shuanglin Wang, Zhuoqun Wang, Haonan Sun, Yujie He, Wei Yao. Effects of eplerenone on cerebral aldosterone levels and brain lesions in spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993). 2020 Aug; 42(6):531-538. doi: 10.1080/10641963.2020.1723615. [PMID: 32020810]
  • Adhish Agarwal, Alfred K Cheung. Mineralocorticoid Receptor Antagonists in ESKD. Clinical journal of the American Society of Nephrology : CJASN. 2020 07; 15(7):1047-1049. doi: 10.2215/cjn.13221019. [PMID: 32269029]
  • Amanda E Garza, Elijah Trefts, Isis A Katayama Rangel, Danielle Brooks, Rene Baudrand, Burhanuddin Moize, Jose R Romero, Sanjay Ranjit, Thitinan Treesaranuwattana, Tham M Yao, Gail K Adler, Luminita H Pojoga, Gordon H Williams. Striatin heterozygous mice are more sensitive to aldosterone-induced injury. The Journal of endocrinology. 2020 06; 245(3):439-450. doi: 10.1530/joe-19-0562. [PMID: 32229698]
  • Milla Marques Hermidorff, Leonardo Vinícius Monteiro de Assis, Joel Alves Rodrigues, Leôncio Lopes Soares, Milton Hércules Guerra Andrade, Antônio José Natali, Mauro Cesar Isoldi. Mineralocorticoid receptor antagonists lead to increased adenosine bioavailability and modulate contractile cardiac parameters. Heart and vessels. 2020 May; 35(5):719-730. doi: 10.1007/s00380-019-01542-7. [PMID: 31820090]
  • Thitinan Treesaranuwattana, Kelly Yin Han Wong, Danielle L Brooks, Chee Sin Tay, Gordon H Williams, Jonathan S Williams, Luminita H Pojoga. Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor. Hypertension (Dallas, Tex. : 1979). 2020 04; 75(4):1045-1053. doi: 10.1161/hypertensionaha.119.13821. [PMID: 32160100]
  • Keisuke Okamura, Masatoshi Matsushima, Fumi Yamamoto, Yosuke Takamiya, Tetsu Okuda, Kazuyuki Shirai, Katsusuke Okamura, Hidenori Urata. A Patient with Bilateral Primary Aldosteronism Refractory to Oral Eplerenone Who Responded to Esaxerenone with Increased Renin Activity. The American journal of case reports. 2020 Jan; 21(?):e920615. doi: 10.12659/ajcr.920615. [PMID: 31907345]
  • Mostafa El Mokadem, Yasser Abd El Hady, Ashraf Aziz. A Prospective Single-Blind Randomized Trial of Ramipril, Eplerenone and Their Combination in Type 2 Diabetic Nephropathy. Cardiorenal medicine. 2020; 10(6):392-401. doi: 10.1159/000508670. [PMID: 32998143]
  • Andrea Vecchiola, Cristóbal A Fuentes, Isidora Solar, Carlos F Lagos, Maria Cecilia Opazo, Natalia Muñoz-Durango, Claudia A Riedel, Gareth I Owen, Alexis M Kalergis, Carlos E Fardella. Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division. Frontiers in endocrinology. 2020; 11(?):223. doi: 10.3389/fendo.2020.00223. [PMID: 32373073]
  • Kawa Dizaye, Zana A Mustafa. The effect of eplerenone on the renin-angiotensin-aldosterone system of rats with thyroid dysfunction. The Journal of pharmacy and pharmacology. 2019 Dec; 71(12):1800-1808. doi: 10.1111/jphp.13168. [PMID: 31579950]
  • Maolin Yu, Mark W Ledeboer, Matthew Daniels, Goran Malojcic, Thomas T Tibbitts, Marie Coeffet-Le Gal, Xin-Ru Pan-Zhou, Amy Westerling-Bui, Maria Beconi, John F Reilly, Peter Mundel, Jean-Christophe Harmange. Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model. ACS medicinal chemistry letters. 2019 Nov; 10(11):1579-1585. doi: 10.1021/acsmedchemlett.9b00430. [PMID: 31749913]
  • Elodie Bousquet, Min Zhao, Alejandra Daruich, Francine Behar-Cohen. Mineralocorticoid antagonists in the treatment of central serous chorioetinopathy: Review of the pre-clinical and clinical evidence. Experimental eye research. 2019 10; 187(?):107754. doi: 10.1016/j.exer.2019.107754. [PMID: 31401003]
  • Marie L Johansen, Morten Schou, Patrick Rossignol, Maria R Holm, Jon Rasmussen, Niels Brandt, Mikkel Frandsen, Elizaveta Chabanova, Flemming Dela, Jens Faber, Caroline Kistorp. Effect of the mineralocorticoid receptor antagonist eplerenone on liver fat and metabolism in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial (MIRAD trial). Diabetes, obesity & metabolism. 2019 10; 21(10):2305-2314. doi: 10.1111/dom.13809. [PMID: 31183945]
  • Keiko Hosohata, Denan Jin, Shinji Takai, Kazunori Iwanaga. Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats. International journal of molecular sciences. 2019 Sep; 20(18):. doi: 10.3390/ijms20184481. [PMID: 31514290]
  • Qi-Qiang Jie, Gang Li, Jiang-Bo Duan, Xue-Bin Li, Wei Yang, Yan-Peng Chu, Shan-Dong Yu, Xiao-Yan Liu, Cheng-Yu Wang, Fei-Fei Liu, Feng Ze, Yu-Wen Huang, Ying Chen, Yan-Sheng Ding, Ji-Hong Guo, Lin Wu. Remodeling of myocardial energy and metabolic homeostasis in a sheep model of persistent atrial fibrillation. Biochemical and biophysical research communications. 2019 09; 517(1):8-14. doi: 10.1016/j.bbrc.2019.05.112. [PMID: 31307785]
  • Yusuke Nakazawa, Shinya Inoue, Yuka Nakamura, Yasuo Iida, Yasuhito Ishigaki, Katsuhito Miyazawa. High-salt diet promotes crystal deposition through hypertension in Dahl salt-sensitive rat model. International journal of urology : official journal of the Japanese Urological Association. 2019 08; 26(8):839-846. doi: 10.1111/iju.14035. [PMID: 31257672]
  • Alessandra Ocello, Sandra La Rosa, Fulvio Fiorini, Salvatore Randone, Rosario Maccarrone, Giorgio Battaglia, Antonio Granata. [Antifibrotic renal role of mineralcorticoid receptor antagonists]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. 2019 Jul; 36(4):. doi: . [PMID: 31373464]
  • Mitsuhiro Nishimoto, Hiroshi Ohtsu, Takeshi Marumo, Wakako Kawarazaki, Nobuhiro Ayuzawa, Kohei Ueda, Daigoro Hirohama, Fumiko Kawakami-Mori, Shigeru Shibata, Miki Nagase, Masashi Isshiki, Shigeyoshi Oba, Tatsuo Shimosawa, Toshiro Fujita. Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in non-diabetic hypertension: a sub-analysis of evaluate study. Hypertension research : official journal of the Japanese Society of Hypertension. 2019 04; 42(4):514-521. doi: 10.1038/s41440-018-0201-7. [PMID: 30631161]
  • Danielle L Brooks, Amanda E Garza, Isis A Katayama, Jose R Romero, Gail K Adler, Luminita H Pojoga, Gordon H Williams. Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice. Endocrinology. 2019 04; 160(4):716-728. doi: 10.1210/en.2018-00989. [PMID: 30726893]
  • João Pedro Ferreira, Paula Abreu, John J V McMurray, Dirk J van Veldhuisen, Karl Swedberg, Stuart J Pocock, John Vincent, Katharina Lins, Patrick Rossignol, Bertram Pitt, Faiez Zannad. Renal function stratified dose comparisons of eplerenone versus placebo in the EMPHASIS-HF trial. European journal of heart failure. 2019 03; 21(3):345-351. doi: 10.1002/ejhf.1400. [PMID: 30768732]
  • Kenneth L Granberg, Zhong-Qing Yuan, Bo Lindmark, Karl Edman, Johan Kajanus, Anders Hogner, Marcus Malmgren, Gavin O'Mahony, Anneli Nordqvist, Jan Lindberg, Stefan Tångefjord, Michael Kossenjans, Christian Löfberg, Jonas Brånalt, Dongmei Liu, Nidhal Selmi, Grigorios Nikitidis, Peter Nordberg, Ahlke Hayen, Anna Aagaard, Eva Hansson, Majlis Hermansson, Ida Ivarsson, Rasmus Jansson-Löfmark, Ulla Karlsson, Ulrika Johansson, Lena William-Olsson, Judith Hartleib-Geschwindner, Krister Bamberg. Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection. Journal of medicinal chemistry. 2019 02; 62(3):1385-1406. doi: 10.1021/acs.jmedchem.8b01523. [PMID: 30596500]
  • Christopher R Heier, Qing Yu, Alyson A Fiorillo, Christopher B Tully, Asya Tucker, Davi A Mazala, Kitipong Uaesoontrachoon, Sadish Srinivassane, Jesse M Damsker, Eric P Hoffman, Kanneboyina Nagaraju, Christopher F Spurney. Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy. Life science alliance. 2019 02; 2(1):. doi: 10.26508/lsa.201800186. [PMID: 30745312]
  • Masayoshi Yamamoto, Yoshihiro Seo, Tomoko Ishizu, Isao Nishi, Yoshie Hamada-Harimura, Tomoko Machino-Ohtsuka, Haruhiko Higuchi, Seika Sai, Tomofumi Nakatsukasa, Akinori Sugano, Masako Baba, Kenichi Obara, Kazutaka Aonuma. Comparison of effects of aldosterone receptor antagonists spironolactone and eplerenone on cardiovascular outcomes and safety in patients with acute decompensated heart failure. Heart and vessels. 2019 Feb; 34(2):279-289. doi: 10.1007/s00380-018-1250-1. [PMID: 30203391]
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