cefaclor (BioDeep_00000398908)

Main id: BioDeep_00000002405

 

natural product


代谢物信息卡片


Cefaclor Impurity C

化学式: C15H14ClN3O4S (367.0394)
中文名称: 头孢克洛杂质C, 头孢克洛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl
InChI: InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DC - Second-generation cephalosporins
A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections[1][2][3][4].

同义名列表

4 个代谢物同义名

Cefaclor Impurity C; cefaclor; Cefaclor (Ceclor); Cefaclor



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表
Cytoplasm 2 ALB, HMGB1
Peripheral membrane protein 2 CYP27A1, HMGB1
Mitochondrion membrane 1 CYP27A1
Nucleus 3 ALB, HMGB1, MPO
cytosol 2 ALB, GPT
dendrite 2 HTR1A, HTR6
centrosome 1 ALB
nucleoplasm 2 HMGB1, MPO
Cell membrane 4 HMGB1, HTR1A, HTR6, TNF
Multi-pass membrane protein 6 ABCC3, HTR1A, HTR6, SLC15A1, SLC22A6, SLC22A8
Synapse 2 HTR1A, HTR6
cell surface 2 HMGB1, TNF
Golgi apparatus 1 ALB
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 1 TNF
Lysosome 1 MPO
endosome 1 HMGB1
plasma membrane 10 ABCC3, HMGB1, HTR1A, HTR6, IFNLR1, IGHE, SLC15A1, SLC22A6, SLC22A8, TNF
Membrane 4 ABCC3, IFNLR1, SLC15A1, SLC22A6
apical plasma membrane 2 SLC15A1, SLC22A8
axon 1 CCK
basolateral plasma membrane 3 ABCC3, SLC22A6, SLC22A8
brush border 1 SLC15A1
caveola 1 SLC22A6
extracellular exosome 5 ALB, GPT, MPO, SLC22A6, SLC22A8
endoplasmic reticulum 2 ALB, HMGB1
extracellular space 10 ALB, CCK, CRP, CXCL8, HMGB1, IGHE, IL2, IL6, MPO, TNF
mitochondrion 1 CYP27A1
protein-containing complex 2 ALB, SLC22A6
intracellular membrane-bounded organelle 1 MPO
Single-pass type I membrane protein 2 IFNLR1, IGHE
Secreted 8 ALB, CCK, CRP, CXCL8, HMGB1, HTRA3, IL2, IL6
extracellular region 11 ALB, CCK, CRP, CXCL8, HMGB1, HTRA3, IGHE, IL2, IL6, MPO, TNF
mitochondrial matrix 1 CYP27A1
Extracellular side 1 HMGB1
anchoring junction 1 ALB
external side of plasma membrane 1 TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 SLC15A1
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 1 TNF
secretory granule 1 MPO
lateral plasma membrane 1 SLC22A8
ciliary basal body 1 ALB
cilium 1 HTR6
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
Chromosome 1 HMGB1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 3 ABCC3, SLC22A6, SLC22A8
[Isoform 2]: Cell membrane 1 IGHE
Cell projection, dendrite 1 HTR1A
basal plasma membrane 2 ABCC3, SLC22A6
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 HMGB1
secretory granule lumen 1 HMGB1
endoplasmic reticulum lumen 2 ALB, IL6
transcription repressor complex 1 HMGB1
platelet alpha granule lumen 1 ALB
azurophil granule lumen 1 MPO
phagocytic vesicle lumen 1 MPO
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
Basal cell membrane 2 ABCC3, SLC22A6
condensed chromosome 1 HMGB1
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
interleukin-6 receptor complex 1 IL6
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • A Alper Öztürk, İrem Namlı, Abdurrahman Aygül. Cefaclor Monohydrate-Loaded Colon-Targeted Nanoparticles for Use in COVID-19 Dependent Coinfections and Intestinal Symptoms: Formulation, Characterization, Release Kinetics, and Antimicrobial Activity. Assay and drug development technologies. 2021 04; 19(3):156-175. doi: 10.1089/adt.2020.1014. [PMID: 33728979]
  • Young Hee Nam, So Hee Lee, Hyo In Rhyou, Young Soo Lee, Seung Hee Park, Young Hee Lee, Yoo Seob Shin, Hae Sim Park, Young Min Ye. Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy. Yonsei medical journal. 2018 Oct; 59(8):968-974. doi: 10.3349/ymj.2018.59.8.968. [PMID: 30187704]
  • M Ali Fadel, Reem H El-Gebaly, Shaimaa A Mohamed, Ashraf M M Abdelbacki. Biophysical control of the growth of Agrobacterium tumefaciens using extremely low frequency electromagnetic waves at resonance frequency. Biochemical and biophysical research communications. 2017 12; 494(1-2):365-371. doi: 10.1016/j.bbrc.2017.10.008. [PMID: 28988110]
  • Shazia Naz, Muhammad Harris Shoaib, Lubna Bashir, Rabia Ismail Yousuf, Fakhsheena Anjum, Fahad Siddiqui, Saima Yaseen. HPLC method development and validation for the determination of Cefaclor in human plasma. Pakistan journal of pharmaceutical sciences. 2017 Sep; 30(5):1645-1649. doi: NULL. [PMID: 29084685]
  • Adel Alagl, Sumit Bedi, Khalid Hassan, Jehan AlHumaid. Use of platelet-rich plasma for regeneration in non-vital immature permanent teeth: Clinical and cone-beam computed tomography evaluation. The Journal of international medical research. 2017 Apr; 45(2):583-593. doi: 10.1177/0300060517692935. [PMID: 28415948]
  • Zdenko Tomić, Ana Tomas, Saša Vukmirović, Momir Mikov, Olga Horvat, Nataša Tomić, Ana Sabo. Do We Bury Antibacterials When Launching? Cefaclor Example. Journal of pharmaceutical sciences. 2016 Mar; 105(3):1295-300. doi: 10.1016/j.xphs.2015.12.003. [PMID: 26886327]
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  • Hye-Soo Yoo, Seung-Hyun Kim, Hyouk-Soo Kwon, Tae-Bum Kim, Young-Hee Nam, Young-Min Ye, Hae-Sim Park. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei medical journal. 2014 Nov; 55(6):1473-83. doi: 10.3349/ymj.2014.55.6.1473. [PMID: 25323882]
  • Chenrong Huang, Wei Wang, Liyan Miao. Determination of cefaclor by UPLC-MS-MS for a Chinese pharmacokinetic study. Journal of chromatographic science. 2014 Aug; 52(7):636-40. doi: 10.1093/chromsci/bmt092. [PMID: 23839802]
  • T Bezgin, A D Yilmaz, B N Celik, H Sönmez. Concentrated platelet-rich plasma used in root canal revascularization: 2 case reports. International endodontic journal. 2014 Jan; 47(1):41-9. doi: 10.1111/iej.12144. [PMID: 23772873]
  • Zhen Zhang, Yun Xiang, Baoxiang Wang, Hongbo Chen, Xiaofang Cai, Xiaomei Wang, Lin Mei, Yi Zheng. Intestinal mucosal permeability of children with cefaclor-associated serum sickness-like reactions. European journal of pediatrics. 2013 Apr; 172(4):537-43. doi: 10.1007/s00431-012-1926-y. [PMID: 23296953]
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  • Ayan Sen. Recurrent cystitis in non-pregnant women. BMJ clinical evidence. 2008 Jul; 2008(?):. doi: NULL. [PMID: 19445741]
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  • Qian Gong, Zhe-yi Hu, Zhi-zhuang Huang, Li-qing Wang, Wen-fang Liu, Xin Guo, Wei Cao, Ting Wang, Ze-neng Cheng. Pharmacokinetic interaction between cefaclor and bromhexine in healthy Chinese volunteers. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2007 Oct; 32(5):855-61. doi: NULL. [PMID: 18007084]
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  • Meng Li, Gail D Anderson, Brian R Phillips, Wei Kong, Danny D Shen, Joanne Wang. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug metabolism and disposition: the biological fate of chemicals. 2006 Apr; 34(4):547-55. doi: 10.1124/dmd.105.006791. [PMID: 16434549]
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