ifosfamide (BioDeep_00000398868)
Main id: BioDeep_00000002193
natural product
代谢物信息卡片
化学式: C7H15Cl2N2O2P (260.0248)
中文名称: 异环磷酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCCl)P(=O)(NCCCl)OC1
InChI: InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AA - Nitrogen mustard analogues
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
同义名列表
2 个代谢物同义名
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:5864
- KEGG: C07047
- KEGGdrug: D00343
- PubChem: 3690
- DrugBank: DB01181
- ChEMBL: CHEMBL1024
- MeSH: Ifosfamide
- CAS: 66849-34-1
- CAS: 3778-73-2
- CAS: 3778-73-2, 36341-88-5, 84711-20-6
- MoNA: CCMSLIB00000078094
- MoNA: CCMSLIB00000078093
- PubChem: 9259
- NIKKAJI: J2.196B
- RefMet: Ifosfamide
- KNApSAcK: 5864
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mai M Younis, Iriny M Ayoub, Mina Y George, Nada M Mostafa, Omayma A Eldahshan. In vivo hepatoprotective and nephroprotective effects of Stenocarpus sinuatus leaf extract against ifosfamide-induced toxicity in rats.
Archiv der Pharmazie.
2024 Feb; 357(2):e2300438. doi:
10.1002/ardp.202300438
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Journal of biochemical and molecular toxicology.
2023 Nov; ?(?):e23570. doi:
10.1002/jbt.23570
. [PMID: 37929796] - Abdollah Arjmand, Melika Mashhadi, Armin Kaveh, Farzaneh Kamranfar, Enayatollah Seydi, Jalal Pourahmad. Mitochondrial Transplantation Therapy against Ifosfamide Induced Toxicity on Rat Renal Proximal Tubular Cells.
Drug research.
2023 Feb; 73(2):113-120. doi:
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Cell transplantation.
2023 Jan; 32(?):9636897231219830. doi:
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Human & experimental toxicology.
2023 Jan; 42(?):9603271221147883. doi:
10.1177/09603271221147883
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Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2022 Aug; 97(6):423-432. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Aug; 1205(?):123331. doi:
10.1016/j.jchromb.2022.123331
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Pediatric blood & cancer.
2022 05; 69(5):e29595. doi:
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Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2022 Mar; 30(3):2755-2766. doi:
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European journal of cancer (Oxford, England : 1990).
2022 03; 163(?):88-97. doi:
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Medicine.
2021 Dec; 100(52):e28411. doi:
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Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2021 Dec; 27(8):1891-1895. doi:
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Nephrologie & therapeutique.
2021 Dec; 17(7):543-546. doi:
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International journal of molecular sciences.
2021 Nov; 22(22):. doi:
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International archives of occupational and environmental health.
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The journal of obstetrics and gynaecology research.
2021 Oct; 47(10):3737-3741. doi:
10.1111/jog.14945
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Advances in chronic kidney disease.
2021 09; 28(5):402-414.e1. doi:
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Journal of clinical pharmacy and therapeutics.
2021 Jun; 46(3):794-799. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
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Cancer medicine.
2021 04; 10(7):2250-2258. doi:
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Scientific reports.
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Pediatric blood & cancer.
2021 01; 68(1):e28747. doi:
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Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2020 Dec; 26(8):1864-1870. doi:
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Medicine.
2020 Oct; 99(44):e22921. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
2020 10; 393(10):1835-1848. doi:
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The International journal of pharmacy practice.
2020 Oct; 28(5):506-511. doi:
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Nutrients.
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Gan to kagaku ryoho. Cancer & chemotherapy.
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- Pramod K Kalambate, Dhanjai, Ankita Sinha, Yankai Li, Yue Shen, Yunhui Huang. An electrochemical sensor for ifosfamide, acetaminophen, domperidone, and sumatriptan based on self-assembled MXene/MWCNT/chitosan nanocomposite thin film.
Mikrochimica acta.
2020 06; 187(7):402. doi:
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Drug research.
2020 Jun; 70(6):265-272. doi:
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. [PMID: 32365382] - Takumi Shiraishi, Terukazu Nakamura, Toshiya Takamura, Masakatsu Oishi, Takeshi Yamada, Yasuhiro Yamada, Takashi Ueda, Atsuko Fujihara, Fumiya Hongo, Koji Okihara, Osamu Ukimura. Less nephrotoxicity of paclitaxel and ifosfamide plus nedaplatin for refractory or relapsed germ cell tumors in patients with impaired renal function.
International journal of urology : official journal of the Japanese Urological Association.
2020 Feb; 27(2):134-139. doi:
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Neurotoxicology.
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Drug research.
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Scientific reports.
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Molecular pharmacology.
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Advances in therapy.
2019 02; 36(2):355-364. doi:
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Pediatric blood & cancer.
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Cancer chemotherapy and pharmacology.
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Cancer science.
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Urology.
2018 Jun; 116(?):e7-e8. doi:
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Pediatric hematology and oncology.
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Nephrologie & therapeutique.
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The Cochrane database of systematic reviews.
2018 Mar; 3(?):CD012860. doi:
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Toxicology in vitro : an international journal published in association with BIBRA.
2018 Feb; 46(?):1-8. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
2018 02; 391(2):219-229. doi:
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. [PMID: 29294142] - Roderick Skinner. Late renal toxicity of treatment for childhood malignancy: risk factors, long-term outcomes, and surveillance.
Pediatric nephrology (Berlin, Germany).
2018 02; 33(2):215-225. doi:
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. [PMID: 28434047] - Mahwash Kamal, Amit Govil, Manish Anand, Bassam G Abu Jawdeh, Silvi Shah. Severe BK polyomavirus-induced hemorrhagic cystitis in a kidney transplant recipient with the absence of renal allograft involvement.
Transplant infectious disease : an official journal of the Transplantation Society.
2018 Feb; 20(1):. doi:
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Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2018; 109(1):25-29. doi:
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British journal of clinical pharmacology.
2017 12; 83(12):2605-2614. doi:
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European journal of cancer (Oxford, England : 1990).
2017 11; 85(?):49-58. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2017 Nov; 23(21):6441-6449. doi:
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Anticancer research.
2017 11; 37(11):6355-6361. doi:
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Pediatric blood & cancer.
2017 Oct; 64(10):. doi:
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Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2017 Jul; 23(5):323-332. doi:
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Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2017 Jun; 23(4):249-254. doi:
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European journal of cancer (Oxford, England : 1990).
2017 05; 76(?):84-92. doi:
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. [PMID: 28284173] - Lance C Pagliaro. Role of High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Men With Previously Treated Germ Cell Tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2017 Apr; 35(10):1036-1040. doi:
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. [PMID: 27992270] - Wan-Jun Sun, Jia-Jia Zhang, Na An, Men Shen, Zhong-Xia Huang, Xin Li. Clinical analysis of 40 multiple myeloma patients with extramedullary plasmacytoma of the head.
The Journal of international medical research.
2016 Dec; 44(6):1462-1473. doi:
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Journal of the Formosan Medical Association = Taiwan yi zhi.
2016 Sep; 115(9):744-51. doi:
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Japanese journal of clinical oncology.
2016 Sep; 46(9):856-61. doi:
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. [PMID: 27380806] - Hiroki Yoshihara, Takahiro Kamiya, Yosuke Hosoya, Daisuke Hasegawa, Chitose Ogawa, Hiroshi Asanuma, Ryuichi Mizuno, Ryota Hosoya, Atsushi Manabe. Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide.
Pediatrics international : official journal of the Japan Pediatric Society.
2016 Aug; 58(8):766-9. doi:
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. [PMID: 27324740] - Keita Kobayashi, Hideyasu Matsuyama, Kosuke Shimizu, Nakanori Fujii, Ryo Inoue, Yoshiaki Yamamoto, Hiroaki Matsumoto, Kazuhiro Nagao. Clinical significance of a second-line chemotherapy regimen with paclitaxel, ifosfamide and nedaplatin for metastatic urothelial carcinoma after failure of cisplatin-based chemotherapy.
Japanese journal of clinical oncology.
2016 Aug; 46(8):775-80. doi:
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. [PMID: 27272172] - Mam Helal. Prenatal effects of transplacental exposure to ifosfamide in rats.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2016 Jul; 91(5):357-68. doi:
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. [PMID: 27124550] - Hiroyuki Inagawa, Toshiyuki Saika, Takashi Nisizawa, Chie Kohchi, Maya Uenobe, Gen-Ichiro Soma. Dewaxed Brown Rice Contains a Significant Amount of Lipopolysaccharide Pointing to Macrophage Activation via TLRs.
Anticancer research.
2016 Jul; 36(7):3599-605. doi:
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. [PMID: 27354629] - Songül Yılmaz, Z Birsin Özçakar, Aysel Taktak, Saba Kiremitçi, Arzu Ensari, Handan Dinçaslan, Fatoş Yalçınkaya. Anti-VEGF-related thrombotic microangiopathy in a child presenting with nephrotic syndrome.
Pediatric nephrology (Berlin, Germany).
2016 Jun; 31(6):1029-32. doi:
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. [PMID: 26928310] - Marjeta Česen, Tina Kosjek, Francesco Busetti, Boris Kompare, Ester Heath. Human metabolites and transformation products of cyclophosphamide and ifosfamide: analysis, occurrence and formation during abiotic treatments.
Environmental science and pollution research international.
2016 Jun; 23(11):11209-11223. doi:
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. [PMID: 26920534] - Pedro Reck Dos Santos, Jin Sakamoto, Manyin Chen, Virginia Linacre, Chantel Arce, Mingyao Liu, Thomas K Waddell, Shaf Keshavjee, Marcelo Cypel. Modified In Vivo Lung Perfusion for Local Chemotherapy: A Preclinical Study With Doxorubicin.
The Annals of thoracic surgery.
2016 Jun; 101(6):2132-40. doi:
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. [PMID: 26952295] - Matthew D Ramirez, Ann C Mertens, Natia Esiashvili, Lillian R Meacham, Karen Wasilewski-Masker. Yield of Urinalysis Screening in Pediatric Cancer Survivors.
Pediatric blood & cancer.
2016 May; 63(5):893-900. doi:
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Pakistan journal of pharmaceutical sciences.
2016 Mar; 29(2):433-7. doi:
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. [PMID: 27087071] - Alessia Dalla Pria, Maggie Bendle, Ramya Ramaswami, Marta Boffito, Mark Bower. The pharmacokinetics of high-dose methotrexate in people living with HIV on antiretroviral therapy.
Cancer chemotherapy and pharmacology.
2016 Mar; 77(3):653-7. doi:
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. [PMID: 26696583] - Luiz Fernando Lopes, Carla Renata Pacheco Donato Macedo, Simone Dos Santos Aguiar, Jose Henrique S Barreto, Gisele Eiras Martins, Viviane Sonaglio, Marcelo Milone, Eduardo Ribeiro Lima, Maria Teresa de Assis Almeida, Paula Maria Azevedo Allemand Lopes, Flora Mitie Watanabe, Maria Lydia Mello D'Andrea, Mara Albonei Pianovski, Renato Melaragno, Sonia Maria Rossi Vianna, Mauber Eduardo Schultz Moreira, Paula Bruniera, Cleyton Zanardo de Oliveira. Lowered Cisplatin Dose and No Bleomycin in the Treatment of Pediatric Germ Cell Tumors: Results of the GCT-99 Protocol From the Brazilian Germ Cell Pediatric Oncology Cooperative Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2016 Feb; 34(6):603-10. doi:
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. [PMID: 26729441] - Masatomo Nishikawa, Hideaki Miyake, Masato Fujisawa. Irinotecan and nedaplatin as salvage therapy for patients with advanced germ cell tumors following intensive treatment with cisplatin-based combination chemotherapies.
International journal of clinical oncology.
2016 Feb; 21(1):162-7. doi:
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. [PMID: 26123313] - Zeynep Ginis, Gulfer Ozturk, Aynur Albayrak, Sefika Nur Kurt, Murat Albayrak, Ersin Fadillioglu. Protective effects of caffeic acid phenethyl ester on ifosfamide-induced central neurotoxicity in rats.
Toxicology and industrial health.
2016 Feb; 32(2):337-43. doi:
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Journal of applied toxicology : JAT.
2016 Feb; 36(2):330-9. doi:
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. [PMID: 26152902] - Veeravan Lekskulchai. Quantitation of anticancer drugs - Cyclophosphamide and ifosfamide in urine and water sewage samples by gas chromatography-mass spectrometry.
International journal of occupational medicine and environmental health.
2016; 29(5):815-22. doi:
10.13075/ijomeh.1896.00773
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Przeglad lekarski.
2016 ; 73(11):805-12. doi:
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. [PMID: 29693342] - J-P Long, F Wan, F Zhang, J Zhou, L-F Don. DTC chemotherapy regimen is associated with higher incidence of premature ovarian failure in women of reproductive age with breast cancer.
European review for medical and pharmacological sciences.
2016; 20(6):1087-92. doi:
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. [PMID: 27049261] - V Kesik, E Demirkaya, M Buyukpamukçu. Urinary neutrophil gelatinase associated lipocalin as a biomarker in ifosfamide induced chronic renal failure.
European review for medical and pharmacological sciences.
2015 Dec; 19(24):4851-7. doi:
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. [PMID: 26744877] - Vered Shkalim-Zemer, Shifra Ash, Helen Toledano, Yehuda Kollender, Josephine Issakov, Isaac Yaniv, Ian J Cohen. Highly effective reduced toxicity dose-intensive pilot protocol for non-metastatic limb osteogenic sarcoma (SCOS 89).
Cancer chemotherapy and pharmacology.
2015 Nov; 76(5):909-16. doi:
10.1007/s00280-015-2865-x
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Annals of the Academy of Medicine, Singapore.
2015 Nov; 44(11):548-9. doi:
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Clinical genitourinary cancer.
2015 Oct; 13(5):453-60. doi:
10.1016/j.clgc.2015.05.003
. [PMID: 26072101] - Marjeta Česen, Tina Kosjek, Maria Laimou-Geraniou, Boris Kompare, Brane Širok, Dimitra Lambropolou, Ester Heath. Occurrence of cyclophosphamide and ifosfamide in aqueous environment and their removal by biological and abiotic wastewater treatment processes.
The Science of the total environment.
2015 Sep; 527-528(?):465-73. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2015 Aug; 33(22):2464-71. doi:
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Bulletin du cancer.
2015 Jul; 102(7-8):627-35. doi:
10.1016/j.bulcan.2015.03.016
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The Journal of comparative neurology.
2015 Jul; 523(10):1474-87. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jun; 992(?):30-5. doi:
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Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2015 Jun; 21(3):188-93. doi:
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Journal of postgraduate medicine.
2015 Apr; 61(2):126-8. doi:
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European journal of medicinal chemistry.
2015 Mar; 92(?):723-31. doi:
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International journal of urology : official journal of the Japanese Urological Association.
2015 Mar; 22(3):288-93. doi:
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European journal of oncology nursing : the official journal of European Oncology Nursing Society.
2015 Feb; 19(1):7-12. doi:
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Toxicology and industrial health.
2015 Feb; 31(2):97-107. doi:
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Journal of medicinal chemistry.
2015 Jan; 58(2):705-17. doi:
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PloS one.
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