Genipin (BioDeep_00000398651)

Main id: BioDeep_00000000465

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


NCGC00186010-03_C11H14O5_Cyclopenta[c]pyran-4-carboxylic acid, 1,4a,5,7a-tetrahydro-1-hydroxy-7-(hydroxymethyl)-, methyl ester, (1R,4aS,7aS)-

化学式: C11H14O5 (226.0841)
中文名称: 京尼平
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 89.74%

分子结构信息

SMILES: COC(=O)C/1=C/O[C@@H](O)[C@H]\2[C@@H]1C\C=C2CO
InChI: InChI=1S/C11H14O5/c1-15-10(13)8-5-16-11(14)9-6(4-12)2-3-7(8)9/h2,5,7,9,11-12,14H,3-4H2,1H3

描述信息

Genipin is an iridoid monoterpenoid. It has a role as an uncoupling protein inhibitor, a hepatotoxic agent, an apoptosis inhibitor, an antioxidant, an anti-inflammatory agent and a cross-linking reagent.
Genipin is a natural product found in Gardenia jasminoides, Rothmannia globosa, and other organisms with data available.
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.593
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.589
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research[1][2].
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research[1][2].
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research[1][2].

同义名列表

29 个代谢物同义名

CYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID, 1,4A,5,7A-TETRAHYDRO-1-HYDROXY-7-(HYDROXYMETHYL)-, METHYL ESTER, (1R-(1.ALPHA.,4A.ALPHA.,7A.ALPHA.))-; CYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID, 1,4A,5,7A-TETRAHYDRO-1-HYDROXY-7-(HYDROXYMETHYL)-, METHYL ESTER, (1R,4AS,7AS)-; Cyclopenta[c]pyran-4-carboxylic acid, 1,4a,5,7a-tetrahydro-1-hydroxy-7-(hydroxymethyl)-, methyl ester, (1R,4aS,7aS)-; CYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID, 1,4A.ALPHA.,5,7A.ALPHA.-TETRAHYDRO-1-HYDROXY-7-(HYDROXYMETHYL)-, METHYL ESTER; Cyclopenta[c]pyran-4-carboxylic acid, 1,4a,5,7a-tetrahydro-1-hydroxy-7-(hydroxymethyl)-, methylester, (1R,4aS,7aS)-; Cyclopenta(c)pyran-4-carboxylic acid, 1,4a-alpha,5,7a-alpha-tetrahydro-1-hydroxy-7-(hydroxymethyl)-, methyl ester; (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester; (1R,4aS,7aS)-1-Hydroxy-7-hydroxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester; methyl (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; (1R,4aS,7aS)-methyl 1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; 1,4a,5,7a-Tetrahydro-1-hydroxy-7-(hydroxymethyl)-cyclopenta(c)pyran-4-carboxylic acid methyl ester; methyl (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1H,4aH,5H,7aH-cyclopenta[c]pyran-4-carboxylate; Methyl (1S,2R,6S)-2-Hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate; Genipin is known as an aglycone dervied from Geniposide.; Genipin, >=98\\% (HPLC), powder; AZKVWQKMDGGDSV-BCMRRPTOSA-N; UNII-A3V2NE52YG; Tox21_500516; (+)-Genipin; A3V2NE52YG; AC1L9CSN; Genipin; (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylic acid methyl ester; (1R,4aS,7aS)-1-hydroxy-7-methylol-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylic acid methyl ester; methyl (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylate; 6902-77-8; C09780; NCGC00186010-03_C11H14O5_Cyclopenta[c]pyran-4-carboxylic acid, 1,4a,5,7a-tetrahydro-1-hydroxy-7-(hydroxymethyl)-, methyl ester, (1R,4aS,7aS)-; Genipin



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

47 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, ALB, ANG, BCL2, BDNF, CASP3, MAPK8, MTOR, NFE2L2, NLRP3, PTGS2, VEGFA
Peripheral membrane protein 2 MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 11 AKT1, ALB, ANG, BCL2, CASP3, HMOX1, MAPK8, MTOR, NFE2L2, NLRP3, VEGFA
cytosol 10 AKT1, ALB, ANG, BCL2, CASP3, HMOX1, MAPK8, MTOR, NFE2L2, NLRP3
dendrite 2 BDNF, MTOR
phagocytic vesicle 1 MTOR
centrosome 2 ALB, NFE2L2
nucleoplasm 6 AKT1, CASP3, HMOX1, MAPK8, MTOR, NFE2L2
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 2 AKT1, TNF
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 1 AKT1
Multi-pass membrane protein 2 UCP1, UCP2
Golgi apparatus membrane 2 MTOR, NLRP3
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 2 TNF, VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 3 ALB, NFE2L2, VEGFA
Golgi membrane 3 INS, MTOR, NLRP3
growth cone 1 ANG
lysosomal membrane 1 MTOR
mitochondrial inner membrane 2 UCP1, UCP2
neuronal cell body 3 ANG, CASP3, TNF
postsynapse 1 AKT1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 2 NFE2L2, NLRP3
Lysosome 1 MTOR
plasma membrane 3 AKT1, NFE2L2, TNF
Membrane 7 AKT1, BCL2, BDNF, HMOX1, MTOR, NLRP3, VEGFA
axon 2 BDNF, MAPK8
caveola 1 PTGS2
extracellular exosome 2 ALB, BMP3
Lysosome membrane 1 MTOR
endoplasmic reticulum 6 ALB, BCL2, HMOX1, NLRP3, PTGS2, VEGFA
extracellular space 9 ALB, ANG, BDNF, BMP3, HMOX1, IL6, INS, TNF, VEGFA
perinuclear region of cytoplasm 2 BDNF, HMOX1
adherens junction 1 VEGFA
mitochondrion 4 BCL2, NLRP3, UCP1, UCP2
protein-containing complex 4 AKT1, ALB, BCL2, PTGS2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 8 ALB, ANG, BDNF, BMP3, IL6, INS, NLRP3, VEGFA
extracellular region 10 ALB, ANG, BDNF, BMP3, ELN, IL6, INS, NLRP3, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 2 ELN, VEGFA
actin cytoskeleton 1 ANG
microtubule cytoskeleton 1 AKT1
nucleolus 1 ANG
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Mitochondrion inner membrane 2 UCP1, UCP2
Membrane raft 1 TNF
pore complex 1 BCL2
spindle 1 AKT1
extracellular matrix 2 ELN, VEGFA
basement membrane 1 ANG
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ELN
secretory granule 1 VEGFA
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 2 AKT1, ALB
chromatin 1 NFE2L2
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
Chromosome 1 ANG
centriole 1 ALB
Nucleus, nucleolus 1 ANG
spindle pole 1 ALB
blood microparticle 1 ALB
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, BDNF, IL6, INS, PTGS2
platelet alpha granule lumen 2 ALB, VEGFA
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
elastic fiber 1 ELN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Kexin Sun, Yanyi Chen, Shijie Zheng, Wenjuan Wan, Ke Hu. Genipin ameliorates diabetic retinopathy via the HIF-1α and AGEs-RAGE pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155596. doi: 10.1016/j.phymed.2024.155596. [PMID: 38626646]
  • Yalu Mi, Hui Shan, Bo Wang, Huidi Tang, Jihui Jia, Xijian Liu, Qing Yang. Genipin inhibits proliferation of gastric cancer cells by inducing ferroptosis: an integrated study of network pharmacology and bioinformatics study. Medical oncology (Northwood, London, England). 2024 Jan; 41(2):46. doi: 10.1007/s12032-023-02283-4. [PMID: 38175425]
  • Zhifeng Cui, Zhe Li, Weichao Dong, Lili Qiu, Jiayu Zhang, Shaoping Wang. Comprehensive Metabolite Identification of Genipin in Rats Using Ultra-High-Performance Liquid Chromatography Coupled with High Resolution Mass Spectrometry. Molecules (Basel, Switzerland). 2023 Aug; 28(17):. doi: 10.3390/molecules28176307. [PMID: 37687136]
  • Haoyan Huang, Yulin Zhao, Chunyan Huang, Ning Lv, Jie Zhao, Shanliang Sun, Chaorui Guo, Di Zhao, Xijing Chen, Yongjie Zhang. Unraveling a Combined Inactivation Mechanism of Cytochrome P450s by Genipin, the Major Reactive Aglycone Derived from Gardeniae Fructus. Chemical research in toxicology. 2023 Aug; ?(?):. doi: 10.1021/acs.chemrestox.3c00102. [PMID: 37622730]
  • Jingjing Wang, Yongwei Qiu, Yaohui Chen, Feng Zhou, Shuaikang Wang, Liping Chen, Yinfang Chen, Riyue Yu, Liping Huang. Synthesis of Methylgenipin and Evaluation of Its Anti-Hepatic Injury Activity. Molecules (Basel, Switzerland). 2023 Jun; 28(12):. doi: 10.3390/molecules28124793. [PMID: 37375346]
  • Lixuan Xiao, Yaning Hou, Zhiyan Xue, Liangjiu Bai, Wenxiang Wang, Hou Chen, Huawei Yang, Lixia Yang, Donglei Wei. Soy Protein Isolate/Genipin-Based Nanoparticles for the Stabilization of Pickering Emulsion to Design Self-Healing Guar Gum-Based Hydrogels. Biomacromolecules. 2023 05; 24(5):2087-2099. doi: 10.1021/acs.biomac.2c01507. [PMID: 37079862]
  • Nittaya Boonmuen, Kanoknetr Suksen, Mintra Kaewkittikhun, Laongthip Ruknarong, Patamawadee Silalai, Rungnapha Saeeng, Arthit Chairoungdua, Sunhapas Soodvilai, Duangrat Tantikanlayaporn. Genipin Analogue (G300) Inhibits Adipogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells through the Suppression of Adipogenic Promoting Factors. Journal of natural products. 2023 May; ?(?):. doi: 10.1021/acs.jnatprod.3c00143. [PMID: 37137165]
  • Rita Rosado-Ramos, Gonçalo M Poças, Daniela Marques, Alexandre Foito, David M Sevillano, Mafalda Lopes-da-Silva, Luís G Gonçalves, Regina Menezes, Marcel Ottens, Derek Stewart, Alain Ibáñez de Opakua, Markus Zweckstetter, Miguel C Seabra, César S Mendes, Tiago Fleming Outeiro, Pedro M Domingos, Cláudia N Santos. Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage. Nature communications. 2023 Apr; 14(1):1918. doi: 10.1038/s41467-023-37561-2. [PMID: 37024503]
  • Kepeng Hu, Erna Jia, Qimeng Zhang, Wei Zheng, Rongjiao Sun, Mengao Qian, Ying Tan, Wanle Hu. Injectable carboxymethyl chitosan-genipin hydrogels encapsulating tea tree oil for wound healing. Carbohydrate polymers. 2023 Feb; 301(Pt B):120348. doi: 10.1016/j.carbpol.2022.120348. [PMID: 36446509]
  • Yajun Wu, Yao Wang, Dongmin Liu. Identification of Genipin as a Potential Treatment for Type 2 Diabetes. International journal of molecular sciences. 2023 Jan; 24(3):. doi: 10.3390/ijms24032131. [PMID: 36768454]
  • Ning Luo, Gui-Bing Chen, Teng Zhang, Jie Zhao, Jing-Nan Fu, Ning Lu, Tao Ma. Genipin Attenuates Sepsis-Induced Splenocyte Apoptosis via the Inhibition of Endoplasmic Reticulum Stress. Biological & pharmaceutical bulletin. 2023; 46(2):187-193. doi: 10.1248/bpb.b22-00563. [PMID: 36724947]
  • Wentao Deng, Yu Yan, Peipei Zhuang, Xiaoxu Liu, Ke Tian, Wenfang Huang, Cai Li. Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management. Drug delivery. 2022 Dec; 29(1):399-412. doi: 10.1080/10717544.2021.2023702. [PMID: 35098821]
  • Li Wang, Ge Chen, Shuyao Wu, Yihua Xu, Chenxi Guo, Manman Wang, Tingming Liang, Zhigang Guo, Hong-Jie Di, Zhigang Hu. Genipin improves lipid metabolism and sperm parametersin obese mice via regulation of miR-132 expression. Acta biochimica et biophysica Sinica. 2022 Sep; 54(9):1278-1288. doi: 10.3724/abbs.2022120. [PMID: 36082932]
  • Magdalena Bryś, Karina Urbańska, Beata Olas. Novel Findings regarding the Bioactivity of the Natural Blue Pigment Genipin in Human Diseases. International journal of molecular sciences. 2022 Jan; 23(2):. doi: 10.3390/ijms23020902. [PMID: 35055094]
  • Hiromasa Yamashita, Mitsue Nishiyama, Katsuya Ohbuchi, Hitomi Kanno, Kazuaki Tsuchiya, Junpei Yamaguchi, Takashi Mizuno, Tomoki Ebata, Masato Nagino, Yukihiro Yokoyama. Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics. Pharmacological research. 2022 01; 175(?):105981. doi: 10.1016/j.phrs.2021.105981. [PMID: 34798264]
  • Man Zhang, Lili Ye, Chuanjing Cheng, Fukui Shen, Lin Niu, Yuanyuan Hou, Gang Bai. Dietary Flavone Baicalein Combinate with Genipin Attenuates Inflammation Stimulated by Lipopolysaccharide in RAW264.7 Cells or Pseudomonas aeruginosa in Mice via Regulating the Expression and Phosphorylation of AKT. Nutrients. 2021 Dec; 13(12):. doi: 10.3390/nu13124462. [PMID: 34960014]
  • Qijun Li, Shiqiang Gong, Weifan Yao, Yibin Yu, Chao Liu, Renjun Wang, Hao Pan, Minjie Wei. PEG-interpenetrated genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier compound formulation for topical drug administration. Artificial cells, nanomedicine, and biotechnology. 2021 Dec; 49(1):345-353. doi: 10.1080/21691401.2021.1879104. [PMID: 33784224]
  • Yaqiong Wang, Jingjing Guo, Bingjie Li, Dong Li, Zhaowei Meng, Shao-Kai Sun. Biocompatible therapeutic albumin/genipin bioglue for postoperative wound adhesion and residual tumor ablation. Biomaterials. 2021 12; 279(?):121179. doi: 10.1016/j.biomaterials.2021.121179. [PMID: 34700226]
  • Fengtao Li, Lijun Song, Jing Chen, Yu Chen, Yongjun Li, Meizi Huang, Wenchang Zhao. Effect of genipin-1-β-d-gentiobioside on diabetic nephropathy in mice by activating AMP-activated protein kinase/silencing information regulator-related enzyme 1/ nuclear factor-κB pathway. The Journal of pharmacy and pharmacology. 2021 Aug; 73(9):1201-1211. doi: 10.1093/jpp/rgab041. [PMID: 33792721]
  • Meiting Li, Nan Cai, Liang Gu, Lijun Yao, Decheng Bi, Weishan Fang, Zhijian Lin, Yan Wu, Hong Xu, Hui Li, Zhangli Hu, Xu Xu. Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer's Disease. Molecular neurobiology. 2021 Aug; 58(8):4134-4144. doi: 10.1007/s12035-021-02389-8. [PMID: 33948899]
  • Yusha Luo, Fangyuan Gao, Ruirui Chang, Xingjie Zhang, Jie Zhong, Jun Wen, Jianlin Wu, Tingting Zhou. Metabolomics based comprehensive investigation of Gardeniae Fructus induced hepatotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Jul; 153(?):112250. doi: 10.1016/j.fct.2021.112250. [PMID: 33964367]
  • Abhishek Indurkar, Ashish Pandit, Ratnesh Jain, Prajakta Dandekar. Plant based cross-linkers for tissue engineering applications. Journal of biomaterials applications. 2021 07; 36(1):76-94. doi: 10.1177/0885328220979273. [PMID: 33342347]
  • Chi Wang, Pei-Xu Chen, Qiong Xiao, Qiu-Ming Yang, Hui-Fen Weng, Yong-Hui Zhang, An-Feng Xiao. Chitosan Activated with Genipin: A Nontoxic Natural Carrier for Tannase Immobilization and Its Application in Enhancing Biological Activities of Tea Extract. Marine drugs. 2021 Mar; 19(3):. doi: 10.3390/md19030166. [PMID: 33808933]
  • Zhong-Shang Xia, Er-Wei Hao, Yan-Ting Wei, Xiao-Tao Hou, Zhang-Mei Chen, Man Wei, Zheng-Cai Du, Jia-Gang Deng. Genipin induces developmental toxicity through oxidative stress and apoptosis in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Mar; 241(?):108951. doi: 10.1016/j.cbpc.2020.108951. [PMID: 33316388]
  • Idalina Gonçalves, Diana Hernández, Cátia Cruz, Joana Lopes, Ana Barra, Cláudia Nunes, José A Lopes da Silva, Paula Ferreira, Manuel A Coimbra. Relevance of genipin networking on rheological, physical, and mechanical properties of starch-based formulations. Carbohydrate polymers. 2021 Feb; 254(?):117236. doi: 10.1016/j.carbpol.2020.117236. [PMID: 33357844]
  • Rongtian Lin, Shuwen Rao, Yanbing Li, Lei Zhang, Liyu Xu, Yepu He, Zhijun Liu, Heru Chen. Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer's disease. European journal of medicinal chemistry. 2021 Feb; 211(?):113067. doi: 10.1016/j.ejmech.2020.113067. [PMID: 33338868]
  • Edgardo Rivera-Delgado, Greg D Learn, Dominic J Kizek, Tejas Kashyap, Emerson J Lai, Horst A von Recum. A Polymeric Delivery System Enables Controlled Release of Genipin for Spatially-Confined In Situ Crosslinking of Injured Connective Tissues. Journal of pharmaceutical sciences. 2021 02; 110(2):815-823. doi: 10.1016/j.xphs.2020.09.044. [PMID: 33190799]
  • Jiyeon Hong, Dahun Jung, Saerom Park, Yujin Oh, Kyeong Keun Oh, Sang Hyun Lee. Immobilization of laccase via cross-linked enzyme aggregates prepared using genipin as a natural cross-linker. International journal of biological macromolecules. 2021 Feb; 169(?):541-550. doi: 10.1016/j.ijbiomac.2020.12.136. [PMID: 33358952]
  • Yihua Xu, Li Wang, Siyuan Cao, Ruihua Hu, Rui Liu, Ke Hua, Zhigang Guo, Hong-Jie Di, Zhigang Hu. Genipin improves reproductive health problems caused by circadian disruption in male mice. Reproductive biology and endocrinology : RB&E. 2020 Dec; 18(1):122. doi: 10.1186/s12958-020-00679-9. [PMID: 33308222]
  • Ruifeng Luo, Meisi Lin, Chen Zhang, Jinfeng Shi, Siyuan Zhang, Qiyan Chen, Yichen Hu, Minyue Zhang, Jinming Zhang, Fei Gao. Genipin-crosslinked human serum albumin coating using a tannic acid layer for enhanced oral administration of curcumin in the treatment of ulcerative colitis. Food chemistry. 2020 Nov; 330(?):127241. doi: 10.1016/j.foodchem.2020.127241. [PMID: 32540526]
  • Xiaofei Fan, Lin Lin, Binxin Cui, Tianming Zhao, Lihong Mao, Yan Song, Xiaoyu Wang, Hongjuan Feng, Yu Qingxiang, Jie Zhang, Kui Jiang, Xiaocang Cao, Bangmao Wang, Chao Sun. Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: More friend than foe. Pharmacological research. 2020 09; 159(?):104945. doi: 10.1016/j.phrs.2020.104945. [PMID: 32454225]
  • Nihui Zhang, Tao Gao, Yao Wang, Juan Liu, Junwei Zhang, Ruijuan Yao, Fang Wu. Modulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing. International journal of biological macromolecules. 2020 Jul; 154(?):835-843. doi: 10.1016/j.ijbiomac.2020.03.161. [PMID: 32194120]
  • Shahla Teimouri, Stefan Kasapis. Morphology of genipin-crosslinked BSA networks yields a measurable effect on the controlled release of vitamin B6. Food chemistry. 2020 Jun; 314(?):126204. doi: 10.1016/j.foodchem.2020.126204. [PMID: 31978719]
  • Min Wang, Zhi-Kuan Yang, Hong Liu, Rui-Qin Li, Yu Liu, Wen-Jun Zhong. Genipin inhibits the scleral expression of miR-29 and MMP2 and promotes COL1A1 expression in myopic eyes of guinea pigs. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2020 May; 258(5):1031-1038. doi: 10.1007/s00417-020-04634-7. [PMID: 32125507]
  • Kai Melvin Schakowski, Jürgen Linders, Katja Bettina Ferenz, Michael Kirsch. Synthesis and characterisation of aqueous haemoglobin-based microcapsules coated by genipin-cross-linked albumin. Journal of microencapsulation. 2020 May; 37(3):193-204. doi: 10.1080/02652048.2020.1715498. [PMID: 31950867]
  • Yibin Yu, Shuo Xu, Shihui Yu, Jinyu Li, Guoxin Tan, Sanming Li, Weisan Pan. A Hybrid Genipin-Cross-Linked Hydrogel/Nanostructured Lipid Carrier for Ocular Drug Delivery: Cellular, ex Vivo, and in Vivo Evaluation. ACS biomaterials science & engineering. 2020 03; 6(3):1543-1552. doi: 10.1021/acsbiomaterials.9b01800. [PMID: 33455373]
  • M-C Wilmot, S H Wakelin. Allergic contact dermatitis caused by a jagua temporary tattoo. Clinical and experimental dermatology. 2020 Mar; 45(2):261-262. doi: 10.1111/ced.14049. [PMID: 31325390]
  • Tianyi Zhao, Yue Zhang, Shuangshuang Mu, Jong Pil Park, Hongshi Bu, Xiangyang Leng, Shumin Wang. Protective effects of genipin on ethanol-induced acute gastric injury in mice by inhibiting NLRP3 inflammasome activation. European journal of pharmacology. 2020 Jan; 867(?):172800. doi: 10.1016/j.ejphar.2019.172800. [PMID: 31805268]
  • Yanting Jiao, Fukui Shen, Zhihua Wang, Lili Ye, Man Zhang, Jie Gao, Yuanyuan Hou, Gang Bai. Genipin, a natural AKT inhibitor, targets the PH domain to affect downstream signaling and alleviates inflammation. Biochemical pharmacology. 2019 12; 170(?):113660. doi: 10.1016/j.bcp.2019.113660. [PMID: 31605673]
  • Ophélie Gourgas, Gregory B Cole, Lisa D Muiznieks, Simon Sharpe, Marta Cerruti. Effect of the Ionic Concentration of Simulated Body Fluid on the Minerals Formed on Cross-Linked Elastin-Like Polypeptide Membranes. Langmuir : the ACS journal of surfaces and colloids. 2019 11; 35(47):15364-15375. doi: 10.1021/acs.langmuir.9b02542. [PMID: 31729882]
  • Qingling Wang, Jiang Jiang, Youling L Xiong. Genipin-Aided Protein Cross-linking to Modify Structural and Rheological Properties of Emulsion-Filled Hempseed Protein Hydrogels. Journal of agricultural and food chemistry. 2019 Nov; 67(46):12895-12903. doi: 10.1021/acs.jafc.9b05665. [PMID: 31682429]
  • Jürgen Kreiter, Anne Rupprecht, Lars Zimmermann, Michael Moschinger, Tatyana I Rokitskaya, Yuri N Antonenko, Lars Gille, Maria Fedorova, Elena E Pohl. Molecular Mechanisms Responsible for Pharmacological Effects of Genipin on Mitochondrial Proteins. Biophysical journal. 2019 11; 117(10):1845-1857. doi: 10.1016/j.bpj.2019.10.021. [PMID: 31706565]
  • Chunnan Li, Meng Lan, Jingwei Lv, Ye Zhang, Xiaochen Gao, Xu Gao, Lihua Dong, Guangming Luo, Hui Zhang, Jiaming Sun. Screening of the Hepatotoxic Components in Fructus Gardeniae and Their Effects on Rat Liver BRL-3A Cells. Molecules (Basel, Switzerland). 2019 Oct; 24(21):. doi: 10.3390/molecules24213920. [PMID: 31671698]
  • Kuang-Dai Li, Kuo Yan, Qiang-Song Wang, Jun-Sheng Tian, Dong Xu, Wen-Yan Zhang, Yuan-Lu Cui. Antidepressant-like effects of dietary gardenia blue pigment derived from genipin and tyrosine. Food & function. 2019 Aug; 10(8):4533-4545. doi: 10.1039/c9fo00480g. [PMID: 31264676]
  • Qiang Tian, Fang Liu, Zhou Xu, Huan Liu, Hao Yin, Zhaolin Sun, Mingcang Chen, Zhixiong Li, Lin Ma, Chenggang Huang. Evaluation of the chemical consistency of Yin-Chen-Hao-Tang prepared by combined and separated decoction methods using high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry coupled with multivariate statistical analysis. Journal of separation science. 2019 May; 42(9):1664-1675. doi: 10.1002/jssc.201800961. [PMID: 30784184]
  • Hsien-Tsung Lu, Wan-Ting Chang, Min-Lang Tsai, Chien-Ho Chen, Wei-Yu Chen, Fwu-Long Mi. Development of Injectable Fucoidan and Biological Macromolecules Hybrid Hydrogels for Intra-Articular Delivery of Platelet-Rich Plasma. Marine drugs. 2019 Apr; 17(4):. doi: 10.3390/md17040236. [PMID: 31010247]
  • Bo Ram Kim, Yoon A Jeong, Min Jee Jo, Seong Hye Park, Yoo Jin Na, Jung Lim Kim, Soyeon Jeong, Hye Kyeong Yun, Sanghee Kang, Dae-Hee Lee, Sang Cheul Oh. Genipin Enhances the Therapeutic Effects of Oxaliplatin by Upregulating BIM in Colorectal Cancer. Molecular cancer therapeutics. 2019 04; 18(4):751-761. doi: 10.1158/1535-7163.mct-18-0196. [PMID: 30787174]
  • Busi Zhao, Lian-Kun Sun, Xianrui Jiang, Yong Zhang, Jinsong Kang, Hao Meng, Hongyan Li, Jing Su. Genipin protects against cerebral ischemia-reperfusion injury by regulating the UCP2-SIRT3 signaling pathway. European journal of pharmacology. 2019 Feb; 845(?):56-64. doi: 10.1016/j.ejphar.2018.12.028. [PMID: 30582911]
  • Na-Na Shen, De-Zheng Gong, Feng-Kai Zou, Yu Yan, Li-Li Guan, Yuan Zou. [Effects of Genipin on the expression of uncoupling protein 1 in brown adipose and white adipose tissues in mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2019 Jan; 35(1):74-78. doi: 10.12047/j.cjap.5692.2019.018. [PMID: 31245957]
  • Jing Li, Jipeng Shi, Peiling Li, Xixia Guo, Tuanjie Wang, Aijuan Liu. Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 β in neonatal rats. Nutrition (Burbank, Los Angeles County, Calif.). 2019 01; 57(?):237-244. doi: 10.1016/j.nut.2018.05.017. [PMID: 30196116]
  • Iramaia Angélica Neri-Numa, Celio Fernando Figueiredo Angolini, Juliano Lemos Bicas, Ana Lucia Tasca Gois Ruiz, Glaucia Maria Pastore. Iridoid blue-based pigments of Genipa americana L. (Rubiaceae) extract: Influence of pH and temperature on color stability and antioxidant capacity during in vitro simulated digestion. Food chemistry. 2018 Oct; 263(?):300-306. doi: 10.1016/j.foodchem.2018.05.001. [PMID: 29784321]
  • Bably Khatun, Nibedita Banik, Anowar Hussain, Anand Ramteke, Tarun Maji. Genipin crosslinked curcumin loaded chitosan/montmorillonite K-10 (MMT) nanoparticles for controlled drug delivery applications. Journal of microencapsulation. 2018 Aug; 35(5):439-453. doi: 10.1080/02652048.2018.1524524. [PMID: 30289012]
  • Jun-Sheng Tian, Lei Zhao, Xiao-Li Shen, Huan Liu, Xue-Mei Qin. 1H NMR-based metabolomics approach to investigating the renal protective effects of Genipin in diabetic rats. Chinese journal of natural medicines. 2018 Apr; 16(4):261-270. doi: 10.1016/s1875-5364(18)30056-6. [PMID: 29703326]
  • Lili Guan, Dezheng Gong, Sirao Yang, Nana Shen, Sai Zhang, Yuchen Li, Qiong Wu, Bo Yuan, Yiping Sun, Ning Dai, Liang Zhu, Yuan Zou. Genipin ameliorates diet-induced obesity via promoting lipid mobilization and browning of white adipose tissue in rats. Phytotherapy research : PTR. 2018 Apr; 32(4):723-732. doi: 10.1002/ptr.6022. [PMID: 29377296]
  • Luisa S Dolci, Anna Liguori, Silvia Panzavolta, Anna Miserocchi, Nadia Passerini, Matteo Gherardi, Vittorio Colombo, Adriana Bigi, Beatrice Albertini. Non-equilibrium atmospheric pressure plasma as innovative method to crosslink and enhance mucoadhesion of econazole-loaded gelatin films for buccal drug delivery. Colloids and surfaces. B, Biointerfaces. 2018 Mar; 163(?):73-82. doi: 10.1016/j.colsurfb.2017.12.030. [PMID: 29278802]
  • Fuguo Shi, Hong Pan, Yi Li, Linyan Huang, Qin Wu, Yuanfu Lu. A sensitive LC-MS/MS method for simultaneous quantification of geniposide and its active metabolite genipin in rat plasma and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2018 Mar; 32(3):. doi: 10.1002/bmc.4126. [PMID: 29088500]
  • Hong Zhong, Ke Chen, Mengyang Feng, Wei Shao, Jun Wu, Kun Chen, Tingming Liang, Chang Liu. Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis. The FEBS journal. 2018 02; 285(3):501-517. doi: 10.1111/febs.14349. [PMID: 29197188]
  • Hong Zhong, Mengting Liu, Yaya Ji, Minjuan Ma, Kun Chen, Tingming Liang, Chang Liu. Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 49(5):1885-1897. doi: 10.1159/000493651. [PMID: 30235442]
  • Yishun Yang, Yue Ding, Tong Zhang. Biotransformation of Geniposide into Genipin by Immobilized Trichoderma reesei and Conformational Study of Genipin. BioMed research international. 2018; 2018(?):2079195. doi: 10.1155/2018/2079195. [PMID: 29850488]
  • Ana Rita C Duarte, Vitor E Santo, Manuela E Gomes, Rui L Reis. Supercritical Fluid Technology as a Tool to Prepare Gradient Multifunctional Architectures Towards Regeneration of Osteochondral Injuries. Advances in experimental medicine and biology. 2018; 1058(?):265-278. doi: 10.1007/978-3-319-76711-6_12. [PMID: 29691826]
  • Lisa D Muiznieks. Genipin Cross-Linking of Elastin and Elastin-Based Proteins. Methods in molecular biology (Clifton, N.J.). 2018; 1798(?):213-221. doi: 10.1007/978-1-4939-7893-9_17. [PMID: 29868963]
  • Grazielle Náthia-Neves, Adriana Gadioli Tarone, Milena Martelli Tosi, Mário Roberto Maróstica Júnior, M Angela A Meireles. Extraction of bioactive compounds from genipap (Genipa americana L.) by pressurized ethanol: Iridoids, phenolic content and antioxidant activity. Food research international (Ottawa, Ont.). 2017 12; 102(?):595-604. doi: 10.1016/j.foodres.2017.09.041. [PMID: 29195990]
  • Je-Won Ko, Na-Rae Shin, Sung-Hyeuk Park, Young-Kwon Cho, Jong-Choon Kim, Chang-Seob Seo, In-Sik Shin. Genipin inhibits allergic responses in ovalbumin-induced asthmatic mice. International immunopharmacology. 2017 Dec; 53(?):49-55. doi: 10.1016/j.intimp.2017.10.010. [PMID: 29035815]
  • Chiung-Hung Chang, Jin-Bin Wu, Jai-Sing Yang, Yen-Ju Lai, Chiu-Hsian Su, Chi-Cheng Lu, Yuan-Man Hsu. The Suppressive Effects of Geniposide and Genipin on Helicobacter pylori Infections In Vitro and In Vivo. Journal of food science. 2017 Dec; 82(12):3021-3028. doi: 10.1111/1750-3841.13955. [PMID: 29135040]
  • Andreas J Bircher, Rita Sigg, Kathrin Scherer Hofmeier, Urs Schlegel, Urs Hauri. Allergic contact dermatitis caused by a new temporary blue-black tattoo dye - sensitization to genipin from jagua (Genipa americana L.) fruit extract. Contact dermatitis. 2017 Dec; 77(6):374-378. doi: 10.1111/cod.12844. [PMID: 28675523]
  • Narges Shahgholian, Ghadir Rajabzadeh, Bizhan Malaekeh-Nikouei. Preparation and evaluation of BSA-based hydrosol nanoparticles cross-linked with genipin for oral administration of poorly water-soluble curcumin. International journal of biological macromolecules. 2017 Nov; 104(Pt A):788-798. doi: 10.1016/j.ijbiomac.2017.06.083. [PMID: 28647524]
  • Min-Jong Seo, Jeong-Min Hong, Seok-Joo Kim, Sun-Mee Lee. Genipin protects d-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling. European journal of pharmacology. 2017 Oct; 812(?):128-137. doi: 10.1016/j.ejphar.2017.07.024. [PMID: 28709622]
  • Eglal Mahgoub, Shanmugam Muthu Kumaraswamy, Kamal Hassan Kader, Balaji Venkataraman, Shreesh Ojha, Ernest Adeghate, Mohanraj Rajesh. Genipin attenuates cisplatin-induced nephrotoxicity by counteracting oxidative stress, inflammation, and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Sep; 93(?):1083-1097. doi: 10.1016/j.biopha.2017.07.018. [PMID: 28738532]
  • Jun-Kyu Shin, Sun-Mee Lee. Genipin protects the liver from ischemia/reperfusion injury by modulating mitochondrial quality control. Toxicology and applied pharmacology. 2017 08; 328(?):25-33. doi: 10.1016/j.taap.2017.05.002. [PMID: 28477916]
  • Hongshan Ge, Fan Zhang, Ping Duan, Nan Zhu, Jiayan Zhang, Feijun Ye, Dan Shan, Hua Chen, XiaoSheng Lu, ChunFang Zhu, Renshan Ge, Zhenkun Lin. Mitochondrial Uncoupling Protein 2 in human cumulus cells is associated with regulating autophagy and apoptosis, maintaining gap junction integrity and progesterone synthesis. Molecular and cellular endocrinology. 2017 03; 443(?):128-137. doi: 10.1016/j.mce.2017.01.020. [PMID: 28089824]
  • Aozhe Zhang, Dingran Chang, Zijian Zhang, Fan Li, Weihong Li, Xu Wang, Yingfu Li, Qian Hua. In Vitro Selection of DNA Aptamers that Binds Geniposide. Molecules (Basel, Switzerland). 2017 Feb; 22(3):. doi: 10.3390/molecules22030383. [PMID: 28264528]
  • Mohammad Nikkhoo, Jaw-Lin Wang, Masoud Abdollahi, Yu-Chun Hsu, Mohamad Parnianpour, Kinda Khalaf. A regenerative approach towards recovering the mechanical properties of degenerated intervertebral discs: Genipin and platelet-rich plasma therapies. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine. 2017 Feb; 231(2):127-137. doi: 10.1177/0954411916681597. [PMID: 28019241]
  • Richi Nakatake, Takumi Tsuda, Takashi Matsuura, Hirokazu Miki, Hidehiko Hishikawa, Hideyuki Matsushima, Morihiko Ishizaki, Kosuke Matsui, Masaki Kaibori, Mikio Nishizawa, Tadayoshi Okumura, Masanori Kon. Genipin Inhibits the Induction of Inducible Nitric Oxide Synthase Through the Inhibition of NF-κB Activation in Rat Hepatocytes. Drug metabolism letters. 2017; 10(4):254-263. doi: 10.2174/1872312810666161020164658. [PMID: 27774888]
  • Shaocheng Chen, Xin Zhao, Peng Sun, Jun Qian, Yanhong Shi, Rui Wang. Preventive effect of Gardenia jasminoides on HCl/ethanol induced gastric injury in mice. Journal of pharmacological sciences. 2017 Jan; 133(1):1-8. doi: 10.1016/j.jphs.2016.05.011. [PMID: 27435384]
  • Tao Zuo, Minghui Zhu, Wenming Xu, Zhixia Wang, Hang Song. Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 43(5):1855-1865. doi: 10.1159/000484074. [PMID: 29049992]
  • Mershen Govender, Yahya E Choonara, Sandy van Vuuren, Pradeep Kumar, Lisa C du Toit, Kennedy Erlwanger, Viness Pillay. A Dual-Biotic System for the Concurrent Delivery of Antibiotics and Probiotics: In Vitro, Ex Vivo, In Vivo and In Silico Evaluation and Correlation. Pharmaceutical research. 2016 12; 33(12):3057-3071. doi: 10.1007/s11095-016-2030-1. [PMID: 27599992]
  • Yanwei Li, Lin Li, Christian Hölscher. Therapeutic Potential of Genipin in Central Neurodegenerative Diseases. CNS drugs. 2016 10; 30(10):889-97. doi: 10.1007/s40263-016-0369-9. [PMID: 27395402]
  • Xiao-Li Shen, Huan Liu, Huan Xiang, Xue-Mei Qin, Guan-Hua Du, Jun-Sheng Tian. Combining biochemical with (1)H NMR-based metabolomics approach unravels the antidiabetic activity of genipin and its possible mechanism. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 129(?):80-89. doi: 10.1016/j.jpba.2016.06.041. [PMID: 27411170]
  • Guo-Qing Huang, Ling-Yun Cheng, Jun-Xia Xiao, Shi-Qing Wang, Xiao-Na Han. Genipin-crosslinked O-carboxymethyl chitosan-gum Arabic coacervate as a pH-sensitive delivery system and microstructure characterization. Journal of biomaterials applications. 2016 08; 31(2):193-204. doi: 10.1177/0885328216651393. [PMID: 27231264]
  • Yi Zhang, Qiang-Song Wang, Kuo Yan, Yun Qi, Gui-Fang Wang, Yuan-Lu Cui. Preparation, characterization, and evaluation of genipin crosslinked chitosan/gelatin three-dimensional scaffolds for liver tissue engineering applications. Journal of biomedical materials research. Part A. 2016 08; 104(8):1863-70. doi: 10.1002/jbm.a.35717. [PMID: 27027247]
  • Pei Jiang, Yuanjie Ma, Yu Gao, Zhixiong Li, Shan Lian, Zhou Xu, Weixin Jiang, Xiaoting Tian, Chenggang Huang. Comprehensive Evaluation of the Metabolism of Genipin-1-β-d-gentiobioside in Vitro and in Vivo by Using HPLC-Q-TOF. Journal of agricultural and food chemistry. 2016 Jul; 64(27):5490-8. doi: 10.1021/acs.jafc.6b01835. [PMID: 27302600]
  • Dawei Yu, Mengsong Shi, Jinwei Bao, Xinyan Yu, Yuhui Li, Wenbo Liu. Genipin ameliorates hypertension-induced renal damage via the angiotensin II-TLR/MyD88/MAPK pathway. Fitoterapia. 2016 Jul; 112(?):244-53. doi: 10.1016/j.fitote.2016.06.010. [PMID: 27343367]
  • Fei Sun, Yuan Jiang, Yanfei Xu, Hongcan Shi, Siquan Zhang, Xingchen Liu, Shu Pan, Gang Ye, Weidong Zhang, Fangbiao Zhang, Chonghao Zhong. Genipin cross-linked decellularized tracheal tubular matrix for tracheal tissue engineering applications. Scientific reports. 2016 Apr; 6(?):24429. doi: 10.1038/srep24429. [PMID: 27080716]
  • Rikang Wang, Jiaqiang Zhao, Lei Zhang, Lizhi Peng, Xinyi Zhang, Wenhua Zheng, Heru Chen. Genipin Derivatives Protect RGC-5 from Sodium Nitroprusside-Induced Nitrosative Stress. International journal of molecular sciences. 2016 Jan; 17(1):. doi: 10.3390/ijms17010117. [PMID: 26797604]
  • Yang Yang, Yifu Yang, Jianwei Hou, Yue Ding, Tong Zhang, Yong Zhang, Jianying Wang, Chenchen Shi, Wenwei Fu, Zhenzhen Cai. The Hydroxyl at Position C1 of Genipin Is the Active Inhibitory Group that Affects Mitochondrial Uncoupling Protein 2 in Panc-1 Cells. PloS one. 2016; 11(1):e0147026. doi: 10.1371/journal.pone.0147026. [PMID: 26771380]
  • Yun Li, Wei Cai, Qian Cai, Yanyun Che, Baosheng Zhao, Jiayu Zhang. Comprehensive characterization of the in vitro and in vivo metabolites of geniposide in rats using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer. Xenobiotica; the fate of foreign compounds in biological systems. 2016; 46(4):357-68. doi: 10.3109/00498254.2015.1079746. [PMID: 26330181]
  • Lei-Chi Dong, Ya-Xi Fan, Qiong Yu, Jiang Ma, Xin Dong, Ping Li, Hui-Jun Li. Synergistic effects of rhubarb-gardenia herb pair in cholestatic rats at pharmacodynamic and pharmacokinetic levels. Journal of ethnopharmacology. 2015 Dec; 175(?):67-74. doi: 10.1016/j.jep.2015.09.012. [PMID: 26376237]
  • Jian-Li Chen, Bi-Yun Shi, Huan Xiang, Wen-Jing Hou, Xue-Mei Qin, Jun-Sheng Tian, Guan-Hua Du. (1)H NMR-based metabolic profiling of liver in chronic unpredictable mild stress rats with genipin treatment. Journal of pharmaceutical and biomedical analysis. 2015 Nov; 115(?):150-8. doi: 10.1016/j.jpba.2015.07.002. [PMID: 26204246]
  • Megan E McGann, Craig M Bonitsky, Mariah L Jackson, Timothy C Ovaert, Stephen B Trippel, Diane R Wagner. Genipin crosslinking of cartilage enhances resistance to biochemical degradation and mechanical wear. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2015 Nov; 33(11):1571-1579. doi: 10.1002/jor.22939. [PMID: 25939430]
  • Lili Li, Yupin Guo, Lianfei Zhao, Yuangang Zu, Huiyan Gu, Lei Yang. Enzymatic Hydrolysis and Simultaneous Extraction for Preparation of Genipin from Bark of Eucommia ulmoides after Ultrasound, Microwave Pretreatment. Molecules (Basel, Switzerland). 2015 Oct; 20(10):18717-31. doi: 10.3390/molecules201018717. [PMID: 26501242]
  • Baeckkyoung Sung, Chanjoong Kim, Min-Ho Kim. Biodegradable colloidal microgels with tunable thermosensitive volume phase transitions for controllable drug delivery. Journal of colloid and interface science. 2015 Jul; 450(?):26-33. doi: 10.1016/j.jcis.2015.02.068. [PMID: 25797395]
  • Speranza Rubattu, Sara Di Castro, Maria Cotugno, Franca Bianchi, Roberto Mattioli, Simona Baima, Rosita Stanzione, Michele Madonna, Cristina Bozzao, Simona Marchitti, Paolo Gelosa, Luigi Sironi, Alice Pignieri, Mariateresa Maldini, Anna Maria Giusti, Mirella Nardini, Giorgio Morelli, Paolo Costantino, Massimo Volpe. Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis. Journal of hypertension. 2015 Jul; 33(7):1465-79. doi: 10.1097/hjh.0000000000000562. [PMID: 25807219]
  • Gabsik Yang, Eun Kyoung Seo, Je-Hyun Lee, Joo Young Lee. Suppression of splenic lymphocyte proliferation by Eucommia ulmoides and genipin. Chemistry & biodiversity. 2015 Apr; 12(4):538-46. doi: 10.1002/cbdv.201400376. [PMID: 25879499]
  • Young-Sun Kwon, Eun-Su Lim, Hye-Min Kim, Yun-Chan Hwang, Kwang-Won Lee, Kyung-San Min. Genipin, a cross-linking agent, promotes odontogenic differentiation of human dental pulp cells. Journal of endodontics. 2015 Apr; 41(4):501-7. doi: 10.1016/j.joen.2014.12.002. [PMID: 25637194]
  • Bing Hu, Liying Zhang, Rong Liang, Fengze Chen, Liping He, Bing Hu, Xiaoxiong Zeng. Cross-linking of interfacial casein layer with genipin prevented pH-induced structural instability and lipase digestibility of the fat droplets. Journal of agricultural and food chemistry. 2015 Feb; 63(7):2033-40. doi: 10.1021/jf505724c. [PMID: 25647169]
  • R Wang, J Yang, L Peng, J Zhao, N Mu, J Huang, P Lazarovici, H Chen, W Zheng. Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways. Neuroscience. 2015 Feb; 286(?):242-50. doi: 10.1016/j.neuroscience.2014.11.056. [PMID: 25485482]
  • Myoungki Son, Minjung Lee, Eunhyun Ryu, Aree Moon, Choon-Sik Jeong, Yong Woo Jung, Gyu Hwan Park, Gi-Ho Sung, Hyosun Cho, Hyojeung Kang. Genipin as a novel chemical activator of EBV lytic cycle. Journal of microbiology (Seoul, Korea). 2015 Feb; 53(2):155-65. doi: 10.1007/s12275-015-4672-9. [PMID: 25626372]
  • Zeyun Li, Edward Welbeck, Li Yang, Chunyong He, Haijun Hu, Ming Song, Kaishun Bi, Zhengtao Wang. A quantitative ¹H nuclear magnetic resonance (qHNMR) method for assessing the purity of iridoids and secoiridoids. Fitoterapia. 2015 Jan; 100(?):187-94. doi: 10.1016/j.fitote.2014.12.001. [PMID: 25510321]
  • Jinke Xu, Satu Strandman, Julian X X Zhu, Jake Barralet, Marta Cerruti. Genipin-crosslinked catechol-chitosan mucoadhesive hydrogels for buccal drug delivery. Biomaterials. 2015 Jan; 37(?):395-404. doi: 10.1016/j.biomaterials.2014.10.024. [PMID: 25453967]