Yohimbine (BioDeep_00000398583)

Main id: BioDeep_00000000695

Secondary id: BioDeep_00000866729

natural product PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


methyl (2S,13bS,14aS,1R,4aR)-2-hydroxy-1,2,3,4,5,8,14,13b,14a,4a-decahydrobenz o[1,2-g]indolo[2,3-a]quinolizinecarboxylate

化学式: C21H26N2O3 (354.19433260000005)
中文名称: 育亨宾
谱图信息: 最多检出来源 Homo sapiens(blood) 2.33%

分子结构信息

SMILES: COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O
InChI: InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1

描述信息

G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals > G04BE - Drugs used in erectile dysfunction
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics
D000089162 - Genitourinary Agents > D064804 - Urological Agents
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2282
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.556
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.553
Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM. IC50 value: 0.6 uM [1] Target: alpha 2-adrenergic receptor in vitro: Yohimbine inhibits alpha2-receptor antagonist with Ki of 1.05 nM, 1.19 nM, and 1.19 nM for α2A, α2B, α2C, respectively. Yohimbine also inhibits 5-HT1B with Ki of 19.9 nM. Yohimbine acts to block the lowering of cAMP by alpha-2 adrenoceptor agonists. yohimbine actually causes a pronounced lowering of tyrosinase activity. [3] in vivo: Yohimbine is an antagonist at alpha2-noradrenaline receptors with putative panicogenic effects in human subjects, was administered to Swiss-Webster mice at doses of 0.5, 1.0, and 2.0 mg/kg. Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice.[2]
Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM. IC50 value: 0.6 uM [1] Target: alpha 2-adrenergic receptor in vitro: Yohimbine inhibits alpha2-receptor antagonist with Ki of 1.05 nM, 1.19 nM, and 1.19 nM for α2A, α2B, α2C, respectively. Yohimbine also inhibits 5-HT1B with Ki of 19.9 nM. Yohimbine acts to block the lowering of cAMP by alpha-2 adrenoceptor agonists. yohimbine actually causes a pronounced lowering of tyrosinase activity. [3] in vivo: Yohimbine is an antagonist at alpha2-noradrenaline receptors with putative panicogenic effects in human subjects, was administered to Swiss-Webster mice at doses of 0.5, 1.0, and 2.0 mg/kg. Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice.[2]

同义名列表

3 个代谢物同义名

Yohimbine; methyl (2S,13bS,14aS,1R,4aR)-2-hydroxy-1,2,3,4,5,8,14,13b,14a,4a-decahydrobenz o[1,2-g]indolo[2,3-a]quinolizinecarboxylate; Yohimbine



数据库引用编号

53 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

78 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Samuel A Bradley, Frederik G Hansson, Beata J Lehka, Daniela Rago, Pedro Pinho, Huadong Peng, Khem B Adhikari, Ahmad K Haidar, Lea G Hansen, Daria Volkova, Maxence Holtz, Sergi Muyo Abad, Xin Ma, Konstantinos Koudounas, Sébastien Besseau, Nicolas Gautron, Céline Mélin, Jillian Marc, Caroline Birer Williams, Vincent Courdavault, Emil D Jensen, Jay D Keasling, Jie Zhang, Michael K Jensen. Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine. ACS synthetic biology. 2024 May; 13(5):1498-1512. doi: 10.1021/acssynbio.4c00039. [PMID: 38635307]
  • Ben A Chindo, Melanie-Jayne R Howes, Sawsan Abuhamdah, Danjuma Mallam, Timothy Micah, Rosemary I Awotula, Robin Battison, Paul L Chazot. Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models. Journal of ethnopharmacology. 2024 Mar; 321(?):117500. doi: 10.1016/j.jep.2023.117500. [PMID: 38030022]
  • Ninh Khac Thanh Tung, Duong Thi Dung, Phan Van Kiem, Dan Thi Thuy Hang, Nguyen Xuan Nhiem, Nguyen Van The, Yohan Seo, Jong Seong Kang, Bui Huu Tai. Alkaloids and Lignans from the Aerial Parts of Rauvolfia tetraphylla Inhibit NO Production in LPS-activated RAW 264.7 Cells. Chemistry & biodiversity. 2024 Mar; 21(3):e202302123. doi: 10.1002/cbdv.202302123. [PMID: 38253808]
  • Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati. Yohimbine ameliorates liver inflammation and fibrosis by regulating oxidative stress and Wnt/β-catenin pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Nov; 123(?):155182. doi: 10.1016/j.phymed.2023.155182. [PMID: 37952411]
  • Olusegun Adebayo Adeoluwa, Anthony Taghogho Eduviere, Gladys Onyinye Adeoluwa, Lily Oghenevovwero Otomewo, Funmilayo Racheal Adeniyi. The monoaminergic pathways are involved in the antidepressant-like effect of quercetin. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Oct; ?(?):. doi: 10.1007/s00210-023-02789-8. [PMID: 37851059]
  • Xingyu Su, Fan Lu, Yihua Chen, Miao Wang, Guoqing Tang, Wan Lin, Yingwen Liu, Huadong Wang, Haiyan Yin, Yiyang Wang. α2-Adrenoreceptor antagonist ameliorates sepsis-associated pulmonary fibrosis by suppressing norepinephrine-mediated fibroblast differentiation via inhibiting PKC activation. Shock (Augusta, Ga.). 2023 Oct; ?(?):. doi: 10.1097/shk.0000000000002240. [PMID: 37878498]
  • Małgorzata Iciek, Magdalena Górny, Magdalena Kotańska, Anna Bilska-Wilkosz, Marta Kaczor-Kamińska, Jacek Zagajewski. Yohimbine Alleviates Oxidative Stress and Suppresses Aerobic Cysteine Metabolism Elevated in the Rat Liver of High-Fat Diet-Fed Rats. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052025. [PMID: 36903271]
  • Geun Joo Choi, Hyun Kang, Oh Haeng Lee, Ji Wung Kwon. Effect of Immature Rubus occidentalis on Postoperative Pain in a Rat Model. Medicina (Kaunas, Lithuania). 2023 Jan; 59(2):. doi: 10.3390/medicina59020264. [PMID: 36837466]
  • Mariane Meurer, Fabiula Felisbino, Fabiana B Müller, Lincon B Somensi, Benhur J Cury, Daniele T Jerônimo, Larissa Venzon, Tauani C S França, Marihá Mariott, Ana C Santos, Ruan Kaio S Nunes, Thaise Boeing, Alexandre Bella-Cruz, Priscila DE Souza, Walter A Roman-Junior, Karuppusamy Arunachalam, Ruberlei G Oliveira, Luisa M Silva. Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.). Anais da Academia Brasileira de Ciencias. 2023; 95(suppl 1):e20220427. doi: 10.1590/0001-3765202320220427. [PMID: 37556712]
  • Nasimudeen R Jabir, Mohd Shahnawaz Khan, Nouf Omar Alafaleq, Huma Naz, Bakrudeen Ali Ahmed. Anticancer potential of yohimbine in drug-resistant oral cancer KB-ChR-8-5 cells. Molecular biology reports. 2022 Oct; 49(10):9565-9573. doi: 10.1007/s11033-022-07847-7. [PMID: 35970968]
  • Vibeizonuo Rupreo, Soching Luikham, Jhimli Bhattacharyya. Protein-binding characteristics of yohimbine, a natural indole alkaloid-based drug for erectile dysfunction. Luminescence : the journal of biological and chemical luminescence. 2022 Sep; 37(9):1532-1540. doi: 10.1002/bio.4327. [PMID: 35816091]
  • Jing Chen, Juan Zhang, Dan-Dan Yang, Zi-Cheng Li, Bo Zhao, Yue Chen, Zhi He. Clonidine ameliorates cerebral ischemia-reperfusion injury by up-regulating the GluN3 subunits of NMDA receptor. Metabolic brain disease. 2022 08; 37(6):1829-1841. doi: 10.1007/s11011-022-01028-y. [PMID: 35727521]
  • Sarah J Baracz, Katherine J Robinson, Amanda L Wright, Anita J Turner, Iain S McGregor, Jennifer L Cornish, Nicholas A Everett. Oxytocin as an adolescent treatment for methamphetamine addiction after early life stress in male and female rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022 07; 47(8):1561-1573. doi: 10.1038/s41386-022-01336-y. [PMID: 35581382]
  • Richard G W Proudman, Juliana Akinaga, Jillian G Baker. The affinity and selectivity of α-adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C-adrenoceptors and comparison with human α1 and β-adrenoceptors. Pharmacology research & perspectives. 2022 04; 10(2):e00936. doi: 10.1002/prp2.936. [PMID: 35224877]
  • R C Douho Djimeli, M L Nchouwet, S L Poualeu Kamani, L M Tchoumba Tchoumi, A Kamanyi, S L Wansi Ngnokam. Antisecretory and Spasmolytic Activities of Aqueous and Ethanolic Stem Bark Extracts of Nauclea diderrichii in Wistar Rats. BioMed research international. 2022; 2022(?):7569848. doi: 10.1155/2022/7569848. [PMID: 35769665]
  • Yani Zhao, Yan Zhang, Yao Li, Min Yang, Jiani Yuan, Yu Cao, Lu Xu, Xuexinyu Ma, Sisong Lin, Junming An, Siwang Wang. Yohimbine hydrochloride inhibits benign prostatic hyperplasia by downregulating steroid 5α-reductase type 2. European journal of pharmacology. 2021 Oct; 908(?):174334. doi: 10.1016/j.ejphar.2021.174334. [PMID: 34265299]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn. Lipid Emulsion Enhances Vasoconstriction Induced by Dexmedetomidine in the Isolated Endothelium-Intact Aorta. International journal of molecular sciences. 2021 Mar; 22(7):. doi: 10.3390/ijms22073309. [PMID: 33804982]
  • Kohei Hayashi, Takaomi Shimokawa, Masayo Yamagata, Kozo Yoneda. Inhibition of α2-adrenoceptor is renoprotective in 5/6 nephrectomy-induced chronic kidney injury rats. Journal of pharmacological sciences. 2021 Jan; 145(1):79-87. doi: 10.1016/j.jphs.2020.11.001. [PMID: 33357783]
  • Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Xingbin Wang, Xinxin Zhang, Zengjun Guo. Cytotoxic Yohimbine-Type Alkaloids from the Leaves of Rauvolfia vomitoria. Chemistry & biodiversity. 2020 Dec; 17(12):e2000647. doi: 10.1002/cbdv.202000647. [PMID: 33044757]
  • Diogo A Fonseca, Mónica Ferreira, Maria Graça Campos, Pedro E Antunes, Manuel J Antunes, Maria Dulce Cotrim. Vascular effects of a polyphenolic fraction from Oxalis pes-caprae L.: role of α-adrenergic receptors Sub-types. Natural product research. 2020 Dec; 34(23):3369-3372. doi: 10.1080/14786419.2018.1564291. [PMID: 30698035]
  • Danuše Tarkowská. A Fast and Reliable UHPLC-MS/MS-Based Method for Screening Selected Pharmacologically Significant Natural Plant Indole Alkaloids. Molecules (Basel, Switzerland). 2020 Jul; 25(14):. doi: 10.3390/molecules25143274. [PMID: 32708364]
  • Manuela Vay, Marleen Julia Meyer, Antje Blank, Gisela Skopp, Peter Rose, Mladen Vassilev Tzvetkov, Gerd Mikus. Oral Yohimbine as a New Probe Drug to Predict CYP2D6 Activity: Results of a Fixed-Sequence Phase I Trial. Clinical pharmacokinetics. 2020 07; 59(7):927-939. doi: 10.1007/s40262-020-00862-6. [PMID: 32060866]
  • Jeffery D Foss, Sunil U Nayak, Christopher S Tallarida, Daniel J Farkas, Sara J Ward, Scott M Rawls. Mitragynine, bioactive alkaloid of kratom, reduces chemotherapy-induced neuropathic pain in rats through α-adrenoceptor mechanism. Drug and alcohol dependence. 2020 04; 209(?):107946. doi: 10.1016/j.drugalcdep.2020.107946. [PMID: 32145665]
  • Takaomi Shimokawa, Kozo Yoneda, Masayo Yamagata, Kohei Hayashi, Shuhei Tomita. Yohimbine ameliorates lipopolysaccharide-induced acute kidney injury in rats. European journal of pharmacology. 2020 Mar; 871(?):172917. doi: 10.1016/j.ejphar.2020.172917. [PMID: 31935395]
  • L Pan, Y Zhang, Y He, Z Chen, S Wang, Y Xia, T J Papadimos, W Lin, X Xu. Dexmedetomidine elevates the lethal dose threshold of bupivacaine in rats: A dosing study. Human & experimental toxicology. 2020 Mar; 39(3):365-373. doi: 10.1177/0960327119889658. [PMID: 31773986]
  • Samuel Obeng, Shyam H Kamble, Morgan E Reeves, Luis F Restrepo, Avi Patel, Mira Behnke, Nelson J-Y Chear, Surash Ramanathan, Abhisheak Sharma, Francisco León, Takato Hiranita, Bonnie A Avery, Lance R McMahon, Christopher R McCurdy. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry. 2020 01; 63(1):433-439. doi: 10.1021/acs.jmedchem.9b01465. [PMID: 31834797]
  • Clara Alba-Betancourt, Amanda Sánchez-Recillas, Angel J Alonso-Castro, David Esquivel-Juárez, Juan R Zapata-Morales, Víctor Yáñez-Pérez, Daniel Álvarez-Camacho, Yessica E Medina-Rivera, Marco M González-Chávez, Deisy Gasca-Martínez, Rolffy Ortiz-Andrade. Antidiarrheal, vasorelaxant, and neuropharmacological actions of the diterpene tilifodiolide. Drug development research. 2019 11; 80(7):981-991. doi: 10.1002/ddr.21578. [PMID: 31343767]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Matthew D Lynes, Sean D Kodani, Yu-Hua Tseng. Lipokines and Thermogenesis. Endocrinology. 2019 10; 160(10):2314-2325. doi: 10.1210/en.2019-00337. [PMID: 31504387]
  • Manuela Vay, Max Sauter, Gerd Mikus, Jürgen Burhenne. Quantification of microdosed oral yohimbine and its major metabolite in human plasma in the picogram range. Bioanalysis. 2019 Aug; 11(16):1459-1467. doi: 10.4155/bio-2019-0129. [PMID: 31411489]
  • Olanrewaju A Salako, Abidemi J Akindele, Aishat O Balogun, Olufunmilayo O Adeyemi. Investigation of Antidepressant, Anxiolytic and Sedative Activities of the Aqueous Leaf Extract of Musa sapientum Linn. (Banana; Musaceae). Drug research. 2019 Feb; 69(3):136-143. doi: 10.1055/a-0651-7978. [PMID: 30075482]
  • Hidenobu Tsutsui, Takaomi Shimokawa, Takeshi Miura, Masashi Takama, Toru Nishinaka, Tomoyuki Terada, Masayo Yamagata, Tokihito Yukimura. Inhibition of α2C-adrenoceptors ameliorates cisplatin-induced acute renal failure in rats. European journal of pharmacology. 2018 Nov; 838(?):113-119. doi: 10.1016/j.ejphar.2018.09.010. [PMID: 30201375]
  • Nathielli Nayara Pauleti, Jonas Mello, Diogo Alexandre Siebert, Gustavo Amadeu Micke, Cláudia Almeida Coelho de Albuquerque, Michele Debiasi Alberton, Sara Cristiane Barauna. Characterisation of phenolic compounds of the ethyl acetate fraction from Tabernaemontana catharinensis and its potential antidepressant-like effect. Natural product research. 2018 Aug; 32(16):1987-1990. doi: 10.1080/14786419.2017.1359167. [PMID: 28764559]
  • Thomas J Flynn, Sanah N Vohra. Simultaneous determination of intestinal permeability and potential drug interactions of complex mixtures using Caco-2 cells and high-resolution mass spectrometry: Studies with Rauwolfia serpentina extract. Chemico-biological interactions. 2018 Jun; 290(?):37-43. doi: 10.1016/j.cbi.2018.05.006. [PMID: 29782822]
  • Megan M Moran-Santa Maria, Brian J Sherman, Kathleen T Brady, Nathaniel L Baker, J Madison Hyer, Chantelle Ferland, Aimee L McRae-Clark. Impact of endogenous progesterone on reactivity to yohimbine and cocaine cues in cocaine-dependent women. Pharmacology, biochemistry, and behavior. 2018 02; 165(?):63-69. doi: 10.1016/j.pbb.2017.11.001. [PMID: 29126857]
  • Jenny-Ann Phan, Anne M Landau, Steen Jakobsen, Dean F Wong, Albert Gjedde. Radioligand binding analysis of α 2 adrenoceptors with [11C]yohimbine in brain in vivo: Extended Inhibition Plot correction for plasma protein binding. Scientific reports. 2017 11; 7(1):15979. doi: 10.1038/s41598-017-16020-1. [PMID: 29167492]
  • Nisha Rao, Henry A Spiller, Nichole L Hodges, Thiphalak Chounthirath, Marcel J Casavant, Amrit K Kamboj, Gary A Smith. An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2017 09; 13(3):227-237. doi: 10.1007/s13181-017-0623-7. [PMID: 28741126]
  • Solomon Umukoro, Somtochukwu I Ogboh, Osarume Omorogbe, Abdul-Lateef A Adekeye, Matthew O Olatunde. Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-Like Activity of Cymbopogon citratus in Mice. Drug research. 2017 Jul; 67(7):419-424. doi: 10.1055/s-0043-106586. [PMID: 28499312]
  • Pollyana S Siqueira-Lima, Renan G Brito, Heitor G Araújo-Filho, Priscila L Santos, Angélica Lucchesi, Adriano A S Araújo, Paula P Menezes, Luciana Scotti, Marcus T Scotti, Irwin R A Menezes, Henrique D M Coutinho, Gokhan Zengin, Abdurrahman Aktumsek, Angelo R Antoniolli, Lucindo J Quintans-Júnior, Jullyana S S Quintans. Anti-hyperalgesic effect of Lippia grata leaf essential oil complexed with β-cyclodextrin in a chronic musculoskeletal pain animal model: Complemented with a molecular docking and antioxidant screening. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jul; 91(?):739-747. doi: 10.1016/j.biopha.2017.05.009. [PMID: 28499245]
  • Xiaowei Xiang, Bing Shang, Xiaozheng Wang, Qinhua Chen. PEEK tube-based online solid-phase microextraction-high-performance liquid chromatography for the determination of yohimbine in rat plasma and its application in pharmacokinetics study. Biomedical chromatography : BMC. 2017 Apr; 31(4):. doi: 10.1002/bmc.3866. [PMID: 27739080]
  • Sachie Sasaki-Hamada, Azusa Suzuki, Yudai Ueda, Kinzo Matsumoto, Jun-Ichiro Oka. Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice. Journal of pharmacological sciences. 2017 Feb; 133(2):110-113. doi: 10.1016/j.jphs.2017.01.002. [PMID: 28233634]
  • Neha, Md Meraj Ansari, Haider A Khan. Yohimbine hydrochloride ameliorates collagen type-II-induced arthritis targeting oxidative stress and inflammatory cytokines in Wistar rats. Environmental toxicology. 2017 Feb; 32(2):619-629. doi: 10.1002/tox.22264. [PMID: 27028940]
  • Luis Jardelino de Lacerda Neto, Andreza Guedes Barbosa Ramos, Valterlucio Santos Sales, Severino Denicio Gonçalves de Souza, Antonia Thassya Lucas Dos Santos, Larissa Rolim de Oliveira, Marta Regina Kerntopf, Thais Rodrigues de Albuquerque, Henrique Douglas Melo Coutinho, Lucindo Jose Quintans-Júnior, Almir Gonçalves Wanderley, Irwin Rose Alencar de Menezes. Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity. Chemico-biological interactions. 2017 Jan; 261(?):56-62. doi: 10.1016/j.cbi.2016.11.020. [PMID: 27871896]
  • Jocelyn Fotso Soh, Hilary R Strong, Noriko Daneshtalab, Reza Tabrizchi. The effect of inflammation on sympathetic nerve mediated contractions in rat isolated caudal artery. European journal of pharmacology. 2016 Dec; 792(?):54-62. doi: 10.1016/j.ejphar.2016.10.030. [PMID: 27793651]
  • Ismail O Ishola, Olufunsho Awodele, Chinedum O Eluogu. Potentials of Mangifera indica in the treatment of depressive-anxiety disorders: possible mechanisms of action. Journal of complementary & integrative medicine. 2016 Sep; 13(3):275-287. doi: 10.1515/jcim-2015-0047. [PMID: 27276531]
  • Takaomi Shimokawa, Hidenobu Tsutsui, Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Masashi Takama, Shuhei Yoshida, Takao Tanba, Ayumi Tojo, Masayo Yamagata, Tokihito Yukimura. Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through α2C-adrenoceptors in rats. European journal of pharmacology. 2016 Jun; 781(?):36-44. doi: 10.1016/j.ejphar.2016.03.059. [PMID: 27041645]
  • Yuan Wang, Faqiang Wang, Duomeng Yang, Xiangxu Tang, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang. Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils. International immunopharmacology. 2016 Jun; 35(?):217-225. doi: 10.1016/j.intimp.2016.03.041. [PMID: 27082997]
  • Pieter A Cohen, Yan-Hong Wang, Gregory Maller, Renan DeSouza, Ikhlas A Khan. Pharmaceutical quantities of yohimbine found in dietary supplements in the USA. Drug testing and analysis. 2016 Mar; 8(3-4):357-69. doi: 10.1002/dta.1849. [PMID: 26391406]
  • Wahid Zada, Sara Zeeshan, Huma Aslam Bhatti, Wajahat Mahmood, Khalid Rauf, Ghulam Abbas. Cinnamomum cassia: an implication of serotonin reuptake inhibition in animal models of depression. Natural product research. 2016; 30(10):1212-4. doi: 10.1080/14786419.2015.1047776. [PMID: 26134381]
  • Olanrewaju A Salako, Abidemi J Akindele, Omotoyosi M Shitta, Olajumoke O Elegunde, Olufunmilayo O Adeyemi. Antidiarrhoeal activity of aqueous leaf extract of Caladium bicolor (Araceae) and its possible mechanisms of action. Journal of ethnopharmacology. 2015 Dec; 176(?):225-31. doi: 10.1016/j.jep.2015.10.035. [PMID: 26514064]
  • Tao Cui, Robert C Kovell, David C Brooks, Ryan P Terlecki. A Urologist's Guide to Ingredients Found in Top-Selling Nutraceuticals for Men's Sexual Health. The journal of sexual medicine. 2015 Nov; 12(11):2105-17. doi: 10.1111/jsm.13013. [PMID: 26531010]
  • R J Bloomer, J M Schriefer, T A Gunnels. Clinical safety assessment of oral higenamine supplementation in healthy, young men. Human & experimental toxicology. 2015 Oct; 34(10):935-45. doi: 10.1177/0960327114565490. [PMID: 25591969]
  • Amir Akhgari, Into Laakso, Tuulikki Seppänen-Laakso, Teijo Yrjönen, Heikki Vuorela, Kirsi-Marja Oksman-Caldentey, Heiko Rischer. Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS. Phytochemical analysis : PCA. 2015 Sep; 26(5):331-8. doi: 10.1002/pca.2567. [PMID: 26095837]
  • Patrícia de Souza Rossignoli, Fernanda Zocatelli Yamamoto, Oduvaldo Câmara Marques Pereira, Agnaldo Bruno Chies. Norepinephrine responses in rat renal and femoral veins are reinforced by vasoconstrictor prostanoids. Vascular pharmacology. 2015 Sep; 72(?):93-100. doi: 10.1016/j.vph.2015.06.017. [PMID: 26141930]
  • Basma Fatima Anwar Husain, Ishira N Nanavaty, Swananda V Marathe, Rajeev Rajendran, Vidita A Vaidya. Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment. Progress in neuro-psychopharmacology & biological psychiatry. 2015 Aug; 61(?):1-9. doi: 10.1016/j.pnpbp.2015.03.004. [PMID: 25784603]
  • Hao Guo, He-fei Zhang, Wen-qi Xu, Qian Du, Jing Zhao, Lei-ming Ren. Differential effects of short- and long-term bupivacaine treatment on α1-adrenoceptor-mediated contraction of isolated rat aorta rings and the reversal effect of lipid emulsion. Acta pharmacologica Sinica. 2015 Aug; 36(8):976-86. doi: 10.1038/aps.2015.40. [PMID: 26073324]
  • Y Harada, S Ro, M Ochiai, K Hayashi, E Hosomi, N Fujitsuka, T Hattori, K Yakabi. Ghrelin enhancer, rikkunshito, improves postprandial gastric motor dysfunction in an experimental stress model. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2015 Aug; 27(8):1089-97. doi: 10.1111/nmo.12588. [PMID: 26088415]
  • Pei Chen, Noella Bryden. Determination of Yohimbine in Yohimbe Bark and Related Dietary Supplements Using UHPLC-UV/MS: Single-Laboratory Validation. Journal of AOAC International. 2015 Jul; 98(4):896-901. doi: 10.5740/jaoacint.13-170. [PMID: 26268969]
  • O A Adeoluwa, A O Aderibigbe, A G Bakre. Evaluation of Antidepressant-like Effect of Olax Subscorpioidea Oliv. (Olacaceae) Extract in Mice. Drug research. 2015 Jun; 65(6):306-11. doi: 10.1055/s-0034-1382010. [PMID: 24992494]
  • Ashkaan Younai, Bi-Shun Zeng, Herbert Y Meltzer, Karl A Scheidt. Enantioselective Syntheses of Heteroyohimbine Natural Products: A Unified Approach through Cooperative Catalysis. Angewandte Chemie (International ed. in English). 2015 Jun; 54(23):6900-4. doi: 10.1002/anie.201502011. [PMID: 25914164]
  • Lisa J Norelli, Chunying Xu. Manic psychosis associated with ginseng: a report of two cases and discussion of the literature. Journal of dietary supplements. 2015 Jun; 12(2):119-25. doi: 10.3109/19390211.2014.902001. [PMID: 24689505]
  • Sikiru Olaitan Balogun, Amilcar Sabino Damazo, Domingos Tabajara de Oliveira Martins. Helicteres sacarolha A. St.- Hil. et al.: gastroprotective and possible mechanism of actions in experimental animals. Journal of ethnopharmacology. 2015 May; 166(?):176-84. doi: 10.1016/j.jep.2015.03.021. [PMID: 25792014]
  • Jianxing Zhang, Zhipeng Wang, Yan Wang, Guobin Zhou, Hongying Li. The effect of dexmedetomidine on inflammatory response of septic rats. BMC anesthesiology. 2015 May; 15(?):68. doi: 10.1186/s12871-015-0042-8. [PMID: 25929655]
  • Sai P Pydi, Appalaraju Jaggupilli, Ken M Nelson, Suzanne R Abrams, Rajinder P Bhullar, Michele C Loewen, Prashen Chelikani. Abscisic Acid Acts as a Blocker of the Bitter Taste G Protein-Coupled Receptor T2R4. Biochemistry. 2015 Apr; 54(16):2622-31. doi: 10.1021/acs.biochem.5b00265. [PMID: 25844797]
  • J Kaufmann, P Martinka, O Moede, M Sendeski, A Steege, M Fähling, M Hultström, M Gaestel, I C Moraes-Silva, T Nikitina, Z Z Liu, O Zavaritskaya, A Patzak. Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries. Acta physiologica (Oxford, England). 2015 Apr; 213(4):920-32. doi: 10.1111/apha.12457. [PMID: 25594617]
  • I O Ishola, S O Olayemi, O K Yemitan, E A Umeh. Antidepressant and anxiolytic effects of the methanol root extract of Capparis thonningii: involvement of monoaminergic, cholinergic and GABAergic systems. Drug research. 2015 Apr; 65(4):205-13. doi: 10.1055/s-0034-1376963. [PMID: 24886981]
  • Adjmal Nahimi, Steen Jakobsen, Ole L Munk, Kim Vang, Jenny A Phan, Anders Rodell, Albert Gjedde. Mapping α2 adrenoceptors of the human brain with 11C-yohimbine. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015 Mar; 56(3):392-8. doi: 10.2967/jnumed.114.145565. [PMID: 25635132]
  • Derick Lucas, James Neal-Kababick, Jerry Zweigenbaum. Characterization and quantitation of yohimbine and its analogs in botanicals and dietary supplements using LC/QTOF-MS and LC/QQQ-MS for determination of the presence of bark extract and yohimbine adulteration. Journal of AOAC International. 2015 Mar; 98(2):330-5. doi: 10.5740/jaoacint.14-246. [PMID: 25905738]
  • Magdalena Dudek, Joanna Knutelska, Marek Bednarski, Leszek Nowiński, Małgorzata Zygmunt, Barbara Mordyl, Monika Głuch-Lutwin, Grzegorz Kazek, Jacek Sapa, Karolina Pytka. A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity. PloS one. 2015; 10(10):e0141327. doi: 10.1371/journal.pone.0141327. [PMID: 26506439]
  • Choy-Eng Nge, Chew-Yan Gan, Kuan-Hon Lim, Kang-Nee Ting, Yun-Yee Low, Toh-Seok Kam. Criofolinine and vernavosine, new pentacyclic indole alkaloids incorporating pyrroloazepine and pyridopyrimidine moieties derived from a common yohimbine precursor. Organic letters. 2014 Dec; 16(24):6330-3. doi: 10.1021/ol503072g. [PMID: 25454201]
  • John Malaty, Irene A Malaty. Hypertensive urgency: an important aetiology of rebound hypertension. BMJ case reports. 2014 Oct; 2014(?):. doi: 10.1136/bcr-2014-206022. [PMID: 25336552]
  • Yun-Beom Sim, Soo-Hyun Park, Sung-Su Kim, Su-Min Lim, Jun-Sub Jung, Hong-Won Suh. Activation of spinal α2 adrenergic receptors induces hyperglycemia in mouse though activating sympathetic outflow. European journal of pharmacology. 2014 Oct; 741(?):316-22. doi: 10.1016/j.ejphar.2014.08.022. [PMID: 25179570]
  • Yusuke Murahata, Yuya Miki, Yoshiaki Hikasa. Antagonistic effects of atipamezole, yohimbine, and prazosin on xylazine-induced diuresis in clinically normal cats. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2014 Oct; 78(4):304-15. doi: . [PMID: 25356000]
  • José Luís Rodrigues Martins, Oscar Romero Lopes Rodrigues, Dayane Moreira da Silva, Pablinny Moreira Galdino, José Realino de Paula, Wanderson Romão, Helber Barcellos da Costa, Boniek Gontijo Vaz, Paulo César Ghedini, Elson Alves Costa. Mechanisms involved in the gastroprotective activity of Celtis iguanaea (Jacq.) Sargent on gastric lesions in mice. Journal of ethnopharmacology. 2014 Sep; 155(3):1616-24. doi: 10.1016/j.jep.2014.08.006. [PMID: 25153020]
  • Theresa M Scott, Jillian K Yeakel, Barry K Logan. Identification of mitragynine and O-desmethyltramadol in Kratom and legal high products sold online. Drug testing and analysis. 2014 Sep; 6(9):959-63. doi: 10.1002/dta.1673. [PMID: 24962931]
  • Andrea Luiza de Oliveira, Jurandir Fernando Comar, Anacharis Babeto de Sá-Nakanishi, Rosane Marina Peralta, Adelar Bracht. The action of p-synephrine on hepatic carbohydrate metabolism and respiration occurs via both Ca(2+)-mobilization and cAMP production. Molecular and cellular biochemistry. 2014 Mar; 388(1-2):135-47. doi: 10.1007/s11010-013-1905-2. [PMID: 24287564]
  • Yusuke Murahata, Asami Yamamoto, Yuya Miki, Yoshiaki Hikasa. Antagonistic effects of atipamezole, yohimbine and prazosin on medetomidine-induced diuresis in healthy cats. The Journal of veterinary medical science. 2014 Mar; 76(2):173-82. doi: 10.1292/jvms.13-0398. [PMID: 24107430]
  • S Umukoro, A T Eduviere, A C Aladeokin, A S Olugbemide. Antidepressant-like property of Jobelyn®, an African unique herbal formulation, in mice. Drug research. 2014 Mar; 64(3):146-50. doi: 10.1055/s-0033-1354366. [PMID: 24002928]
  • Sae Uchida, Fusako Kagitani. Effects of electrical stimulation of autonomic nerves to the ovary on the ovarian testosterone secretion rate in rats. Autonomic neuroscience : basic & clinical. 2014 Feb; 180(?):48-52. doi: 10.1016/j.autneu.2013.10.007. [PMID: 24220239]
  • Heather K Knych, Scott D Stanley. Effects of three antagonists on selected pharmacodynamic effects of sublingually administered detomidine in the horse. Veterinary anaesthesia and analgesia. 2014 Jan; 41(1):36-47. doi: 10.1111/vaa.12081. [PMID: 24134603]
  • Markus R Meyer, Achim Caspar, Simon D Brandt, Hans H Maurer. A qualitative/quantitative approach for the detection of 37 tryptamine-derived designer drugs, 5 β-carbolines, ibogaine, and yohimbine in human urine and plasma using standard urine screening and multi-analyte approaches. Analytical and bioanalytical chemistry. 2014 Jan; 406(1):225-37. doi: 10.1007/s00216-013-7425-9. [PMID: 24173660]
  • Sang-Rok Lee, Johnhenry M Schriefer, Trint A Gunnels, Innocence C Harvey, Richard J Bloomer. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acids and energy expenditure in human subjects. Lipids in health and disease. 2013 Oct; 12(?):148. doi: 10.1186/1476-511x-12-148. [PMID: 24139127]
  • Alessandro Gozzi, Stefano Lepore, Elena Vicentini, Emilio Merlo-Pich, Angelo Bifone. Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2013 Oct; 38(11):2120-30. doi: 10.1038/npp.2013.109. [PMID: 23736277]
  • Alan C Swann, Marijn Lijffijt, Scott D Lane, Blake Cox, Joel L Steinberg, F Gerard Moeller. Norepinephrine and impulsivity: effects of acute yohimbine. Psychopharmacology. 2013 Sep; 229(1):83-94. doi: 10.1007/s00213-013-3088-7. [PMID: 23559222]
  • Tatiani Sorregotti, Joyce Mendes-Gomes, Javier Leonardo Rico, Robert John Rodgers, Ricardo Luiz Nunes-de-Souza. Ethopharmacological analysis of the open elevated plus-maze in mice. Behavioural brain research. 2013 Jun; 246(?):76-85. doi: 10.1016/j.bbr.2013.02.035. [PMID: 23470900]
  • I A Bukhari, A Dar. Behavioral profile of Hypericum perforatum (St. John's Wort) extract. A comparison with standard antidepressants in animal models of depression. European review for medical and pharmacological sciences. 2013 Apr; 17(8):1082-9. doi: ". [PMID: 23661522]
  • M Sandberg, U Pettersson, J Henriksnäs, L Jansson. The α2-adrenoceptor antagonist yohimbine normalizes increased islet blood flow in GK rats: a model of type 2 diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2013 Mar; 45(3):252-4. doi: 10.1055/s-0032-1323843. [PMID: 23015611]
  • Ali Kurt, Metin Ingec, Unal Isaoglu, Mehmet Yilmaz, Nihal Cetin, Muhammet Calik, Beyzagul Polat, Fatih Akcay, Cemal Gundogdu, Halis Suleyman. An investigation about the inhibition of acute ischemia/reperfusion damage by dexmedetomidine in rat ovarian tissue. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2013 Mar; 29(3):222-5. doi: 10.3109/09513590.2012.665104. [PMID: 23230861]
  • Vijayasankar Raman, Bharathi Avula, Ahmed M Galal, Yan-Hong Wang, Ikhlas A Khan. Microscopic and UPLC-UV-MS analyses of authentic and commercial yohimbe (Pausinystalia johimbe) bark samples. Journal of natural medicines. 2013 Jan; 67(1):42-50. doi: 10.1007/s11418-012-0642-2. [PMID: 22402817]
  • Yiyang Wang, Xiaohui Yu, Faqiang Wang, Yuan Wang, Yanping Wang, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang. Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic α2A-adrenergic receptor. PloS one. 2013; 8(5):e63622. doi: 10.1371/journal.pone.0063622. [PMID: 23691077]
  • Liang Ye, Zhengping Hu, Guangying Du, Jianzhao Zhang, Qiuju Dong, Fenghua Fu, Jingwei Tian. Antidepressant-like effects of the extract from Cimicifuga foetida L. Journal of ethnopharmacology. 2012 Dec; 144(3):683-91. doi: 10.1016/j.jep.2012.10.013. [PMID: 23069943]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Steven Berman, Brandall Suyenobu, Bruce D Naliboff, Joshua Bueller, Jean Stains, Heng Wong, Mark Mandelkern, Leah Fitzgerald, Gordon Ohning, Arpana Gupta, Jennifer S Labus, Kirsten Tillisch, Emeran A Mayer. Evidence for alterations in central noradrenergic signaling in irritable bowel syndrome. NeuroImage. 2012 Dec; 63(4):1854-63. doi: 10.1016/j.neuroimage.2012.08.028. [PMID: 22917679]
  • Heather K DiMaio Knych, Vanessa Covarrubias, Eugene P Steffey. Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse. Veterinary anaesthesia and analgesia. 2012 Nov; 39(6):574-83. doi: 10.1111/j.1467-2995.2012.00776.x. [PMID: 23035904]
  • André R S Colla, Daniele G Machado, Luis E B Bettio, Guilherme Colla, Michele D A Magina, Inês M C Brighente, Ana Lúcia S Rodrigues. Involvement of monoaminergic systems in the antidepressant-like effect of Eugenia brasiliensis Lam. (Myrtaceae) in the tail suspension test in mice. Journal of ethnopharmacology. 2012 Sep; 143(2):720-31. doi: 10.1016/j.jep.2012.07.038. [PMID: 22884868]
  • Ying-Jin Zhang, Wei Huang, Xi Huang, Yang Wang, Zhe Wang, Cheng Wang, Bing-Wu Zhong, Chen-Xia Sheng, Bing Wang, Si-Fang Zhang, Nan-Xiang Su, Zhao-Qian Liu, Hong-Hao Zhou, Ping Ren. Fructus Aurantii induced antidepressant effect via its monoaminergic mechanism and prokinetic action in rat. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Sep; 19(12):1101-7. doi: 10.1016/j.phymed.2012.05.015. [PMID: 22770641]
  • Kelly L Conrad, Adeola R Davis, Yuval Silberman, Douglas J Sheffler, Angela D Shields, Sam A Saleh, Namita Sen, Heinrich J G Matthies, Jonathan A Javitch, Craig W Lindsley, Danny G Winder. Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2012 Sep; 37(10):2253-66. doi: 10.1038/npp.2012.76. [PMID: 22617356]
  • Roberta A Thomas, Marshall S Scicchitano, Rosanna C Mirabile, Nancy T Chau, Kendall S Frazier, Heath C Thomas. MicroRNA changes in rat mesentery and serum associated with drug-induced vascular injury. Toxicology and applied pharmacology. 2012 Aug; 262(3):310-20. doi: 10.1016/j.taap.2012.05.009. [PMID: 22627061]