Nantenine (BioDeep_00000003985)
natural product
代谢物信息卡片
O-Methyl domesticine
化学式: C20H21NO4 (339.1471)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 54.55%
分子结构信息
SMILES: c12c(cc3c(c1)c1c4[C@H](C3)N(CCc4cc(c1OC)OC)C)OCO2
InChI: InChI=1S/C20H21NO4/c1-21-5-4-11-7-17(22-2)20(23-3)19-13-9-16-15(24-10-25-16)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3
描述信息
A natural product found in Corydalis cava and Nandina domestica.
Annotation level-1
同义名列表
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:68992
- KEGG: C19985
- PubChem: 197001
- PubChem: 181743
- Metlin: METLIN73472
- ChEMBL: CHEMBL179440
- ChEMBL: CHEMBL467094
- KNApSAcK: C00027150
- KNApSAcK: C00025953
- CAS: 2565-01-7
- CAS: 2565-1-7
- CAS: 42971-15-3
- MoNA: PR310593
- MoNA: RIKENPlaSMA000598
- MoNA: RIKENPlaSMA000589
- MoNA: RIKENPlaSMA000584
- MoNA: RIKENPlaSMA000571
- MoNA: RIKENPlaSMA000566
- MoNA: RIKENPlaSMA000557
- MoNA: RIKENPlaSMA000548
- PMhub: MS000013983
- MetaboLights: MTBLC68992
- PubChem: 135626451
- LOTUS: LTS0132161
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
77 个相关的物种来源信息
- 22140 - Annonaceae: LTS0132161
- 41773 - Berberidaceae: LTS0132161
- 121072 - Cassytha: LTS0132161
- 121074 - Cassytha pubescens: 10.1071/CH9662331
- 121074 - Cassytha pubescens: LTS0132161
- 3463 - Corydalis: LTS0132161
- 581246 - Corydalis cava:
- 581246 - Corydalis cava: 10.2307/4117899
- 581246 - Corydalis cava: LTS0132161
- 38914 - Corydalis solida: 10.1055/S-2007-969652
- 38914 - Corydalis solida: 10.1139/V69-178
- 38914 - Corydalis solida: LTS0132161
- 458692 - Corydalis yanhusuo: 10.1016/0031-9422(93)85312-F
- 458692 - Corydalis yanhusuo: LTS0132161
- 458692 - Corydalis yanhusuo: NA
- 128612 - Dehaasia: LTS0132161
- 610223 - Dehaasia hainanensis: 10.1177/1934578X0700200115
- 610223 - Dehaasia hainanensis: LTS0132161
- 128613 - Dehaasia incrassata:
- 128613 - Dehaasia incrassata: 10.1016/0031-9422(89)80062-7
- 128613 - Dehaasia incrassata: 10.1016/0040-4020(96)00312-2
- 128613 - Dehaasia incrassata: 10.1021/NP960002Q
- 128613 - Dehaasia incrassata: LTS0132161
- 2759 - Eukaryota: LTS0132161
- 56852 - Glaucium: LTS0132161
- 63795 - Glossocalyx: LTS0132161
- 1317845 - Glossocalyx brevipes: 10.1021/NP50041A025
- 1317845 - Glossocalyx brevipes: LTS0132161
- 63805 - Glossocalyx longicuspis: 10.1021/NP50041A025
- 295145 - Guatteria: LTS0132161
- 295159 - Guatteria dumetorum: 10.1055/S-2005-916179
- 295159 - Guatteria dumetorum: LTS0132161
- 3433 - Lauraceae: LTS0132161
- 3398 - Magnoliopsida: LTS0132161
- 3455 - Menispermaceae: LTS0132161
- 2912267 - Mespilodaphne macrophylla:
- 41775 - Nandina: LTS0132161
- 41776 - Nandina domestica:
- 41776 - Nandina domestica: 10.1002/JPS.2600730435
- 41776 - Nandina domestica: 10.1248/YAKUSHI1881.1926.535_742
- 41776 - Nandina domestica: 10.1248/YAKUSHI1881.1926.536_833
- 41776 - Nandina domestica: LTS0132161
- 63801 - Ocotea: LTS0132161
- 881603 - Ocotea lancifolia: 10.1007/978-1-4899-1783-6_3
- 881603 - Ocotea lancifolia: LTS0132161
- 1930893 - Ocotea macrophylla:
- 1930893 - Ocotea macrophylla: 10.1007/978-1-4899-1783-6_3
- 1930893 - Ocotea macrophylla: 10.1016/0031-9422(75)85390-8
- 1930893 - Ocotea macrophylla: LTS0132161
- 3465 - Papaveraceae: LTS0132161
- 200994 - Platycapnos: LTS0132161
- 200995 - Platycapnos spicata:
- 200995 - Platycapnos spicata: 10.1016/0031-9422(91)83200-5
- 200995 - Platycapnos spicata: 10.1016/0031-9422(93)85255-P
- 200995 - Platycapnos spicata: 10.3987/COM-90-5356
- 200995 - Platycapnos spicata: LTS0132161
- 1095361 - Platycapnos tenuiloba: 10.1016/0031-9422(91)83200-5
- 3440 - Ranunculaceae: LTS0132161
- 63803 - Siparuna: LTS0132161
- 1129716 - Siparuna gesnerioides: 10.1055/S-2006-959620
- 1129716 - Siparuna gesnerioides: LTS0132161
- 141960 - Siparuna pauciflora:
- 141960 - Siparuna pauciflora: 10.1016/S0031-9422(03)00098-0
- 141960 - Siparuna pauciflora: 10.1055/S-2006-962547
- 141960 - Siparuna pauciflora: LTS0132161
- 104773 - Siparunaceae: LTS0132161
- 147243 - Stephania: LTS0132161
- 425106 - Stephania tetrandra: 10.1021/NP50084A023
- 425106 - Stephania tetrandra: LTS0132161
- 35493 - Streptophyta: LTS0132161
- 46968 - Thalictrum: LTS0132161
- 1277765 - Thalictrum atriplex: 10.1007/S10600-015-1235-6
- 1277765 - Thalictrum atriplex: LTS0132161
- 1264570 - Thalictrum sachalinense: 10.1016/S0040-4020(01)82640-5
- 1264570 - Thalictrum sachalinense: LTS0132161
- 58023 - Tracheophyta: LTS0132161
- 33090 - Viridiplantae: LTS0132161
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dinesh Kumar Patel, Kanika Patel. Therapeutic Potential and Pharmacological Activities of (+)-Nantenine in Medicine: An Aporphine Class phytocomponent of Nandina domestica Thunberg.
Infectious disorders drug targets.
2023 Oct; ?(?):. doi:
10.2174/0118715265244269231010090316. [PMID: 37881077] - N Lall, N Kishore, D Bodiba, G More, E Tshikalange, H Kikuchi, Y Oshima. Alkaloids from aerial parts of Annona senegalensis against Streptococcus mutans.
Natural product research.
2017 Aug; 31(16):1944-1947. doi:
10.1080/14786419.2016.1263847. [PMID: 27984920] - Cai-Ying Peng, Jian-Qun Liu, Rui Zhang, Ji-Cheng Shu. A new alkaloid from the fruit of Nandina domestica Thunb.
Natural product research.
2014; 28(15):1159-64. doi:
10.1080/14786419.2014.921166. [PMID: 24897106] - Takuro Ueki, Tatsuhiro Akaishi, Hidenobu Okumura, Kazuho Abe. Extract from Nandina domestica inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in human pulmonary epithelial A549 cells.
Biological & pharmaceutical bulletin.
2012; 35(7):1041-7. doi:
10.1248/bpb.b110709. [PMID: 22791150] - Muneo Tsukiyama, Takuro Ueki, Yoichi Yasuda, Hiroko Kikuchi, Tatsuhiro Akaishi, Hidenobu Okumura, Kazuho Abe. Beta2-adrenoceptor-mediated tracheal relaxation induced by higenamine from Nandina domestica Thunberg.
Planta medica.
2009 Oct; 75(13):1393-9. doi:
10.1055/s-0029-1185743. [PMID: 19468973] - Muneo Tsukiyama, Tatsuhiro Akaishi, Takuro Ueki, Hidenobu Okumura, Kazuho Abe. The extract from Nandina domestica THUNBERG inhibits histamine- and serotonin-induced contraction in isolated guinea pig trachea.
Biological & pharmaceutical bulletin.
2007 Nov; 30(11):2063-8. doi:
10.1248/bpb.30.2063. [PMID: 17978476] - William E Fantegrossi, Christina Lynn Kiessel, P Tarn Leach, C Van Martin, Rachel Lynn Karabenick, X Chen, Y Ohizumi, Thomas Ullrich, Kenner C Rice, James H Woods. Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice.
Psychopharmacology.
2004 May; 173(3-4):270-7. doi:
10.1007/s00213-003-1741-2. [PMID: 14740148] - Francisco Orallo. Acute cardiovascular effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in anaesthetised normotensive rats.
Planta medica.
2004 Feb; 70(2):117-26. doi:
10.1055/s-2004-815487. [PMID: 14994188] - Rosana de A Ribeiro, Lucia Garcez do Carmo, Irina Vladimirova, Neide H Jurkiewicz, Aron Jurkiewicz. Nantenine blocks muscle contraction and Ca2+ transient induced by noradrenaline and K+ in rat vas deferens.
European journal of pharmacology.
2003 May; 470(1-2):37-43. doi:
10.1016/s0014-2999(03)01758-8. [PMID: 12787829] - Bachtiar Indra, Takeshi Tadano, Osamu Nakagawasai, Yuichiro Arai, Hajime Yasuhara, Yasushi Ohizumi, Kensuke Kisara. Suppressive effect of nantenine, isolated from Nandina domestica Thunberg, on the 5-hydroxy-L-tryptophan plus clorgyline-induced head-twitch response in mice.
Life sciences.
2002 Apr; 70(22):2647-56. doi:
10.1016/s0024-3205(02)01562-x. [PMID: 12269391] - F Orallo, A F Alzueta. Preliminary study of the vasorelaxant effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in rat aorta.
Planta medica.
2001 Dec; 67(9):800-6. doi:
10.1055/s-2001-18848. [PMID: 11745014] - R A Ribeiro, G Rodríguez de Lores Arnaiz. In vitro dose dependent inverse effect of nantenine on synaptosomal membrane K+-p-NPPase activity.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2001 Mar; 8(2):107-11. doi:
10.1078/0944-7113-00013. [PMID: 11315751] - R A Ribeiro, G Rodríguez de Lores Arnaiz. Nantenine and papaverine differentially modify synaptosomal membrane enzymes.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2000 Jul; 7(4):313-23. doi:
10.1016/s0944-7113(00)80050-1. [PMID: 10969726] - N Shoji, A Umeyama, T Takemoto, Y Ohizumi. Serotonergic receptor antagonist from Nandina domestica Thunberg.
Journal of pharmaceutical sciences.
1984 Apr; 73(4):568-70. doi:
10.1002/jps.2600730435. [PMID: 6726648]
