TETRAMISOLE (BioDeep_00000398466)

   


代谢物信息卡片


Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-

化学式: C11H12N2S (204.07211519999998)
中文名称: 四米唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CSC2=NC(CN21)C3=CC=CC=C3
InChI: InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2

描述信息

C308 - Immunotherapeutic Agent > C210 - Immunoadjuvant > C2141 - Chemo Immunostimulant Adjuvant
C2140 - Adjuvant

同义名列表

2 个代谢物同义名

Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-; TETRAMISOLE



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qinghua Liu, Jiaxing Sun, Yangdou Dong, Pan Li, Jin Wang, Yulan Wang, Yanwu Xu, Xinrui Tian, Bowei Wu, Peifeng He, Qi Yu, Xuechun Lu, Jimin Cao. Tetramisole is a new IK1 channel agonist and exerts IK1 -dependent cardioprotective effects in rats. Pharmacology research & perspectives. 2022 08; 10(4):e00992. doi: 10.1002/prp2.992. [PMID: 35880674]
  • Moritz Losacker, Marica Hundertmark, Siegfried Zörntlein, Jörg Röhrich, Cornelius Hess. Chiral pharmacokinetics of tetramisole stereoisomers-Enantioselective quantification of levamisole and dexamisole in serum samples from users of adulterated cocaine. Drug testing and analysis. 2022 Jun; 14(6):1053-1064. doi: 10.1002/dta.3227. [PMID: 35060339]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Edwin K Jackson, Dongmei Cheng, Vladimir B Ritov, Zaichuan Mi. Alkaline Phosphatase Activity Is a Key Determinant of Vascular Responsiveness to Norepinephrine. Hypertension (Dallas, Tex. : 1979). 2020 10; 76(4):1308-1318. doi: 10.1161/hypertensionaha.120.15822. [PMID: 32829665]
  • Jessica Maria Leite Dos Santos, Janaélia Ferreira Vasconcelos, Gracielle Araújo Frota, Edilson Pereira de Freitas, Marcel Teixeira, Luiz da Silva Vieira, Claudia Maria Leal Bevilaqua, Jomar Patrício Monteiro. Quantitative molecular diagnosis of levamisole resistance in populations of Haemonchus contortus. Experimental parasitology. 2019 Oct; 205(?):107734. doi: 10.1016/j.exppara.2019.107734. [PMID: 31394093]
  • M K Vijayasarathi, C Sreekumar, R Venkataramanan, M Raman. Influence of sustained deworming pressure on the anthelmintic resistance status in strongyles of sheep under field conditions. Tropical animal health and production. 2016 Oct; 48(7):1455-62. doi: 10.1007/s11250-016-1117-3. [PMID: 27509876]
  • Mathias Haarhaus, Hans J Arnqvist, Per Magnusson. Calcifying human aortic smooth muscle cells express different bone alkaline phosphatase isoforms, including the novel B1x isoform. Journal of vascular research. 2013; 50(2):167-74. doi: 10.1159/000346161. [PMID: 23328739]
  • E Giuliani, G Albertini, C Vaccari, A Manenti, A Barbieri. Multi-organ failure following severe cocaine-tetramisole intoxication in a body-packer. Anaesthesia and intensive care. 2012 May; 40(3):562-4. doi: NULL. [PMID: 22577932]
  • John F Casale, Valerie L Colley, Donald F Legatt. Determination of phenyltetrahydroimidazothiazole enantiomers (Levamisole/Dexamisole) in illicit cocaine seizures and in the urine of cocaine abusers via chiral capillary gas chromatography-flame-ionization detection: clinical and forensic perspectives. Journal of analytical toxicology. 2012 Mar; 36(2):130-5. doi: 10.1093/jat/bkr025. [PMID: 22337783]
  • David Reboutier, Cécile Frankart, Régine Vedel, Mathias Brault, Ronald G Duggleby, Jean Pierre Rona, Marie Anne Barny, François Bouteau. A CFTR chloride channel activator prevents HrpN(ea)-induced cell death in Arabidopsis thaliana suspension cells. Plant physiology and biochemistry : PPB. 2005 Jun; 43(6):567-72. doi: 10.1016/j.plaphy.2005.03.003. [PMID: 15936204]
  • T Schenk, N M G M Appels, D A van Elswijk, H Irth, U R Tjaden, J van der Greef. A generic assay for phosphate-consuming or -releasing enzymes coupled on-line to liquid chromatography for lead finding in natural products. Analytical biochemistry. 2003 May; 316(1):118-26. doi: 10.1016/s0003-2697(03)00038-1. [PMID: 12694734]
  • C P Swarnkar, P K Sanyal, D Singh, F A Khan, P S Bhagwan. Anthelmintic resistance on an organized sheep farm in India. Tropical animal health and production. 2001 Jul; 33(4):305-12. doi: 10.1023/a:1010536019210. [PMID: 11474864]
  • F A Khan, P K Sanyal, C P Swarnkar, D Singh, P S Bhagwan. Comparative anthelmintic activity of strategic sustained low-level administration of albendazole in feed pellets compared to single doses of closantel and tetramisole against natural ovine parasitic gastroenteritis. Tropical animal health and production. 1999 Aug; 31(4):193-204. doi: 10.1023/a:1005223025851. [PMID: 10504099]
  • M Onsgard-Meyer, A L McCoy, F G Knox. Effect of bromotetramisole on renal phosphate excretion. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1996 Nov; 213(2):193-5. doi: 10.3181/00379727-213-44050. [PMID: 8931664]
  • C J Denier, H A Vergnes, A Brisson-Lougarre, J G Grozdea, A E Fournie, A G Klaebe, J J Perie. Inhibition by sodium thiophosphate and L-p-bromotetramisole of neutrophil alkaline phosphatase in normal and trisomy 21 pregnancies. Annals of clinical biochemistry. 1996 May; 33 ( Pt 3)(?):215-8. doi: 10.1177/000456329603300307. [PMID: 8791984]
  • K Crawford, H Weissig, F Binette, J L Millán, P F Goetinck. Tissue-nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures. Developmental dynamics : an official publication of the American Association of Anatomists. 1995 Sep; 204(1):48-56. doi: 10.1002/aja.1002040107. [PMID: 8563025]
  • J Praslicka, P Pilko, M Várady, J Corba. [Levamisole- and tetramisole-resistant gastrointestinal nematodes in sheep]. Veterinarni medicina. 1995 Feb; 40(2):45-8. doi: . [PMID: 7740715]
  • L Wang, R Shao, R A Good. [Relation between age of mice and activity and characteristics of serum alkaline phosphatase]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 1994 Oct; 16(5):383-6. doi: NULL. [PMID: 7720132]
  • M Nishino, S Tsujimura, M Kuba, A Kumon. N omega-phosphoarginine phosphatase from rat renal microsome was alkaline phosphatase. Archives of biochemistry and biophysics. 1994 Jul; 312(1):101-6. doi: 10.1006/abbi.1994.1286. [PMID: 8031115]
  • A Bergmann. [Udder compatibility of tetramisole and levamisole hydrochloride and suggestion for the prescription of their intramammary use in cattle against Prototheca zopfii]. Berliner und Munchener tierarztliche Wochenschrift. 1993 Aug; 106(8):253-6. doi: NULL. [PMID: 8216186]
  • D Sarrouilhe, T Métayé, G Rivet, P Lalégerie, M Baudry. Stabilization of phospho-intermediates of rat liver plasma membrane alkaline phosphatase by uncompetitive inhibition. Relation with phosphate uptake into hepatocytes. Cellular and molecular biology (Noisy-le-Grand, France). 1993 Jul; 39(5):469-77. doi: NULL. [PMID: 8374502]
  • M C Delisle, V Vachon, S Giroux, M Potier, R Laprade, R Béliveau. Molecular size of the renal sodium/phosphate symporter in native and reconstituted systems. Biochimica et biophysica acta. 1992 Feb; 1104(1):132-6. doi: 10.1016/0005-2736(92)90141-8. [PMID: 1550840]
  • M Vermeir, N Boens. Partitioning of (+-)-5,6-dihydro-6-phenyl-2-n-alkyl-imidazo- [2,1-b]thiazoles into large unilamellar liposomes: a steady-state fluorescence quenching study. Biochimica et biophysica acta. 1992 Feb; 1104(1):63-72. doi: 10.1016/0005-2736(92)90132-6. [PMID: 1550854]
  • M Vermeir, N Boens. Determination of the partition of the tetramisole derivative (+-)-5,6-dihydro-6-phenyl-2-n-propyl-imidazo[2,1-b]thiazole into liposomal membranes by fluorescence quenching of the membrane probe 8-(2-anthryl)-octanoic acid. European biophysics journal : EBJ. 1992; 21(1):47-56. doi: 10.1007/bf00195443. [PMID: 1516560]
  • C G Bellows, J E Aubin, J N Heersche. Initiation and progression of mineralization of bone nodules formed in vitro: the role of alkaline phosphatase and organic phosphate. Bone and mineral. 1991 Jul; 14(1):27-40. doi: 10.1016/0169-6009(91)90100-e. [PMID: 1868267]
  • T Kuwana, S B Rosalki. Measurement of alkaline phosphatase of intestinal origin in plasma by p-bromotetramisole inhibition. Journal of clinical pathology. 1991 Mar; 44(3):236-7. doi: 10.1136/jcp.44.3.236. [PMID: 2013625]
  • D Mayer, H J Hacker, P Bannasch. Re-evaluation of the specificity of adenylyl (beta,gamma-methylene)diphosphonate as a substrate for adenylate cyclase. The Histochemical journal. 1991 Feb; 23(2):100-6. doi: 10.1007/bf01047114. [PMID: 1717407]
  • M Chicault, C Luu-Duc, A Boucherle. Drug-protein interactions. Comparative studies of levamisole and structural analogs or agents with immunomodulatory effect on the mechanism of protein aggregation. Arzneimittel-Forschung. 1990 Jan; 40(1):55-7. doi: NULL. [PMID: 2340000]
  • R Aggarwal, S N Sanyal, S Khera. Ascaridia galli: effect of some anthelmintics on amino acid uptake and macromolecular synthesis in vitro. Acta veterinaria Hungarica. 1990; 38(4):255-62. doi: ". [PMID: 1712148]
  • D E Amacher, C V Higgins, S J Schomaker, R J Clay. Further characterization of serum alkaline phosphatase from male and female beagle dogs. Enzyme. 1989; 42(1):1-7. doi: 10.1159/000469000. [PMID: 2776712]
  • M J Peake, M Pejakovic, G H White. Quantitative method for determining serum alkaline phosphatase isoenzyme activity: estimation of intestinal component. Journal of clinical pathology. 1988 Feb; 41(2):202-6. doi: 10.1136/jcp.41.2.202. [PMID: 3350981]
  • R Béliveau, G Fortier, V Vachon. Effect of magnesium on ATP labelling by kidney brush border membrane. The International journal of biochemistry. 1988; 20(4):375-80. doi: 10.1016/0020-711x(88)90204-2. [PMID: 3130279]
  • J Prokopic, B Kotrlá, I Pavlásek, P Kolár, H Rasková, J Lavický. [Efficacy of levimasole and nilverm on gastrointestinal nematodes in cattle and their effect on milk yield]. Angewandte Parasitologie. 1985 Aug; 26(3):131-8. doi: NULL. [PMID: 4061958]
  • M Iu Treus, G M Dvoĭnoe. [Helminths in an Askaniia-Nova herd of eland and experiences in eradicating Strongylata infestation]. Parazitologiia. 1985 Mar; 19(2):156-8. doi: NULL. [PMID: 4011310]
  • D G Williams, P G Byfield, D W Moss. Inhibition of human alkaline phosphatase isoenzymes by the affinity reagent reactive yellow 13. Enzyme. 1985; 33(2):70-4. doi: 10.1159/000469409. [PMID: 4006899]
  • H von Rechenberg, P Fister, E Eigenbrodt, K J Matthes, L Róka. Fructose 1,6-bisphosphatase in the diagnosis of chronic hepatitis. I. Activity measurements of fructose 1,6-bisphosphatase in human serum. Clinica chimica acta; international journal of clinical chemistry. 1984 Mar; 137(3):255-62. doi: 10.1016/0009-8981(84)90113-x. [PMID: 6321061]
  • G M Bhopale, B S Bhatnagar. Serum protein profile of mice during infection with of Ancylostoma caninum and after the administration of tetramisole and levamisole. Journal of hygiene, epidemiology, microbiology, and immunology. 1984; 28(4):455-9. doi: . [PMID: 6084695]
  • K Mees. Ultrastructural localization of K+-dependent, ouabain-sensitive NPPase (Na-K-ATPase) in the guinea pig inner ear. Acta oto-laryngologica. 1983 Mar; 95(3-4):277-89. doi: 10.3109/00016488309130944. [PMID: 6301205]
  • D R Pledger, C J Steele, A Belfield, R S Hutchison, A S McLelland. A routine method for alkaline phosphatase assay in pregnancy serum. Clinica chimica acta; international journal of clinical chemistry. 1982 Jun; 122(1):71-4. doi: 10.1016/0009-8981(82)90096-1. [PMID: 7094346]
  • M G Brunette, V W Dennis. Effects of L-bromotetramisole on phosphate transport by the proximal renal tubule: failure to demonstrate a direct involvement of alkaline phosphate. Canadian journal of physiology and pharmacology. 1982 Mar; 60(3):276-81. doi: 10.1139/y82-038. [PMID: 7074419]
  • W Frick, H J Süsse, J Landmann, H J Rummler. [Control of ascariasis in swine]. Archiv fur experimentelle Veterinarmedizin. 1982; 36(5):801-8. doi: NULL. [PMID: 7165459]
  • A W Skillen, J Harrison. Serum alkaline phosphatase of intestinal origin: detection by acrylamide gel electrophoresis and L-p-bromotetramisole inhibition compared. Clinical chemistry. 1980 May; 26(6):786. doi: NULL. [PMID: 7371166]
  • A Malassiné. [Alkaline phosphatase activity in the placental labyrinth of the cat and problems of specific localization of transport adenosine triphosphatase. An ultrastructural study (author's transl)]. Histochemistry. 1980; 65(3):239-48. doi: 10.1007/bf00493173. [PMID: 6246041]
  • K I Altaif. Effect of anthelmintic treatment on the performance of Awassi sheep in Iraq. Tropical animal health and production. 1979 Nov; 11(4):241-5. doi: 10.1007/bf02237812. [PMID: 552676]
  • P M Bayer, F Gabl, E Knoth. [Measuring the activity of the placental isoenzyme of alkaline phosphatase: 3 methods compared (author's transl)]. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1979 Sep; 17(9):605-7. doi: NULL. [PMID: 501308]
  • G J Doellgast, P J Meis. Use of specific inhibitors to disciminate alkaline phosphatase isoenzymes originating from human liver, placenta and intestine: absence of meconial alkaline phosphatase in maternal serum. Clinical chemistry. 1979 Jul; 25(7):1230-3. doi: 10.1093/clinchem/25.7.1230. [PMID: 455643]
  • J A Firth, A Farr, H Koppel. The localization and properties of membrane adenosine triphosphatases in the guinea-pig placenta. Histochemistry. 1979 Jun; 61(2):157-65. doi: 10.1007/bf00496528. [PMID: 222715]
  • S R Hootman, C W Philpott. Ultracytochemical localization of Na+,K+-activated ATPase in chloride cells from the gills of a euryhaline teleost. The Anatomical record. 1979 Jan; 193(1):99-129. doi: 10.1002/ar.1091930107. [PMID: 216285]
  • J Cabaret, A Dakkak, L Alahkam. [Elimination of L1 larvae of Protostrongylidae in ovine feces: nature of the distribution, effect of animal's age and anthelminthic treatment]. Annales de la Societe belge de medecine tropicale. 1978 Dec; 58(4):309-14. doi: NULL. [PMID: 754655]
  • M Gupta, K L Arora, S Mithal, B N Tandon. Effect of periodic deworming on nutritional status of ascaris-infested preschool children receiving supplementary food. Lancet (London, England). 1977 Jul; 2(8029):108-10. doi: 10.1016/s0140-6736(77)90119-2. [PMID: 69194]
  • H Van Belle, M E De Broe, R J Wieme. L-p-Bromotetramisole, a new reagent for use in measuring placental or intestinal isoenzymes of alkaline phosphatase in human serum. Clinical chemistry. 1977 Mar; 23(3):454-9. doi: 10.1093/clinchem/23.3.454. [PMID: 837532]
  • J Vyhnálek, J Kocman, J Skaloud. [Effectiveness of Nilzan and Dovenix in the treatment of fascioliasis in cattle and sheep]. Veterinarni medicina. 1976 Jul; 21(7):427-33. doi: . [PMID: 827048]
  • E T Lyons, J H Drudge, S C Tolliver. Studies on the development and chemotherapy of larvae of Parascaris equorum (Nematoda: Ascaridoidea) in experimentally and naturally infected foals. The Journal of parasitology. 1976 Jun; 62(3):453-9. doi: NULL. [PMID: 945338]
  • A Coumbaras, M Larivière, B Beauvais, G Languillat, M Turquet. [The average degree of parasitosis, a criterion for evaluation of the geohelminthic contamination of a population, and for application of santiary measures]. Bulletin de la Societe de pathologie exotique et de ses filiales. 1976 Jan; 69(1):95-100. doi: NULL. [PMID: 1036479]
  • J Pavlícek, I Dyková. [Tetramisol, piperazine, and metrifonate treatment of experimental invasion by Ascaridia galli in chickens of differents ages]. Veterinarni medicina. 1976; 21(6):353-8. doi: . [PMID: 826003]
  • J A Firth, B Y Marland. The significance of inhibitor-resistant alkaline phosphatase in the cytochemical demonstration of transport adenosine triphosphatase. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1975 Aug; 23(8):571-4. doi: 10.1177/23.8.169303. [PMID: 169303]
  • G C Hunter. The occurrence and establishment of parasites in a pig herd established by hysterectomy. Research in veterinary science. 1974 Jul; 17(1):28-31. doi: 10.1016/s0034-5288(18)33702-0. [PMID: 4422678]
  • T J Hayes, M Mitrovic. Use of Obeliscoides cuniculi-infected rabbits to test for anthelmintic activity. American journal of veterinary research. 1974 May; 35(5):743-7. doi: NULL. [PMID: 4830444]
  • H J Smith. The effects of anthelmintic treatments on the development of gastrointestinal parasitism in calves. Canadian journal of comparative medicine : Revue canadienne de medecine comparee. 1974 Apr; 38(2):139-44. doi: . [PMID: 4274819]
  • M Borgers. The cytochemical application of new potent inhibitors of alkaline phosphatases. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1973 Sep; 21(9):812-24. doi: 10.1177/21.9.812. [PMID: 4741290]