venlafaxine (BioDeep_00000397918)
Main id: BioDeep_00000001591
natural product
代谢物信息卡片
venlafaxine
化学式: C17H27NO2 (277.20416819999997)
中文名称: D,L-文拉法辛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O
InChI: InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D000068760 - Serotonin and Noradrenaline Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
D049990 - Membrane Transport Modulators
CONFIDENCE Reference Standard (Level 1)
同义名列表
1 个代谢物同义名
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:9943
- KEGG: C07187
- KEGGdrug: D08670
- KEGGdrug: D82446
- PubChem: 5656
- DrugBank: DB00285
- ChEMBL: CHEMBL637
- MeSH: Venlafaxine Hydrochloride
- CAS: 540726-98-5
- CAS: 93413-69-5
- MoNA: WA000322
- MoNA: WA000321
- MoNA: WA000320
- MoNA: WA000319
- MoNA: WA000318
- MoNA: VF-NPL-LTQ000478
- MoNA: FiehnHILIC002410
- MoNA: FiehnHILIC000847
- MoNA: TUE00813
- MoNA: TUE00812
- MoNA: TUE00811
- PubChem: 9396
- NIKKAJI: J347.732K
- RefMet: Venlafaxine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qiang Chen, Xinru Chen, Yuqing Zhu, Xiali Yu. A relatively rare traditional Chinese medicine pattern of primary Sjögren syndrome: A case report.
Medicine.
2024 Apr; 103(15):e37744. doi:
10.1097/md.0000000000037744. [PMID: 38608118] - Rachel E Dawe, Leslie M Bragg, Hadi A Dhiyebi, Mark R Servos, Paul M Craig. Investigating wastewater treatment plant effluent and pharmaceutical exposure on innate cytokine expression of darters (Etheostoma spp.) in the Grand River watershed.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2024 Jan; 269(?):110875. doi:
10.1016/j.cbpb.2023.110875. [PMID: 37315837] - Radka Kodešová, Helena Švecová, Aleš Klement, Miroslav Fér, Antonín Nikodem, Ganna Fedorova, Oleksandra Rieznyk, Martin Kočárek, Alina Sadchenko, Alica Chroňáková, Roman Grabic. Contamination of water, soil, and plants by micropollutants from reclaimed wastewater and sludge from a wastewater treatment plant.
The Science of the total environment.
2023 Oct; 907(?):167965. doi:
10.1016/j.scitotenv.2023.167965. [PMID: 37866592] - Pradeep Kumkar, Chandani R Verma, Štěpán Hýsek, Manoj Pise, Sonia Źółtowska, Sachin M Gosavi, Filip Mercl, Matěj Božik, Lukáš Praus, Kateřina Hanková, Radek Rinn, Pavel Klouček, Miloslav Petrtýl, Lukáš Kalous. Contaminants and their ecological risk assessment in beach sediments and water along the Maharashtra coast of India: A comprehensive approach using microplastics, heavy metal(loid)s, pharmaceuticals, personal care products and plasticizers.
The Science of the total environment.
2023 Jun; ?(?):164712. doi:
10.1016/j.scitotenv.2023.164712. [PMID: 37301381] - Carla Alves, Wagner Antonio Tamagno, Aline Pompermaier, Ana Paula Vanin, Leonardo José Gil Barcellos. Neurotoxicological effects of venlafaxine on Caenorhabditis elegans and Danio rerio.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2023 May; 271(?):109658. doi:
10.1016/j.cbpc.2023.109658. [PMID: 37192702] - Millaray Sierra-Olea, Simon Kölle, Emil Bein, Thorsten Reemtsma, Oliver J Lechtenfeld, Uwe Hübner. Isotopically labeled ozone: A new approach to elucidate the formation of ozonation products.
Water research.
2023 Apr; 233(?):119740. doi:
10.1016/j.watres.2023.119740. [PMID: 36822109] - Wei Shen, Yanlin Tao, Fang Zheng, Houyuan Zhou, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu. The alteration of gut microbiota in venlafaxine-ameliorated chronic unpredictable mild stress-induced depression in mice.
Behavioural brain research.
2023 Mar; 446(?):114399. doi:
10.1016/j.bbr.2023.114399. [PMID: 36963638] - Alvin Richards-Belle, Isabelle Austin-Zimmerman, Baihan Wang, Eirini Zartaloudi, Marius Cotic, Caitlin Gracie, Noushin Saadullah Khani, Yanisa Wannasuphoprasit, Marta Wronska, Yogita Dawda, David Pj Osborn, Elvira Bramon. Associations of antidepressants and antipsychotics with lipid parameters: Do CYP2C19/CYP2D6 genes play a role? A UK population-based study.
Journal of psychopharmacology (Oxford, England).
2023 Feb; ?(?):2698811231152748. doi:
10.1177/02698811231152748. [PMID: 36772859] - Ilaeira Rapti, Theodora Kourkouta, Evrydiki-Maria Malisova, Triantafyllos Albanis, Ioannis Konstantinou. Photocatalytic Degradation of Inherent Pharmaceutical Concentration Levels in Real Hospital WWTP Effluents Using g-C3N4 Catalyst on CPC Pilot Scale Reactor.
Molecules (Basel, Switzerland).
2023 Jan; 28(3):. doi:
10.3390/molecules28031170. [PMID: 36770837] - Vasiliki G Beretsou, Maria-Christina Nika, Kyriakos Manoli, Costas Michael, Qian Sui, Lian Lundy, D Michael Revitt, Nikolaos S Thomaidis, Despo Fatta-Kassinos. Multiclass target analysis of contaminants of emerging concern including transformation products, soil bioavailability assessment and retrospective screening as tools to evaluate risks associated with reclaimed water reuse.
The Science of the total environment.
2022 Dec; 852(?):158391. doi:
10.1016/j.scitotenv.2022.158391. [PMID: 36049679] - Mariana N Miranda, Ana R Lado Ribeiro, Adrián M T Silva, M Fernando R Pereira. Can aged microplastics be transport vectors for organic micropollutants? - Sorption and phytotoxicity tests.
The Science of the total environment.
2022 Dec; 850(?):158073. doi:
10.1016/j.scitotenv.2022.158073. [PMID: 35981591] - Patricia K Akao, Aviv Kaplan, Dror Avisar, Amit Dhir, Adi Avni, Hadas Mamane. Removal of carbamazepine, venlafaxine and iohexol from wastewater effluent using coupled microalgal-bacterial biofilm.
Chemosphere.
2022 Dec; 308(Pt 2):136399. doi:
10.1016/j.chemosphere.2022.136399. [PMID: 36099989] - Somayeh Golbaz, Mirzaman Zamanzadeh, Kamyar Yaghmaeian, Ramin Nabizadeh, Nushin Rastkari, Hadi Esfahani. Occurrence and removal of psychiatric pharmaceuticals in the Tehran South Municipal Wastewater Treatment Plant.
Environmental science and pollution research international.
2022 Nov; ?(?):. doi:
10.1007/s11356-022-23667-5. [PMID: 36374381] - Evsen Yavuz-Guzel, Aslı Atasoy, İsmail Ethem Gören, Nebile Daglioglu. Impact of COVID- 19 pandemic on antidepressants consumptions by wastewater analysis in Turkey.
The Science of the total environment.
2022 Sep; 838(Pt 2):155916. doi:
10.1016/j.scitotenv.2022.155916. [PMID: 35568186] - Zi-Rong Li, De-Guo Liu, Sheng Xie, Yu-Hong Wang, Yuan-Shan Han, Chun-Yan Li, Man-Shu Zou, Hai-Xing Jiang. Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats.
European journal of pharmacology.
2022 Sep; 930(?):175149. doi:
10.1016/j.ejphar.2022.175149. [PMID: 35878808] - Christine Wegler, Aljona Saleh, Annika Lindqvist, Hedvig Nordeng, John Smeraglia, Pawel Baranczewski. Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Aug; 1205(?):123340. doi:
10.1016/j.jchromb.2022.123340. [PMID: 35732105] - Bassam Shaaban Mohammed, Sayed M Derayea, Yasser F Hassan, Ahmed A Abu-Hassan. Resonance Rayleigh scattering approach based on association complex formation with erythrosine B for determination of venlafaxine, application to the dosage form and spiked human plasma.
Luminescence : the journal of biological and chemical luminescence.
2022 Jul; 37(7):1215-1222. doi:
10.1002/bio.4290. [PMID: 35582967] - Abdul Aala Fazli, Bala Krishna Panigrahy, Varinder Kumar, Syed Naiem Raza, Bilal Ahmad Zarger, Taha Umair Wani, Shavej Ahmad, Arshad Khuroo, Nisar Ahmad Khan. Multiple-reaction monitoring (MRM) LC-MS/MS quantitation of venlafaxine and its O-desmethyl metabolite for a preclinical pharmacokinetic study in rabbits.
Scientific reports.
2022 Jun; 12(1):9322. doi:
10.1038/s41598-022-13389-6. [PMID: 35661132] - Fahad Aldosary, Sandhaya Norris, Philippe Tremblay, Jonathan S James, James C Ritchie, Pierre Blier. Differential Potency of Venlafaxine, Paroxetine, and Atomoxetine to Inhibit Serotonin and Norepinephrine Reuptake in Patients With Major Depressive Disorder.
The international journal of neuropsychopharmacology.
2022 04; 25(4):283-292. doi:
10.1093/ijnp/pyab086. [PMID: 34958348] - Dongmin Yan, Ming Wu, Wenjuan Hu, Yue Li, Jingyi Jin, Shaoqing Yan, Wei Zhu, Chaoyang Ye, Jia Liu, Guobin Liu, Bo Tan. Effects of Zuojin Pill (Rhizoma Coptidis and Fructus Evodiae preparation) on the pharmacokinetics and side effects of venlafaxine in humans.
Basic & clinical pharmacology & toxicology.
2022 Apr; 130(4):522-530. doi:
10.1111/bcpt.13713. [PMID: 35132786] - Fabiane de Santi, Flávia L Beltrame, Beatriz M Rodrigues, Natália F Scaramele, Flávia L Lopes, Paulo S Cerri, Estela Sasso-Cerri. Venlafaxine-induced adrenergic signaling stimulates Leydig cells steroidogenesis via Nur77 overexpression: A possible role of EGF.
Life sciences.
2022 Jan; 289(?):120069. doi:
10.1016/j.lfs.2021.120069. [PMID: 34688693] - Francesco Benedetti, Igor Branchi, Sara Poletti, Cristina Lorenzi, Giorgia Bigai, Cristina Colombo, Raffaella Zanardi. Adiponectin predicts poor response to antidepressant drugs in major depressive disorder.
Human psychopharmacology.
2021 11; 36(6):e2793. doi:
10.1002/hup.2793. [PMID: 33945186] - L Kolding, V Ehrenstein, L Pedersen, P Sandager, O B Petersen, N Uldbjerg, L H Pedersen. Antidepressant use in pregnancy and severe cardiac malformations: Danish register-based study.
BJOG : an international journal of obstetrics and gynaecology.
2021 11; 128(12):1949-1957. doi:
10.1111/1471-0528.16772. [PMID: 34036715] - Hazuki Komahashi-Sasaki, Norio Yasui-Furukori, Taro Sasaki, Masataka Shinozaki, Yuki Hayashi, Kazuko Kato, Yoshimasa Inoue, Shoko Tsuchimine, Takashi Watanabe, Norio Sugawara, Kazutaka Shimoda. Effects of CYP2D6 Genotypes on Venlafaxine Metabolism in Japanese Psychiatric Patients With Depression.
Therapeutic drug monitoring.
2021 10; 43(5):681-687. doi:
10.1097/ftd.0000000000000854. [PMID: 33306568] - Mater Hussen Mahnashi, Zeeshan Jabbar, Alamgeer, Hafiz Muhammad Irfan, Mulazim Hussain Asim, Muhammad Akram, Ahmed Saif, Mohammed Abdulrahman Alshahrani, Mohammed Ali Alshehri, Saeed Ahmed Asiri. Venlafaxine demonstrated anti-arthritic activity possibly through down regulation of TNF-α, IL-6, IL-1β, and COX-2.
Inflammopharmacology.
2021 Oct; 29(5):1413-1425. doi:
10.1007/s10787-021-00849-0. [PMID: 34302591] - Sune Forsberg, Lis Abazi, Pär Forsman. Successful use of extended cardiopulmonary resuscitation followed by extracorporeal oxygenation after venlafaxine-induced takotsubo cardiomyopathy and cardiac arrest: a case report.
Journal of medical case reports.
2021 Sep; 15(1):485. doi:
10.1186/s13256-021-03031-w. [PMID: 34579764] - Ainitze Labaka, Eneritz Gómez-Lazaro, Olatz Goñi-Balentziaga, Joana Pérez-Tejada, Oscar Vegas, Larraitz Garmendia. Venlafaxine reduces the striatal il6/il10 ratio and increases hippocampal GR expression in female mice subjected to chronic social instability stress.
Stress (Amsterdam, Netherlands).
2021 09; 24(5):561-571. doi:
10.1080/10253890.2021.1895111. [PMID: 33769212] - Zhongxia Shen, Feng Wang, Lijun Cui, Lie Ren, Xiujuan Hong, Yonggui Yuan, Xinhua Shen. Higher baseline serum adiponectin predicts better treatment remission in patients with generalized anxiety disorder treated with escitalopram.
Annals of palliative medicine.
2021 07; 10(7):7634-7643. doi:
10.21037/apm-21-1542. [PMID: 34353051] - Nima Elhami, Lars Engerström. [Venlafaxine was suspected to have triggered life-threatening takotsubo syndrome].
Lakartidningen.
2021 06; 118(?):. doi:
NULL. [PMID: 34100266] - Taro Sasaki, Norio Yasui-Furukori, Hazuki Komahashi-Sasaki, Masataka Shinozaki, Yuki Hayashi, Kazuko Kato, Yoshimasa Inoue, Shoko Tsuchimine, Takashi Watanabe, Norio Sugawara, Kazutaka Shimoda. CYP2D6*10 polymorphism and the enantioselective O-desmethylation of S-(+)- and R-(-)-venlafaxine in Japanese psychiatric patients.
Basic & clinical pharmacology & toxicology.
2021 May; 128(5):677-685. doi:
10.1111/bcpt.13560. [PMID: 33470005] - Stefanie Fekete, Maike Scherf-Clavel, Manfred Gerlach, Marcel Romanos, Sarah Kittel-Schneider, Stefan Unterecker, Karin Egberts. Dose-Corrected Serum Concentrations and Metabolite to Parent Compound Ratios of Venlafaxine and Risperidone from Childhood to Old Age.
Pharmacopsychiatry.
2021 May; 54(3):117-125. doi:
10.1055/a-1302-8108. [PMID: 33291155] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Lucia Carboni, Bruno Delafont, Elena Ivanchenko, Emiliangelo Ratti, Susan M Learned, Robert Alexander, Enrico Domenici. Folate metabolism biomarkers from two randomised placebo-controlled clinical studies with paroxetine and venlafaxine.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2021 04; 22(4):315-321. doi:
10.1080/15622975.2020.1805509. [PMID: 32787676] - G Drevin, N Picard, N Jousset, M Briet, C Abbara. Pitfalls and challenges associated with phenoconversion in forensic toxcicology.
Forensic science international. Genetics.
2021 03; 51(?):102433. doi:
10.1016/j.fsigen.2020.102433. [PMID: 33278816] - Eduardo Tozatto, Jhohann Richard de Lima Benzi, Adriana Rocha, Eduardo Barbosa Coelho, Vera Lucia Lanchote. Nifedipine Does Not Alter the Pharmacokinetics of Venlafaxine Enantiomers in Healthy Subjects Phenotyped for CYP2D6, CYP2C19, and CYP3A.
Journal of clinical pharmacology.
2021 03; 61(3):319-327. doi:
10.1002/jcph.1745. [PMID: 32974907] - Na Wu, Liangjie Liu, Decheng Ren, Fan Yuan, Yan Bi, Zhenming Guo, Binyin Hou, Lei Ji, Ke Han, Mofan Feng, Kai Su, Tao Yu, Xingwang Li, Fengping Yang, Xueli Sun, Zaiquan Dong, Shunying Yu, Zhenghui Yi, Yifeng Xu, Lin He, Shaochang Wu, Longyou Zhao, Cai Changqun, Yi Shi, Guang He. No Association Between SLC6A4 Gene Polymorphisms With Treatment Remission to Venlafaxine in Han Chinese Depressive Patients.
Clinical neuropharmacology.
2021 Mar; 44(2):53-56. doi:
10.1097/wnf.0000000000000436. [PMID: 33480616] - Jianjun Wang, Fiammetta Cosci. Neonatal Withdrawal Syndrome following Late in utero Exposure to Selective Serotonin Reuptake Inhibitors: A Systematic Review and Meta-Analysis of Observational Studies.
Psychotherapy and psychosomatics.
2021 ; 90(5):299-307. doi:
10.1159/000516031. [PMID: 33971648] - Jan Engelmann, Stefanie Wagner, Andreas Solheid, David P Herzog, Nadine Dreimüller, Marianne B Müller, André Tadić, Christoph Hiemke, Klaus Lieb. Tolerability of High-Dose Venlafaxine After Switch From Escitalopram in Nonresponding Patients With Major Depressive Disorder.
Journal of clinical psychopharmacology.
2021 Jan; 41(1):62-66. doi:
10.1097/jcp.0000000000001312. [PMID: 33208708] - Hongmin Gong, Xiaoyan Du, Lin Wu, Jing Wei, Qing Tan, Rui Zhao, Ming Lei, Libo Zhao. Discontinuation Syndrome of Extended-Release Venlafaxine during the COVID-19 Epidemic.
Psychiatria Danubina.
2021; 33(1):121-122. doi:
NULL. [PMID: 33857057] - P Rodrigues, V Cunha, L Oliva-Teles, M Ferreira, L Guimarães. Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment.
Journal of hazardous materials.
2020 12; 400(?):123171. doi:
10.1016/j.jhazmat.2020.123171. [PMID: 32593945] - Lauren M Behlke, Eric J Lenze, Vy Pham, J Philip Miller, Timothy W Smith, Yasmina Saade, Jordan F Karp, Charles F Reynolds, Daniel M Blumberger, Cristiana Stefan, Benoit H Mulsant. The Effect of Venlafaxine on Electrocardiogram Intervals During Treatment for Depression in Older Adults.
Journal of clinical psychopharmacology.
2020 Nov; 40(6):553-559. doi:
10.1097/jcp.0000000000001287. [PMID: 33044352] - Yue Li, Juan Li, Dongmin Yan, Qian Wang, Jingyi Jin, Bo Tan, Furong Qiu. Influence of Zuojin Pill on the Metabolism of Venlafaxine in Vitro and in Rats and Associated Herb-Drug Interaction.
Drug metabolism and disposition: the biological fate of chemicals.
2020 10; 48(10):1044-1052. doi:
10.1124/dmd.120.000048. [PMID: 32561594] - Lúcia H M L M Santos, Ana Luísa Maulvault, Adrián Jaén-Gil, António Marques, Damià Barceló, Sara Rodríguez-Mozaz. Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach.
The Science of the total environment.
2020 Oct; 737(?):140226. doi:
10.1016/j.scitotenv.2020.140226. [PMID: 32575024] - Maike Scherf-Clavel, Leif Hommers, Catherina Wurst, Saskia Stonawski, Jürgen Deckert, Katharina Domschke, Stefan Unterecker, Andreas Menke. Higher venlafaxine serum concentrations necessary for clinical improvement? Time to re-evaluate the therapeutic reference range of venlafaxine.
Journal of psychopharmacology (Oxford, England).
2020 10; 34(10):1105-1111. doi:
10.1177/0269881120936509. [PMID: 32669065] - Melodi A Bowman, Nathan C Mitchell, W Anthony Owens, Rebecca E Horton, Wouter Koek, Lynette C Daws. Effect of concurrent organic cation transporter blockade on norepinephrine clearance inhibiting- and antidepressant-like actions of desipramine and venlafaxine.
European journal of pharmacology.
2020 Sep; 883(?):173285. doi:
10.1016/j.ejphar.2020.173285. [PMID: 32697958] - Zhan-Zhang Wang, Shu-Hua Deng, Hao-Yang Lu, Lu Li, Xiu-Qing Zhu, Jin-Qing Hu, Huan-Shan Xie, Hong-Zhen Chen, Yu-Qing Chen, Ming Zhang, Zi-Yan Fang, Yu-Guan Wen, De-Wei Shang. Effect of venlafaxine dosage, valproic acid concentration, sex, and age on steady state dose-corrected concentrations of venlafaxine and O-desmethylvenlafaxine: A retrospective analysis of therapeutic drug monitoring data in a Chinese population.
Human psychopharmacology.
2020 05; 35(3):e2733. doi:
10.1002/hup.2733. [PMID: 32239743] - Michael Paulzen, Georgios Schoretsanitis, Gerhard Gründer, Cordula Franz, Julia C Stingl, Marc Augustin. Pregnancy exposure to venlafaxine-Therapeutic drug monitoring in maternal blood, amniotic fluid and umbilical cord blood and obstetrical outcomes.
Journal of affective disorders.
2020 04; 266(?):578-584. doi:
10.1016/j.jad.2020.02.010. [PMID: 32056930] - Martin Kertys, Michaela Krivosova, Igor Ondrejka, Igor Hrtanek, Ingrid Tonhajzerova, Juraj Mokry. Simultaneous determination of fluoxetine, venlafaxine, vortioxetine and their active metabolites in human plasma by LC-MS/MS using one-step sample preparation procedure.
Journal of pharmaceutical and biomedical analysis.
2020 Mar; 181(?):113098. doi:
10.1016/j.jpba.2020.113098. [PMID: 31978643] - Marianne K Kringen, Line S Bråten, Tore Haslemo, Espen Molden. The Influence of Combined CYP2D6 and CYP2C19 Genotypes on Venlafaxine and O-Desmethylvenlafaxine Concentrations in a Large Patient Cohort.
Journal of clinical psychopharmacology.
2020 Mar; 40(2):137-144. doi:
10.1097/jcp.0000000000001174. [PMID: 32134850] - Feifei Chen, Hui Jiang, Jia Xu, Shuanghu Wang, Deru Meng, Peiwu Geng, Dapeng Dai, Quan Zhou, Yunfang Zhou. In Vitro and In Vivo Rat Model Assessments of the Effects of Vonoprazan on the Pharmacokinetics of Venlafaxine.
Drug design, development and therapy.
2020; 14(?):4815-4824. doi:
10.2147/dddt.s276704. [PMID: 33204067] - Peishan Cai, Xiang Xiong, Dan Li, Yu Zhou, Chaomei Xiong. Magnetic solid-phase extraction coupled with UHPLC-MS/MS for four antidepressants and one metabolite in clinical plasma and urine samples.
Bioanalysis.
2020 Jan; 12(1):35-52. doi:
10.4155/bio-2019-0171. [PMID: 31849264] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Waldemar Elikowski, Małgorzata Małek-Elikowska, Teresa Ganowicz-Kaatz, Natalia Fertała, Magdalena Zawodna, Alina Baszko, Marek Słomczyński. Transient left ventricular hypertrophy in a 30-year-old female with chronic emotional stress and depression treated with venlafaxine.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2019 Oct; 47(280):144-149. doi:
. [PMID: 31760397] - Georgios Schoretsanitis, Ekkehard Haen, Christoph Hiemke, Katharina Endres, Florian Ridders, Tanja Veselinovic, Gerhard Gründer, Michael Paulzen. Pharmacokinetic correlates of venlafaxine: associated adverse reactions.
European archives of psychiatry and clinical neuroscience.
2019 Oct; 269(7):851-857. doi:
10.1007/s00406-019-01005-0. [PMID: 30923938] - Siyuan Sun, Sisi Zhou, Shaowei Lei, Shujie Zhu, Kai Wang, Huidi Jiang, Hui Zhou. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Oct; 49(10):1237-1243. doi:
10.1080/00498254.2018.1542188. [PMID: 30472912] - Xiao-Qian Lin, Ping Wang, Wen-Ke Cai, Gui-Li Xu, Mei Yang, Meng-Di Zhou, Mei Sun, Fang He, Gong-Hao He. The Associations Between CYP2D6 Metabolizer Status and Pharmacokinetics and Clinical Outcomes of Venlafaxine: A Systematic Review and Meta-Analysis.
Pharmacopsychiatry.
2019 Sep; 52(5):222-231. doi:
10.1055/a-0792-1340. [PMID: 30485867] - Hiroshi Kawai, Reiko Iwadate, Takuya Ishibashi, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumoto. Antidepressants with different mechanisms of action show different chronopharmacological profiles in the tail suspension test in mice.
Chronobiology international.
2019 09; 36(9):1194-1207. doi:
10.1080/07420528.2019.1625360. [PMID: 31198056] - Dan Liu, Xiao-Ya Hu, Hai-Jian Xia, Li-Jia Wang, Ping Shi, Xiang-Pan Chen, Qi-Xin Zhou. Antidepressant effect of venlafaxine in chronic unpredictable stress: Evidence of the involvement of key enzymes responsible for monoamine neurotransmitter synthesis and metabolism.
Molecular medicine reports.
2019 Sep; 20(3):2954-2962. doi:
10.3892/mmr.2019.10489. [PMID: 31322231] - Christoph Kowalewski, Ekkehard Haen, Christoph Hiemke, Florian Ridders, Katharina Endres, Gerhard Gründer, Michael Paulzen, Georgios Schoretsanitis. Cytochrome P450-mediated inhibition of venlafaxine metabolism by trimipramine.
International clinical psychopharmacology.
2019 09; 34(5):241-246. doi:
10.1097/yic.0000000000000268. [PMID: 31094902] - Lucia Carboni, Dennis J McCarthy, Bruno Delafont, Michele Filosi, Elena Ivanchenko, Emiliangelo Ratti, Susan M Learned, Robert Alexander, Enrico Domenici. Biomarkers for response in major depression: comparing paroxetine and venlafaxine from two randomised placebo-controlled clinical studies.
Translational psychiatry.
2019 08; 9(1):182. doi:
10.1038/s41398-019-0521-7. [PMID: 31375659] - Georgios Schoretsanitis, Ekkehard Haen, Gerhard Gründer, Christoph Hiemke, Katharina Endres, Florian Ridders, Christoph U Correll, Michael Paulzen. Pharmacokinetics of venlafaxine in treatment responders and non-responders: a retrospective analysis of a large naturalistic database.
European journal of clinical pharmacology.
2019 Aug; 75(8):1109-1116. doi:
10.1007/s00228-019-02675-4. [PMID: 30968172] - Abdullah Al Maruf, Alexandra Greenslade, Paul D Arnold, Chad Bousman. Antidepressant pharmacogenetics in children and young adults: A systematic review.
Journal of affective disorders.
2019 07; 254(?):98-108. doi:
10.1016/j.jad.2019.05.025. [PMID: 31112844] - Georgios Schoretsanitis, Marc Augustin, Helena Saßmannshausen, Cordula Franz, Gerhard Gründer, Michael Paulzen. Antidepressants in breast milk; comparative analysis of excretion ratios.
Archives of women's mental health.
2019 06; 22(3):383-390. doi:
10.1007/s00737-018-0905-3. [PMID: 30116895] - Biswa Ranjan Mishra, Rituparna Maiti, Santanu Nath, Pallabi Sahoo, Monalisa Jena, Archana Mishra. Effect of Sertraline, Dosulepin, and Venlafaxine on Non-BDNF Neurotrophins in Patients With Depression: A Cohort Study.
Journal of clinical psychopharmacology.
2019 May; 39(3):220-225. doi:
10.1097/jcp.0000000000001022. [PMID: 30932945] - Ryosuke Arakawa, Per Stenkrona, Akihiro Takano, Jonas Svensson, Max Andersson, Sangram Nag, Yuko Asami, Yoko Hirano, Christer Halldin, Johan Lundberg. Venlafaxine ER Blocks the Norepinephrine Transporter in the Brain of Patients with Major Depressive Disorder: a PET Study Using [18F]FMeNER-D2.
The international journal of neuropsychopharmacology.
2019 04; 22(4):278-285. doi:
10.1093/ijnp/pyz003. [PMID: 30649319] - Muhammed A Saad, Ayman E El-Sahar, Rabab H Sayed, Eman M Elbaz, Hebatullah S Helmy, Mahmoud A Senousy. Venlafaxine Mitigates Depressive-Like Behavior in Ovariectomized Rats by Activating the EPO/EPOR/JAK2 Signaling Pathway and Increasing the Serum Estradiol Level.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2019 04; 16(2):404-415. doi:
10.1007/s13311-018-00680-6. [PMID: 30361931] - Ahmed T Ahmed, Joanna M Biernacka, Gregory Jenkins, A John Rush, Gen Shinozaki, Marin Veldic, Simon Kung, William V Bobo, Daniel K Hall-Flavin, Richard M Weinshilboum, Liewei Wang, Mark A Frye. Pharmacokinetic-Pharmacodynamic interaction associated with venlafaxine-XR remission in patients with major depressive disorder with history of citalopram / escitalopram treatment failure.
Journal of affective disorders.
2019 03; 246(?):62-68. doi:
10.1016/j.jad.2018.12.021. [PMID: 30578947] - Maike Scherf-Clavel, Lydia Samanski, Leif G Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2.
International clinical psychopharmacology.
2019 03; 34(2):93-100. doi:
10.1097/yic.0000000000000250. [PMID: 30557209] - Nadine Theofel, Philipp Möller, Elke Vejmelka, Kerstin Kastner, Sonja Roscher, Stefan Scholtis, Michael Tsokos. A Fatal Case Involving N-Ethyldeschloroketamine (2-Oxo-PCE) and Venlafaxine.
Journal of analytical toxicology.
2019 Mar; 43(2):e2-e6. doi:
10.1093/jat/bky063. [PMID: 30365028] - Thomas Iliou, Pauline Casta, Judy Lequeux, Liselotte Pochard, Elisabeth Frauger, Michel Spadari, Joëlle Micallef. Venlafaxine Abuse in a Patient With a History of Methylphenidate Abuse: A Case Report.
Journal of clinical psychopharmacology.
2019 Mar; 39(2):172-174. doi:
10.1097/jcp.0000000000001011. [PMID: 30811375] - Ana Luísa Maulvault, Carolina Camacho, Vera Barbosa, Ricardo Alves, Patrícia Anacleto, Pedro Pousão-Ferreira, Rui Rosa, António Marques, Mário Sousa Diniz. Living in a multi-stressors environment: An integrated biomarker approach to assess the ecotoxicological response of meagre (Argyrosomus regius) to venlafaxine, warming and acidification.
Environmental research.
2019 02; 169(?):7-25. doi:
10.1016/j.envres.2018.10.021. [PMID: 30399468] - Ahmed H Eid, Amany M Gad, Ebtehal Mohammad Fikry, Hany H Arab. Venlafaxine and carvedilol ameliorate testicular impairment and disrupted spermatogenesis in rheumatoid arthritis by targeting AMPK/ERK and PI3K/AKT/mTOR pathways.
Toxicology and applied pharmacology.
2019 02; 364(?):83-96. doi:
10.1016/j.taap.2018.12.014. [PMID: 30578887] - Víctor Navarro, Ilham Boulahfa, Amadeu Obach, Dídac Jerez, Maribel Diaz-Ricart, Cristóbal Gastó, Joana Guarch. Switching to Imipramine Versus Add-on Mirtazapine in Venlafaxine-Resistant Major Depression: A 10-Week Randomized Open Study.
Journal of clinical psychopharmacology.
2019 Jan; 39(1):63-66. doi:
10.1097/jcp.0000000000000988. [PMID: 30516574] - Gudrun Hefner, Martina Hahn, Matthias Hohner, Sybille C Roll, Ansgar Klimke, Christoph Hiemke. QTc Time Correlates with Amitriptyline and Venlafaxine Serum Levels in Elderly Psychiatric Inpatients.
Pharmacopsychiatry.
2019 Jan; 52(1):38-43. doi:
10.1055/s-0044-102009. [PMID: 29466824] - Zhongxia Shen, Jianying Zhu, Yonggui Yuan, Lie Ren, Mincai Qian, Min Lin, Min Cai, Zhen Zhang, Xinhua Shen. The roles of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in predicting treatment remission in a Chinese Han population with generalized anxiety disorder.
Psychiatry research.
2019 01; 271(?):319-324. doi:
10.1016/j.psychres.2018.08.111. [PMID: 30529313] - Yong-Liang Zhu, Shuang-Long Li, Ke-Li Chen, Kun-Peng Ma, De-Qian Wu, Xiang-Jun Qiu. Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles.
Drug design, development and therapy.
2019; 13(?):3343-3355. doi:
10.2147/dddt.s221927. [PMID: 31571835] - Georgios Schoretsanitis, Ekkehard Haen, Christoph Hiemke, Bianca Fay, Sandra Unholzer, Christoph U Correll, Gerhard Gründer, Michael Paulzen. Sex and body weight are major determinants of venlafaxine pharmacokinetics.
International clinical psychopharmacology.
2018 11; 33(6):322-329. doi:
10.1097/yic.0000000000000234. [PMID: 30028351] - Marc Augustin, Georgios Schoretsanitis, Gerhard Gründer, Ekkehard Haen, Michael Paulzen. How to Treat Hypertension in Venlafaxine-Medicated Patients-Pharmacokinetic Considerations in Prescribing Amlodipine and Ramipril.
Journal of clinical psychopharmacology.
2018 Oct; 38(5):498-501. doi:
10.1097/jcp.0000000000000929. [PMID: 30102628] - Ana Luísa Maulvault, Lúcia H M L M Santos, Carolina Camacho, Patrícia Anacleto, Vera Barbosa, Ricardo Alves, Pedro Pousão Ferreira, Albert Serra-Compte, Damià Barceló, Sara Rodriguez-Mozaz, Rui Rosa, Mário Diniz, António Marques. Antidepressants in a changing ocean: Venlafaxine uptake and elimination in juvenile fish (Argyrosomus regius) exposed to warming and acidification conditions.
Chemosphere.
2018 Oct; 209(?):286-297. doi:
10.1016/j.chemosphere.2018.06.004. [PMID: 29933165] - Ana Luísa Maulvault, Lúcia H M L M Santos, José Ricardo Paula, Carolina Camacho, Vasco Pissarra, Fabiola Fogaça, Vera Barbosa, Ricardo Alves, Pedro Pousão Ferreira, Damià Barceló, Sara Rodriguez-Mozaz, António Marques, Mário Diniz, Rui Rosa. Differential behavioural responses to venlafaxine exposure route, warming and acidification in juvenile fish (Argyrosomus regius).
The Science of the total environment.
2018 Sep; 634(?):1136-1147. doi:
10.1016/j.scitotenv.2018.04.015. [PMID: 29660870] - Karolina Bogatko, Ewa Poleszak, Aleksandra Szopa, Elżbieta Wyska, Piotr Wlaź, Katarzyna Świąder, Aleksandra Wlaź, Urszula Doboszewska, Karol Rojek, Anna Serefko. The influence of selective A1 and A2A receptor antagonists on the antidepressant-like activity of moclobemide, venlafaxine and bupropion in mice.
The Journal of pharmacy and pharmacology.
2018 Sep; 70(9):1200-1208. doi:
10.1111/jphp.12954. [PMID: 29943503] - Michael Paulzen, Georgios Schoretsanitis, Christoph Hiemke, Gerhard Gründer, Ekkehard Haen, Marc Augustin. Reduced clearance of venlafaxine in a combined treatment with quetiapine.
Progress in neuro-psychopharmacology & biological psychiatry.
2018 07; 85(?):116-121. doi:
10.1016/j.pnpbp.2018.04.014. [PMID: 29702137] - Diana L D Lima, Carla Patrícia Silva, Marta Otero. Dispersive liquid-liquid microextraction for the quantification of venlafaxine in environmental waters.
Journal of environmental management.
2018 Jul; 217(?):71-77. doi:
10.1016/j.jenvman.2018.03.060. [PMID: 29597109] - Melad G Paulis, Essam M Hafez, Nashwa F El-Tahawy, Mohmed K M Aly. Toxicological Assessment of Venlafaxine: Acute and Subchronic Toxicity Study in Rats.
International journal of toxicology.
2018 Jul; 37(4):327-334. doi:
10.1177/1091581818777470. [PMID: 29862856] - Dalia H El-Kashef, Maha H Sharawy. Venlafaxine mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats.
Chemico-biological interactions.
2018 Jun; 290(?):110-118. doi:
10.1016/j.cbi.2018.05.015. [PMID: 29852128] - Mahdi Ghorbani, Mahmoud Chamsaz, Mohsen Aghamohammadhasan, Alireza Shams. Ultrasonic assisted magnetic dispersive solid phase microextraction for pre concentration of serotonin-norepinephrine reuptake inhibitor drugs.
Analytical biochemistry.
2018 06; 551(?):7-18. doi:
10.1016/j.ab.2018.05.003. [PMID: 29750941] - Guodong Gu, Michelle Black, Colt Cookson, Anna Fiorella, Yinghe Li, Steven H Gorman, Ray Bakhtiar. Validation of an LC-MS/MS method for simultaneous quantification of venlafaxine and its five metabolites in rat plasma and its application in a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jun; 1087-1088(?):29-35. doi:
10.1016/j.jchromb.2018.04.033. [PMID: 29704798] - Maxim Kuzin, Georgios Schoretsanitis, Ekkehard Haen, Benedikt Stegmann, Christoph Hiemke, Gerhard Gründer, Michael Paulzen. Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine.
Clinical pharmacokinetics.
2018 06; 57(6):729-737. doi:
10.1007/s40262-017-0591-8. [PMID: 28866861] - Katharina Ebert, Elena Maurice, Richard Lukačin, Christian Fleischhaker, Eberhard Schulz, Dieter Ebert, Hans-Willi Clement. Serum and Saliva Concentrations of Venlafaxine, O-Desmethylvenlafaxine, Quetiapine, and Citalopram in Psychiatric Patients.
Therapeutic drug monitoring.
2018 06; 40(3):351-355. doi:
10.1097/ftd.0000000000000508. [PMID: 29746434] - Mohammad Taghi Mansouri, Bahareh Naghizadeh, Behnam Ghorbanzadeh, Soheila Alboghobeish, Neda Amirgholami, Gholamreza Houshmand, Omar Cauli. Venlafaxine prevents morphine antinociceptive tolerance: The role of neuroinflammation and the l-arginine-nitric oxide pathway.
Experimental neurology.
2018 05; 303(?):134-141. doi:
10.1016/j.expneurol.2018.02.009. [PMID: 29453978] - Caroline M Mitchell, Sujatha Srinivasan, Anna Plantinga, Michael C Wu, Susan D Reed, Katherine A Guthrie, Andrea Z LaCroix, Tina Fiedler, Matthew Munch, Congzhou Liu, Noah G Hoffman, Ian A Blair, Katherine Newton, Ellen W Freeman, Hadine Joffe, Lee Cohen, David N Fredricks. Associations between improvement in genitourinary symptoms of menopause and changes in the vaginal ecosystem.
Menopause (New York, N.Y.).
2018 05; 25(5):500-507. doi:
10.1097/gme.0000000000001037. [PMID: 29206774] - Maria Skibinska, Pawel Kapelski, Aleksandra Rajewska-Rager, Joanna Pawlak, Aleksandra Szczepankiewicz, Beata Narozna, Joanna Twarowska-Hauser, Monika Dmitrzak-Weglarz. Brain-derived neurotrophic factor (BDNF) serum level in women with first-episode depression, correlation with clinical and metabolic parameters.
Nordic journal of psychiatry.
2018 Apr; 72(3):191-196. doi:
10.1080/08039488.2017.1415373. [PMID: 29235396] - Yi Zhao, Li Zhang, Yao Peng, Qiming Yue, Li Hai, Li Guo, Qiantao Wang, Yong Wu. GLUT1 -mediated venlafaxine-thiamine disulfide system-glucose conjugates with 'lock-in' function for central nervous system delivery.
Chemical biology & drug design.
2018 03; 91(3):707-716. doi:
10.1111/cbdd.13128. [PMID: 29063718] - A Yingyu Zhou, B Wei Song, C Yilei Fu, D Denis Baranenko, E Jiaping Wang, F Yongzhi Li, G Weihong Lu. Acanthopanax senticosus reduces brain injury in mice exposed to low linear energy transfer radiation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Mar; 99(?):781-790. doi:
10.1016/j.biopha.2018.01.001. [PMID: 29710476] - Michael Paulzen, Ekkehard Haen, Christoph Hiemke, Bianca Fay, Sandra Unholzer, Gerhard Gründer, Georgios Schoretsanitis. Antidepressant polypharmacy and the potential of pharmacokinetic interactions: Doxepin but not mirtazapine causes clinically relevant changes in venlafaxine metabolism.
Journal of affective disorders.
2018 02; 227(?):506-511. doi:
10.1016/j.jad.2017.11.046. [PMID: 29156365] - Marwa F Mansour, Mona M Abd El-Moety, Ehab F El Kady, N M El Guindi, Ann Van Schepdael, S M El-Moghazy Aly. Venlafaxine Determination in Pharmaceutical Formulation and Serum by Ion-Selective Electrodes.
Current pharmaceutical design.
2018; 24(22):2625-2630. doi:
10.2174/1381612824666180727112730. [PMID: 30051780] - Chun-Yen Chen, Yi-Wei Yeh, Shin-Chang Kuo, Chih-Sung Liang, Pei-Shen Ho, Chang-Chih Huang, Che-Hung Yen, Jia-Fwu Shyu, Ru-Band Lu, San-Yuan Huang. Differences in immunomodulatory properties between venlafaxine and paroxetine in patients with major depressive disorder.
Psychoneuroendocrinology.
2018 Jan; 87(?):108-118. doi:
10.1016/j.psyneuen.2017.10.009. [PMID: 29055264] - Ewa Banach, Aleksandra Szczepankiewicz, Anna Leszczyńska-Rodziewicz, Joanna Pawlak, Monika Dmitrzak-Węglarz, Dorota Zaremba, Joanna Twarowska-Hauser. Venlafaxine and sertraline does not affect the expression of genes regulating stress response in female MDD patients.
Psychiatria polska.
2017 Dec; 51(6):1029-1038. doi:
10.12740/pp/76329. [PMID: 29432501] - Jaya Thomas, Razia Khanam, Divya Vohora. Activation of indoleamine 2, 3- dioxygenase pathway by olanzapine augments antidepressant effects of venlafaxine in mice.
Psychiatry research.
2017 12; 258(?):444-448. doi:
10.1016/j.psychres.2017.08.083. [PMID: 28911850]