doxazosin (BioDeep_00000397848)
Main id: BioDeep_00000002375
Volatile Flavor Compounds
代谢物信息卡片
化学式: C23H25N5O5 (451.18556)
中文名称: R-多沙唑嗪, 多沙唑嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
InChI: InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26)
描述信息
C - Cardiovascular system > C02 - Antihypertensives > C02C - Antiadrenergic agents, peripherally acting > C02CA - Alpha-adrenoreceptor antagonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3293
同义名列表
3 个代谢物同义名
数据库引用编号
29 个数据库交叉引用编号
- ChEBI: CHEBI:95247
- ChEBI: CHEBI:4708
- KEGG: C06970
- KEGGdrug: D07874
- PubChem: 6604102
- PubChem: 3157
- DrugBank: DB00590
- ChEMBL: CHEMBL1363589
- ChEMBL: CHEMBL707
- MeSH: Doxazosin
- CAS: 70918-17-1
- CAS: 137888-77-8
- CAS: 74191-85-8
- MoNA: EQ329356
- MoNA: EQ329355
- MoNA: EQ329354
- MoNA: EQ329353
- MoNA: EQ329352
- MoNA: EQ329351
- MoNA: EQ329306
- MoNA: EQ329305
- MoNA: EQ329304
- MoNA: EQ329303
- MoNA: EQ329302
- MoNA: EQ329301
- PubChem: 9184
- NIKKAJI: J21.371C
- RefMet: Doxazosin
- KNApSAcK: 4708
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yi Zheng, Fuding Bai, Nan Zhang, Huifeng Wu. Analysis of Voiding Impairment after Prostate Biopsy and the Effect of Doxazosin Treatment: Outcomes from a Regional Cancer Center.
Urologia internationalis.
2022; 106(1):97-102. doi:
10.1159/000517534
. [PMID: 34404051] - Marta Araujo-Castro, Rogelio Garcia Centeno, María-Carmen López-García, Cristina Lamas, Cristina Álvarez-Escolá, María Calatayud Gutiérrez, Concepción Blanco-Carrera, Paz de Miguel Novoa, Nuria Valdés, Paola Gracia Gimeno, Mariana Tomé Fernández-Ladreda, César Mínguez Ojeda, Juan Carlos Percovich Hualpa, Mireia Mora, Óscar Vidal, Ana Serrano Romero, Felicia Alexandra Hanzu, Victoria Gómez Dos Santos. Risk factors for intraoperative complications in pheochromocytomas.
Endocrine-related cancer.
2021 09; 28(11):695-703. doi:
10.1530/erc-21-0230
. [PMID: 34379605] - Jianming Guo, Rong Tang. Efficacy and tolerability of doxazosin gastro-intestinal therapeutic system versus tamsulosin in patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: A systematic review and meta-analysis.
Medicine.
2021 Aug; 100(33):e26955. doi:
10.1097/md.0000000000026955
. [PMID: 34414962] - Hikaru Hori. Doxazosin improved COVID-19 associated nightmare in a patient with major depressive disorder: a case report with a positive rechallenge.
International clinical psychopharmacology.
2021 07; 36(4):221-223. doi:
10.1097/yic.0000000000000364
. [PMID: 34030164] - Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Nicole Fischer, Sakibul Huq, Adham M Khalafallah, Marco Trevisan, Pär Sparen, Juan J Carrero, Akihiko Nishimura, Brian Caffo, Elizabeth A Stuart, Renyuan Bai, Verena Staedtke, David L Thomas, Nickolas Papadopoulos, Ken W Kinzler, Bert Vogelstein, Shibin Zhou, Chetan Bettegowda, Maximilian F Konig, Brett D Mensh, Joshua T Vogelstein, Susan Athey. Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection.
eLife.
2021 06; 10(?):. doi:
10.7554/elife.61700
. [PMID: 34114951] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Gregory L Hundemer, Greg A Knoll, William Petrcich, Swapnil Hiremath, Marcel Ruzicka, Kevin D Burns, Cedric Edwards, Ann Bugeja, Emily Rhodes, Manish M Sood. Kidney, Cardiac, and Safety Outcomes Associated With α-Blockers in Patients With CKD: A Population-Based Cohort Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 02; 77(2):178-189.e1. doi:
10.1053/j.ajkd.2020.07.018
. [PMID: 32920153] - P Iglesias, E Santacruz, P García-Sancho, A P Marengo, F Guerrero-Pérez, H Pian, C Fajardo, C Villabona, J J Díez. Pheochromocytoma: A three-decade clinical experience in a multicenter study.
Revista clinica espanola.
2021 Jan; 221(1):18-25. doi:
10.1016/j.rceng.2019.12.011
. [PMID: 33998473] - Makinna C Oestreich, Robin Wm Vernooij, Niranjan J Sathianathen, Eu Chang Hwang, Gretchen M Kuntz, Alex Koziarz, Charles D Scales, Philipp Dahm. Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults.
The Cochrane database of systematic reviews.
2020 11; 11(?):CD013393. doi:
10.1002/14651858.cd013393.pub2
. [PMID: 33179245] - Mahmoud A Omar, Abobakr A Mohamed, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad. Mending the fluorescence of two α-blockers through a semiquinoid formation: Hyphenated with experimental design optimization.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Oct; 240(?):118624. doi:
10.1016/j.saa.2020.118624
. [PMID: 32604051] - Samar Rezq, Ahmed M Nasr, Aya Shaheen, Shimaa M Elshazly. Doxazosin down-regulates sodium-glucose cotransporter-2 and exerts a renoprotective effect in rat models of acute renal injury.
Basic & clinical pharmacology & toxicology.
2020 May; 126(5):413-423. doi:
10.1111/bcpt.13371
. [PMID: 31788938] - Michael Doumas, Konstantinos P Imprialos, Manolis S Kallistratos, Athanasios J Manolis. Recent advances in understanding and managing resistant/refractory hypertension.
F1000Research.
2020; 9(?):. doi:
10.12688/f1000research.21669.1
. [PMID: 32201574] - Daryl I Shorter, Xuefeng Zhang, Coreen B Domingo, Ellen M Nielsen, Thomas R Kosten, David A Nielsen. Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an alpha-1 adrenoreceptor subtype D genetic variant.
The American journal of drug and alcohol abuse.
2020; 46(2):184-193. doi:
10.1080/00952990.2019.1674864
. [PMID: 31914324] - N O Mansour. Validated RP-HPLC method for quantification of doxazosin in human plasma: Application in a bioequivalence study.
Annales pharmaceutiques francaises.
2020 Jan; 78(1):42-48. doi:
10.1016/j.pharma.2019.10.003
. [PMID: 31796268] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
. [PMID: 31515284] - Xuefeng Zhang, David A Nielsen, Coreen B Domingo, Daryl I Shorter, Ellen M Nielsen, Thomas R Kosten. Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin.
Addiction biology.
2019 05; 24(3):531-538. doi:
10.1111/adb.12611
. [PMID: 29498170] - Kyle Johnson, Suzanne Oparil, Barry R Davis, Larisa G Tereshchenko. Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study.
Journal of the American Heart Association.
2019 04; 8(8):e011961. doi:
10.1161/jaha.119.011961
. [PMID: 30943832] - Mahmoud A Omar, Mohamed A Hammad, Baher I Salman. Micellar enhanced spectrofluorimetric approach for nanogram detection of certain α1 -blocker drugs: Application in pharmaceutical preparations and human plasma.
Luminescence : the journal of biological and chemical luminescence.
2018 Nov; 33(7):1226-1234. doi:
10.1002/bio.3539
. [PMID: 30094938] - Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown. Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.
The lancet. Diabetes & endocrinology.
2018 06; 6(6):464-475. doi:
10.1016/s2213-8587(18)30071-8
. [PMID: 29655877] - Mahmoud A Omar, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad, Abobakr A Mohamed. An efficient spectrofluorimetric method adopts doxazosin, terazosin and alfuzosin coupling with orthophthalaldehyde: Application in human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Apr; 195(?):215-222. doi:
10.1016/j.saa.2018.01.077
. [PMID: 29414581] - Daniel Cervantes-Garcia, Adriana Guadalupe Cuellar-Juarez, Gissela Borrego-Soto, Augusto Rojas-Martinez, Liseth Rubi Aldaba-Muruato, Eva Salinas, Javier Ventura-Juarez, Martin Humberto Muñoz-Ortega. Adenoviral‑bone morphogenetic protein‑7 and/or doxazosin therapies promote the reversion of fibrosis/cirrhosis in a cirrhotic hamster model.
Molecular medicine reports.
2017 Dec; 16(6):9431-9440. doi:
10.3892/mmr.2017.7785
. [PMID: 29039539] - Thomas M MacDonald, Bryan Williams, David J Webb, Steve Morant, Mark Caulfield, J Kennedy Cruickshank, Ian Ford, Peter Sever, Isla S Mackenzie, Sandosh Padmanabhan, Gerald P McCann, Jackie Salsbury, Gordon McInnes, Morris J Brown. Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial.
Journal of the American Heart Association.
2017 Nov; 6(11):. doi:
10.1161/jaha.117.006986
. [PMID: 29151036] - Sanket S Dhruva, Chenxi Huang, Erica S Spatz, Andreas C Coppi, Frederick Warner, Shu-Xia Li, Haiqun Lin, Xiao Xu, Curt D Furberg, Barry R Davis, Sara L Pressel, Ronald R Coifman, Harlan M Krumholz. Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).
Hypertension (Dallas, Tex. : 1979).
2017 07; 70(1):94-102. doi:
10.1161/hypertensionaha.117.09221
. [PMID: 28559399] - Kodai Suzuki, Takahito Miyake, Hideshi Okada, Fuminori Yamaji, Yuichiro Kitagawa, Tetsuya Fukuta, Ryu Yasuda, Yoshihito Tanaka, Haruka Okamoto, Sho Nachi, Tomoaki Doi, Takahiro Yoshida, Keisuke Kumada, Shozo Yoshida, Hiroaki Ushikoshi, Izumi Toyoda, Shinji Ogura. Thyrotoxic and pheochromocytoma multisystem crisis: a case report.
Journal of medical case reports.
2017 Jun; 11(1):173. doi:
10.1186/s13256-017-1299-y
. [PMID: 28641581] - Chun-Sheng Song, Jia-You Zhao, Jun Guo, De-Gui Chang, Lei Chen, Rui Zhang, Fu Wang. [Treatment of Benign Prostatic Hyperplasia by Longbishu Capsule Combined Doxazosin Mesylate Tablet].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2016 Dec; 36(12):1465-1469. doi:
"
. [PMID: 30650291] - V I Kirpatovskii, I S Mudraya, S V Revenko, A Yu Bablumyan, N K Adamyan, V P Ivanov. Effect of Doxazosin on Autonomic Nervous Control and Urodynamics of Rat Urinary Bladder during Modeled Infravesical Obstruction.
Bulletin of experimental biology and medicine.
2016 Sep; 161(5):657-661. doi:
10.1007/s10517-016-3479-y
. [PMID: 27709382] - Yung-Chin Lee, Yung-Shun Juan, Chia-Chu Liu, Bo-Ying Bao, Chii-Jye Wang, Wen-Jeng Wu, Chun-Nung Huang, Shu-Pin Huang. The association of endothelial nitric oxide synthase (eNOS) G894T gene polymorphism with responsiveness to a selective α1 -blocker in men with benign prostatic hyperplasia related lower urinary tract symptoms.
BJU international.
2016 08; 118(2):313-9. doi:
10.1111/bju.13468
. [PMID: 26940040] - Qian Du, De-zhi Kong, Pan-pan Zhang, Lei-ming Ren. [Quantification of (-)doxazosin at very low concentration in rat plasma samples by SPE-LC-MS/MS].
Yao xue xue bao = Acta pharmaceutica Sinica.
2016 07; 51(7):1125-9. doi:
NULL
. [PMID: 29897217] - Steven A Kaplan, Jeannette Y Lee, Alan G Meehan, John W Kusek. Time Course of Incident Adverse Experiences Associated with Doxazosin, Finasteride and Combination Therapy in Men with Benign Prostatic Hyperplasia: The MTOPS Trial.
The Journal of urology.
2016 06; 195(6):1825-9. doi:
10.1016/j.juro.2015.11.065
. [PMID: 26678956] - Paweł Kroll, Ewa Gajewska, Jacek Zachwieja, Magdalena Sobieska, Przemysław Mańkowski. An Evaluation of the Efficacy of Selective Alpha-Blockers in the Treatment of Children with Neurogenic Bladder Dysfunction--Preliminary Findings.
International journal of environmental research and public health.
2016 Mar; 13(3):. doi:
10.3390/ijerph13030321
. [PMID: 26999168] - Mahmoud A Omar, Mohamed A Hammad, Baher I Salman, Sayed M Derayea. Highly sensitive spectrofluorimetric method for determination of doxazosin through derivatization with fluorescamine; Application to content uniformity testing.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2016 Mar; 157(?):55-60. doi:
10.1016/j.saa.2015.12.012
. [PMID: 26716887] - José A T Poloni, Lauro da F Beltrão, Elizete Keitel, Tiana Tasca, Liane N Rotta. Trichomonas vaginalis erythrophagocytosis in the urine sediment.
International journal of STD & AIDS.
2016 Feb; 27(2):157-8. doi:
10.1177/0956462415610680
. [PMID: 26468272] - Mariola Chudzik, Joanna Równicka-Zubik, Jadwiga Pożycka, Bartosz Pawelczak, Anna Sulkowska. Analysis of Aged Human Serum Albumin Affinity for Doxazosin.
Current protein & peptide science.
2016; 17(2):198-208. doi:
10.2174/1389203716666151102103923
. [PMID: 26521959] - Bryan Williams, Thomas M MacDonald, Steve Morant, David J Webb, Peter Sever, Gordon McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Jackie Salsbury, Isla Mackenzie, Sandosh Padmanabhan, Morris J Brown. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial.
Lancet (London, England).
2015 Nov; 386(10008):2059-2068. doi:
10.1016/s0140-6736(15)00257-3
. [PMID: 26414968] - Qing Li, Dezhi Kong, Qian Du, Jing Zhao, Yaqin Zhen, Tonghui Li, Leiming Ren. Enantioselective pharmacokinetics of doxazosin and pharmacokinetic interaction between the isomers in rats.
Chirality.
2015 Oct; 27(10):738-44. doi:
10.1002/chir.22483
. [PMID: 26205661] - Dezhi Kong, Qing Li, Panpan Zhang, Wei Zhang, Yaqin Zhen, Leiming Ren. The truth about the lower plasma concentration of the (-)-isomer after racemic doxazosin administration in rats: Stereoselective inhibition of the (-)-isomer by the (+)-isomer at CYP3A.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Sep; 77(?):238-45. doi:
10.1016/j.ejps.2015.06.022
. [PMID: 26116989] - Onur Telli, Mehmet Ilker Gokce, Erdem Ozturk, Evren Suer, Murat Mermerkaya, Faraj Afandiyev, Cihat Ozcan, Adil Gucal Guclu, Tarkan Soygur, Berk Burgu. What is the best option for 10-20mm renal pelvic stones undergoing ESWL in the pediatric population: stenting, alpha blockers or conservative follow-up?.
Journal of pediatric surgery.
2015 Sep; 50(9):1532-4. doi:
10.1016/j.jpedsurg.2014.11.045
. [PMID: 25783320] - Victor C Lin, Chun-Hou Liao, Chung-Cheng Wang, Hann-Chorng Kuo. 5α-Reductase inhibitor is less effective in men with small prostate volume and low serum prostatic specific antigen level.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2015 Sep; 114(9):865-71. doi:
10.1016/j.jfma.2013.08.006
. [PMID: 24064231] - Ai Ping Li, Huanjun Peng, Jing Dong Peng, Ming Qiong Zhou, Jing Zhang. Rayleigh light scattering detection of three α1-adrenoceptor antagonists coupled with high performance liquid chromatograph.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Aug; 147(?):178-84. doi:
10.1016/j.saa.2015.02.062
. [PMID: 25840026] - De-gui Chang, Guang-sen Li, Cheng-hua Peng, Xu-jun Yu, Pei-hai Zhang, Ming-shuai Bi, Di-ang Chen, Yao-dong You, Xing-zhi Yang. [Longbishu Capsule combined with mesylate doxazosin: an efficacious therapy for benign prostatic hyperplasia].
Zhonghua nan ke xue = National journal of andrology.
2015 Feb; 21(2):165-9. doi:
NULL
. [PMID: 25796693] - Nannan Gao, Hao Wu, Yafen Chang, Xiaozhen Guo, Lizhen Zhang, Liming Du, Yunlong Fu. Mixed micelle cloud point-magnetic dispersive μ-solid phase extraction of doxazosin and alfuzosin.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Jan; 134(?):10-6. doi:
10.1016/j.saa.2014.06.095
. [PMID: 24995413] - Junjun Huang, Fei He, Minyi Huang, Xiawen Liu, Yan Xiong, Yajian Huang, Liu Zhu, Ya Yang, Xingjie Xu, Mu Yuan. Novel naftopidil-related derivatives and their biological effects as alpha1-adrenoceptors antagonists and antiproliferative agents.
European journal of medicinal chemistry.
2015; 96(?):83-91. doi:
10.1016/j.ejmech.2015.04.005
. [PMID: 25874333] - Gen Yasuda, Sanae Saka, Daisaku Ando, Nobuhito Hirawa. Effects of doxazosin as the third agent on morning hypertension and position-related blood pressure changes in diabetic patients with chronic kidney disease.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2015; 37(1):75-81. doi:
10.3109/10641963.2014.913599
. [PMID: 24866870] - Massimiliano Tognolini, Alessio Lodola. Targeting the Eph-ephrin System with Protein-Protein Interaction (PPI) Inhibitors.
Current drug targets.
2015; 16(10):1048-56. doi:
10.2174/1389450116666150825144457
. [PMID: 26302794] - Chun-Sheng Song, Jun Guo, De-Gui Chang, Lei Chen, Rui Zhang, Jia-You Zhao, Fu Wang, Qiang Zhang. Effect of Longbishu capsule () plus doxazosin on benign prostatic hyperplasia: a randomized controlled trial.
Chinese journal of integrative medicine.
2014 Nov; 20(11):818-22. doi:
10.1007/s11655-014-1844-0
. [PMID: 24938449] - Chyng-Wen Fwu, Paul W Eggers, Ziya Kirkali, Kevin T McVary, Pamela K Burrows, John W Kusek. Change in sexual function in men with lower urinary tract symptoms/benign prostatic hyperplasia associated with long-term treatment with doxazosin, finasteride and combined therapy.
The Journal of urology.
2014 Jun; 191(6):1828-34. doi:
10.1016/j.juro.2013.12.014
. [PMID: 24342143] - Fatih Akın, Cengizhan Kılıçaslan, Ece Selma Solak, Meltem Uzun, Serhat Aygün, Şükrü Arslan. Posterior reversible encephalopathy syndrome in children: report of three cases.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.
2014 Mar; 30(3):535-40. doi:
10.1007/s00381-013-2342-y
. [PMID: 24356805] - Yayoi Matsuda, Hisaya Kawate, Shingo Shimada, Chitose Matsuzaki, Hiromi Nagata, Masahiro Adachi, Keizo Ohnaka, Masatoshi Nomura, Ryoichi Takayanagi. Perioperative sequential monitoring of hemodynamic parameters in patients with pheochromocytoma using the Non-Invasive Cardiac System (NICaS).
Endocrine journal.
2014; 61(6):571-5. doi:
10.1507/endocrj.ej13-0471
. [PMID: 24621777] - Jing Zhao, De-zhi Kong, Qing Li, Ya-qin Zhen, Miao Wang, Yan Zhao, Dong-kai Wang, Lei-ming Ren. (-)Doxazosin is a necessary component for the hypotensive effect of (±)doxazosin during long-term administration in conscious rats.
Acta pharmacologica Sinica.
2014 Jan; 35(1):48-57. doi:
10.1038/aps.2013.154
. [PMID: 24335843] - Fatih Tarhan, Osman Çelik, Çağatay Tosun, Gökhan Faydacı, Bilal Eryıldırım. Comparison of the efficacy of isosorbide mononitrate and doxazosin in the treatment of lower urinary tract symptoms and benign prostatic hyperplasia: a randomized clinical trial.
Urologia internationalis.
2014; 93(1):17-21. doi:
10.1159/000357034
. [PMID: 24643055] - J-F Jhang, Y-H Jiang, H-C Kuo. Adding Cyclooxygenase-2 inhibitor to alpha blocker for patients with benign prostate hyperplasia and elevated serum prostate specific antigen could not improve prostate biopsy detection rate but improve lower urinary tract symptoms.
International journal of clinical practice.
2013 Dec; 67(12):1327-33. doi:
10.1111/ijcp.12220
. [PMID: 24246211] - Yang-Yun Wang, Guo-Wei Shi, Jia-Yang He, Yan-Bin Zhang. [Cardura monotherapy versus combination therapy of cardura and tolterodine L-tartrate tablets for II° ? benign prostatic hyperplasia with overactive bladder].
Zhonghua nan ke xue = National journal of andrology.
2013 Dec; 19(12):1099-102. doi:
NULL
. [PMID: 24432622] - Jia-an Sun, De-zhi Kong, Ya-qin Zhen, Qing Li, Wei Zhang, Jiang-hua Zhang, Zhi-wei Yin, Lei-ming Ren. Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in vitro.
Acta pharmacologica Sinica.
2013 Dec; 34(12):1568-74. doi:
10.1038/aps.2013.120
. [PMID: 24241343] - E L Vishnevskiĭ, O B Loran, N B Guseva, S S Nikitin. [Features of neurohumoral regulation in children with combined dysfunction of the pelvic organs].
Urologiia (Moscow, Russia : 1999).
2013 Nov; ?(6):90-6. doi:
NULL
. [PMID: 24649773] - Carolina Gonçalves Pupe, Flávia Almada Do Carmo, Valéria Pereira De Sousa, Marlene Lopes, Bárbara Abrahim-Vieira, António José Ribeiro, Francisco Veiga, Carlos Rangel Rodrigues, Cristina Padula, Patrizia Santi, Lucio Mendes Cabral. Development of a doxazosin and finasteride transdermal system for combination therapy of benign prostatic hyperplasia.
Journal of pharmaceutical sciences.
2013 Nov; 102(11):4057-64. doi:
10.1002/jps.23715
. [PMID: 23983168] - Cavit Ceylan, Taner Ceylan, Omer Gokhan Doluoglu, Selcen Yuksel, Koray Agras. Comparing the effectiveness of intranasal desmopressin and doxazosin in men with nocturia: a pilot randomized clinical trial.
Urology journal.
2013 09; 10(3):993-8. doi:
NULL
. [PMID: 24078508] - D Shorter, J A Lindsay, T R Kosten. The alpha-1 adrenergic antagonist doxazosin for treatment of cocaine dependence: A pilot study.
Drug and alcohol dependence.
2013 Jul; 131(1-2):66-70. doi:
10.1016/j.drugalcdep.2012.11.021
. [PMID: 23306096] - Ya-Qin Zhen, De-Zhi Kong, Qing Li, Jing Zhao, Lei-Ming Ren. [Determination of doxazosin enantiomers in rat plasma and investigation of their chiral inversion].
Yao xue xue bao = Acta pharmaceutica Sinica.
2013 Jun; 48(6):901-5. doi:
NULL
. [PMID: 23984526] - Berit Packert Jensen, Judith Maree Dalrymple, Evan James Begg. Transfer of doxazosin into breast milk.
Journal of human lactation : official journal of International Lactation Consultant Association.
2013 May; 29(2):150-3. doi:
10.1177/0890334412473203
. [PMID: 23439864] - Y-C Lee, C-C Liu, Y-S Juan, W-J Wu, W-M Li, H-C Yeh, C-J Wang, C-N Huang, C-H Huang, S-P Huang. The impact of metabolic syndrome on the responsiveness to α1-blocker in men with BPH/LUTS.
International journal of clinical practice.
2013 Apr; 67(4):356-62. doi:
10.1111/ijcp.12086
. [PMID: 23409734] - Katiane Cella Gabriel, Rafael Rodrigues Dihl, Mauricio Lehmann, Maria Luiza Reguly, Marc François Richter, Heloisa Helena Rodrigues de Andrade. Homologous recombination induced by doxazosin mesylate and saw palmetto in the Drosophila wing-spot test.
Journal of applied toxicology : JAT.
2013 Mar; 33(3):209-13. doi:
10.1002/jat.1740
. [PMID: 22015851] - Meghan L O'Neil, Lauren E Beckwith, Carrie L Kincaid, Dennis D Rasmussen. The α1-adrenergic receptor antagonist, doxazosin, reduces alcohol drinking in alcohol-preferring (P) Rats.
Alcoholism, clinical and experimental research.
2013 Feb; 37(2):202-12. doi:
10.1111/j.1530-0277.2012.01884.x
. [PMID: 22758213] - Cédric M Hysek, Matthias E Liechti. Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Psychopharmacology.
2012 Dec; 224(3):363-76. doi:
10.1007/s00213-012-2761-6
. [PMID: 22700038] - Omer Kutlu, Mehmet Yalcinkaya, Selcuk Kutlu, Gulsum O Elpek, Ismail T Köksal, Erdal Kukul. Effect of doxazosin on expression of eNOS in rat kidney in the presence of partial bladder outlet obstruction.
Journal of nephrology.
2012 Sep; 25(5):750-4. doi:
10.5301/jn.5000055
. [PMID: 22135033] - Osama M Zaytoun, Rachid Yakoubi, Abdel Rahman M Zahran, Khaled Fouda, Essam Marzouk, Salah Gaafar, Khaled Fareed. Tamsulosin and doxazosin as adjunctive therapy following shock-wave lithotripsy of renal calculi: randomized controlled trial.
Urological research.
2012 Aug; 40(4):327-32. doi:
10.1007/s00240-011-0410-x
. [PMID: 21837534] - Bing Li, Wansheng Gao, Chuanjiang Dong, Xiaomin Han, Shuqiang Li, Renfeng Jia, Chuanguo Xiao. Long-term safety, tolerability, and efficacy of α1-adrenergic blocker in young men with primary bladder neck obstruction: results from a single centre in China.
International urology and nephrology.
2012 Jun; 44(3):711-6. doi:
10.1007/s11255-011-0096-6
. [PMID: 22130960] - Amy I Lynch, John H Eckfeldt, Barry R Davis, Charles E Ford, Eric Boerwinkle, Catherine Leiendecker-Foster, Donna K Arnett. Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
Pharmacogenetics and genomics.
2012 May; 22(5):355-66. doi:
10.1097/fpc.0b013e3283516ff8
. [PMID: 22388798] - Miroslav Solar, Eva Malirova, Marek Ballon, Radek Pelouch, Jiri Ceral. Confirmatory testing in primary aldosteronism: extensive medication switching is not needed in all patients.
European journal of endocrinology.
2012 Apr; 166(4):679-86. doi:
10.1530/eje-11-0914
. [PMID: 22253400] - Karthik Ananthasubramaniam, Robert Weiss, Bruce McNutt, Barbara Klauke, Kathleen Feaheny, Stan Bukofzer. A randomized, double-blind, placebo-controlled study of the safety and tolerance of regadenoson in subjects with stage 3 or 4 chronic kidney disease.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.
2012 Apr; 19(2):319-29. doi:
10.1007/s12350-011-9508-3
. [PMID: 22259009] - I Kasacka, E Arciszewska. Dynamics of calcitonin gene-related peptide-like cells changes in the lungs of two-kidney, one-clip rats.
European journal of histochemistry : EJH.
2012 Mar; 56(1):e10. doi:
10.4081/ejh.2012.e10
. [PMID: 22472888] - M Stowasser, A H Ahmed, E Pimenta, P J Taylor, R D Gordon. Factors affecting the aldosterone/renin ratio.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2012 Mar; 44(3):170-6. doi:
10.1055/s-0031-1295460
. [PMID: 22147655] - Ahmed S El-Hefnawy, Tamer Helmy, Mohamed M El-Assmy, Osama Sarhan, Ashraf T Hafez, Mohammed Dawaba. Doxazosin versus tizanidine for treatment of dysfunctional voiding in children: a prospective randomized open-labeled trial.
Urology.
2012 Feb; 79(2):428-33. doi:
10.1016/j.urology.2011.10.043
. [PMID: 22196407] - Marijana Erceg, Maria Vertzoni, Helena Cerić, Miljenko Dumić, Biserka Cetina-Čižmek, Christos Reppas. In vitro vs. canine data for assessing early exposure of doxazosin base and its mesylate salt.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2012 Feb; 80(2):402-9. doi:
10.1016/j.ejpb.2011.10.004
. [PMID: 22019530] - Naokazu Hamada, Yoshihiro Nishi, Yuji Tajiri, Kentaro Setoyama, Ryozo Kamimura, Kenkichi Miyahara, Norihito Nuruki, Hiroshi Hosoda, Kenji Kangawa, Masayasu Kojima, Hiroharu Mifune. Disrupted regulation of ghrelin production under antihypertensive treatment in spontaneously hypertensive rats.
Circulation journal : official journal of the Japanese Circulation Society.
2012; 76(6):1423-9. doi:
10.1253/circj.cj-11-1345
. [PMID: 22447011] - Gastone Leonetti, Colin G Egan. Use of carvedilol in hypertension: an update.
Vascular health and risk management.
2012; 8(?):307-22. doi:
10.2147/vhrm.s31578
. [PMID: 22661898] - Blas Gil-Extremera, Pedro Cía-Gómez. Hypertension in the elderly.
International journal of hypertension.
2012; 2012(?):859176. doi:
10.1155/2012/859176
. [PMID: 21876789] - Martin H de Borst, Ferdau L Nauta, Liffert Vogt, Gozewijn D Laverman, Ron T Gansevoort, Gerjan Navis. Indomethacin reduces glomerular and tubular damage markers but not renal inflammation in chronic kidney disease patients: a post-hoc analysis.
PloS one.
2012; 7(5):e37957. doi:
10.1371/journal.pone.0037957
. [PMID: 22662255] - B Padilla-Fernández, P Antúnez-Plaza, M F Lorenzo-Gómez, M Rodríguez-González, A Martín-Rodríguez, J M Silva-Abuín. Paraganglioma of prostatic origin.
Clinical medicine insights. Case reports.
2012; 5(?):69-75. doi:
10.4137/ccrep.s9742
. [PMID: 22661903] - Paul Hamberg, Margaret M Woo, Lin-Chi Chen, Jaap Verweij, Maria Grazia Porro, Lily Zhao, Wenkui Li, Diane van der Biessen, Sunil Sharma, Thomas Hengelage, Maja de Jonge. Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor.
Cancer chemotherapy and pharmacology.
2011 Sep; 68(3):805-13. doi:
10.1007/s00280-011-1693-x
. [PMID: 21706316] - Domenic A Sica, Barry Carter, William Cushman, Lee Hamm. Thiazide and loop diuretics.
Journal of clinical hypertension (Greenwich, Conn.).
2011 Sep; 13(9):639-43. doi:
10.1111/j.1751-7176.2011.00512.x
. [PMID: 21896142] - Kinge van der Heide, Ann de Haes, Götz Jk Wietasch, Ans Cp Wiesfeld, Herman Gd Hendriks. Torsades de pointes during laparoscopic adrenalectomy of a pheochromocytoma: a case report.
Journal of medical case reports.
2011 Aug; 5(?):368. doi:
10.1186/1752-1947-5-368
. [PMID: 21838875] - Mohammad A Tahir, Olga Dmitrieva, Simon de Lusignan, Jeremy van Vlymen, Tom Chan, Ramez Golmohamad, Kevin Harris, Charles Tomson, Nicola Thomas, Hugh Gallagher. Confidence and quality in managing CKD compared with other cardiovascular diseases and diabetes mellitus: a linked study of questionnaire and routine primary care data.
BMC family practice.
2011 Aug; 12(?):83. doi:
10.1186/1471-2296-12-83
. [PMID: 21819552] - S V Tomov, P A Flume, A E Stenbit, M E Ullian. Prerenal azotemia from excessive sweating in an adult with a cystic fibrosis gene mutation.
Indian journal of nephrology.
2011 Jul; 21(3):194-7. doi:
10.4103/0971-4065.82637
. [PMID: 21886981] - Jae-Wook Chung, Seock Hwan Choi, Bum Soo Kim, Tae-Hwan Kim, Eun Sang Yoo, Chun Il Kim, Kyung Seop Lee, Tae Gyun Kwon. Efficacy and Tolerability of Tamsulosin 0.4 mg in Patients with Symptomatic Benign Prostatic Hyperplasia.
Korean journal of urology.
2011 Jul; 52(7):479-84. doi:
10.4111/kju.2011.52.7.479
. [PMID: 21860769] - F J Martinez-Martin, H Rodriguez-Rosas, I Peiro-Martinez, P Soriano-Perera, P Pedrianes-Martin, C Comi-Diaz. Olmesartan/amlodipine vs olmesartan/hydrochlorothiazide in hypertensive patients with metabolic syndrome: the OLAS study.
Journal of human hypertension.
2011 Jun; 25(6):346-53. doi:
10.1038/jhh.2010.104
. [PMID: 21107432] - Martin Johansson. Lord of the rings: a promising novel treatment for renal cell carcinoma?.
European urology.
2011 May; 59(5):745-6. doi:
10.1016/j.eururo.2011.01.024
. [PMID: 21276657] - Shinichi Sakamoto, Steven Schwarze, Natasha Kyprianou. Anoikis disruption of focal adhesion-Akt signaling impairs renal cell carcinoma.
European urology.
2011 May; 59(5):734-44. doi:
10.1016/j.eururo.2010.12.038
. [PMID: 21269758] - Wei Gan, Shao-Feng Zhang, Hong-Tao Jia, Sheng Xie, Mao-Hua Luo, Yun-Fei Li. [Tolterodine tartrate combined with alpha-receptor blocker for benign prostatic hyperplasia with detrusor overactivity].
Zhonghua nan ke xue = National journal of andrology.
2011 Apr; 17(4):348-50. doi:
. [PMID: 21548214]
- Kazuomi Kario. [Series, clinical study from Japan and its reflections; Japan Morning Surge-1 (JMS-1) study].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.
2011 Feb; 100(2):524-30. doi:
10.2169/naika.100.524
. [PMID: 21400896] - Richard Sherva, Charles E Ford, John H Eckfeldt, Barry R Davis, Eric Boerwinkle, Donna K Arnett. Pharmacogenetic effect of the stromelysin (MMP3) polymorphism on stroke risk in relation to antihypertensive treatment: the genetics of hypertension associated treatment study.
Stroke.
2011 Feb; 42(2):330-5. doi:
10.1161/strokeaha.110.593798
. [PMID: 21183746] - R Morimoto, M Kudo, O Murakami, K Takase, S Ishidoya, Y Nakamura, T Ishibashi, S Takahashi, Y Arai, T Suzuki, H Sasano, S Ito, F Satoh. Difficult-to-control hypertension due to bilateral aldosterone-producing adrenocortical microadenomas associated with a cortisol-producing adrenal macroadenoma.
Journal of human hypertension.
2011 Feb; 25(2):114-21. doi:
10.1038/jhh.2010.35
. [PMID: 20463748] - M Heras, A Saiz, J Pardo, M J Fernández-Reyes, R Sánchez, F Alvarez-Ude. [Rapidly progressive renal failure as the onset of an IgA nephropathy in an elderly patient].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2011; 31(2):234-6. doi:
10.3265/nefrologia.pre2010.nov.10661
. [PMID: 21461025] - Alice Dillard, Nirupa R Matthan, Alice H Lichtenstein. Use of hamster as a model to study diet-induced atherosclerosis.
Nutrition & metabolism.
2010 Dec; 7(?):89. doi:
10.1186/1743-7075-7-89
. [PMID: 21143982] - He Xiao, Han-Zhong Li, Zhong-Ming Huang, Yong-Qiang Li. [Clinical effectiveness and safety of combined therapy with an alpha-blocker and an anticholinergic drug for patients with benign prostatic hyperplasia].
Zhonghua wai ke za zhi [Chinese journal of surgery].
2010 Dec; 48(23):1771-3. doi:
NULL
. [PMID: 21211380] - Ki Hong Kim, Young Sig Kim. Correlation of male overactive bladder with intravesical prostatic protrusion.
Korean journal of urology.
2010 Dec; 51(12):843-6. doi:
10.4111/kju.2010.51.12.843
. [PMID: 21221204] - Yu-Chun Zhou, Guo-Shou Xia, Yu-Yang Xue, Xin-Dong Zhang, Lian-Wen Zheng, Bao-Fang Jin. [Kidney-tonifying and dampness-expelling Chinese herbal medicine combined with doxazosin for the treatment of chronic epididymitis].
Zhonghua nan ke xue = National journal of andrology.
2010 Dec; 16(12):1143-6. doi:
"
. [PMID: 21348207] - Lukáš Chytil, Branislav Strauch, Josef Cvačka, Věra Marešová, Jiří Widimský, Robert Holaj, Ondřej Slanař. Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: application to document non-compliance of patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Nov; 878(30):3167-73. doi:
10.1016/j.jchromb.2010.09.032
. [PMID: 20974552] - Peng Zhang, Zhi-Jin Wu, Yong Yang, Xiao-Dong Zhang. [Clinical efficacy of a short-term regimen of Cardura XL on lower urinary tract symptoms and international prognostic scoring system in the treatment of benign prostatic hyperplasia].
Zhonghua yi xue za zhi.
2010 Nov; 90(40):2826-9. doi:
NULL
. [PMID: 21162792] - James Tacklind, Howard A Fink, Roderick Macdonald, Indy Rutks, Timothy J Wilt. Finasteride for benign prostatic hyperplasia.
The Cochrane database of systematic reviews.
2010 Oct; ?(10):CD006015. doi:
10.1002/14651858.cd006015.pub3
. [PMID: 20927745]