gemfibrozil (BioDeep_00000397811)
Main id: BioDeep_00000002443
代谢物信息卡片
gemfibrozil
化学式: C15H22O3 (250.1568862)
中文名称: 吉非罗齐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
InChI: InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98150 - Fibrate Antilipidemic Agent
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065687 - Cytochrome P-450 CYP2C8 Inhibitors
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AB - Fibrates
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3071
Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.
同义名列表
2 个代谢物同义名
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:5296
- KEGG: C07020
- KEGGdrug: D00334
- KEGGdrug: D83091
- PubChem: 3463
- DrugBank: DB01241
- ChEMBL: CHEMBL457
- MeSH: Gemfibrozil
- CAS: 114413-98-8
- CAS: 25812-30-0
- MoNA: EQ307156
- MoNA: EQ307155
- MoNA: EQ307154
- MoNA: EQ307153
- MoNA: EQ307152
- MoNA: EQ307151
- MoNA: EQ307106
- MoNA: EQ307105
- MoNA: EQ307104
- MoNA: EQ307103
- MoNA: EQ307102
- MoNA: EQ307101
- PubChem: 9232
- PDB-CCD: 4TX
- RefMet: Gemfibrozil
- medchemexpress: HY-B0258
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kathryn L Linge, Yolanta Gruchlik, Francesco Busetti, Una Ryan, Cynthia A Joll. Use of micropollutant indicator ratios to characterize wastewater treatment plant efficiency and to identify wastewater impact on groundwater.
Journal of environmental management.
2024 May; 358(?):120822. doi:
10.1016/j.jenvman.2024.120822. [PMID: 38599088] - Anne Kuebart, Katharina Gross, Charlotte Maicher, Max Sonnenschein, Annika Raupach, Jan Schulz, Richard Truse, Stefan Hof, Carsten Marcus, Christian Vollmer, Inge Bauer, Olaf Picker, Borna Relja, Anna Herminghaus. Gemfibrozil Improves Microcirculatory Oxygenation of Colon and Liver without Affecting Mitochondrial Function in a Model of Abdominal Sepsis in Rats.
International journal of molecular sciences.
2023 Dec; 25(1):. doi:
10.3390/ijms25010262. [PMID: 38203431] - Sumita Raha, Debashis Dutta, Ramesh K Paidi, Kalipada Pahan. Lipid-Lowering Drug Gemfibrozil Protects Mice from Tay-Sachs Disease via Peroxisome Proliferator-Activated Receptor α.
Cells.
2023 12; 12(24):. doi:
10.3390/cells12242791. [PMID: 38132111] - Hugo Alarie, Nadia Côté, Luc Gaudreau, Magali Houde, Pedro A Segura. Are 20-hydroxyecdysone and related genes potential biomarkers of sublethal exposure to lipid-altering contaminants?.
Environmental science and pollution research international.
2023 Dec; 30(60):126104-126115. doi:
10.1007/s11356-023-31087-2. [PMID: 38010540] - Mehraveh Sadeghi Ivraghi, Mohammad Yasin Zamanian, Reena Gupta, Harun Achmad, Hashem O Alsaab, Ahmed Hjazi, Rosario Mireya Romero-Parra, Enas R Alwaily, Beneen M Hussien, Elham Hakimizadeh. Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms.
CNS neuroscience & therapeutics.
2023 Oct; ?(?):. doi:
10.1111/cns.14473. [PMID: 37904726] - Nan Wang, Yujing Zhao, Meiyan Wu, Na Li, Chaoying Yan, Hongyan Guo, Qiao Li, Qing Li, Qiang Wang. Gemfibrozil Alleviates Cognitive Impairment by Inhibiting Ferroptosis of Astrocytes via Restoring the Iron Metabolism and Promoting Antioxidant Capacity in Type 2 Diabetes.
Molecular neurobiology.
2023 Sep; ?(?):. doi:
10.1007/s12035-023-03589-0. [PMID: 37697219] - Débora Jesabel Pérez, Lucas Rodrigo Lombardero, William Joseph Doucette. Influence of exposure time, physicochemical properties, and plant transpiration on the uptake dynamics and translocation of pharmaceutical and personal care products in the aquatic macrophyte Typha latifolia.
The Science of the total environment.
2023 Jun; ?(?):165107. doi:
10.1016/j.scitotenv.2023.165107. [PMID: 37364828] - Neha Kamal, Raveendran Sindhu, Preeti Chaturvedi Bhargava. Biodegradation of emerging organic pollutant gemfibrozil: Mechanism, kinetics and pathway modelling.
Bioresource technology.
2023 Apr; 374(?):128749. doi:
10.1016/j.biortech.2023.128749. [PMID: 36796732] - Laongdao Thongnak, Nattavadee Pengrattanachot, Sasivimon Promsan, Nichakorn Phengpol, Prempree Sutthasupha, Krit Jaikumkao, Anusorn Lungkaphin. Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway.
Archives of pharmacal research.
2023 Mar; ?(?):. doi:
10.1007/s12272-023-01439-0. [PMID: 36966452] - Venkateswarlu Korthikunta, Rohit Singh, Rohit Srivastava, Jyotsana Pandey, Atul Srivastava, Upma Chaturvedi, Akansha Mishra, Arvind K Srivastava, Akhilesh K Tamrakar, Narender Tadigoppula. Design, synthesis, and evaluation of benzofuran-based chromenochalcones for antihyperglycemic and antidyslipidemic activities.
RSC medicinal chemistry.
2023 Mar; 14(3):470-481. doi:
10.1039/d2md00341d. [PMID: 36970150] - Mohammad Ali Karimi, Mehdi Goudarzi, Mohammad Javad Khodayar, Layasadat Khorsandi, Saeed Mehrzadi, Iman Fatemi. Gemfibrozil palliates adriamycin-induced testicular injury in male rats via modulating oxidative, endocrine and inflammatory changes in rats.
Tissue & cell.
2023 Feb; 82(?):102037. doi:
10.1016/j.tice.2023.102037. [PMID: 36863109] - Cornel Manuel Bachmann, Daniel Janitschke, Anna Andrea Lauer, Tobias Erhardt, Tobias Hartmann, Marcus Otto Walter Grimm, Heike Sabine Grimm. Gemfibrozil-Induced Intracellular Triglyceride Increase in SH-SY5Y, HEK and Calu-3 Cells.
International journal of molecular sciences.
2023 Feb; 24(3):. doi:
10.3390/ijms24032972. [PMID: 36769295] - Malabendu Jana, Debashis Dutta, Jit Poddar, Kalipada Pahan. Activation of PPARα exhibits therapeutic efficacy in a mouse model of juvenile neuronal ceroid lipofuscinosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2023 Jan; ?(?):. doi:
10.1523/jneurosci.2447-21.2023. [PMID: 36697260] - Elham Hakimizadeh, Saeedeh Tadayon, Mohammad Yasin Zamanian, Afsaneh Soltani, Lydia Giménez-Llort, Mahsa Hassanipour, Iman Fatemi. Gemfibrozil, a lipid-lowering drug, improves hepatorenal damages in a mouse model of aging.
Fundamental & clinical pharmacology.
2023 Jan; ?(?):. doi:
10.1111/fcp.12865. [PMID: 36600528] - Trinita K Barboza, Leonardo Susta, Alex Zur Linden, Sara Gardhouse, Hugues Beaufrère. Association of plasma metabolites and diagnostic imaging findings with hepatic lipidosis in bearded dragons (Pogona vitticeps) and effects of gemfibrozil therapy.
PloS one.
2023; 18(2):e0274060. doi:
10.1371/journal.pone.0274060. [PMID: 36735707] - Muhammad Hassan Naeem Goraya, Ehsan Ul Haq Abbasi, Muhammad Kashif Amin, Faisal Inayat, Muhammad Junaid Ashraf, Mahrukh Qayyum, Nadeem Hussain, Gul Nawaz, Muhammad Adnan Zaman, Adnan Malik. Acute pancreatitis secondary to tamoxifen-associated hypertriglyceridemia: A clinical update.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2023 Jan; 29(1):218-225. doi:
10.1177/10781552221093969. [PMID: 35410558] - Sanjeeb Mohapatra, Daniel Snow, Patrick Shea, Andy Gálvez-Rodríguez, Manish Kumar, Lokesh P Padhye, Suparna Mukherji. Photodegradation of a mixture of five pharmaceuticals commonly found in wastewater: Experimental and computational analysis.
Environmental research.
2023 01; 216(Pt 3):114659. doi:
10.1016/j.envres.2022.114659. [PMID: 36328221] - Halina Falfushynska, Dmytro Poznanskyi, Nadiia Kasianchuk, Oksana Horyn, Oksana Bodnar. Multimarker Responses of Zebrafish to the Effect of Ibuprofen and Gemfibrozil in Environmentally Relevant Concentrations.
Bulletin of environmental contamination and toxicology.
2022 Dec; 109(6):1010-1017. doi:
10.1007/s00128-022-03607-2. [PMID: 36074127] - Jielin Xu, Chengsheng Mao, Yuan Hou, Yuan Luo, Jessica L Binder, Yadi Zhou, Lynn M Bekris, Jiyoung Shin, Ming Hu, Fei Wang, Charis Eng, Tudor I Oprea, Margaret E Flanagan, Andrew A Pieper, Jeffrey Cummings, James B Leverenz, Feixiong Cheng. Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer's disease.
Cell reports.
2022 11; 41(9):111717. doi:
10.1016/j.celrep.2022.111717. [PMID: 36450252] - Manish B Shah. Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges.
Biomolecules.
2022 09; 12(9):. doi:
10.3390/biom12091218. [PMID: 36139056] - Min Zhao, Junzu Shi, Wei Li, Chunjing Guan, Chen Sun, Ying Peng, Jiang Zheng. Metabolic Activation of Gemfibrozil Mediated by Cytochrome P450 Enzymes and Sulfotransferases.
Chemical research in toxicology.
2022 07; 35(7):1257-1266. doi:
10.1021/acs.chemrestox.2c00054. [PMID: 35763595] - Elham Hakimizadeh, Mohammad Yassin Zamanian, Vitaliy Viktorovich Borisov, Lydia Giménez-Llort, Vahid Ehsani, Ayat Kaeidi, Jalal Hassanshahi, Fatemeh Khajehasani, Sajjadeh Movahedinia, Iman Fatemi. Gemfibrozil, a lipid-lowering drug, reduces anxiety, enhances memory, and improves brain oxidative stress in d-galactose-induced aging mice.
Fundamental & clinical pharmacology.
2022 Jun; 36(3):501-508. doi:
10.1111/fcp.12752. [PMID: 34989025] - Stefano Liberi, Sara Linciano, Giulia Moro, Luca De Toni, Laura Cendron, Alessandro Angelini. Structural Analysis of Human Serum Albumin in Complex with the Fibrate Drug Gemfibrozil.
International journal of molecular sciences.
2022 Feb; 23(3):. doi:
10.3390/ijms23031769. [PMID: 35163693] - Limei Hu, Rui Ding, Xiangping Nie. Comparison of toxic effects of atorvastatin and gemfibrozil on Daphnia magna.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2022 Feb; 252(?):109224. doi:
10.1016/j.cbpc.2021.109224. [PMID: 34756985] - Xinli Han, Qianying Lv, Haimei Liu, Rufeng Dai, Jiaojiao Liu, Qian Shen, Li Sun, Jia Rao, Jing Chen, Yihui Zhai, Hong Xu. PPARα agonist exerts protective effects in podocyte injury via inhibition of the ANGPTL3 pathway.
Experimental cell research.
2021 10; 407(2):112753. doi:
10.1016/j.yexcr.2021.112753. [PMID: 34499887] - Nina Hanke, José David Gómez-Mantilla, Naoki Ishiguro, Peter Stopfer, Valerie Nock. Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions.
Pharmaceutical research.
2021 Oct; 38(10):1645-1661. doi:
10.1007/s11095-021-03109-6. [PMID: 34664206] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Carl G Gottschalk, Malabendu Jana, Avik Roy, Dhruv R Patel, Kalipada Pahan. Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease via PPARα-Dependent Astrocytic GDNF Pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2021 03; 41(10):2287-2300. doi:
10.1523/jneurosci.3018-19.2021. [PMID: 33514677] - Mohsen Zabihi, Fatemeh Askarian, Seyedhossein Hekmatimoghaddam, Mohammad Sajjad Zabihi, Firouzeh Vahidi. Combination of atorvastatin and gemfibrozil plus physical activity: an animal model of statin/fibrate-induced myopathy.
Somatosensory & motor research.
2021 03; 38(1):90-94. doi:
10.1080/08990220.2020.1846514. [PMID: 33263458] - Nabil N Al-Hashimi, Majed H Shtaiwi, Saja H Hamed, Amjad H El-Sheikh, Rand O Shahin, Linda S Banisakher, Dua'a M Tahboub. Development of Dioctyl Phthalate@Fe3O4 Nanocomposite Reinforced Hollow Fiber Solid/ Liquid Phase Microextraction Followed by HPLC-DAD for the Determination of Atorvastatin and Gemfibrozil in Human Urine.
Pharmaceutical nanotechnology.
2021; 9(5):372-382. doi:
10.2174/2211738510666211222113358. [PMID: 34951377] - Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue.
Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1. [PMID: 32808185] - Azam Hosseinzadeh, Mehdi Goudarzi, Iman Fatemi, Mohammad Javad Khodayar, Saeed Mehrzadi, Hamid Reza Khalili, Mohammad Ali Karimi. Gemfibrozil attenuates doxorubicin induced toxicity in renal tissues of male rats by reducing the oxidative insult and inflammation.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2020 Oct; 95(7):532-539. doi:
10.1080/10520295.2020.1730967. [PMID: 32242747] - Z-J Zhang, Y-H Yuan, M-S Ma, Y-H Hong, Z-X Sun, Y-W Xu, M Wei, Z-Q Qiu. Lipid status and linear relationship between total cholesterol and triglycerides in glycogen storage disease type I.
European review for medical and pharmacological sciences.
2020 10; 24(19):10036-10044. doi:
10.26355/eurrev_202010_23218. [PMID: 33090409] - Jonathan Q Tran, Peijin Zhang, Atalanta Ghosh, Liangang Liu, Mary Syto, Xiaomin Wang, Maria Palmisano. Single-Dose Pharmacokinetics of Ozanimod and its Major Active Metabolites Alone and in Combination with Gemfibrozil, Itraconazole, or Rifampin in Healthy Subjects: A Randomized, Parallel-Group, Open-Label Study.
Advances in therapy.
2020 10; 37(10):4381-4395. doi:
10.1007/s12325-020-01473-0. [PMID: 32857315] - Nicolette E Andrzejczyk, Justin B Greer, Eric Nelson, Junqian Zhang, John M Rimoldi, Rama S V Gadepalli, Isaiah Edwards, Daniel Schlenk. Novel Disinfection Byproducts Formed from the Pharmaceutical Gemfibrozil Are Bioaccumulative and Elicit Increased Toxicity Relative to the Parent Compound in Marine Polychaetes (Neanthes arenaceodentata).
Environmental science & technology.
2020 09; 54(18):11127-11136. doi:
10.1021/acs.est.0c01080. [PMID: 32794702] - Yuan Luo, Chun-Ting Hu, Fang Qiao, Xiao-Dan Wang, Jian G Qin, Zhen-Yu Du, Li-Qiao Chen. Gemfibrozil improves lipid metabolism in Nile tilapia Oreochromis niloticus fed a high-carbohydrate diet through peroxisome proliferator activated receptor-α activation.
General and comparative endocrinology.
2020 09; 296(?):113537. doi:
10.1016/j.ygcen.2020.113537. [PMID: 32540489] - Gabriel Rufino Estrela, Adriano Cleis Arruda, Heron Fernandes Vieira Torquato, Leandro Ceotto Freitas-Lima, Mauro Sérgio Perilhão, Frederick Wasinski, Alexandre Budu, Ricardo Ambrósio Fock, Edgar Julian Paredes-Gamero, Ronaldo Carvalho Araujo. Gemfibrozil Induces Anemia, Leukopenia and Reduces Hematopoietic Stem Cells via PPAR-α in Mice.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21145050. [PMID: 32708962] - Jing Han, Junjie Fu, Qimeng Yang, Feng Zhou, Xinyu Chen, Chenglin Li, Jian Yin. Rational design and biological evaluation of gemfibrozil modified Xenopus GLP-1 derivatives as long-acting hypoglycemic agents.
European journal of medicinal chemistry.
2020 Jul; 198(?):112389. doi:
10.1016/j.ejmech.2020.112389. [PMID: 32388115] - Yu Yang, Yu Zhao, Wenzhen Li, Yuyao Wu, Xin Wang, Yijie Wang, Tingmei Liu, Tinghong Ye, Yongmei Xie, Zhiqiang Cheng, Jun He, Peng Bai, Yiwen Zhang, Liang Ouyang. Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment.
European journal of medicinal chemistry.
2020 Jul; 197(?):112311. doi:
10.1016/j.ejmech.2020.112311. [PMID: 32339855] - Meral Kayıkçıoğlu, Shafa Shahbazova, Firdovsi İbrahimov, Levent Hürkan Can. Cumulative non-HDL-cholesterol burden in patients with hypertriglyceridemia receiving long-term fibrate therapy: Real life data from a lipid clinic cohort.
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir.
2020 06; 48(4):359-367. doi:
10.5543/tkda.2019.25169. [PMID: 32519982] - Meera Tugnait, Neeraj Gupta, Michael J Hanley, Daryl Sonnichsen, David Kerstein, David J Dorer, Karthik Venkatakrishnan, Narayana Narasimhan. Effects of Strong CYP2C8 or CYP3A Inhibition and CYP3A Induction on the Pharmacokinetics of Brigatinib, an Oral Anaplastic Lymphoma Kinase Inhibitor, in Healthy Volunteers.
Clinical pharmacology in drug development.
2020 02; 9(2):214-223. doi:
10.1002/cpdd.723. [PMID: 31287236] - Adriano Cleis Arruda, Mauro Sérgio Perilhão, Warley Almeida Santos, Marcos Fernandes Gregnani, Alexandre Budu, José Cesar Rosa Neto, Gabriel Rufino Estrela, Ronaldo Carvalho Araujo. PPARα-Dependent Modulation by Metformin of the Expression of OCT-2 and MATE-1 in the Kidney of Mice.
Molecules (Basel, Switzerland).
2020 Jan; 25(2):. doi:
10.3390/molecules25020392. [PMID: 31963528] - Yumiko Mizukawa, Yoko Amagase, Tetsuro Urushidani. Extraction of peroxisome proliferator-activated receptor α agonist-induced lipid metabolism-related and unrelated genes in rat liver and analysis of their genomic location.
The Journal of toxicological sciences.
2020; 45(8):449-473. doi:
10.2131/jts.45.449. [PMID: 32741897] - Jean-Charles Fruchart, Raul D Santos. SPPARM alpha: the Lazarus effect.
Current opinion in lipidology.
2019 12; 30(6):419-427. doi:
10.1097/mol.0000000000000640. [PMID: 31577610] - Denise Türk, Nina Hanke, Sarah Wolf, Sebastian Frechen, Thomas Eissing, Thomas Wendl, Matthias Schwab, Thorsten Lehr. Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug-Drug-Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole.
Clinical pharmacokinetics.
2019 12; 58(12):1595-1607. doi:
10.1007/s40262-019-00777-x. [PMID: 31129789] - Tianlang Zhang, Junlang Qiu, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. Uptake of pharmaceuticals acts as an abiotic stress and triggers variation of jasmonates in Malabar spinach (Basella alba. L).
Chemosphere.
2019 Dec; 236(?):124711. doi:
10.1016/j.chemosphere.2019.124711. [PMID: 31549668] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - M J Gallardo-Altamirano, P Maza-Márquez, N Montemurro, B Rodelas, F Osorio, C Pozo. Linking microbial diversity and population dynamics to the removal efficiency of pharmaceutically active compounds (PhACs) in an anaerobic/anoxic/aerobic (A2O) system.
Chemosphere.
2019 Oct; 233(?):828-842. doi:
10.1016/j.chemosphere.2019.06.017. [PMID: 31200141] - Roberta Natália Cestari, Adriana Rocha, Renê Donizeti Ribeiro de Oliveira, Vera Lucia Lanchote. UPLC-MS/MS method for gemfibrozil determination in plasma with application to a pharmacokinetic study in healthy Brazilian volunteers.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Sep; 1125(?):121712. doi:
10.1016/j.jchromb.2019.121712. [PMID: 31336317] - Y H Chen, Z Zhan, P Hu, H Ren, M L Peng. [A new attempt with lipoprotein lipase agonists in the treatment of nonalcoholic steatohepatitis].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2019 Jul; 27(7):533-540. doi:
10.3760/cma.j.issn.1007-3418.2019.07.011. [PMID: 31357780] - Shamaila Fraz, Abigail H Lee, Simon Pollard, Krishna Srinivasan, Abhilasha Vermani, Joanna Y Wilson. Parental gemfibrozil exposure impacts zebrafish F1 offspring, but not subsequent generations.
Aquatic toxicology (Amsterdam, Netherlands).
2019 Jul; 212(?):194-204. doi:
10.1016/j.aquatox.2019.04.020. [PMID: 31132737] - Katsuhito Watanabe, Shingo Oda, Akiko Matsubara, Sho Akai, Tsuyoshi Yokoi. Establishment and characterization of a mouse model of rhabdomyolysis by coadministration of statin and fibrate.
Toxicology letters.
2019 Jun; 307(?):49-58. doi:
10.1016/j.toxlet.2019.03.001. [PMID: 30853469] - Gowoon Lee, Sangwoo Lee, Nayoung Ha, Younglim Kho, Kyunghwa Park, Pilje Kim, Byeongwoo Ahn, Sunmi Kim, Kyungho Choi. Effects of gemfibrozil on sex hormones and reproduction related performances of Oryzias latipes following long-term (155 d) and short-term (21 d) exposure.
Ecotoxicology and environmental safety.
2019 May; 173(?):174-181. doi:
10.1016/j.ecoenv.2019.02.015. [PMID: 30772707] - Kentaro Konishi, Tsuyoshi Minematsu, Yasuhisa Nagasaka, Kenji Tabata. Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment.
Biopharmaceutics & drug disposition.
2019 May; 40(5-6):176-187. doi:
10.1002/bdd.2181. [PMID: 30985942] - Matti K Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J Neuvonen, Mikko Niemi, Janne T Backman. Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.
Drug metabolism and disposition: the biological fate of chemicals.
2019 04; 47(4):377-385. doi:
10.1124/dmd.118.084665. [PMID: 30630815] - Manish Bodas, Garrett Pehote, David Silverberg, Erich Gulbins, Neeraj Vij. Autophagy augmentation alleviates cigarette smoke-induced CFTR-dysfunction, ceramide-accumulation and COPD-emphysema pathogenesis.
Free radical biology & medicine.
2019 02; 131(?):81-97. doi:
10.1016/j.freeradbiomed.2018.11.023. [PMID: 30500419] - Habib Haybar, Mehdi Goudarzi, Saeed Mehrzadi, Azadeh Aminzadeh, Mohammad Javad Khodayar, Mojtaba Kalantar, Iman Fatemi. Effect of gemfibrozil on cardiotoxicity induced by doxorubicin in male experimental rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jan; 109(?):530-535. doi:
10.1016/j.biopha.2018.10.101. [PMID: 30551518] - Huiying Hua, Julin Yang, Hante Lin, Yang Xi, Manyun Dai, Gangming Xu, Fuyan Wang, Lihong Liu, Tingqi Zhao, Jing Huang, Frank J Gonzalez, Aiming Liu. PPARα-independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling.
The Journal of pharmacy and pharmacology.
2018 Dec; 70(12):1630-1642. doi:
10.1111/jphp.13014. [PMID: 30251457] - Safaa Behiry, Ahmed Rabie, Mahmoud Kora, Wesam Ismail, Dina Sabry, Ahmed Zahran. Effect of combination sildenafil and gemfibrozil on cisplatin-induced nephrotoxicity; role of heme oxygenase-1.
Renal failure.
2018 Nov; 40(1):371-378. doi:
10.1080/0886022x.2018.1455596. [PMID: 29707997] - Qiuguo Fu, Stacia Dudley, Chengliang Sun, Daniel Schlenk, Jay Gan. Stable Isotope Labeling-Assisted Metabolite Probing for Emerging Contaminants in Plants.
Analytical chemistry.
2018 09; 90(18):11040-11047. doi:
10.1021/acs.analchem.8b02807. [PMID: 30141618] - Walter Masson, Emiliano Rossi, Daniel Siniawski, Juan Damonte, Ana Halsband, Ramiro Barolo, Miguel Scaramal. Severe hypertriglyceridemia. Clinical characteristics and therapeutic management.
Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis.
2018 Sep; 30(5):217-223. doi:
10.1016/j.arteri.2018.03.005. [PMID: 29789213] - Joanna Doummar, Michel Aoun. Assessment of the origin and transport of four selected emerging micropollutants sucralose, Acesulfame-K, gemfibrozil, and iohexol in a karst spring during a multi-event spring response.
Journal of contaminant hydrology.
2018 08; 215(?):11-20. doi:
10.1016/j.jconhyd.2018.06.003. [PMID: 29983209] - A Barreto, L G Luis, P Paíga, L H M L M Santos, C Delerue-Matos, A M V M Soares, K Hylland, S Loureiro, M Oliveira. A multibiomarker approach highlights effects induced by the human pharmaceutical gemfibrozil to gilthead seabream Sparus aurata.
Aquatic toxicology (Amsterdam, Netherlands).
2018 Jul; 200(?):266-274. doi:
10.1016/j.aquatox.2018.05.012. [PMID: 29807214] - Xiujuan Kong, Zihao Wu, Ziran Ren, Kaiheng Guo, Shaodong Hou, Zhechao Hua, Xuchun Li, Jingyun Fang. Degradation of lipid regulators by the UV/chlorine process: Radical mechanisms, chlorine oxide radical (ClO•)-mediated transformation pathways and toxicity changes.
Water research.
2018 06; 137(?):242-250. doi:
10.1016/j.watres.2018.03.004. [PMID: 29550727] - Chamara Dalugama, Manoji Pathirage, S A M Kularatne. Delayed presentation of severe rhabdomyolysis leading to acute kidney injury following atorvastatin-gemfibrozil combination therapy: a case report.
Journal of medical case reports.
2018 May; 12(1):143. doi:
10.1186/s13256-018-1685-0. [PMID: 29784023] - Shamaila Fraz, Abigail H Lee, Joanna Y Wilson. Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio).
Aquatic toxicology (Amsterdam, Netherlands).
2018 May; 198(?):1-9. doi:
10.1016/j.aquatox.2018.02.006. [PMID: 29494825] - Yu-Fei Ni, Hao Wang, Qiu-Yan Gu, Fei-Ying Wang, Ying-Jie Wang, Jin-Liang Wang, Bo Jiang. Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system.
Journal of psychopharmacology (Oxford, England).
2018 04; 32(4):469-481. doi:
10.1177/0269881118762072. [PMID: 29534628] - W A Banks, S A Farr, T S Salameh, M L Niehoff, E M Rhea, J E Morley, A J Hanson, K M Hansen, S Craft. Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance.
International journal of obesity (2005).
2018 03; 42(3):391-397. doi:
10.1038/ijo.2017.231. [PMID: 28990588] - Dylan Steinkey, Ebrahim Lari, Samuel G Woodman, Kim H Luong, Charles S Wong, Greg G Pyle. Effects of gemfibrozil on the growth, reproduction, and energy stores of Daphnia magna in the presence of varying food concentrations.
Chemosphere.
2018 Feb; 192(?):75-80. doi:
10.1016/j.chemosphere.2017.10.124. [PMID: 29100124] - Shirin Bruderer, Marc Petersen-Sylla, Margaux Boehler, Tatiana Remeňová, Atef Halabi, Jasper Dingemanse. Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects.
British journal of clinical pharmacology.
2017 12; 83(12):2778-2788. doi:
10.1111/bcp.13379. [PMID: 28715853] - Mazhar Hussain, Muhammad Nauman Shad, Lubna Akhtar. Pioglitazone attenuates cardiometabolic risk factors in non-diabetic patients with dyslipidemia.
JPMA. The Journal of the Pakistan Medical Association.
2017 Dec; 67(12):1884-1888. doi:
NULL. [PMID: 29256535] - Min Luo, Manyun Dai, Hante Lin, Minzhu Xie, Jiao Lin, Aiming Liu, Julin Yang. Species-related exposure of phase II metabolite gemfibrozil 1-O-β-glucuronide between human and mice: A net induction of mouse P450 activity was revealed.
Biopharmaceutics & drug disposition.
2017 Dec; 38(9):535-542. doi:
10.1002/bdd.2105. [PMID: 28946176] - Cunzhong Shi, Luo Min, Julin Yang, Manyun Dai, Danjun Song, Huiying Hua, Gangming Xu, Frank J Gonzalez, Aiming Liu. Peroxisome Proliferator-Activated Receptor α Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil.
Basic & clinical pharmacology & toxicology.
2017 Sep; 121(3):169-174. doi:
10.1111/bcpt.12794. [PMID: 28374976] - A Barreto, L G Luis, A M V M Soares, P Paíga, L H M L M Santos, C Delerue-Matos, K Hylland, S Loureiro, M Oliveira. Genotoxicity of gemfibrozil in the gilthead seabream (Sparus aurata).
Mutation research. Genetic toxicology and environmental mutagenesis.
2017 Sep; 821(?):36-42. doi:
10.1016/j.mrgentox.2017.05.011. [PMID: 28735742] - Klaus H Hebig, Laura G Groza, Michelle J Sabourin, Traugott J Scheytt, Carol J Ptacek. Transport behavior of the pharmaceutical compounds carbamazepine, sulfamethoxazole, gemfibrozil, ibuprofen, and naproxen, and the lifestyle drug caffeine, in saturated laboratory columns.
The Science of the total environment.
2017 Jul; 590-591(?):708-719. doi:
10.1016/j.scitotenv.2017.03.031. [PMID: 28284639] - Kyeongsoon Kim, Hynda K Kleinman, Hahn-Jun Lee, Kalipada Pahan. Safety and potential efficacy of gemfibrozil as a supportive treatment for children with late infantile neuronal ceroid lipofuscinosis and other lipid storage disorders.
Orphanet journal of rare diseases.
2017 06; 12(1):113. doi:
10.1186/s13023-017-0663-8. [PMID: 28623936] - Arunava Ghosh, Suresh Babu Rangasamy, Khushbu K Modi, Kalipada Pahan. Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis.
Journal of neurochemistry.
2017 05; 141(3):423-435. doi:
10.1111/jnc.13987. [PMID: 28199020] - Ferena Sayar, Nasrin Akhondi, Soltanali Fallah, Amir Abbas Moalemnia, Azra Cheraghi. Association of Serum Triglyceride Level and Gemfibrozil Consumption With Periodontal Status.
Journal of periodontology.
2017 05; 88(5):457-463. doi:
10.1902/jop.2016.160366. [PMID: 27958766] - Beatriz Salesa, María D Ferrando, María J Villarroel, Encarna Sancho. Effect of the lipid regulator Gemfibrozil in the Cladocera Daphnia magna at different temperatures.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2017 Feb; 52(3):228-234. doi:
10.1080/10934529.2016.1246937. [PMID: 27835067] - Danjun Song, Min Luo, Manyun Dai, Shizhong Bu, Weihua Wang, Burong Zhang, Frank J Gonzalez, Aiming Liu. PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate.
Canadian journal of physiology and pharmacology.
2017 Feb; 95(2):199-205. doi:
10.1139/cjpp-2016-0140. [PMID: 27918198] - Vandana Panda, Kinjal Mistry, S Sudhamani, Mukesh Nandave, Shreesh Kumar Ojha. Amelioration of Abnormalities Associated with the Metabolic Syndrome by Spinacia oleracea (Spinach) Consumption and Aerobic Exercise in Rats.
Oxidative medicine and cellular longevity.
2017; 2017(?):2359389. doi:
10.1155/2017/2359389. [PMID: 28798859] - Aleksi Tornio, Pertti J Neuvonen, Mikko Niemi, Janne T Backman. Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters.
Expert opinion on drug metabolism & toxicology.
2017 Jan; 13(1):83-95. doi:
10.1080/17425255.2016.1227791. [PMID: 27548563] - Tobias Jakob, Alain J Nordmann, Stefan Schandelmaier, Ignacio Ferreira-González, Matthias Briel. Fibrates for primary prevention of cardiovascular disease events.
The Cochrane database of systematic reviews.
2016 11; 11(?):CD009753. doi:
10.1002/14651858.cd009753.pub2. [PMID: 27849333] - Aziz A Al-Habsi, Andrey Massarsky, Thomas W Moon. Exposure to gemfibrozil and atorvastatin affects cholesterol metabolism and steroid production in zebrafish (Danio rerio).
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2016 Sep; 199(?):87-96. doi:
10.1016/j.cbpb.2015.11.009. [PMID: 26627126] - Jingshuai Ma, Wenying Lv, Ping Chen, Yida Lu, Fengliang Wang, Fuhua Li, Kun Yao, Guoguang Liu. Photodegradation of gemfibrozil in aqueous solution under UV irradiation: kinetics, mechanism, toxicity, and degradation pathways.
Environmental science and pollution research international.
2016 Jul; 23(14):14294-306. doi:
10.1007/s11356-016-6451-5. [PMID: 27055889] - Seung Jun Yang, Bong Jin Kim, Lingxuan Mo, Hyo-Kyung Han. Alteration of the intravenous and oral pharmacokinetics of valsartan via the concurrent use of gemfibrozil in rats.
Biopharmaceutics & drug disposition.
2016 Jul; 37(5):245-51. doi:
10.1002/bdd.2001. [PMID: 26663350] - Juan Antonio Martín-Navarro, Vladimir Petkov-Stoyanov, María José Gutiérrez-Sánchez, Luis Pedraza-Cezón. Acute renal failure secondary to interstitial acute nephritis and Fanconi syndrome for metamizole and gemfibrozil.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2016 May; 36(3):321-3. doi:
10.1016/j.nefro.2015.06.022. [PMID: 26306948] - Rui-Lin Liu, Zhi-Qi Zhang, Wang-Hui Jing, Lu Wang, Zhi-Min Luo, Rui-Miao Chang, Ai-Guo Zeng, Wei Du, Chun Chang, Qiang Fu. β-Cyclodextrin anchoring onto pericarpium granati-derived magnetic mesoporous carbon for selective capture of lopid in human serum and pharmaceutical wastewater samples.
Materials science & engineering. C, Materials for biological applications.
2016 May; 62(?):605-13. doi:
10.1016/j.msec.2016.02.004. [PMID: 26952464] - Barbara S Wiggins, Joseph J Saseen, Pamela B Morris. Gemfibrozil in Combination with Statins-Is It Really Contraindicated?.
Current atherosclerosis reports.
2016 Apr; 18(4):18. doi:
10.1007/s11883-016-0571-8. [PMID: 26932225] - Minho Hong, Ki Duk Song, Hak-Kyo Lee, SunShin Yi, Yong Seok Lee, Tae-Hwe Heo, Hyun Sik Jun, Sung-Jo Kim. Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential.
In vitro cellular & developmental biology. Animal.
2016 Mar; 52(3):349-355. doi:
10.1007/s11626-015-9979-7. [PMID: 26659390] - Henrik Kjeldal, Nicolette A Zhou, Dirk K Wissenbach, Martin von Bergen, Heidi L Gough, Jeppe L Nielsen. Genomic, Proteomic, and Metabolite Characterization of Gemfibrozil-Degrading Organism Bacillus sp. GeD10.
Environmental science & technology.
2016 Jan; 50(2):744-55. doi:
10.1021/acs.est.5b05003. [PMID: 26683816] - Zahra Kashi, Abdolkarim Mahrooz, Anvarsadat Kianmehr, Ahad Alizadeh. The Role of Metformin Response in Lipid Metabolism in Patients with Recent-Onset Type 2 Diabetes: HbA1c Level as a Criterion for Designating Patients as Responders or Nonresponders to Metformin.
PloS one.
2016; 11(3):e0151543. doi:
10.1371/journal.pone.0151543. [PMID: 26978661] - Sophie Bussière-Côté, Teye Omlin, Eliana de Càssia Pinheiro, Jean-Michel Weber. Gemfibrozil disrupts the metabolism of circulating lipids in bobwhite quails.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2016 Jan; 179(?):137-43. doi:
10.1016/j.cbpc.2015.09.011. [PMID: 26432161] - Dogan Kose, Nuriye Tarakci, Zeliha Esin Celik, Husamettin Vatansev, Emine Ayca Cimbek, Serdar Ugras, Yasar Sen, Umran Caliskan, Yavuz Koksal. Effects of Prednisolone, L-Asparaginase, Gemfibrozil, and Combinations of These Elements on Mice Lipid Profile, Liver, and Pancreas.
Journal of pediatric hematology/oncology.
2016 Jan; 38(1):e42-9. doi:
10.1097/mph.0000000000000484. [PMID: 26599986] - Jorge F Henriques, Ana Rita Almeida, Thayres Andrade, Olga Koba, Oksana Golovko, Amadeu M V M Soares, Miguel Oliveira, Inês Domingues. Effects of the lipid regulator drug gemfibrozil: A toxicological and behavioral perspective.
Aquatic toxicology (Amsterdam, Netherlands).
2016 Jan; 170(?):355-364. doi:
10.1016/j.aquatox.2015.09.017. [PMID: 26482382] - Irina Iakovleva, Kristoffer Brännström, Lina Nilsson, Anna L Gharibyan, Afshan Begum, Intissar Anan, Malin Walfridsson, A Elisabeth Sauer-Eriksson, Anders Olofsson. Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma.
Journal of medicinal chemistry.
2015 Aug; 58(16):6507-15. doi:
10.1021/acs.jmedchem.5b00544. [PMID: 26214366] - Kutcharin Phunikhom, Kovit Khampitak, Chantana Aromdee, Tarinee Arkaravichien, Jintana Sattayasai. Effect of Andrographis paniculata Extract on Triglyceride Levels of the Patients with Hypertriglyceridemia: A Randomized Controlled Trial.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2015 Jul; 98 Suppl 6(?):S41-7. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2015 Jul; 43(7):1108-18. doi:
10.1124/dmd.115.064303. [PMID: 25941268] - I G Sharina, M Sobolevsky, A Papakyriakou, N Rukoyatkina, G A Spyroulias, S Gambaryan, E Martin. The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies.
British journal of pharmacology.
2015 May; 172(9):2316-29. doi:
10.1111/bph.13055. [PMID: 25536881]