5-Oxoete (BioDeep_00000397613)
Main id: BioDeep_00000003306
代谢物信息卡片
化学式: C20H30O3 (318.21948299999997)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 50%
分子结构信息
SMILES: C(O)(=O)CCCC(=O)/C=C/C=C\C/C=C\C/C=C\CCCCC
InChI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+
描述信息
An oxoicosatetraenoic acid having a 5-oxo group; and (6E)-, (8Z), (11Z)- and (14Z)-double bonds.
同义名列表
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:52449
- KEGG: C14732
- PubChem: 5283159
- ChEMBL: CHEMBL18028
- LipidMAPS: LMFA03060011
- CAS: 106154-18-1
- CAS: 126432-17-5
- MoNA: UT000189
- MoNA: UT000188
- MoNA: UT000187
- MoNA: UT000186
- MoNA: UT000185
- MoNA: UT000184
- MoNA: UT000183
- MoNA: UT000182
- MoNA: UT000181
- MetaboLights: MTBLC52449
- PubChem: 17395731
- NIKKAJI: J661.539B
- RefMet: 5-Oxo-ETE
分类词条
相关代谢途径
Reactome(10)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kenneth D Maus, Daniel J Stephenson, Anika N Ali, Henry Patrick MacKnight, Huey-Jing Huang, Jordi Serrats, Minjung Kim, Robert F Diegelmann, Charles E Chalfant. Ceramide kinase regulates acute wound healing by suppressing 5-oxo-ETE biosynthesis and signaling via its receptor OXER1.
Journal of lipid research.
2022 04; 63(4):100187. doi:
10.1016/j.jlr.2022.100187. [PMID: 35219746] - Roxana Coras, Arthur Kavanaugh, Angela Kluzniak, Dustina Holt, Amy Weilgosz, Armando Aaron, Oswald Quehenberger, Christopher Ritchlin, Monica Guma. Differences in oxylipin profile in psoriasis versus psoriatic arthritis.
Arthritis research & therapy.
2021 07; 23(1):200. doi:
10.1186/s13075-021-02575-y. [PMID: 34303373] - Qiong Lai, Guangying Yuan, Le Shen, Lu Zhang, Fei Fu, Zeliang Liu, Yuanyuan Zhang, Junping Kou, Shijia Liu, Boyang Yu, Fang Li. Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1.
Basic research in cardiology.
2021 01; 116(1):3. doi:
10.1007/s00395-021-00844-0. [PMID: 33484341] - Natalia Celejewska-Wójcik, Aleksander Kania, Karolina Górka, Paweł Nastałek, Krzysztof Wójcik, Anna Gielicz, Lucyna Mastalerz, Marek Sanak, Krzysztof Sładek. Eicosanoids and Eosinophilic Inflammation of Airways in Stable COPD.
International journal of chronic obstructive pulmonary disease.
2021 ; 16(?):1415-1424. doi:
10.2147/copd.s298678. [PMID: 34079245] - William S Powell, Joshua Rokach. Targeting the OXE receptor as a potential novel therapy for asthma.
Biochemical pharmacology.
2020 09; 179(?):113930. doi:
10.1016/j.bcp.2020.113930. [PMID: 32240653] - Marcin Banaszczak, Dominika Maciejewska, Arleta Drozd, Karina Ryterska, Dominika Jamioł Milc, Joanna Raszeja-Wyszomirska, Ewa Wunsch, Pedro González-Muniesa, Ewa Stachowska. 5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease.
Medicina (Kaunas, Lithuania).
2020 Feb; 56(2):. doi:
10.3390/medicina56020058. [PMID: 32028646] - Lisa A Miller, Chantal Cossette, Shishir Chourey, Qiuji Ye, Chintam Nagendra Reddy, Joshua Rokach, William S Powell. Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non-human primates.
British journal of pharmacology.
2020 01; 177(2):360-371. doi:
10.1111/bph.14872. [PMID: 31655023] - Marcin Surmiak, Anna Gielicz, Darko Stojkov, Rafał Szatanek, Katarzyna Wawrzycka-Adamczyk, Shida Yousefi, Hans-Uwe Simon, Marek Sanak. LTB4 and 5-oxo-ETE from extracellular vesicles stimulate neutrophils in granulomatosis with polyangiitis.
Journal of lipid research.
2020 01; 61(1):1-9. doi:
10.1194/jlr.m092072. [PMID: 31740445] - Isabel Neuman, Mariana Cooke, Nicolás Agustín Lemiña, Marcelo G Kazanietz, Fabiana Cornejo Maciel. 5-oxo-ETE activates migration of H295R adrenocortical cells via MAPK and PKC pathways.
Prostaglandins & other lipid mediators.
2019 10; 144(?):106346. doi:
10.1016/j.prostaglandins.2019.106346. [PMID: 31301403] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
10.1038/s41598-018-28477-9. [PMID: 29968805] - Gail E Grant, Joshua Rokach, William S Powell. 5-Oxo-ETE and the OXE receptor.
Prostaglandins & other lipid mediators.
2009 Sep; 89(3-4):98-104. doi:
10.1016/j.prostaglandins.2009.05.002. [PMID: 19450703] - Takeshi Hosoi, Yutaka Koguchi, Emiko Sugikawa, Aiko Chikada, Koji Ogawa, Naoki Tsuda, Naoki Suto, Shiho Tsunoda, Tomoyasu Taniguchi, Tetsuo Ohnuki. Identification of a novel human eicosanoid receptor coupled to G(i/o).
The Journal of biological chemistry.
2002 Aug; 277(35):31459-65. doi:
10.1074/jbc.m203194200. [PMID: 12065583] - J T O'Flaherty, J S Taylor, M J Thomas. Receptors for the 5-oxo class of eicosanoids in neutrophils.
The Journal of biological chemistry.
1998 Dec; 273(49):32535-41. doi:
10.1074/jbc.273.49.32535. [PMID: 9829988]