13-KODE (BioDeep_00000397606)

Main id: BioDeep_00000003301

 

natural product


代谢物信息卡片


(9Z,11E)-13-Oxooctadeca-9,11-dienoic acid

化学式: C18H30O3 (294.2195)
中文名称: 13-酮-9Z，11E-十八碳二烯酸
谱图信息: 最多检出来源 Mus musculus(blood) 7.05%

分子结构信息

SMILES: C(CCCCCCC/C=C\C=C\C(=O)CCCCC)(=O)O
InChI: InChI=1S/C18H30O3/c1-2-3-11-14-17(19)15-12-9-7-5-4-6-8-10-13-16-18(20)21/h7,9,12,15H,2-6,8,10-11,13-14,16H2,1H3,(H,20,21)/b9-7-,15-12+

描述信息

同义名列表

7 个代谢物同义名

(9Z,11E)-13-Oxooctadeca-9,11-dienoic acid; 13-keto-9Z,11E-octadecadienoic acid; 13-OXO-ODE; FA 18:3;O; 13-OxoODE; 13-KODE; 13-Keto-9Z,11E-octadecadienoic acid



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALOX5, CRYZ, CYP2B6, MYC, NFE2, PNPLA3, PPARG, RB1
Peripheral membrane protein 3 ALOX5, CYP1B1, CYP2B6
Endoplasmic reticulum membrane 6 CYP1B1, CYP2B6, FADS1, FADS2, HMOX1, PNPLA3
Nucleus 6 GABPA, HMOX1, MYC, NFE2, PPARG, RB1
cytosol 6 ALOX5, CRYZ, GPT, HMOX1, PPARG, RB1
nucleoplasm 7 ALOX5, GABPA, HMOX1, MYC, NFE2, PPARG, RB1
RNA polymerase II transcription regulator complex 2 NFE2, PPARG
Cell membrane 3 CYSLTR2, TNF, TRPV1
Cytoplasmic side 1 HMOX1
Multi-pass membrane protein 4 CYSLTR2, FADS1, FADS2, TRPV1
cell surface 1 TNF
Golgi membrane 1 INS
lysosomal membrane 1 EGF
neuronal cell body 2 TNF, TRPV1
Cytoplasm, cytosol 1 ALOX5
plasma membrane 5 CYSLTR2, EGF, FADS2, TNF, TRPV1
Membrane 8 CYP1B1, EGF, FADS1, FADS2, HMOX1, MYC, PNPLA3, TRPV1
extracellular exosome 3 CRYZ, EGF, GPT
endoplasmic reticulum 1 HMOX1
extracellular space 6 ALOX5, CXCL8, EGF, HMOX1, INS, TNF
perinuclear region of cytoplasm 3 ALOX5, HMOX1, PPARG
mitochondrion 3 CRYZ, CYP1B1, FADS1
protein-containing complex 1 MYC
intracellular membrane-bounded organelle 4 CYP1B1, CYP2B6, FADS1, PPARG
Microsome membrane 2 CYP1B1, CYP2B6
Secreted 2 CXCL8, INS
extracellular region 5 ALOX5, CXCL8, EGF, INS, TNF
mitochondrial outer membrane 1 HMOX1
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 2 TNF, TRPV1
nucleolus 1 MYC
recycling endosome 1 TNF
Single-pass type II membrane protein 2 PNPLA3, TNF
postsynaptic membrane 1 TRPV1
Cytoplasm, perinuclear region 1 ALOX5
Membrane raft 1 TNF
spindle 1 RB1
GABA-ergic synapse 1 TRPV1
PML body 2 NFE2, RB1
Postsynaptic cell membrane 1 TRPV1
receptor complex 1 PPARG
Cell projection, neuron projection 1 TRPV1
chromatin 5 GABPA, MYC, NFE2, PPARG, RB1
phagocytic cup 1 TNF
Nucleus, nucleolus 1 MYC
nuclear envelope 2 ALOX5, MYC
Nucleus envelope 1 ALOX5
endosome lumen 1 INS
Lipid droplet 1 PNPLA3
[Isoform 1]: Endoplasmic reticulum membrane 1 FADS1
Nucleus, nucleoplasm 1 MYC
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 2 ALOX5, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 ALOX5
platelet alpha granule lumen 1 EGF
transport vesicle 1 INS
RNA polymerase II transcription repressor complex 1 MYC
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
SWI/SNF complex 1 RB1
Single-pass type IV membrane protein 1 HMOX1
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
clathrin-coated endocytic vesicle membrane 1 EGF
protein-DNA complex 1 NFE2
Rough endoplasmic reticulum 1 MYC
[Isoform 2]: Endoplasmic reticulum membrane 1 FADS1
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
Nucleus intermembrane space 1 ALOX5
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • Navneet Kishore, Pradeep Kumar, Karuna Shanker, Akhilesh Kumar Verma. Human disorders associated with inflammation and the evolving role of natural products to overcome. European journal of medicinal chemistry. 2019 Oct; 179(?):272-309. doi: 10.1016/j.ejmech.2019.06.034. [PMID: 31255927]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Izabella Surowiec, Sandra Gouveia-Figueira, Judy Orikiiriza, Elisabeth Lindquist, Mari Bonde, Jimmy Magambo, Charles Muhinda, Sven Bergström, Johan Normark, Johan Trygg. The oxylipin and endocannabidome responses in acute phase Plasmodium falciparum malaria in children. Malaria journal. 2017 09; 16(1):358. doi: 10.1186/s12936-017-2001-y. [PMID: 28886714]
  • W Raphael, L Halbert, G A Contreras, L M Sordillo. Association between polyunsaturated fatty acid-derived oxylipid biosynthesis and leukocyte inflammatory marker expression in periparturient dairy cows. Journal of dairy science. 2014; 97(6):3615-25. doi: 10.3168/jds.2013-7656. [PMID: 24731638]
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  • Rosario Zamora, Emerenciana Gallardo, Francisco J Hidalgo. Strecker degradation of phenylalanine initiated by 2,4-decadienal or methyl 13-oxooctadeca-9,11-dienoate in model systems. Journal of agricultural and food chemistry. 2007 Feb; 55(4):1308-14. doi: 10.1021/jf062838x. [PMID: 17300152]
  • Stacy K Seeley, Julie A Poposki, John Maksimchuk, Jill Tebbe, Jon Gaudreau, Bengt Mannervik, Arthur W Bull. Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid. Biochimica et biophysica acta. 2006 Jul; 1760(7):1064-70. doi: 10.1016/j.bbagen.2006.02.020. [PMID: 16624487]
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  • A W Bull, J C Bronstein. Production of unsaturated carbonyl compounds during metabolism of hydroperoxy fatty acids by colonic homogenates. Carcinogenesis. 1990 Oct; 11(10):1699-704. doi: 10.1093/carcin/11.10.1699. [PMID: 2208585]