Telmisartan (BioDeep_00000397581)

Main id: BioDeep_00000001581

 

natural product


代谢物信息卡片


Telmisartan aka 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid

化学式: C33H30N4O2 (514.236864)
中文名称: 替米沙坦
谱图信息: 最多检出来源 Homo sapiens(blood) 0.3%

分子结构信息

SMILES: C1=C(C(=CC=C1)C2=CC=C(C=C2)CN3C(=NC4=C3C=C(C=C4C)C5N(C6=C(N=5)C=CC=C6)C)CCC)C(O)=O
InChI: InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)

描述信息

C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09C - Angiotensin ii receptor blockers (arbs), plain > C09CA - Angiotensin ii receptor blockers (arbs), plain
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C66930 - Angiotensin II Receptor Antagonist
D057911 - Angiotensin Receptor Antagonists > D047228 - Angiotensin II Type 1 Receptor Blockers
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 2251
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 63
CONFIDENCE standard compound; INTERNAL_ID 8191
This spectrum was obtained at The Multidisciplinary Research Laboratory at Antenor Orrego Private University, Trujillo, La Libertad, Peru.The sample was obtained from a pharmacy.; The sample was dissolved in 1:1 acetonitrile:water and passed through a ACQUITY UPLC BEH C18 1.7um column at 0.6 mL/min in ramp of MPA: 0.1\\\% Formic Acid in water; MPB: 0.1\\\% Formic Acid in Acetonitrile; Contact us: http://www.upao.edu.pe/labinm/
Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

同义名列表

4 个代谢物同义名

Telmisartan; Telmisartan aka 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid; Telmisartan (Micardis); BIBR 277



数据库引用编号

49 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • L I Liusheng, Zhao Mingming, Chang Meiying, S I Yuan, Zhao Jinning, Yang Bin, Zhang Yu. Protective effect of modified Huangqi Chifeng decoction on immunoglobulin A nephropathy through toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B signaling pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Apr; 44(2):324-333. doi: 10.19852/j.cnki.jtcm.20240203.001. [PMID: 38504538]
  • Lu Xu, Qin Zhao, Yiqiong Xie, Ge Bai, Hongwen Liu, Qi Chen, Hongjue Duan, Lishan Wang, Hang Xu, Yuxiang Sun, Gao Ling, Weihong Ge, Yun Zhu. Telmisartan loading thermosensitive hydrogel repairs gut epithelial barrier for alleviating inflammatory bowel disease. Colloids and surfaces. B, Biointerfaces. 2024 Apr; 236(?):113799. doi: 10.1016/j.colsurfb.2024.113799. [PMID: 38367290]
  • Radka Kodešová, Helena Švecová, Aleš Klement, Miroslav Fér, Antonín Nikodem, Ganna Fedorova, Oleksandra Rieznyk, Martin Kočárek, Alina Sadchenko, Alica Chroňáková, Roman Grabic. Contamination of water, soil, and plants by micropollutants from reclaimed wastewater and sludge from a wastewater treatment plant. The Science of the total environment. 2023 Oct; 907(?):167965. doi: 10.1016/j.scitotenv.2023.167965. [PMID: 37866592]
  • Noha A T Abbas, Fawkia A Fayed, Rabab Saber El Sebaey, Heba A Hassan. Telmisartan and candesartan promote browning of white adipose tissue and reverse fatty liver changes in high fat diet fed male albino rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Oct; ?(?):. doi: 10.1007/s00210-023-02771-4. [PMID: 37831115]
  • Tian Xia, Lu-Lu Xu, Peng-Yue Guo, Wan-Ting Shi, Yan-Qiong Cheng, Ai-Jun Liu. Synergism of amlodipine and telmisartan or candesartan on blood pressure reduction by using SynergyFinder 3.0 and probability sum test in vivo. Pharmacology research & perspectives. 2023 04; 11(2):e01064. doi: 10.1002/prp2.1064. [PMID: 36810974]
  • Himanshu Sankrityayan, Vishwadeep Shelke, Ajinath Kale, Anil Bhanudas Gaikwad. Evaluating the potential of tauroursodeoxycholic acid as add-on therapy in amelioration of streptozotocin-induced diabetic kidney disease. European journal of pharmacology. 2023 Mar; 942(?):175528. doi: 10.1016/j.ejphar.2023.175528. [PMID: 36690052]
  • Xin Guan, Jianbing Wu, Jiahui Geng, Duorui Ji, Dasha Wei, Yong Ling, Yihua Zhang, Guojun Jiang, Tao Pang, Zhangjian Huang. A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis. Translational stroke research. 2022 Dec; ?(?):. doi: 10.1007/s12975-022-01121-5. [PMID: 36577854]
  • Nirmal Aravindaraj, Jeseeta Suresh, Venkateshwaran Krishnaswami, Shanmugarathinam Alagarsamy, Ruckmani Kandasamy. Guar gum based oral films for hypertensive urgencies. Natural product research. 2022 Dec; 36(24):6470-6473. doi: 10.1080/14786419.2022.2039919. [PMID: 35167380]
  • Xiuhong Zhou, Ma Yire A Zezi, Dandan Li, Jian Wang. Telmisartan ameliorates LPS-induced pneumonia in rats through regulation of the PPARγ/NF-κB pathway. Microbiology and immunology. 2022 Jul; 66(7):371-378. doi: 10.1111/1348-0421.12981. [PMID: 35485217]
  • Yan Wang, Tengrui Zhang, Chen Li, Jia Guo, Baohui Xu, Lixiang Xue. Telmisartan attenuates human glioblastoma cells proliferation and oncogenicity by inducing the lipid oxidation. Asia-Pacific journal of clinical oncology. 2022 Jun; 18(3):217-223. doi: 10.1111/ajco.13574. [PMID: 33945216]
  • Vian Ahmed Wasta Esmail, Marwan S M Al-Nimer, Mohammed Omer Mohammed. Effects of Orlistat or Telmisartan on the Serum Free Fatty Acids in Non-alcoholic Fatty Liver Disease Patients: An Open-Labeled Randomized Controlled Study. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 2022 05; 33(5):421-426. doi: 10.5152/tjg.2020.19365. [PMID: 35678800]
  • B Rudresh Gowda, N Prakash, C R Santhosh, B H Pavithra, Rashmi Rajashekaraiah, M L Sathyanarayana, Suguna Rao, Prashantkumar Waghe, K R Anjan Kumar, G R Shivaprasad, Y Muralidhar. Effect of Telmisartan on Arsenic-Induced (Sub-chronic) Perturbations in Redox Homeostasis, Pro-inflammatory Cascade and Aortic Dysfunction in Wistar Rats. Biological trace element research. 2022 Apr; 200(4):1776-1790. doi: 10.1007/s12011-021-02804-0. [PMID: 34339004]
  • Aswathy R Devan, Bhagyalakshmi Nair, Ayana R Kumar, Lekshmi R Nath. An insight into the role of telmisartan as PPAR-γ/α dual activator in the management of nonalcoholic fatty liver disease. Biotechnology and applied biochemistry. 2022 Apr; 69(2):461-468. doi: 10.1002/bab.2123. [PMID: 33578449]
  • Paris J Baptiste, Angel Y S Wong, Anna Schultze, Marianne Cunnington, Johannes F E Mann, Catherine Clase, Clémence Leyrat, Laurie A Tomlinson, Kevin Wing. Effects of ACE inhibitors and angiotensin receptor blockers: protocol for a UK cohort study using routinely collected electronic health records with validation against the ONTARGET trial. BMJ open. 2022 03; 12(3):e051907. doi: 10.1136/bmjopen-2021-051907. [PMID: 35260450]
  • Shaoqi Zuo, Haoyu Meng, Jiahui Liang, Huajun Zhen, Ying Zhu, Yanbin Zhao, Kun Zhang, Jiayin Dai. Residues of Cardiovascular and Lipid-Lowering Drugs Pose a Risk to the Aquatic Ecosystem despite a High Wastewater Treatment Ratio in the Megacity Shanghai, China. Environmental science & technology. 2022 02; 56(4):2312-2322. doi: 10.1021/acs.est.1c05520. [PMID: 35129343]
  • Samar A Antar, Walied Abdo, Reda S Taha, Amira E Farage, Laila E El-Moselhy, Mohamed E Amer, Ahmed S Abdel Monsef, Amer M Abdel Hamid, Emadeldin M Kamel, Ahmad F Ahmeda, Ayman M Mahmoud. Telmisartan attenuates diabetic nephropathy by mitigating oxidative stress and inflammation, and upregulating Nrf2/HO-1 signaling in diabetic rats. Life sciences. 2022 Feb; 291(?):120260. doi: 10.1016/j.lfs.2021.120260. [PMID: 34968466]
  • Yanjun Cui, Ying Li, Xiao Li, Liju Fan, Xueru He, Yuhao Fu, Zhanjun Dong. A Simple UPLC/MS-MS Method for Simultaneous Determination of Lenvatinib and Telmisartan in Rat Plasma, and Its Application to Pharmacokinetic Drug-Drug Interaction Study. Molecules (Basel, Switzerland). 2022 Feb; 27(4):. doi: 10.3390/molecules27041291. [PMID: 35209080]
  • Shufei Zeng, Denis Delic, Chang Chu, Yingquan Xiong, Ting Luo, Xiaoyi Chen, Mohamed M S Gaballa, Yao Xue, Xin Chen, Yaochen Cao, Ahmed A Hasan, Kai Stadermann, Sandra Frankenreiter, Lianghong Yin, Bernhard K Krämer, Thomas Klein, Berthold Hocher. Antifibrotic effects of low dose SGLT2 Inhibition with empagliflozin in comparison to Ang II receptor blockade with telmisartan in 5/6 nephrectomised rats on high salt diet. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Feb; 146(?):112606. doi: 10.1016/j.biopha.2021.112606. [PMID: 34968924]
  • Lei Zheng, Zhifeng Zhao, Jiayun Lin, Hongjie Li, Guangbo Wu, Xiaoliang Qi, Xiaolou Lou, Yongyang Bao, Haizhong Huo, Meng Luo. Telmisartan relieves liver fibrosis and portal hypertension by improving vascular remodeling and sinusoidal dysfunction. European journal of pharmacology. 2022 Jan; 915(?):174713. doi: 10.1016/j.ejphar.2021.174713. [PMID: 34942161]
  • Mohamed A Morsy, Seham A Abdel-Gaber, Rehab A Rifaai, Mostafa M Mohammed, Anroop B Nair, Walaa Yehia Abdelzaher. Protective mechanisms of telmisartan against hepatic ischemia/reperfusion injury in rats may involve PPARγ-induced TLR4/NF-κB suppression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112374. doi: 10.1016/j.biopha.2021.112374. [PMID: 34915671]
  • Fenqing Shang, Xuan Guo, Yueer Chen, Chen Wang, Jie Gao, Ergang Wen, Baochang Lai, Liang Bai. Endothelial MicroRNA-483-3p Is Hypertension-Protective. Oxidative medicine and cellular longevity. 2022; 2022(?):3698219. doi: 10.1155/2022/3698219. [PMID: 35222797]
  • Zerrin Kutlu, Arzu Bilen, Muhammet Celik, Adem Maman, Mine Gulaboglu, Ayhan Kul, Zeynep Celik, Zekai Halici. The relationship of telmisartan with sclerostin in the osteoporosis model induced by ovariectomy in rats. The Journal of pharmacy and pharmacology. 2021 Dec; 73(12):1693-1702. doi: 10.1093/jpp/rgab123. [PMID: 34874446]
  • Di Chang, Ting-Ting Xu, Shi-Jun Zhang, Yu Cai, Shu-Dan Min, Zhen Zhao, Chun-Qiang Lu, Yuan-Cheng Wang, Shenghong Ju. Telmisartan ameliorates cardiac fibrosis and diastolic function in cardiorenal heart failure with preserved ejection fraction. Experimental biology and medicine (Maywood, N.J.). 2021 12; 246(23):2511-2521. doi: 10.1177/15353702211035058. [PMID: 34342551]
  • Ki Young Huh, Sang Won Lee, Si Beum Lee, Kyung Tae Kim, In-Jin Jang, SeungHwan Lee. Pharmacokinetic Interaction Among Ezetimibe, Rosuvastatin, and Telmisartan. Clinical pharmacology in drug development. 2021 11; 10(11):1290-1296. doi: 10.1002/cpdd.926. [PMID: 33647189]
  • Xiaolin Zhan, Wei Chen, Jian Chen, Changjiang Lei, Liqin Wei. Telmisartan Mitigates High-Glucose-Induced Injury in Renal Glomerular Endothelial Cells (rGECs) and Albuminuria in Diabetes Mice. Chemical research in toxicology. 2021 09; 34(9):2079-2086. doi: 10.1021/acs.chemrestox.1c00159. [PMID: 34464088]
  • Robert Krysiak, Marcin Basiak, Witold Szkróbka, Bogusław Okopień. The Impact of Telmisartan on Cardiometabolic Risk Factors in Hypertensive Male Siblings of Women With Polycystic Ovary Syndrome. Journal of clinical pharmacology. 2021 09; 61(9):1165-1173. doi: 10.1002/jcph.1872. [PMID: 33837974]
  • JungMin Choi, Ki-Chul Sung, Sang-Hyun Ihm, Chang-Hwan Yoon, Seung Woo Park, Sung-Ha Park, Jang-Young Kim, Sung-Uk Kwon, Hae-Young Lee. Central blood pressure lowering effect of telmisartan-rosuvastatin single-pill combination in hypertensive patients combined with dyslipidemia: A pilot study. Journal of clinical hypertension (Greenwich, Conn.). 2021 09; 23(9):1664-1674. doi: 10.1111/jch.14345. [PMID: 34384001]
  • Tamara Lang, Markus Himmelsbach, Franz Mlynek, Wolfgang Buchberger, Christian W Klampfl. Uptake and bio-transformation of telmisartan by cress (Lepidium sativum) from sewage treatment plant effluents using high-performance liquid chromatography/drift-tube ion-mobility quadrupole time-of-flight mass spectrometry. Environmental science and pollution research international. 2021 Sep; 28(36):50790-50798. doi: 10.1007/s11356-021-14289-4. [PMID: 33973117]
  • Laura Beckmann, Axel Künstner, Marco L Freschi, Gianna Huber, Ines Stölting, Saleh M Ibrahim, Misa Hirose, Miriam Freitag, Ewan A Langan, Urte Matschl, Christina E Galuska, Beate Fuchs, Johannes K Knobloch, Hauke Busch, Walter Raasch. Telmisartan induces a specific gut microbiota signature which may mediate its antiobesity effect. Pharmacological research. 2021 08; 170(?):105724. doi: 10.1016/j.phrs.2021.105724. [PMID: 34116209]
  • Gangadhar Surabhi, Shubhajit Dhara, Anusree Maneesh, Kajal Chakraborty, Lokanatha Valluru, Sambasiva Reddy Chenchula. Polygalacto-fucopyranose from marine alga as a prospective antihypertensive lead. International journal of biological macromolecules. 2021 Jul; 183(?):589-599. doi: 10.1016/j.ijbiomac.2021.04.140. [PMID: 33933545]
  • Julie Lecavalier, Lyanne Fifle, Romain Javard. Treatment of proteinuria in dogs with telmisartan: A retrospective study. Journal of veterinary internal medicine. 2021 Jul; 35(4):1810-1818. doi: 10.1111/jvim.16146. [PMID: 33969924]
  • Zhi Zhang, Fa-Zhan Wang, Zai-Xin Li, Xiang-Rong Song. Telmisartan Attenuates the Growth of Epithelium-like Cells and Glomerular Injury in Spontaneously Hypertensive Rats. Current medical science. 2021 Jun; 41(3):498-504. doi: 10.1007/s11596-021-2368-4. [PMID: 34129200]
  • Safy Badr, Samar Rezq, Rasha H Abdelghany. Endogenous β-endorphin plays a pivotal role in angiotensin II-mediated central neurochemical changes and pressor response. Chemico-biological interactions. 2021 Jun; 342(?):109475. doi: 10.1016/j.cbi.2021.109475. [PMID: 33872574]
  • Jin Wang, Dan Li, Zhinan Zhang, Yan Zhang, Zhandong Lei, Wenwen Jin, Jimin Cao, Xiangying Jiao. Autoantibody against angiotensin II type I receptor induces pancreatic β-cell apoptosis via enhancing autophagy. Acta biochimica et biophysica Sinica. 2021 May; 53(6):784-795. doi: 10.1093/abbs/gmab049. [PMID: 33928341]
  • Brittany L Fowler, Darko Stefanovski, Rebecka S Hess, Kathryn McGonigle. Effect of telmisartan, angiotensin-converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs. Journal of veterinary internal medicine. 2021 May; 35(3):1231-1237. doi: 10.1111/jvim.16102. [PMID: 33769606]
  • Toshihide Takagi, Takato Masada, Keiko Minami, Makoto Kataoka, Ken-Ichi Izutsu, Kazuki Matsui, Shinji Yamashita. In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System: Explanation for Variable Plasma Exposure after Oral Administration. Molecular pharmaceutics. 2021 04; 18(4):1711-1719. doi: 10.1021/acs.molpharmaceut.0c01207. [PMID: 33629861]
  • Yahya M Naguib, Rehab M Samaka, Mohamed S Rizk, Omnia Ameen, Shaimaa M Motawea. Countering adipose tissue dysfunction could underlie the superiority of telmisartan in the treatment of obesity-related hypertension. Cardiovascular diabetology. 2021 03; 20(1):70. doi: 10.1186/s12933-021-01259-w. [PMID: 33761942]
  • Sri Nagarjun Batchu, Harmandeep Kaur, Veera Ganesh Yerra, Suzanne L Advani, M Golam Kabir, Youan Liu, Thomas Klein, Andrew Advani. Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker-Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19. Diabetes. 2021 03; 70(3):759-771. doi: 10.2337/db20-0765. [PMID: 33310740]
  • Xiao-Nan Wang, Ying Li, Lu Meng, Cong-Yang Ding, Zhan-Jun Dong. Evaluation of influence of telmisartan on the pharmacokinetics and tissue distribution of canagliflozin in rats and mice. Annals of palliative medicine. 2021 Mar; 10(3):3086-3096. doi: 10.21037/apm-21-65. [PMID: 33752434]
  • Chang Hee Kim, Sol Ip Kang, Dongseong Shin. Pharmacokinetic Interaction Between Telmisartan and Rosuvastatin/Ezetimibe After Multiple Oral Administration in Healthy Subjects. Advances in therapy. 2021 02; 38(2):1094-1105. doi: 10.1007/s12325-020-01592-8. [PMID: 33326064]
  • Ahmed Elsonbaty, Mohamed A Hasan, Maya S Eissa, Wafaa S Hassan, Sara Abdulwahab. Synchronous Spectrofluorimetry Coupled with Third-Order Derivative Signal Processing for the Simultaneous Quantitation of Telmisartan and Chlorthalidone Drug Combination in Human Plasma. Journal of fluorescence. 2021 Jan; 31(1):97-106. doi: 10.1007/s10895-020-02639-3. [PMID: 33089428]
  • Valeria R Martínez, María V Aguirre, Juan S Todaro, Augusto Martins Lima, Nikolaos Stergiopulos, Evelina G Ferrer, Patricia Am Williams. Zinc complexation improves angiotensin II receptor type 1 blockade and in vivo antihypertensive activity of telmisartan. Future medicinal chemistry. 2021 01; 13(1):13-23. doi: 10.4155/fmc-2020-0093. [PMID: 33243020]
  • Yoshie Tsujiya, Ai Hasegawa, Motohiro Yamamori, Noboru Okamura. Telmisartan-Induced Cytotoxicity via G2/M Phase Arrest in Renal Cell Carcinoma Cell Lines. Biological & pharmaceutical bulletin. 2021; 44(12):1878-1885. doi: 10.1248/bpb.b21-00654. [PMID: 34853271]
  • Mahmoud Teaima, Rehab Abdelmonem, Yomna A Adel, Mohamed A El-Nabarawi, Tayseer M El-Nawawy. Transdermal Delivery of Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement and Comparative Pharmacokinetic Study in Rats. Drug design, development and therapy. 2021; 15(?):4603-4614. doi: 10.2147/dddt.s327860. [PMID: 34785889]
  • Yuichi Miyagawa, Ryota Akabane, Atsushi Sakatani, Mizuki Ogawa, Masayoshi Nagakawa, Hirosumi Miyakawa, Naoyuki Takemura. Effects of telmisartan on proteinuria and systolic blood pressure in dogs with chronic kidney disease. Research in veterinary science. 2020 Dec; 133(?):150-156. doi: 10.1016/j.rvsc.2020.09.019. [PMID: 32992126]
  • Asti Swari Paramanindita, Yahdiana Harahap, Budi Prasaja, Tri Rahayu Wijayanti, Windy Lusthom, Raden Efi Sofiah, Monika Sandra, Yunia Trisari. A bioequivalence study of two telmisartan 80 mg tablets in healthy Indonesian subjects: an open label, three-way, three-period, partial replicate crossover study. Drug development and industrial pharmacy. 2020 Nov; 46(11):1747-1752. doi: 10.1080/03639045.2020.1820042. [PMID: 32892655]
  • Bianca N Lourenço, Amanda E Coleman, Scott A Brown, Chad W Schmiedt, Max C Parkanzky, Kate E Creevy. Efficacy of telmisartan for the treatment of persistent renal proteinuria in dogs: A double-masked, randomized clinical trial. Journal of veterinary internal medicine. 2020 Nov; 34(6):2478-2496. doi: 10.1111/jvim.15958. [PMID: 33165969]
  • Rodolfo Pedro Rothlin, Héctor Miguel Vetulli, Mariano Duarte, Facundo Germán Pelorosso. Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID-19. Drug development research. 2020 11; 81(7):768-770. doi: 10.1002/ddr.21679. [PMID: 32356926]
  • Chia Siang Kow, Syed Shahzad Hasan. The Potential Benefit of Telmisartan to Protect Overweight Patients with COPD from the Acquisition of COVID-19. Obesity (Silver Spring, Md.). 2020 11; 28(11):2035. doi: 10.1002/oby.22976. [PMID: 32692903]
  • Alexandre Duvignaud, Edouard Lhomme, Thierry Pistone, Racha Onaisi, Rémi Sitta, Valérie Journot, Duc Nguyen, Nathan Peiffer-Smadja, Antoine Crémer, Stéphane Bouchet, Thomas Darnaud, Delphine Poitrenaud, Lionel Piroth, Christine Binquet, Jean-François Michel, Benjamin Lefèvre, David Lebeaux, Josselin Lebel, Julie Dupouy, Caroline Roussillon, Anne Gimbert, Linda Wittkop, Rodolphe Thiébaut, Joanna Orne-Gliemann, Jean-Philippe Joseph, Laura Richert, Xavier Anglaret, Denis Malvy. Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial). Trials. 2020 Oct; 21(1):846. doi: 10.1186/s13063-020-04619-1. [PMID: 33050924]
  • Farshad M Shirazi, Shireen Banerji, Samaneh Nakhaee, Omid Mehrpour. Effect of angiotensin II blockers on the prognosis of COVID-19: a toxicological view. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2020 Oct; 39(10):2001-2002. doi: 10.1007/s10096-020-03932-6. [PMID: 32557325]
  • Valeria R Martínez, María V Aguirre, Juan S Todaro, Evelina G Ferrer, Patricia A M Williams. Improvement of the Anticancer Activities of Telmisartan by Zn(II) Complexation and Mechanisms of Action. Biological trace element research. 2020 Oct; 197(2):454-463. doi: 10.1007/s12011-019-02013-w. [PMID: 31863274]
  • Päivi Hirvensalo, Aleksi Tornio, Terhi Launiainen, Maria Paile-Hyvärinen, Tuija Tapaninen, Mikko Neuvonen, Janne T Backman, Mikko Niemi. UGT1A3 and Sex Are Major Determinants of Telmisartan Pharmacokinetics-A Comprehensive Pharmacogenomic Study. Clinical pharmacology and therapeutics. 2020 10; 108(4):885-895. doi: 10.1002/cpt.1928. [PMID: 32498119]
  • Xuan Jin, Moo Hyun Kim, Ki Hoon Han, Soon Jun Hong, Jeong-Cheon Ahn, Jung-Hoon Sung, Jin-Man Cho, Han Cheol Lee, So-Yeon Choi, Kyounghoon Lee, Woo-Shik Kim, Moo-Yong Rhee, Ju Han Kim, Seung Pyo Hong, Byung Su Yoo, Eun Joo Cho, Jae-Hwan Lee, Pum-Joon Kim, Chang-Gyu Park, Min Su Hyon, Jin Ho Shin, Sang Hyun Lee, Ki Chul Sung, Jinyong Hwang, Kihwan Kwon, In-Ho Chae, Jeong-Sook Seo, Hyungseop Kim, Hana Lee, Yoonhwa Cho, Hyo-Soo Kim. Efficacy and safety of co-administered telmisartan/amlodipine and rosuvastatin in subjects with hypertension and dyslipidemia. Journal of clinical hypertension (Greenwich, Conn.). 2020 10; 22(10):1835-1845. doi: 10.1111/jch.13893. [PMID: 32937023]
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