Levetiracetam (BioDeep_00000397514)
Main id: BioDeep_00000001486
代谢物信息卡片
Levetiracetam
化学式: C8H14N2O2 (170.1055)
中文名称: 左乙拉西坦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C(=O)N)N1CCCC1=O
InChI: InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1
描述信息
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
C26170 - Protective Agent > C1509 - Neuroprotective Agent
CONFIDENCE standard compound; INTERNAL_ID 1605
同义名列表
3 个代谢物同义名
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:6437
- KEGG: C07841
- KEGGdrug: D00709
- PubChem: 5284583
- DrugBank: DB01202
- ChEMBL: CHEMBL1286
- MeSH: Levetiracetam
- CAS: 102767-28-2
- MoNA: AU160531
- MoNA: AU160530
- MoNA: AU160510
- MoNA: AU160509
- MoNA: AU160508
- MoNA: AU160507
- MoNA: FiehnHILIC002049
- MoNA: FiehnHILIC000477
- MoNA: AU160505
- MoNA: AU160504
- MoNA: AU160503
- MoNA: AU160502
- MoNA: AU160501
- PubChem: 10043
- PDB-CCD: UKX
- NIKKAJI: J523.599E
- RefMet: Levetiracetam
- KNApSAcK: 6437
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zahra Jamali, Mohammad Hosein Molaei-Farsangi, Habibeh Ahmadipour, Bahareh Bahmanbijari, Fatemeh Sabzevari, Zahra Daei Parizi. Comparison of the effect of phenobarbital & levetiracetam in the treatment of neonatal abstinence syndrome (NAS) as adjuvant treatment in neonates admitted to the neonatal intensive care unit: a randomized clinical trial.
BMC pregnancy and childbirth.
2024 Apr; 24(1):242. doi:
10.1186/s12884-024-06433-y. [PMID: 38580935] - Mansi Athalye, Divya Teli, Mehul Chorawala, Abhilasha Sharma, Rashmin Patel, Kamal Dua, Sachin Kumar Singh, Gaurav Gupta, Mrunali Patel. Apolipoprotein E3 functionalized lipid-drug conjugated nanoparticles of Levetiracetam for enhanced delivery to the brain: In-vitro cell line studies and in-vivo study.
International journal of biological macromolecules.
2023 Nov; 254(Pt 2):127799. doi:
10.1016/j.ijbiomac.2023.127799. [PMID: 37923037] - Keyvan Amirshahrokhi, Mahsa Imani. Levetiracetam attenuates experimental ulcerative colitis through promoting Nrf2/HO-1 antioxidant and inhibiting NF-κB, proinflammatory cytokines and iNOS/NO pathways.
International immunopharmacology.
2023 Apr; 119(?):110165. doi:
10.1016/j.intimp.2023.110165. [PMID: 37068340] - Asmaa A Mahmoud, Hesham M Aboelghar, Sabry Moawad Abdelmageed, Heba M Abdallah, Mohamed I Garib, Nahla M S Abd El Hady. Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs.
Pediatric research.
2022 12; 92(6):1606-1612. doi:
10.1038/s41390-022-02132-6. [PMID: 35688962] - Esmaeil Behmard, Ebrahim Barzegari, Sohrab Najafipour, Amin Kouhpayeh, Younes Ghasemi, Ali A Asadi-Pooya. Efflux dynamics of the antiseizure drug, levetiracetam, through the P-glycoprotein channel revealed by advanced comparative molecular simulations.
Scientific reports.
2022 08; 12(1):13674. doi:
10.1038/s41598-022-17994-3. [PMID: 35953704] - Shan Zhou, Ruitong Li, Ziyi Chen, Ruina Ren, Xueding Wang, Qilin Dai, Dingshen Wen, Yanping Guan, Xiaoxu Zhang, Siyuan Tang, Liemin Zhou, Min Huang. LC-MS/MS quantification of levetiracetam, lamotrigine and 10-hydroxycarbazepine in TDM of epileptic patients.
Biomedical chromatography : BMC.
2022 Aug; 36(8):e5393. doi:
10.1002/bmc.5393. [PMID: 35527473] - Elias Konrath, Franz Marhold, Wolfgang Kindler, Florian Scheichel, Branko Popadic, Katrin Blauensteiner, Bernadette Calabek, Elisabeth Freydl, Michael Weber, Robin Ristl, Katharina Hainz, Camillo Sherif, Stefan Oberndorfer. Perioperative levetiracetam for seizure prophylaxis in seizure-naive brain tumor patients with focus on neurocognitive functioning.
BMC neurology.
2022 Jul; 22(1):250. doi:
10.1186/s12883-022-02762-7. [PMID: 35804291] - Fatma Ilgaz, Selin Seda Timur, Cemil Can Eylem, Emirhan Nemutlu, Çiğdem Eroğlu Erdem, Hakan Eroğlu, Hülya Gökmen-Özel. Do Thickening Agents Used in Dysphagia Diet Affect Drug Bioavailability?.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2022 Jul; 174(?):106197. doi:
10.1016/j.ejps.2022.106197. [PMID: 35489612] - Raphaelle Beau-Lejdstrom, Lai San Hong, Xabier Garcia de Albeniz, Florin Floricel, Johan Lorenzen, Francois Bonfitto, Linda Kalilani, Christian Loesch, Graham Luscombe, Susana Perez-Gutthann, Isabelle Mottet, Nadia Foskett. Incidence of Acute Renal Failure in Patients Using Levetiracetam Versus Other Antiseizure Medications: A Voluntary Post-Authorization Safety Study.
Drug safety.
2022 Jul; 45(7):781-790. doi:
10.1007/s40264-022-01193-0. [PMID: 35761158] - Federico Cucchiara, Giacomo Luci, Noemi Giannini, Filippo Sean Giorgi, Paola Orlandi, Marta Banchi, Antonello Di Paolo, Francesco Pasqualetti, Romano Danesi, Guido Bocci. Association of plasma levetiracetam concentration, MGMT methylation and sex with survival of chemoradiotherapy-treated glioblastoma patients.
Pharmacological research.
2022 07; 181(?):106290. doi:
10.1016/j.phrs.2022.106290. [PMID: 35680010] - Torleiv Svendsen, Eylert Brodtkorb, Hanna L Linge, Margrete L Burns, Svein I Johannessen, Karl O Nakken, Morten I Lossius, Cecilie Johannessen Landmark. Efficacy, tolerability and pharmacokinetic variability of brivaracetam in adults with difficult-to-treat epilepsy.
Epilepsy research.
2022 Jul; 183(?):106946. doi:
10.1016/j.eplepsyres.2022.106946. [PMID: 35609355] - Madhava Vijayakumar, Ajitha Bk, Biju George, Vijayalakshmi Bhatia. Vitamin D Status in Children on Anticonvulsant Therapy.
Indian journal of pediatrics.
2022 06; 89(6):541-545. doi:
10.1007/s12098-021-03853-y. [PMID: 34318406] - Ricardo Blanco-Castañeda, Yessica Zapata-Vázquez, Blanca P Lazalde-Ramos, Daniel Enríquez-Mendiola, Ismael Lares-Asseff, Carlos Galaviz-Hernández, Gerardo Martínez, Martha Sosa-Macías. Effect of levetiracetam on the gene expression of placental transporters in a murine model.
Epilepsia.
2022 05; 63(5):1266-1275. doi:
10.1111/epi.17195. [PMID: 35174498] - Shamir N Kalaria, Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V Gobburu, Mathangi Gopalakrishnan. Development and Use of an Ex-Vivo In-Vivo Correlation to Predict Antiepileptic Drug Clearance in Patients Undergoing Continuous Renal Replacement Therapy.
Pharmaceutical research.
2022 May; 39(5):827-836. doi:
10.1007/s11095-022-03287-x. [PMID: 35552966] - Kouji Fukuyama, Motohiro Okada. Brivaracetam and Levetiracetam Suppress Astroglial L-Glutamate Release through Hemichannel via Inhibition of Synaptic Vesicle Protein.
International journal of molecular sciences.
2022 Apr; 23(9):. doi:
10.3390/ijms23094473. [PMID: 35562864] - Berk Can Kantarci, Ahmet Sanli, Seyhmus Gavas, Aylin Toplu, Zehra Nur Turgan Asik, Ozlem Tugce Cilingir-Kaya, Medine Gulcebi Idrizoglu, Feriha Ercan, Filiz Onat. Effects of in utero exposure to valproate or levetiracetam on the seizures and newborn histopathology of genetic absence epilepsy rats.
Neuroscience letters.
2022 04; 776(?):136574. doi:
10.1016/j.neulet.2022.136574. [PMID: 35271996] - Colleen Elizabeth Howing, Farzad Razi, Wael Hakmeh. Resolution of status epilepticus after ketamine administration.
The American journal of emergency medicine.
2022 Apr; 54(?):328.e1-328.e2. doi:
10.1016/j.ajem.2021.10.052. [PMID: 34763960] - Page B Pennell, Ashwin Karanam, Kimford J Meador, Elizabeth Gerard, Laura Kalayjian, Patricia Penovich, Abigail Matthews, Thomas M McElrath, Angela K Birnbaum. Antiseizure Medication Concentrations During Pregnancy: Results From the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) Study.
JAMA neurology.
2022 04; 79(4):370-379. doi:
10.1001/jamaneurol.2021.5487. [PMID: 35157004] - Alessandro Orsini, Sayla Bernasconi, Maria Cristina Bianchi, Ilaria Trivelli, Maria Cristina Menconi, Margherita Nardi, Andrea Santangelo, Gabriella Casazza, Niccolò Carli, Maria Grazia Esposito, Diego Peroni, Pasquale Striano, Thomas Foiadelli, Alice Bonuccelli. PRES-like leukoencephalopathy presenting with status epilepticus associated with Brentuximab Vedotin treatment.
Acta bio-medica : Atenei Parmensis.
2022 03; 92(S4):e2021416. doi:
10.23750/abm.v92is4.12665. [PMID: 35441608] - Giulia Liparoti, Beatrice Burchiani, Elisabetta Mencaroni, Domenico Tripodi, Giuseppe Di Cara, Alberto Verrotti. Individualizing doses of antiepileptic drugs.
Expert opinion on drug metabolism & toxicology.
2022 Mar; 18(3):219-233. doi:
10.1080/17425255.2022.2075342. [PMID: 35523739] - Mohaddeseh Sadat Alavi, Sahar Fanoudi, Mahmoud Hosseini, Hamid R Sadeghnia. Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer's disease.
Metabolic brain disease.
2022 03; 37(3):689-700. doi:
10.1007/s11011-021-00888-0. [PMID: 35098412] - Kengo Hatanaka, Yoshito Kamijo, Takeshi Kitamoto, Tomoki Hanazawa, Tomohiro Yoshizawa, Hidenobu Ochiai, Yoshiyuki Haga. Effectiveness of multiple-dose activated charcoal in lamotrigine poisoning: a case series.
Clinical toxicology (Philadelphia, Pa.).
2022 Mar; 60(3):379-381. doi:
10.1080/15563650.2021.1953518. [PMID: 34405740] - H S Nandini, K L Krishna, Chinnappa Apattira. Combination of Ocimum sanctum extract and Levetiracetam ameliorates cognitive dysfunction and hippocampal architecture in rat model of Alzheimer's disease.
Journal of chemical neuroanatomy.
2022 03; 120(?):102069. doi:
10.1016/j.jchemneu.2021.102069. [PMID: 34973350] - Yun Liu, Yang Zou, Yijun Wang, Fan Jiang, Wenjing Xu, Shuyun Liu, Jingying Jia, Chen Yu, Liming Fang, Liwei Hu, Kanyin E Zhang, Jingwen Long, Huahua Pu. Bioequivalence and Safety of Levetiracetam Granules and Oral Solution: A Randomized, Single-Dose, 2-Period Crossover Study in Healthy Chinese Volunteers Under a Fasting Condition.
Clinical pharmacology in drug development.
2022 03; 11(3):372-378. doi:
10.1002/cpdd.1063. [PMID: 35157781] - Sudhir C Sarangi, Sachin Kumar, Manjari Tripathi, Thomas Kaleekal, Surender Singh, Yogendra K Gupta. Antiepileptic-drug tapering and seizure recurrence: Correlation with serum drug levels and biomarkers in persons with epilepsy.
Indian journal of pharmacology.
2022 Jan; 54(1):24-32. doi:
10.4103/ijp.ijp_253_21. [PMID: 35343204] - Natalie Dinavitser, Elkana Kohn, Maya Berlin, Nurit Brandriss, Adina Bar-Chaim, Rimona Keidar, Ayelet Livne, David Stepensky, Matitiahu Berkovitch, Revital Sheinberg. Levetiracetam in lactation: How much is excreted into human breast milk?.
British journal of clinical pharmacology.
2022 01; 88(1):199-205. doi:
10.1111/bcp.14940. [PMID: 34131926] - Camila De Avila, Luis F Rauseo Lopez, Yamini Mandelia. Acute COVID-19 Infection Associated With Necrotizing Disseminated Acute Leukoencephalopathy and Brain Microhemorrhages in a Pediatric Patient.
The Pediatric infectious disease journal.
2021 12; 40(12):e493-e496. doi:
10.1097/inf.0000000000003302. [PMID: 34533490] - Zhengchao Ji, Lei Yin, Yanyan Li, Xiaoquan Yang, Lin Lin, Lingling Liu, Yi Jiang, Jing Huang. Development and validation of a liquid chromatography-tandem mass spectrometry method with triple-stage fragmentation to determine levetiracetam in epileptic patient serum and its application in therapeutic drug monitoring.
Journal of separation science.
2021 Dec; 44(23):4255-4263. doi:
10.1002/jssc.202100639. [PMID: 34648229] - Rajpushpa Labh, Rachna Gupta, Manish Narang, Sumita Halder, Rajarshi Kar. Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy.
Epilepsy & behavior : E&B.
2021 12; 125(?):108358. doi:
10.1016/j.yebeh.2021.108358. [PMID: 34717170] - Manon Tauzin, Jean-Marc Tréluyer, Rima Nabbout, Nicole Chemaly, Thierry Billette de Villemeur, Isabelle Desguerre, Gabrielle Lui, Ines Gana, Sana Boujaafar, Yi Zheng, Sihem Benaboud, Naim Bouazza, Camille Chenevier-Gobeaux, Cécile Freihuber, Déborah Hirt. Predictive Performance of Population Pharmacokinetic Models of Levetiracetam in Children and Evaluation of Dosing Regimen.
Journal of clinical pharmacology.
2021 10; 61(10):1366-1375. doi:
10.1002/jcph.1910. [PMID: 33997989] - Aatma Ram, Hafiz Jeelani, Dilpat Kumar, Heeren Patel. Generalised myoclonus associated with COVID-19 infection.
BMJ case reports.
2021 Jul; 14(7):. doi:
10.1136/bcr-2021-243780. [PMID: 34301706] - Ryohei Otani, Ryoji Yamada, Kei Kawaguchi, Miyu Kikuchi, Yoshihiro Kushihara, Nobusada Shinoura. Utility of monitoring the serum levetiracetam concentration for intraoperative seizure control during awake craniotomy.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2021 Jul; 89(?):279-282. doi:
10.1016/j.jocn.2021.05.028. [PMID: 34119281] - Abhishek G Sathe, Usha Mishra, Vijay Ivaturi, Richard C Brundage, James C Cloyd, Jordan J Elm, James M Chamberlain, Robert Silbergleit, Jaideep Kapur, Daniel H Lowenstein, Shlomo Shinnar, Hannah R Cock, Nathan B Fountain, Lynn Babcock, Lisa D Coles. Early Exposure of Fosphenytoin, Levetiracetam, and Valproic Acid After High-Dose Intravenous Administration in Young Children With Benzodiazepine-Refractory Status Epilepticus.
Journal of clinical pharmacology.
2021 06; 61(6):763-768. doi:
10.1002/jcph.1801. [PMID: 33336359] - Dennis Klimpel, Anne Hagemann, Christian G Bien, Bertin Dufaux, Theodor W May, Christian Brandt. Therapeutic Drug Monitoring of Lamotrigine, Lacosamide, and Levetiracetam in Dried Capillary Blood-Determination of Conversion Factors for Serum-Based Reference Ranges.
Therapeutic drug monitoring.
2021 06; 43(3):394-400. doi:
10.1097/ftd.0000000000000890. [PMID: 33851939] - Catherine E DeFino, Jason N Barreto, Amanda G Pawlenty, Michael W Ruff, Ivan D Carabenciov, Kristin C Mara, Carrie A Thompson. Lack of drug interaction between levetiracetam and high-dose methotrexate in patients with lymphoma.
Pharmacotherapy.
2021 05; 41(5):430-439. doi:
10.1002/phar.2516. [PMID: 33655525] - Fekade Bruck Sime, Jason A Roberts, Rosalind L Jeffree, Saurabh Pandey, Santosh Adiraju, Amelia Livermore, Jenie Butler, Suzanne L Parker, Steven C Wallis, Jeffrey Lipman, Menino Osbert Cotta. Population Pharmacokinetics of Levetiracetam in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage Exhibiting Augmented Renal Clearance.
Clinical pharmacokinetics.
2021 05; 60(5):655-664. doi:
10.1007/s40262-020-00979-8. [PMID: 33428169] - Wei-Chong Dong, Jia-Liang Guo, Xiu-Ling Yang, Shu-Mei Wang, Ye Yuan, Meng-Qiang Zhao, Ye Jiang, Zhi-Qing Zhang. A Direct Injection Technique to Improve Biosafety to Analyze Levetiracetam Concentrations in Human Serum and Its Application in Therapeutic Drug Monitoring.
Therapeutic drug monitoring.
2021 04; 43(2):292-297. doi:
10.1097/ftd.0000000000000802. [PMID: 32947555] - Bahareh Michelle Schweiger, Aaron-James Lao, Jane Tavyev. A Case Series of Patients With Central Hypothyroidism From Oxcarbazepine Therapy.
Journal of child neurology.
2021 03; 36(3):237-242. doi:
10.1177/0883073820962926. [PMID: 33030389] - Patricia Papa, Florencia Oricchio, Mariana Ginés, Cecilia Maldonado, Araceli Tashjian, Manuel Ibarra, Mariana Percovich, Pietro Fagiolino, Berta Pedragosa, Marta Vázquez. Pharmacokinetics of Subcutaneous Levetiracetam in Palliative Care Patients.
Journal of palliative medicine.
2021 02; 24(2):248-251. doi:
10.1089/jpm.2019.0525. [PMID: 32267792] - Maziar Emamikhah, Mansoureh Babadi, Mehrnoush Mehrabani, Mehdi Jalili, Maryam Pouranian, Peyman Daraie, Fahimeh Mohaghegh, Sharmin Aghavali, Maryam Zaribafian, Mohammad Rohani. Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature.
Journal of neurovirology.
2021 02; 27(1):26-34. doi:
10.1007/s13365-020-00941-1. [PMID: 33492608] - Reem Odi, Valentina Franco, Emilio Perucca, Meir Bialer. Bioequivalence and switchability of generic antiseizure medications (ASMs): A re-appraisal based on analysis of generic ASM products approved in Europe.
Epilepsia.
2021 02; 62(2):285-302. doi:
10.1111/epi.16802. [PMID: 33426641] - Madihah Hepburn, Naresh Mullaguri, Pravin George, Stephen Hantus, Vineet Punia, Adarsh Bhimraj, Christopher R Newey. Acute Symptomatic Seizures in Critically Ill Patients with COVID-19: Is There an Association?.
Neurocritical care.
2021 02; 34(1):139-143. doi:
10.1007/s12028-020-01006-1. [PMID: 32462412] - Kathryn Chappell, Lauren A Kimmons, J Tyler Haller, Robert B Canada, Hui He, Joanna Q Hudson. Levetiracetam pharmacokinetics in critically ill patients undergoing renal replacement therapy.
Journal of critical care.
2021 02; 61(?):216-220. doi:
10.1016/j.jcrc.2020.10.032. [PMID: 33217623] - Luca Zombori, Melody Bacon, Hannah Wood, Fiona Chatterjee, Ramesh Venkateswaran, Simona Lampariello, Michael Yoong. Severe cortical damage associated with COVID-19 case report.
Seizure.
2021 Jan; 84(?):66-68. doi:
10.1016/j.seizure.2020.11.014. [PMID: 33285362] - Katsuhito Nagai, Yoshikazu Ryuno, Yoshihito Iwanami, Sachiko Omotani, Shuhei Fukuno, Yasutoshi Hatsuda, Hiroki Konishi, Michiaki Myotoku. Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats.
PloS one.
2021; 16(11):e0259400. doi:
10.1371/journal.pone.0259400. [PMID: 34752482] - Kai-Li Shi, Jun-Xiu Guo, Hui-Min Zhao, Han Hong, Chuan-Zi Yang, Yun-Hong Wu, Li-Jun Du. The effect of levetiracetam and oxcarbazepine monotherapy on thyroid hormones and bone metabolism in children with epilepsy: A prospective study.
Epilepsy & behavior : E&B.
2020 12; 113(?):107555. doi:
10.1016/j.yebeh.2020.107555. [PMID: 33242769] - H Takamura, P Chongphaibulpatana, Y Uzuka. Comparison of pharmacokinetics of intragastrically and intrarectally administered levetiracetam tablets in healthy non-epileptic dogs.
Polish journal of veterinary sciences.
2020 Dec; 23(4):491-494. doi:
10.24425/pjvs.2020.134697. [PMID: 33480487] - Opeyemi Samson Osuntokun, Stephen Olumide Akinsomisoye, Gbola Olayiwola, Kabiru Isola Adedokun, Olayemi Olutobi Oladokun. Carbamazepine adversely altered the pituitary-testicular axis with resultant reproductive dysfunctions than levetiracetam or carbamazepine-levetiracetam adjuvant treatment in male Wistar rat.
Andrologia.
2020 Dec; 52(11):e13871. doi:
10.1111/and.13871. [PMID: 33126292] - Ting Zhao, Jing Yu, Ting-Ting Wang, Jie Feng, Wen-Bo Zhao, Li Sun, Lu-Hai Yu, Hong-Jian Li, Yan Sun. Impact of ABCB1 Polymorphism on Levetiracetam Serum Concentrations in Epileptic Uygur Children in China.
Therapeutic drug monitoring.
2020 12; 42(6):886-892. doi:
10.1097/ftd.0000000000000805. [PMID: 32890316] - Yi Guo, Zhonghua Lin, Yulan Huang, Liang Yu. Effects of valproate, lamotrigine, and levetiracetam monotherapy on bone health in newly diagnosed adult patients with epilepsy.
Epilepsy & behavior : E&B.
2020 12; 113(?):107489. doi:
10.1016/j.yebeh.2020.107489. [PMID: 33220583] - Marc A Brouwer, Stijn P G van Vugt, Jeroen Jaspers Focks, Sander A J Damen, Freek W A Verheugt. Rivaroxaban Plasma Levels and Levetiracetam.
Annals of internal medicine.
2020 11; 173(9):770-771. doi:
10.7326/l20-1063. [PMID: 33137266] - Vineet Punia. Rivaroxaban Plasma Levels and Levetiracetam.
Annals of internal medicine.
2020 11; 173(9):771-772. doi:
10.7326/l20-1065. [PMID: 33137272] - Francesco Paciullo, Cinzia Costa, Paolo Gresele. Rivaroxaban Plasma Levels and Levetiracetam.
Annals of internal medicine.
2020 11; 173(9):772. doi:
10.7326/l20-1066. [PMID: 33137271] - Maja Hellfritzsch, Jakob Christensen, Lars Peter Nielsen. Rivaroxaban Plasma Levels and Levetiracetam.
Annals of internal medicine.
2020 11; 173(9):771. doi:
10.7326/l20-1064. [PMID: 33137273] - Laxmikant S Deshpande, Robert E Blair, Matthew Halquist, Leon Kosmider, Robert J DeLorenzo. Intramuscular atenolol and levetiracetam reduce mortality in a rat model of paraoxon-induced status epilepticus.
Annals of the New York Academy of Sciences.
2020 11; 1480(1):219-232. doi:
10.1111/nyas.14500. [PMID: 32961584] - Imran A Moinuddin. Suspected Levetiracetam-Induced Rhabdomyolysis: A Case Report and Literature Review.
The American journal of case reports.
2020 Oct; 21(?):e926064. doi:
10.12659/ajcr.926064. [PMID: 33112844] - Sheng Feng, Brandi Bridgewater, Erin C Strickland, Gregory McIntire. A Rapid LC-MS-MS Method for the Quantitation of Antiepileptic Drugs in Urine.
Journal of analytical toxicology.
2020 Oct; 44(7):688-696. doi:
10.1093/jat/bkaa095. [PMID: 32744607] - Elif Söylemez, Oya Öztürk, Sezin Alpaydın Baslo, Zeynep Ezgi Balçık, Dilek Ataklı. Metabolic syndrome and obstructive sleep apnea syndrome among patients with epilepsy on monotherapy.
Epilepsy & behavior : E&B.
2020 10; 111(?):107296. doi:
10.1016/j.yebeh.2020.107296. [PMID: 32769040] - Ronald C Reed, William E Rosenfeld, Susan M Lippmann, Rene M J C Eijkemans, Dorothee G A Kasteleijn-Nolst Trenité. Rapidity of CNS Effect on Photoparoxysmal Response for Brivaracetam vs. Levetiracetam: A Randomized, Double-blind, Crossover Trial in Photosensitive Epilepsy Patients.
CNS drugs.
2020 10; 34(10):1075-1086. doi:
10.1007/s40263-020-00761-1. [PMID: 32949370] - Eleni Karatza, Sophia L Markantonis, Andria Savvidou, Anastasia Verentzioti, Anna Siatouni, Athanasia Alexoudi, Stylianos Gatzonis, Evgenia Mavrokefalou, Vangelis Karalis. Pharmacokinetic and pharmacodynamic modeling of levetiracetam: investigation of factors affecting the clinical outcome.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Sep; 50(9):1090-1100. doi:
10.1080/00498254.2020.1746981. [PMID: 32208795] - B Le Daré, A Degremont, E Polard, I Morel, A Biraben, T Gicquel. Clinical and biological assessment of lamotrigine and levetiracetam plasma assays at the Rennes University Hospital.
Revue neurologique.
2020 Sep; 176(7-8):601-607. doi:
10.1016/j.neurol.2019.11.006. [PMID: 32178878] - Shamir N Kalaria, Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V Gobburu, Mathangi Gopalakrishnan. A Practice-Based, Clinical Pharmacokinetic Study to Inform Levetiracetam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemofiltration (PADRE-01).
Clinical and translational science.
2020 09; 13(5):950-959. doi:
10.1111/cts.12782. [PMID: 32223067] - Cem Önal, Aykut Kul, Murat Ozdemir, Olcay Sagirli. Determination of levetiracetam in human plasma by online heart-cutting liquid chromatography: Application to therapeutic drug monitoring.
Journal of separation science.
2020 Sep; 43(18):3590-3596. doi:
10.1002/jssc.202000504. [PMID: 32644231] - Menino O Cotta, Mohd H Abdul-Aziz, Otto R Frey, Fekade B Sime, Jason A Roberts, Anka C Roehr. What Are the Predictors for Achieving Therapeutic Levetiracetam Serum Concentrations in Adult Neurological Patients?.
Therapeutic drug monitoring.
2020 08; 42(4):626-630. doi:
10.1097/ftd.0000000000000731. [PMID: 31977751] - Hale Afshar, Zeynab Yassin, Saeed Kalantari, Oldooz Aloosh, Tayebeh Lotfi, Mehdi Moghaddasi, Alireza Sadeghipour, Maziar Emamikhah. Evolution and resolution of brain involvement associated with SARS- CoV2 infection: A close Clinical - Paraclinical follow up study of a case.
Multiple sclerosis and related disorders.
2020 Aug; 43(?):102216. doi:
10.1016/j.msard.2020.102216. [PMID: 32464585] - Francesco Paciullo, Cinzia Costa, Paolo Gresele. Rivaroxaban Plasma Levels and Levetiracetam: A Case Report.
Annals of internal medicine.
2020 07; 173(1):71-72. doi:
10.7326/l19-0712. [PMID: 32283551] - Sana Somani, Sandipan Pati, Tyler Gaston, Alissa Chitlangia, Shruti Agnihotri. De Novo Status Epilepticus in patients with COVID-19.
Annals of clinical and translational neurology.
2020 07; 7(7):1240-1244. doi:
10.1002/acn3.51071. [PMID: 32407609] - Cory W Romans, Thomas K Day, Joshua J Smith. Oxidative red blood cell damage associated with propofol and intravenous lipid emulsion therapy in a dog treated for 5-fluorouracil toxicosis.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2020 Jul; 30(4):481-486. doi:
10.1111/vec.12958. [PMID: 32407575] - Xiaoyang Li, Richard A Himes, Lyndsey C Prosser, Charleston F Christie, Emma Watt, Sharon F Edwards, Cameron S Metcalf, Peter J West, Karen S Wilcox, Sherine S L Chan, C James Chou. Discovery of the First Vitamin K Analogue as a Potential Treatment of Pharmacoresistant Seizures.
Journal of medicinal chemistry.
2020 06; 63(11):5865-5878. doi:
10.1021/acs.jmedchem.0c00168. [PMID: 32390424] - Atena Mahdavi, Amirmansour Alavi Naeini, Mohammadreza Najafi, Mohammadreza Maracy, Mohammadreza Aghaye Ghazvini. Effect of levetiracetam drug on antioxidant and liver enzymes in epileptic patients: case-control study.
African health sciences.
2020 Jun; 20(2):984-990. doi:
10.4314/ahs.v20i2.55. [PMID: 33163067] - Patrick M Wieruszewski, Arnaldo Lopez-Ruiz, Robert C Albright, Jennifer E Fugate, Erin Frazee Barreto. Lacosamide Pharmacokinetics in a Critically Ill Patient During Continuous Renal Replacement Therapy.
Journal of pharmacy practice.
2020 Jun; 33(3):395-398. doi:
10.1177/0897190018803765. [PMID: 30336720] - María Patricia Hernández-Mitre, Susanna Edith Medellín-Garibay, Ildefonso Rodríguez-Leyva, Cristian Jazmín Rodríguez-Pinal, Sergio Zarazúa, Helgi Helene Jung-Cook, Jason A Roberts, Silvia Romano-Moreno, Rosa Del Carmen Milán-Segovia. Population Pharmacokinetics and Dosing Recommendations of Levetiracetam in Adult and Elderly Patients With Epilepsy.
Journal of pharmaceutical sciences.
2020 06; 109(6):2070-2078. doi:
10.1016/j.xphs.2020.02.018. [PMID: 32113977] - Sahar A Harby, Rasha A Nassra, Jaidaa F Mekky, Samia M Ali, Cherine A Ismail. Correlation of levetiracetam concentration in peripheral blood mononuclear cells with clinical efficacy: A sensitive monitoring biomarker in patients with epilepsy.
Seizure.
2020 May; 78(?):71-77. doi:
10.1016/j.seizure.2020.03.009. [PMID: 32213443] - José Luis Cortes-Altamirano, Samuel Reyes-Long, Herlinda Bonilla-Jaime, Denise Clavijo-Cornejo, Javier Vargas, Cindy Bandala, Alfonso Alfaro-Rodriguez. Acute administration of levetiracetam in tonic pain model modulates gene expression of 5HT1A and 5HT7 receptors in the thalamus of rats (Rattus norvergicus).
Molecular biology reports.
2020 May; 47(5):3389-3396. doi:
10.1007/s11033-020-05419-1. [PMID: 32285329] - Vinayagamoorthy Vignesh, Ramachandran Rameshkumar, Subramanian Mahadevan. Comparison of Phenytoin, Valproate and Levetiracetam in Pediatric Convulsive Status Epilepticus: A Randomized Double-blind Controlled Clinical Trial.
Indian pediatrics.
2020 03; 57(3):222-227. doi:
. [PMID: 32198861] - John M Cunningham, Katherine V Sachs, Rebecca Allyn. Cefepime-Induced Neurotoxicity Presenting with Nonconvulsive Status Epilepticus Admitted as a Stroke Alert.
The American journal of case reports.
2020 Mar; 21(?):e921643. doi:
10.12659/ajcr.921643. [PMID: 32147665] - Maria Mendoza Aguilera, María Dolores Bellés Medall, Tamara Álvarez Martín, Óscar Pascual Marmaneu, Carla Liñana Granell, Raúl Ferrando Piqueres. Therapeutic drug monitoring of levetiracetam in daily clinical practice: high-performance liquid chromatography versus immunoassay.
European journal of hospital pharmacy : science and practice.
2020 03; 27(e1):e2-e6. doi:
10.1136/ejhpharm-2018-001616. [PMID: 32296497] - Sudhir Chandra Sarangi, Soumya S Pattnaik, Jatinder Katyal, Thomas Kaleekal, A K Dinda. An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy.
Journal of ethnopharmacology.
2020 Mar; 249(?):112389. doi:
10.1016/j.jep.2019.112389. [PMID: 31739106] - Elif Karatoprak, Oyku Tosun. Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy.
Brain & development.
2020 Feb; 42(2):165-170. doi:
10.1016/j.braindev.2019.11.004. [PMID: 31806254] - Kunihiko Araki, Tomohiko Nakamura, Yuko Takeuchi, Saori Morozumi, Katsunori Horie, Yasushi Kobayashi, Osamu Kawakami, Fumio Sobue, Takuya Ueda, Kensuke Hamada, Tetsuo Ando, Yushi Inoue, Keizo Yasui, Kunio Morozumi, Shoichi Maruyama, Masahisa Katsuno. Pharmacological monitoring of antiepileptic drugs in epilepsy patients on haemodialysis.
Epileptic disorders : international epilepsy journal with videotape.
2020 Feb; 22(1):90-102. doi:
10.1684/epd.2020.1139. [PMID: 32031531] - Nahid Shahabadi, Saba Hadidi, Farshad Shiri. New water-soluble Fe3O4@SiO2 magnetic nanoparticles functionalized with levetiracetam drug for adsorption of essential biomolecules by case studies of DNA and HSA.
Journal of biomolecular structure & dynamics.
2020 01; 38(1):283-294. doi:
10.1080/07391102.2019.1569557. [PMID: 30777505] - Bhuvanachandra Pasupuleti, Vamshikrishna Gone, Ravali Baddam, Raj Kumar Venisetty, Om Prakash Prasad. Clinical Impact of Co-medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study.
Current drug metabolism.
2020; 21(2):126-131. doi:
10.2174/1389200221666200218121050. [PMID: 32067615] - Georgia Koukou, Sandra Niendorf, Britt Hornei, Jan-U Schlump, Andreas C Jenke, Sonja Jacobsen. Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report.
Journal of medical case reports.
2019 Nov; 13(1):341. doi:
10.1186/s13256-019-2302-6. [PMID: 31757225] - Gretchen L Birbeck, Susan T Herman, Edmund V Capparelli, Fraction K Dzinjalamala, Samah G Abdel Baki, Macpherson Mallewa, Neema M Toto, Douglas G Postels, Joseph C Gardiner, Terrie E Taylor, Karl B Seydel. A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
BMC pediatrics.
2019 11; 19(1):399. doi:
10.1186/s12887-019-1766-2. [PMID: 31672143] - Katarzyna Socała, Elżbieta Wyska, Małgorzata Szafarz, Dorota Nieoczym, Piotr Wlaź. Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies.
Neuropharmacology.
2019 11; 158(?):107733. doi:
10.1016/j.neuropharm.2019.107733. [PMID: 31377197] - Achilleas Attilakos, Argirios Dinopoulos, Maria Paschalidou, Maria Tsirouda, Anastasia Garoufi. Monitoring of biochemical parameters and coagulation tests in children with epilepsy treated with levetiracetam monotherapy.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.
2019 11; 35(11):2033-2034. doi:
10.1007/s00381-019-04225-w. [PMID: 31152218] - M A Sancho-Zamora, N Espadas-Hervás, I Cañada-Millas. [Maintenance of plasma levels of levetiracetam in subcutaneous, continuous and prolonged palliative infusion by elastomeric infusors].
Revista de neurologia.
2019 Nov; 69(9):392-393. doi:
10.33588/rn.6909.2019210. [PMID: 31657452] - Erik R Johnson, Amanda R Taylor, Dawn M Boothe, Heather L Gray-Edwards, Randolph L Winter, Doug R Martin. Pharmacokinetics of a commercially available product and a compounded formulation of extended-release levetiracetam after oral administration of a single dose in cats.
American journal of veterinary research.
2019 Oct; 80(10):950-956. doi:
10.2460/ajvr.80.10.950. [PMID: 31556719] - Achilleas Attilakos, Argirios Dinopoulos, Maria Tsirouda, Maria Paschalidou, Alexia Prasouli, Adiana Stamati, Nefeli Parasxou, Anastasia Garoufi. Effect of levetiracetam monotherapy on lipid profiles and thyroid hormones in children with epilepsy: A prospective study.
Epilepsy research.
2019 09; 155(?):106162. doi:
10.1016/j.eplepsyres.2019.106162. [PMID: 31301589] - Fardous A Mohamed, Marwa F B Ali, Azza H Rageh, Aya M Mostafa. Highly sensitive UHPLC-DAD method for simultaneous determination of two synergistically acting antiepileptic drugs; levetiracetam and lacosamide: Application to pharmaceutical tablets and human urine.
Biomedical chromatography : BMC.
2019 Sep; 33(9):e4554. doi:
10.1002/bmc.4554. [PMID: 30985932] - Jie Fu, Lilei Peng, Jinglun Li, Tao Tao, Yangmei Chen. Effects of Second-Generation Antiepileptic Drugs Compared to First-Generation Antiepileptic Drugs on Bone Metabolism in Patients with Epilepsy: A Meta-Analysis.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2019 Aug; 51(8):511-521. doi:
10.1055/a-0963-0054. [PMID: 31408897] - Yaohua Cao, Xin He, Lina Zhao, Yuwen He, Sen Wang, Tiantian Zhang, Jie Jiang. Efficacy and safety of Levetiracetam as adjunctive treatment in children with focal onset seizures: A systematic review and meta-analysis.
Epilepsy research.
2019 07; 153(?):40-48. doi:
10.1016/j.eplepsyres.2019.04.001. [PMID: 30965274] - Ekram Nemr Abd-Al-Haleem, Shaimaa Salah Eldeen-Hussein, Hanan Abdel-Hameed Fahmy, Ragia Ali Mahmoud-Taha. Effect of gamma radiation on combination therapy of certain antiepileptic drugs in rats.
Pakistan journal of pharmaceutical sciences.
2019 Jul; 32(4):1589-1597. doi:
. [PMID: 31608878] - Pınar Haznedar, Özlem Doğan, Pelin Albayrak, Gökçen Öz Tunçer, Serap Teber, Gülhis Deda, F Tuba Eminoglu. Effects of levetiracetam and valproic acid treatment on liver function tests, plasma free carnitine and lipid peroxidation in childhood epilepsies.
Epilepsy research.
2019 07; 153(?):7-13. doi:
10.1016/j.eplepsyres.2019.03.009. [PMID: 30925397] - Sevim Şahin, Semra Atasoy Yılmaz, Ali Cansu, Tülay Kamaşak, Elif Acar Arslan, Neşe Kaklıkkaya. Changes in Serum Valproate and Levetiracetam Levels Related to Sex Steroids in Adolescent Girls.
Pediatric neurology.
2019 07; 96(?):76-78. doi:
10.1016/j.pediatrneurol.2019.03.010. [PMID: 31023605] - Blanka Koristkova, Milan Grundmann, Hana Brozmanova, Ivana Kacirova. Lamotrigine drug interactions in combination therapy and the influence of therapeutic drug monitoring on clinical outcomes in paediatric patients.
Basic & clinical pharmacology & toxicology.
2019 Jul; 125(1):26-33. doi:
10.1111/bcpt.13203. [PMID: 30681278] - Patrik Olsson, Arne Reimers, Kristina Källén. Quality of life after switching to generic levetiracetam - A prospective comparative study.
Epilepsy & behavior : E&B.
2019 07; 96(?):169-174. doi:
10.1016/j.yebeh.2019.04.029. [PMID: 31150996] - Joana Gonçalves, Joana Bicker, Filipa Gouveia, Joana Liberal, Rui Caetano Oliveira, Gilberto Alves, Amílcar Falcão, Ana Fortuna. Nose-to-brain delivery of levetiracetam after intranasal administration to mice.
International journal of pharmaceutics.
2019 Jun; 564(?):329-339. doi:
10.1016/j.ijpharm.2019.04.047. [PMID: 31015006] - Sjoerd J Finnema, Samantha Rossano, Mika Naganawa, Shannan Henry, Hong Gao, Richard Pracitto, Ralph P Maguire, Joël Mercier, Sophie Kervyn, Jean-Marie Nicolas, Henrik Klitgaard, Steven DeBruyn, Christian Otoul, Paul Martin, Pierandrea Muglia, David Matuskey, Nabeel B Nabulsi, Yiyun Huang, Rafal M Kaminski, Jonas Hannestad, Armel Stockis, Richard E Carson. A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers.
Epilepsia.
2019 05; 60(5):958-967. doi:
10.1111/epi.14701. [PMID: 30924924]
