methimazole (BioDeep_00000397481)
Main id: BioDeep_00000002534
代谢物信息卡片
2-mercapto-1-methylimidazole
化学式: C4H6N2S (114.0252)
中文名称: 2-巯基-1-甲基咪唑(甲硫咪唑), 2-巯基-1-甲基咪唑, 甲巯咪唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: Cn(c1)c(S)nc1
InChI: InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
描述信息
H - Systemic hormonal preparations, excl. sex hormones and insulins > H03 - Thyroid therapy > H03B - Antithyroid preparations > H03BB - Sulfur-containing imidazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D013956 - Antithyroid Agents
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C885 - Antithyroid Agent
CONFIDENCE standard compound; INTERNAL_ID 1167
同义名列表
4 个代谢物同义名
2-mercapto-1-methylimidazole; methimazole; Thiamazole; Methimazole
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:50673
- KEGG: C07190
- KEGGdrug: D00401
- PubChem: 1349907
- DrugBank: DB00763
- ChEMBL: CHEMBL1515
- MeSH: Methimazole
- CAS: 223768-14-7
- CAS: 85916-84-3
- CAS: 60-56-0
- MoNA: WA001413
- MoNA: WA001412
- MoNA: WA001411
- MoNA: AU116709
- MoNA: AU116708
- MoNA: AU116707
- MoNA: AU116606
- MoNA: AU116603
- MoNA: AU116602
- PubChem: 9399
- PDB-CCD: MMZ
- RefMet: Methimazole
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- James C Fazioli, Margaret K Mulligan, Erin K Ison, J Alex Pasternak. Impact of methimazole-induced hypothyroidism on postnatal swine.
Physiological reports.
2024 Apr; 12(8):e16007. doi:
10.14814/phy2.16007. [PMID: 38658325] - Zhenxing Zhang, Min Meng, Qiong Wu, Jeong-Han Kim, Yongzhe Zhu. Biodegradation and metabolic pathway of quinalphos by Cunninghamella elegans ATCC36112.
Biotechnology letters.
2023 May; ?(?):. doi:
10.1007/s10529-023-03393-9. [PMID: 37195489] - Gaëlle Schils, Ellen De Paepe, Bruno Lapauw, Ellen Vanden Broecke, Laurens Van Mulders, Lynn Vanhaecke, Aurélie Lyssens, Lisa Stammeleer, Sylvie Daminet. Evaluation of potential thiamazole exposure of owners of orally treated hyperthyroid cats.
Journal of feline medicine and surgery.
2022 06; 24(6):e138-e141. doi:
10.1177/1098612x221091738. [PMID: 35471087] - S Balasurya, Mohammad K Okla, Ibrahim A Alaraidh, Walid Soufan, Abdullah A Al-Ghamdi, Syed R Ahamad, Mostafa A Abdel-Maksoud, Hamada AbdElgawad, Lija L Raju, Ajith M Thomas, S Sudheer Khan. Photodegradation of 5-flurouracil, carvedilol, para-chlorophenol and methimazole with 3D MnWO4 nanoflower modified Ag2WO4 nanorods: A non-genotoxic nanomaterial for water treatment.
Chemosphere.
2022 Jun; 297(?):134130. doi:
10.1016/j.chemosphere.2022.134130. [PMID: 35257704] - Julio Alvarez Gamero, Victor García Ruiz, Jose Paz Ibarra. Use of unconventional antithyroid therapy in patients with thiamazole agranulocytosis in the context of the COVID-19 pandemic.
Archives of endocrinology and metabolism.
2022 03; 66(1):132-133. doi:
10.20945/2359-3997000000453. [PMID: 35263055] - Daiki Setoyama, Ho Yeop Lee, Ji Sun Moon, Jingwen Tian, Yea Eun Kang, Ju Hee Lee, Minho Shong, Dongchon Kang, Hyon-Seung Yi. Immunometabolic signatures predict recovery from thyrotoxic myopathy in patients with Graves' disease.
Journal of cachexia, sarcopenia and muscle.
2022 02; 13(1):355-367. doi:
10.1002/jcsm.12889. [PMID: 34970859] - Ichiro Kobayashi, Masaki Shimomura, Masahiro Ueki, Shunichiro Takezaki, Yuka Okura, Mitsuru Nawate, Masafumi Yamada, Yutaka Takahashi, Tadashi Ariga. Development of Graves' disease during drug-free remission of juvenile dermatomyositis.
Modern rheumatology case reports.
2022 Jan; 6(1):55-58. doi:
10.1093/mrcr/rxab006. [PMID: 34515780] - Louise Ramhøj, Terje Svingen, Caroline Frädrich, Eddy Rijntjes, Eva K Wirth, Katrine Pedersen, Josef Köhrle, Marta Axelstad. Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring.
Toxicology letters.
2022 Jan; 354(?):44-55. doi:
10.1016/j.toxlet.2021.10.010. [PMID: 34757178] - Mengxue Yang, Xiaodi Zheng, Yueyue Wu, Rui Zhang, Qian Yang, Zhiyan Yu, Jun Liu, Bingbing Zha, Qihai Gong, Bo Yang, Bowen Sun, Miao Zeng. Preliminary Observation of the Changes in the Intestinal Flora of Patients With Graves' Disease Before and After Methimazole Treatment.
Frontiers in cellular and infection microbiology.
2022; 12(?):794711. doi:
10.3389/fcimb.2022.794711. [PMID: 35402292] - Daniela Gallo, Lorenzo Mortara, Giovanni Veronesi, Simona Am Cattaneo, Angelo Genoni, Matteo Gallazzi, Carlo Peruzzo, Paolo Lasalvia, Paola Moretto, Antonino Bruno, Alberto Passi, Andrea Pini, Andrea Nauti, Maria Antonietta Lavizzari, Michele Marinò, Giulia Lanzolla, Maria Laura Tanda, Luigi Bartalena, Eliana Piantanida. Add-On Effect of Selenium and Vitamin D Combined Supplementation in Early Control of Graves' Disease Hyperthyroidism During Methimazole Treatment.
Frontiers in endocrinology.
2022; 13(?):886451. doi:
10.3389/fendo.2022.886451. [PMID: 35784564] - Sara Trzos, Paweł Link-Lenczowski, Grzegorz Sokołowski, Ewa Pocheć. Changes of IgG N-Glycosylation in Thyroid Autoimmunity: The Modulatory Effect of Methimazole in Graves' Disease and the Association With the Severity of Inflammation in Hashimoto's Thyroiditis.
Frontiers in immunology.
2022; 13(?):841710. doi:
10.3389/fimmu.2022.841710. [PMID: 35370997] - Lijing Sun, Liguo Wu, Yaqin An, Minghua Zhang, Bingjie Hou, Hongmei Liu. The effects of levothyroxine combined with methimazole on the clinical efficacy of hyperthyroidism treatment.
Pakistan journal of pharmaceutical sciences.
2022 Jan; 35(1(Special)):369-373. doi:
. [PMID: 35236650] - Dongchun Zhu, Shiqi Zhang, Xi Cao, Quan Xia, Qiu Zhang, Datong Deng, Shan Gao, Haixia Yu, Yaru Liu, Haiyun Zhou, Fangbiao Tao, Xuqun Sun. Thionamide-induced Agranulocytosis: A Retrospective Analysis of 36 Patients With Hyperthyroidism.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2021 Dec; 27(12):1183-1188. doi:
10.1016/j.eprac.2021.06.017. [PMID: 34216800] - Toshie Iijima, Teruo Jojima, Soichiro Hosonuma, Eriko Ohhira, Takuya Tomaru, Takahiko Kogai, Isao Usui, Yoshimasa Aso. Symptomatic hypocalcemia after treatment for hyperthyroidism in a woman with chromosome 22q11.2 deletion syndrome complicated by Graves' disease: longitudinal changes in the number of subsets of CD4 and CD8 lymphocytes after thyroidectomy.
Endocrine journal.
2021 Oct; 68(10):1187-1195. doi:
10.1507/endocrj.ej20-0717. [PMID: 33980771] - Stephanie Allelein, Matthias Schott. [Graves' Disease].
Deutsche medizinische Wochenschrift (1946).
2021 10; 146(20):1337-1343. doi:
10.1055/a-1258-5429. [PMID: 34644794] - Yoon-Kyung Ji, Shin-Hee Kim. Myopathy Associated with Treatment of Graves' Disease.
Medicina (Kaunas, Lithuania).
2021 Sep; 57(10):. doi:
10.3390/medicina57101016. [PMID: 34684053] - Jinhui Zeng, Fangtao Luo, Zhihua Lin, Yinghong Chen, Xiaoyun Wang, Yuanhao Song. Rash and cholestatic liver injury caused by methimazole in a woman with Turner syndrome and Graves's disease: a case report and literature review.
BMC endocrine disorders.
2021 Sep; 21(1):179. doi:
10.1186/s12902-021-00819-1. [PMID: 34479513] - J Chen, W Wang, Z Guo, S Huang, H Lei, P Zang, B Lu, J Shao, P Gu. Associations between gut microbiota and thyroidal function status in Chinese patients with Graves' disease.
Journal of endocrinological investigation.
2021 Sep; 44(9):1913-1926. doi:
10.1007/s40618-021-01507-6. [PMID: 33481211] - S Khamisi, M Lundqvist, P Emadi, K Almby, Ö Ljunggren, F A Karlsson. Serum thyroglobulin is associated with orbitopathy in Graves' disease.
Journal of endocrinological investigation.
2021 Sep; 44(9):1905-1911. doi:
10.1007/s40618-021-01505-8. [PMID: 33515213] - Lijuan Sun, Hui Jen Goh, Sanjay Verma, Priya Govindharajulu, Suresh Anand Sadananthan, Navin Michael, Yaligar Jadegoud, Christiani Jeyakumar Henry, S Sendhil Velan, Pei Shan Yeo, Yingshan Lee, Brenda Su Ping Lim, Huiling Liew, Chee Kian Chew, Timothy Peng Lim Quek, Shaikh A K K Abdul Shakoor, Wai Han Hoi, Siew Pang Chan, Daniel Ek Chew, Rinkoo Dalan, Melvin Khee Shing Leow. Metabolic effects of brown fat in transitioning from hyperthyroidism to euthyroidism.
European journal of endocrinology.
2021 Aug; 185(4):553-563. doi:
10.1530/eje-21-0366. [PMID: 34342595] - Shuang Tan, Long Chen, Likun Jin, Xiaomin Fu. The efficiency and safety of methimazole and propylthiouracil in hyperthyroidism: A meta-analysis of randomized controlled trials.
Medicine.
2021 Jul; 100(30):e26707. doi:
10.1097/md.0000000000026707. [PMID: 34397700] - Ye Liu, Xing Li, Yikun Zhu, Jiong Liu, Sunjun Liu. Subclinical hypothyroidism contributes to poor glycemic control in patients with type 2 diabetes mellitus, and ellagic acid attenuates methimazole-induced abnormal glucose metabolism in mice model.
Journal of food biochemistry.
2021 06; 45(6):e13753. doi:
10.1111/jfbc.13753. [PMID: 33955004] - Weihao Shi, Yijun Huang, Zhou Yang, Liang Zhu, Bo Yu. Reduction of TMAO level enhances the stability of carotid atherosclerotic plaque through promoting macrophage M2 polarization and efferocytosis.
Bioscience reports.
2021 05; 41(6):. doi:
10.1042/bsr20204250. [PMID: 33969376] - Fereidoun Azizi, Atieh Amouzegar, Hengameh Abdi. Efficacy of low-dose methimazole in control of multiple relapses of Graves' hyperthyroidism: a case report.
Journal of medical case reports.
2021 Apr; 15(1):189. doi:
10.1186/s13256-021-02788-4. [PMID: 33888159] - Yusaku Mori, Munenori Hiromura, Michishige Terasaki, Hideki Kushima, Makoto Ohara, Tomoyasu Fukui, Yasuyoshi Takahashi, Sho-Ichi Yamagishi. Very rare case of Graves' disease with resistance to methimazole: a case report and literature review.
The Journal of international medical research.
2021 Mar; 49(3):300060521996192. doi:
10.1177/0300060521996192. [PMID: 33682498] - Keiichi Washio, Mizuki Uenaka, Kenji Tanimura, Masashi Deguchi, Kosuke Nishida, Kazumichi Fujioka, Hideto Yamada. Fetal Goitrous Hyperthyroidism in a Pregnant Woman with Triiodothyronine-Predominant Graves' Disease.
The Kobe journal of medical sciences.
2021 Feb; 66(4):E153-E158. doi:
. [PMID: 33994519] - Fereidoun Azizi, Hengameh Abdi, Atieh Amouzegar. Control of Graves' hyperthyroidism with very long-term methimazole treatment: a clinical trial.
BMC endocrine disorders.
2021 Jan; 21(1):16. doi:
10.1186/s12902-020-00670-w. [PMID: 33446181] - Cesidio Giuliani, Ines Bucci, Giorgio Napolitano. Phenylmethimazole is a candidate drug for the treatment of severe forms of coronavirus disease 2019 (COVID-19) as well as other virus-induced 'cytokines storm'.
Medical hypotheses.
2021 Jan; 146(?):110473. doi:
10.1016/j.mehy.2020.110473. [PMID: 33385879] - Jing-E Zhu, Hui-Li Zhang, Song-Yuan Yu, Hui-Xiong Xu. US-guided percutaneous microwave ablation for hyperthyroidism and immediate treatment response evaluation with contrast-enhanced ultrasound.
Clinical hemorheology and microcirculation.
2021; 79(3):435-444. doi:
10.3233/ch-211180. [PMID: 34092625] - George J Kahaly. Management of Graves Thyroidal and Extrathyroidal Disease: An Update.
The Journal of clinical endocrinology and metabolism.
2020 12; 105(12):. doi:
10.1210/clinem/dgaa646. [PMID: 32929476] - Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue.
Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1. [PMID: 32808185] - Fereidoun Azizi. Long-Term Treatment of Hyperthyroidism with Antithyroid Drugs: 35 Years of Personal Clinical Experience.
Thyroid : official journal of the American Thyroid Association.
2020 10; 30(10):1451-1457. doi:
10.1089/thy.2019.0814. [PMID: 32253999] - M Mateu-Salat, E Urgell, A Chico. SARS-COV-2 as a trigger for autoimmune disease: report of two cases of Graves' disease after COVID-19.
Journal of endocrinological investigation.
2020 Oct; 43(10):1527-1528. doi:
10.1007/s40618-020-01366-7. [PMID: 32686042] - Chunyan Xie, Chaozhu He, Jun Gao, Shulei Jia. Efficacy and safety of tripterygium glycosides in the treatment of hyperthyroidism: A systemic review and meta-analysis.
Medicine.
2020 Sep; 99(38):e22282. doi:
10.1097/md.0000000000022282. [PMID: 32957384] - Maorong Wang, Yerong Yu. THERAPEUTIC EFFECTS OF COMBINATION REGIMENS INCLUDING METHIMAZOLE ON GRAVES HYPERTHYROIDISM: A NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2020 Jun; 26(6):675-687. doi:
10.4158/ep-2019-0555. [PMID: 32160045] - Maribel Méndez-Tepepa, Dafne Zepeda-Pérez, Marlen Espindola-Lozano, Julia Rodríguez-Castelán, Omar Arroyo-Helguera, Pablo Pacheco, Leticia Nicolás-Toledo, Estela Cuevas-Romero. Hypothyroidism modifies differentially the content of lipids and glycogen, lipid receptors, and intraepithelial lymphocytes among oviductal regions of rabbits.
Reproductive biology.
2020 Jun; 20(2):247-253. doi:
10.1016/j.repbio.2020.02.004. [PMID: 32089504] - Yusuke Ito, Hiroyuki Sakai, Hidenori Nagao, Ryota Suzuki, Masato Odawara, Kouichi Minato. Development of a high-performance liquid chromatography-tandem mass spectrometric method for the determination of Methimazole in human blood matrices.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 May; 1144(?):122083. doi:
10.1016/j.jchromb.2020.122083. [PMID: 32251990] - Baimei Zeng, Ling Yuan, Jun Chu, Yanqing Yang, Shide Lin. Challenges in early identification of causes and treatment of cholestasis in patients with hyperthyroidism: a case report and literature review.
The Journal of international medical research.
2020 Mar; 48(3):300060519891018. doi:
10.1177/0300060519891018. [PMID: 31840543] - Ahmed Y F Mahmoud, Casey J Rusin, Mark T McDermott. Gold nanostars as a colloidal substrate for in-solution SERS measurements using a handheld Raman spectrometer.
The Analyst.
2020 Feb; 145(4):1396-1407. doi:
10.1039/c9an02439e. [PMID: 32016204] - Abigail Shell, Joshua W Sullivan. Acute Kidney Injury Following Methimazole Initiation: A Case Report.
Journal of pharmacy practice.
2020 Feb; 33(1):99-101. doi:
10.1177/0897190018789277. [PMID: 30111225] - Izumi Hiratsuka, Hiroya Yamada, Mitsuyasu Itoh, Megumi Shibata, Takeshi Takayanagi, Masaki Makino, Yoshihisa Sugimura, Nobuki Hayakawa, Shuji Hashimoto, Atsushi Suzuki. Changes in Serum Immunoglobulin G4 Levels in Patients with Newly Diagnosed Graves' Disease.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2020 Feb; 128(2):119-124. doi:
10.1055/a-0669-9333. [PMID: 30235492] - Haixia Liu, Qihang Ma, Xinli Han, Wenwen Huang. Bone mineral density and its correlation with serum 25-hydroxyvitamin D levels in patients with hyperthyroidism.
The Journal of international medical research.
2020 Feb; 48(2):300060520903666. doi:
10.1177/0300060520903666. [PMID: 32043416] - Bo Liu, Li Wen, Qian Ran, Si Zhang, Junhao Hu, Mingfu Gong, Dong Zhang. Dysregulation within the salience network and default mode network in hyperthyroid patients: a follow-up resting-state functional MRI study.
Brain imaging and behavior.
2020 Feb; 14(1):30-41. doi:
10.1007/s11682-018-9961-6. [PMID: 30259292] - Iman Hassan, Hisham El-Masri, Jermaine Ford, Amanda Brennan, Sakshi Handa, Katie Paul Friedman, Mary E Gilbert. Extrapolating In Vitro Screening Assay Data for Thyroperoxidase Inhibition to Predict Serum Thyroid Hormones in the Rat.
Toxicological sciences : an official journal of the Society of Toxicology.
2020 02; 173(2):280-292. doi:
10.1093/toxsci/kfz227. [PMID: 31697382] - Taisuke Uchida, Hideki Yamaguchi, Chinami Kushima, Tadato Yonekawa, Masamitsu Nakazato. Elevated levels of circulating fibroblast growth factor 23 with hypercalcemia following discontinuation of denosumab.
Endocrine journal.
2020 Jan; 67(1):31-35. doi:
10.1507/endocrj.ej19-0198. [PMID: 31527321] - Ran Lu, Haining Wang, Tianpei Hong, Hongwei Gao. Myopathy after rapid correction of hyperthyroidism: A case report and review of literature.
Medicine.
2020 Jan; 99(3):e18878. doi:
10.1097/md.0000000000018878. [PMID: 32011514] - Xuesong Li, Jialin Yang, Shasha Jin, Yu Dai, Yujuan Fan, Xiaofang Fan, Zhigang Li, Jianhua Yang, Wai-Ping Yau, Haishu Lin, Weimin Cai, Xiaoqiang Xiang. Mechanistic examination of methimazole-induced hepatotoxicity in patients with Grave's disease: a metabolomic approach.
Archives of toxicology.
2020 01; 94(1):231-244. doi:
10.1007/s00204-019-02618-z. [PMID: 31740989] - Reza Heidari, Fatemeh Ahmadi, Hamid Reza Rahimi, Negar Azarpira, Massood Hosseinzadeh, Asma Najibi, Hossein Niknahad. Exacerbated liver injury of antithyroid drugs in endotoxin-treated mice.
Drug and chemical toxicology.
2019 Nov; 42(6):615-623. doi:
10.1080/01480545.2018.1459668. [PMID: 29722569] - Giorgio Grossi, Andrea Zoia, Paola Palagiano, Nadia Leoni, Federica Bubini-Regini, Eleonora Malerba, Angelo Peli, Giacomo Biagi, Federico Fracassi. Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats.
Open veterinary journal.
2019 10; 9(3):196-204. doi:
10.4314/ovj.v9i3.3. [PMID: 31998612] - Dan Li, Yangyao Li, Yun Chen, Haiyan Li, Yuqi She, Xialan Zhang, Shuang Chen, Wanying Chen, Guodong Qiu, Haiqing Huang, Shuyao Zhang. Neuroprotection of reduced thyroid hormone with increased estrogen and progestogen in postpartum depression.
Bioscience reports.
2019 09; 39(9):. doi:
10.1042/bsr20182382. [PMID: 31406011] - Aydilek Dagdeviren Cakir, Nur Canpolat, Seha Saygili, Isin Kilicaslan, Hande Turan, Oya Ercan, Olcay Evliyaoglu. Proteinuria in a patient with Graves' disease: Answers.
Pediatric nephrology (Berlin, Germany).
2019 08; 34(8):1383-1385. doi:
10.1007/s00467-019-04221-x. [PMID: 30843111] - Aydilek Dagdeviren Cakir, Nur Canpolat, Seha Saygili, Isin Kilicaslan, Hande Turan, Oya Ercan, Olcay Evliyaoglu. Proteinuria in a patient with Graves' disease: Questions.
Pediatric nephrology (Berlin, Germany).
2019 08; 34(8):1379-1381. doi:
10.1007/s00467-019-04220-y. [PMID: 30843109] - C Giusti. The Th1 chemokine MIG in Graves' Disease: a narrative review of the literature.
La Clinica terapeutica.
2019 Jul; 170(4):e285-e290. doi:
10.7417/ct.2019.2149. [PMID: 31304517] - George J Kahaly, Christian Wüster, Paul D Olivo, Tanja Diana. High Titers of Thyrotropin Receptor Antibodies Are Associated With Orbitopathy in Patients With Graves Disease.
The Journal of clinical endocrinology and metabolism.
2019 07; 104(7):2561-2568. doi:
10.1210/jc.2018-02705. [PMID: 30753531] - Takuya Noda, Hideaki Shiga, Kentaro Yamada, Masayuki Harita, Yukari Nakamura, Tomoko Ishikura, Masami Kumai, Zenji Kawakami, Atsushi Kaneko, Toshihisa Hatta, Hiromi Sakata-Haga, Hiroki Shimada, Takaki Miwa. Effects of Tokishakuyakusan on Regeneration of Murine Olfactory Neurons In Vivo and In Vitro.
Chemical senses.
2019 05; 44(5):327-338. doi:
10.1093/chemse/bjz023. [PMID: 30989168] - Fereidoun Azizi, Miralireza Takyar, Elham Madreseh, Atieh Amouzegar. Long-term Methimazole Therapy in Juvenile Graves' Disease: A Randomized Trial.
Pediatrics.
2019 05; 143(5):. doi:
10.1542/peds.2018-3034. [PMID: 31040197] - Aya Yoshihara, Yuqian Luo, Yuko Ishido, Kensei Usukura, Kenzaburo Oda, Mariko Sue, Akira Kawashima, Naoki Hiroi, Koichi Suzuki. Inhibitory effects of methimazole and propylthiouracil on iodotyrosine deiodinase 1 in thyrocytes.
Endocrine journal.
2019 Apr; 66(4):349-357. doi:
10.1507/endocrj.ej18-0380. [PMID: 30814441] - Xin-Hua Xiao, Xiao-Yan Qi, Jiao-Yang Li, Yi-Bing Wang, Ya-Di Wang, Zhe-Zhen Liao, Jing Yang, Li Ran, Ge-Bo Wen, Jiang-Hua Liu. Serum zinc-α2-glycoprotein levels are elevated and correlated with thyroid hormone in newly diagnosed hyperthyroidism.
BMC endocrine disorders.
2019 Jan; 19(1):12. doi:
10.1186/s12902-019-0336-9. [PMID: 30670019] - Vishal J Patel, Amit A Joharapurkar, Samadhan G Kshirsagar, Brijesh K Sutariya, Maulik S Patel, Rajesh H Bahekar, Mukul R Jain. Activation of GLP-1 and Glucagon Receptors Regulates Bile Homeostasis Independent of Thyroid Hormone.
Current molecular pharmacology.
2019; 12(2):139-146. doi:
10.2174/1874467212666190212112402. [PMID: 30747091] - Fangyuan Chen, Jianming Yang, Yanqun Liu, Wen Wang, Li Zhu, Wei Wang, Jun Yang, Wei You. Insulin autoimmune syndrome: Three case reports.
Medicine.
2018 Dec; 97(51):e13486. doi:
10.1097/md.0000000000013486. [PMID: 30572448] - Zunera Hakim, Akbar Waheed, Salman Bakhtiar, Najamul Hasan, Bareera Hakim. Potentiating effect of rifampicin on methimazole induced hepatotoxicity in mice.
Pakistan journal of pharmaceutical sciences.
2018 Nov; 31(6):2373-2377. doi:
. [PMID: 30473507] - Henry B Burch, David S Cooper. ANNIVERSARY REVIEW: Antithyroid drug therapy: 70 years later.
European journal of endocrinology.
2018 Oct; 179(5):R261-R274. doi:
10.1530/eje-18-0678. [PMID: 30320502] - Ádám Tölgyesi, Anupam Giri, Eniko Barta, Thomas J McDonald, Virender K Sharma. Determination of Thyreostats in Urine Using Supported Liquid Extraction and Mixed-Mode Cation-Exchange Solid-Phase Extraction: Screening and Confirmatory Methods.
Journal of chromatographic science.
2018 Oct; 56(9):858-866. doi:
10.1093/chromsci/bmy054. [PMID: 29878072] - Jiman Kim, Tae-Hun Kim. A methimazole resistant patient with Graves' disease (GD): A case report of mid-term management with herbal decoctions mainly composed of Anemarrhena Bunge.
Complementary therapies in medicine.
2018 Aug; 39(?):109-113. doi:
10.1016/j.ctim.2018.05.015. [PMID: 30012381] - Nazar Ali Korejo, Quanwei Wei, Kaizhi Zheng, Dagan Mao, Rashid Ali Korejo, Atta Hussain Shah, Fangxiong Shi. Contemporaneous effects of diabetes mellitus and hypothyroidism on spermatogenesis and immunolocalization of Claudin-11 inside the seminiferous tubules of mice.
BMC developmental biology.
2018 06; 18(1):15. doi:
10.1186/s12861-018-0174-4. [PMID: 29940839] - Sebastian Witek, Barbara Wozniak, Iwona Matraszek-Zuchowska, Andrzej Posyniak. Analysis of thyreostats in bovine feces using ultra high performance liquid chromatography with tandem mass spectrometry.
Journal of separation science.
2018 Mar; 41(5):1083-1090. doi:
10.1002/jssc.201701069. [PMID: 29266785] - Qingling Guo, Dan Wu, Huixin Yu, Jiandong Bao, Shiqiao Peng, Zhongyan Shan, Haixia Guan, Weiping Teng. Alterations of Global DNA Methylation and DNA Methyltransferase Expression in T and B Lymphocytes from Patients with Newly Diagnosed Autoimmune Thyroid Diseases After Treatment: A Follow-Up Study.
Thyroid : official journal of the American Thyroid Association.
2018 03; 28(3):377-385. doi:
10.1089/thy.2017.0301. [PMID: 29336230] - E L Lushnikova, D E Semenov, D B Nikityuk, E V Koldysheva, M G Klinnikova. Intracellular Reorganization of Cardiomyocytes in Dyslipidemic Cardiomyopathies.
Bulletin of experimental biology and medicine.
2018 Mar; 164(4):508-513. doi:
10.1007/s10517-018-4022-0. [PMID: 29504114] - Daphné Rochel, Myriam Burger, Patrick Nguyen, Laetitia Jaillardon. Insulin-like growth factor type 1 concentrations in hyperthyroid cats before and after treatment with thiamazole.
Journal of feline medicine and surgery.
2018 02; 20(2):179-183. doi:
10.1177/1098612x17694735. [PMID: 29172902] - Denise P Carvalho, Corinne Dupuy. Thyroid hormone biosynthesis and release.
Molecular and cellular endocrinology.
2017 Dec; 458(?):6-15. doi:
10.1016/j.mce.2017.01.038. [PMID: 28153798] - Hua Yang, Yilei Cong, Tengfei Wu, Hong Tang, Muhao Ma, Juanhua Zeng, Wenya Zhang, Zhen Lian, Xinyu Yang. Clinical efficacy of Yingliu mixture combined with metimazole for treating diffuse goitre with hyperthyroidism and its impact on related cytokines.
Pharmaceutical biology.
2017 Dec; 55(1):258-263. doi:
10.1080/13880209.2016.1260595. [PMID: 27927064] - Marcin R Tatara, Marcin Gołyński, Radosław P Radzki, Marek Bieńko, Witold Krupski. Effects of long-term oral administration of methimazole on femur and tibia properties in male Wistar rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Oct; 94(?):124-128. doi:
10.1016/j.biopha.2017.07.107. [PMID: 28759749] - Mahmoud Al-Majdoub, Mikael Lantz, Peter Spégel. Treatment of Swedish Patients with Graves' Hyperthyroidism Is Associated with Changes in Acylcarnitine Levels.
Thyroid : official journal of the American Thyroid Association.
2017 09; 27(9):1109-1117. doi:
10.1089/thy.2017.0218. [PMID: 28699427] - T Toimela, O Huttala, E Sabell, M Mannerström, J R Sarkanen, T Ylikomi, T Heinonen. Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free medium.
Reproductive toxicology (Elmsford, N.Y.).
2017 06; 70(?):116-125. doi:
10.1016/j.reprotox.2016.11.015. [PMID: 27915012] - Qi Wei, Bo Hu, Yuan Xue, David Kibe Mburu, Xian Tao, Jianya Su. Effects of methimazole on Drosophila glucolipid metabolism in vitro and in vivo.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2017 Jun; 196(?):54-60. doi:
10.1016/j.cbpc.2017.03.011. [PMID: 28341216] - Tzlil Tabachnik, Tatiana Kisliouk, Asaf Marco, Noam Meiri, Aron Weller. Thyroid Hormone-Dependent Epigenetic Regulation of Melanocortin 4 Receptor Levels in Female Offspring of Obese Rats.
Endocrinology.
2017 04; 158(4):842-851. doi:
10.1210/en.2016-1854. [PMID: 28324105] - M Leo, L Bartalena, G Rotondo Dottore, E Piantanida, P Premoli, I Ionni, M Di Cera, E Masiello, L Sassi, M L Tanda, F Latrofa, P Vitti, C Marcocci, M Marinò. Effects of selenium on short-term control of hyperthyroidism due to Graves' disease treated with methimazole: results of a randomized clinical trial.
Journal of endocrinological investigation.
2017 Mar; 40(3):281-287. doi:
10.1007/s40618-016-0559-9. [PMID: 27734319] - Andrea Looney, Joseph Wakshlag. Dietary Management of Hyperthyroidism in a Dog.
Journal of the American Animal Hospital Association.
2017 Mar; 53(2):111-118. doi:
10.5326/jaaha-ms-6385. [PMID: 28282233] - Hiromi Wada. Acoustic alterations of ultrasonic vocalization in rat pups induced by perinatal hypothyroidism.
Neurotoxicology.
2017 03; 59(?):175-182. doi:
10.1016/j.neuro.2016.05.017. [PMID: 27241349] - Aleksandra Hernik, Ewelina Szczepanek-Parulska, Bogusz Falkowski, Hanna Komarowska, Michał Drews, Marek Ruchała. A diabetic patient with suppurative thyroiditis due to Salmonella enterica complicated by acute kidney injury.
Polish archives of internal medicine.
2017 02; 127(2):131-132. doi:
10.20452/pamw.3957. [PMID: 28267139] - Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Daniela Zanini, Andréia M Cardoso, Fátima H Abadalla, Gustavo R Thomé, Camila Murussi, Carla R N Polachini, Diéssica P Delenogare, Vania L Loro, Vera M Morsch, Maria R C Schetinger. Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Dec; 84(?):1849-1857. doi:
10.1016/j.biopha.2016.10.109. [PMID: 27832996] - Ying Peng, Yicheng Qi, Fengjiao Huang, Xinxin Chen, Yulin Zhou, Lei Ye, Weiqing Wang, Guang Ning, Shu Wang. Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease.
Oncotarget.
2016 Nov; 7(48):78680-78687. doi:
10.18632/oncotarget.12019. [PMID: 27637079] - Shu Kikuta, Yu Matsumoto, Akihito Kuboki, Tsuguhisa Nakayama, Daiya Asaka, Nobuyoshi Otori, Hiromi Kojima, Takashi Sakamoto, Kashio Akinori, Kaori Kanaya, Rumi Ueha, Ryoji Kagoya, Hironobu Nishijima, Makiko Toma-Hirano, Yayoi Kikkawa, Kenji Kondo, Koichi Tsunoda, Tempei Miyaji, Takuhiro Yamaguchi, Kazunori Kataoka, Kensaku Mori, Tatsuya Yamasoba. Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder.
Scientific reports.
2016 10; 6(?):35361. doi:
10.1038/srep35361. [PMID: 27734933] - Izumi Hiratsuka, Hiroya Yamada, Eiji Munetsuna, Shuji Hashimoto, Mitsuyasu Itoh. Circulating MicroRNAs in Graves' Disease in Relation to Clinical Activity.
Thyroid : official journal of the American Thyroid Association.
2016 10; 26(10):1431-1440. doi:
10.1089/thy.2016.0062. [PMID: 27610819] - Hossein Niknahad, Akram Jamshidzadeh, Reza Heidari, Zeynab Hosseini, Keivan Mobini, Forouzan Khodaei, Mohammad Mehdi Ommati, Narges Abdoli, Nahid Keshavarz, Mandana Bazyari, Asma Najibi. Paradoxical effect of methimazole on liver mitochondria: In vitro and in vivo.
Toxicology letters.
2016 Sep; 259(?):108-115. doi:
10.1016/j.toxlet.2016.08.003. [PMID: 27506418] - Yasuaki Uematsu, Sho Akai, Tomoaki Tochitani, Shingo Oda, Toru Yamada, Tsuyoshi Yokoi. MicroRNA-mediated Th2 bias in methimazole-induced acute liver injury in mice.
Toxicology and applied pharmacology.
2016 09; 307(?):1-9. doi:
10.1016/j.taap.2016.07.008. [PMID: 27421576] - Rika Hirashima, Hirofumi Michimae, Hiroaki Takemoto, Aya Sasaki, Yoshinori Kobayashi, Tomoo Itoh, Robert H Tukey, Ryoichi Fujiwara. Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity.
Molecular pharmacology.
2016 09; 90(3):265-74. doi:
10.1124/mol.116.104174. [PMID: 27413119] - Lingyan Zhou, Shuyan Ding, Yujie Li, Laicheng Wang, Wenbin Chen, Tao Bo, Kunpeng Wu, Congcong Li, Xiaojing Liu, Jiajun Zhao, Chao Xu, Ling Gao. Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism.
Scientific reports.
2016 08; 6(?):31381. doi:
10.1038/srep31381. [PMID: 27539723] - Mark E Peterson, Jade N Guterl, Mark Rishniw, Michael R Broome. EVALUATION OF QUANTITATIVE THYROID SCINTIGRAPHY FOR DIAGNOSIS AND STAGING OF DISEASE SEVERITY IN CATS WITH HYPERTHYROIDISM: COMPARISON OF THE PERCENT THYROIDAL UPTAKE OF PERTECHNETATE TO THYROID-TO-SALIVARY RATIO AND THYROID-TO-BACKGROUND RATIOS.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.
2016 Jul; 57(4):427-40. doi:
10.1111/vru.12360. [PMID: 27062212] - Dhiãnah Santini de Oliveira Chachamovitz, Patrícia Dos Santos Vigário, Silvana Oliveira E Silva, Letícia B B de Mello Teixeira, Michele Lopes Fagundes, Mário Vaisman, Patrícia de F Dos S Teixeira. Does low-normal serum TSH level adversely impact cognition in elderly adults and might methimazole therapy improve outcomes?.
Endocrine journal.
2016 May; 63(5):495-505. doi:
10.1507/endocrj.ej15-0458. [PMID: 27052122] - Jeremy A Leonard, Yu-Mei Tan, Mary Gilbert, Kristin Isaacs, Hisham El-Masri. Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-Throughput in vitro Data, High-Throughput Exposure Modeling, and Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling.
Toxicological sciences : an official journal of the Society of Toxicology.
2016 05; 151(1):57-70. doi:
10.1093/toxsci/kfw022. [PMID: 26865668] - Sho Akai, Yasuaki Uematsu, Koichi Tsuneyama, Shingo Oda, Tsuyoshi Yokoi. Kupffer cell-mediated exacerbation of methimazole-induced acute liver injury in rats.
Journal of applied toxicology : JAT.
2016 May; 36(5):702-15. doi:
10.1002/jat.3202. [PMID: 26177832] - Yong Ding, Jialiu Xing, Zewu Qiu, Yong Wang, Youren Zhang, Yi Fang, Xiaobo Peng, Yahong Long, Pei Deng. RADIOACTIVE IODINE THERAPY WITHOUT RECENT ANTITHYROID DRUG PRETREATMENT FOR HYPERTHYROIDISM COMPLICATED BY SEVERE HYPERBILIRUBINEMIA DUE TO HEPATIC DYSFUNCTION: EXPERIENCE OF A CHINESE MEDICAL CENTER.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2016 Feb; 22(2):173-9. doi:
10.4158/ep15736.or. [PMID: 26492542] - Mark E Peterson, Michael R Broome, Mark Rishniw. Prevalence and degree of thyroid pathology in hyperthyroid cats increases with disease duration: a cross-sectional analysis of 2096 cats referred for radioiodine therapy.
Journal of feline medicine and surgery.
2016 Feb; 18(2):92-103. doi:
10.1177/1098612x15572416. [PMID: 25673019] - L Bartalena, H B Burch, K D Burman, G J Kahaly. A 2013 European survey of clinical practice patterns in the management of Graves' disease.
Clinical endocrinology.
2016 Jan; 84(1):115-20. doi:
10.1111/cen.12688. [PMID: 25581877] - R G Ahmed, M Abdel-Latif, F Ahmed. Protective effects of GM-CSF in experimental neonatal hypothyroidism.
International immunopharmacology.
2015 Dec; 29(2):538-543. doi:
10.1016/j.intimp.2015.10.001. [PMID: 26453507] - Tullaya Sitasuwan, Suchanan Hanamornroongruang, Thavatchai Peerapatdit, Nuntakorn Thongtang. Coexistence of Graves' disease and unilateral functioning Struma ovarii: a case report.
BMC endocrine disorders.
2015 Nov; 15(?):68. doi:
10.1186/s12902-015-0060-z. [PMID: 26530865] - Se Hee Min, Anita Phung, Tae Jung Oh, Kyou-Sup Han, Man Jin Kim, Jee Min Kim, Ji Hyun Lee, Young Joo Park. Therapeutic Plasmapheresis Enabling Radioactive Iodine Treatment in a Patient with Thyrotoxicosis.
Journal of Korean medical science.
2015 Oct; 30(10):1531-4. doi:
10.3346/jkms.2015.30.10.1531. [PMID: 26425054] - Qing-mu Li, Jung-ping Wei, Min Li, Shu-hua Meng. [Effect of Jiakangning Capsule on Thyroid Function and Akt/mTOR Signal Pathway of Graves' Disease Mice: an Experimental Study].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2015 Sep; 35(9):1119-24. doi:
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