Noreugenin (BioDeep_00000000397)

 

Secondary id: BioDeep_00001867497

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-methyl-

化学式: C10H8O4 (192.0422568)
中文名称: 去甲丁香色原酮, 去甲丁香色原酮
谱图信息: 最多检出来源 Viridiplantae(plant) 1.53%

分子结构信息

SMILES: CC1=CC(=O)C2=C(C=C(C=C2O1)O)O
InChI: InChI=1S/C10H8O4/c1-5-2-7(12)10-8(13)3-6(11)4-9(10)14-5/h2-4,11,13H,1H3

描述信息

Noreugenin is a member of the class of chromones in which the 1,4-benzopyrone skeleton is substituted with a methyl group at position 2 and with hydroxy groups at positions 5 and 7. A natural product, it is found in Pisonia aculeata. It has a role as a plant metabolite. It is a member of chromones and a member of resorcinols. It is a conjugate acid of a noreugenin(1-).
Noreugenin is a natural product found in Crossosoma bigelovii, Schumanniophyton magnificum, and other organisms with data available.
Noreugenin, also known as 5,7-dihydroxy-2-methyl-4h-1-benzopyran-4-one, is a member of the class of compounds known as chromones. Chromones are compounds containing a benzopyran-4-one moiety. Noreugenin is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Noreugenin can be found in carrot and wild carrot, which makes noreugenin a potential biomarker for the consumption of these food products.
Noreugenin, 5,7-dihydroxy-2-methyl-4H-chromen-4-one, is a new chromone from Aloe arborescens. (Amaryllidaceae)[1].

同义名列表

18 个代谢物同义名

4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-methyl-; 4H-1-Benzopyran-4-one,5,7-dihydroxy-2-methyl-; 5,7-Dihydroxy-2-methyl-4H-1-benzopyran-4-one; 5,7-Dihydroxy-2-methyl-4H-chromen-4-one #; 5,7-Dihydroxy-2-methyl-4H-chromen-4-one; 5,7-dihydroxy-2-methylbenzopyran-4-one; 5,7-dihydroxy-2-methyl-chromen-4-one; 5,7-dihydroxy-2-methylchromen-4-one; Chromone, 5,7-dihydroxy-2-methyl-; DIHYDROXY METHYLCHROMONE [INCI]; 5,7-Dihydroxy-2-methylchromone; 5,7-Dihydroxy-2-methylchromome; 2-Methyl-5,7-dihydroxychromone; 2-Methyl-5,7-dihydroxychromon; dihydroxymethylchromone; UNII-M0KFC1Q5JC; M0KFC1Q5JC; Noreugenin



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Modibo S Malefo, Thanyani E Ramadwa, Ibukun M Famuyide, Lyndy J McGaw, Jacobus N Eloff, Molahlehi S Sonopo, Mamoalosi A Selepe. Synthesis and Antifungal Activity of Chromones and Benzoxepines from the Leaves of Ptaeroxylon obliquum. Journal of natural products. 2020 08; 83(8):2508-2517. doi: 10.1021/acs.jnatprod.0c00587. [PMID: 32790311]
  • Ming-Chun Wu, Chien-Fang Peng, Ih-Sheng Chen, Ian-Lih Tsai. Antitubercular chromones and flavonoids from Pisonia aculeata. Journal of natural products. 2011 May; 74(5):976-82. doi: 10.1021/np1008575. [PMID: 21542597]
  • Jean Jules Kezetas Bankeu, Sufyan Awad Alkarim Mustafa, Anar Sahib Gojayev, Bruno Djakou Lenta, Didérot Tchamo Noungoué, Silvère Augustin Ngouela, Khalid Asaad, Mohammed Iqbal Choudhary, Sean Prigge, Akif Alekper Guliyev, Augustin Ephrem Nkengfack, Etienne Tsamo, Muhammad Shaiq Ali. Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae). Chemical & pharmaceutical bulletin. 2010 Dec; 58(12):1661-5. doi: 10.1248/cpb.58.1661. [PMID: 21139276]
  • Ikuro Abe. Engineered biosynthesis of plant polyketides: structure-based and precursor-directed approach. Topics in current chemistry. 2010; 297(?):45-66. doi: 10.1007/128_2009_22. [PMID: 21495256]
  • Paul Klausmeyer, Qin Zhou, Dominic A Scudiero, Badarch Uranchimeg, Giovanni Melillo, John H Cardellina, Robert H Shoemaker, Ching-Jer Chang, Thomas G McCloud. Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii. Journal of natural products. 2009 May; 72(5):805-12. doi: 10.1021/np8006342. [PMID: 19405508]
  • Ting Zhang, Hongqing Wang, Guanhua Du, Ruoyun Chen. [Study on chemical constituents from roots of Saussurea lappa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 May; 34(10):1223-4. doi: . [PMID: 19673381]
  • Ikuro Abe, Hiroyuki Morita, Satoshi Oguro, Hisashi Noma, Kiyofumi Wanibuchi, Nobuo Kawahara, Yukihiro Goda, Hiroshi Noguchi, Toshiyuki Kohno. Structure-based engineering of a plant type III polyketide synthase: formation of an unnatural nonaketide naphthopyrone. Journal of the American Chemical Society. 2007 May; 129(18):5976-80. doi: 10.1021/ja070375l. [PMID: 17439126]
  • Hiroyuki Morita, Shin Kondo, Tsuyoshi Abe, Hiroshi Noguchi, Shigetoshi Sugio, Ikuro Abe, Toshiyuki Kohno. Crystallization and preliminary crystallographic analysis of a novel plant type III polyketide synthase that produces pentaketide chromone. Acta crystallographica. Section F, Structural biology and crystallization communications. 2006 Sep; 62(Pt 9):899-901. doi: 10.1107/s174430910602968x. [PMID: 16946474]
  • K Suresh Babu, Ashok K Tiwari, Pullela V Srinivas, Amtul Z Ali, B China Raju, J Madhusudana Rao. Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson. Bioorganic & medicinal chemistry letters. 2004 Jul; 14(14):3841-5. doi: 10.1016/j.bmcl.2004.04.062. [PMID: 15203173]
  • Wenyi Kang, Xiaojiang Hao, Guohong Li. [Study on the constituents from Neonauclea sessilifolia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2002 Dec; 25(12):875-7. doi: ". [PMID: 12685347]
  • C Q Hu, K Chen, Q Shi, R E Kilkuskie, Y C Cheng, K H Lee. Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids. Journal of natural products. 1994 Jan; 57(1):42-51. doi: 10.1021/np50103a006. [PMID: 8158164]