gamma-Tocotrienol (BioDeep_00000395484)

 

Secondary id: BioDeep_00000003564, BioDeep_00000400388, BioDeep_00000861638

human metabolite PANOMIX_OTCML-2023 Endogenous Antitumor activity


代谢物信息卡片


2,7,8-TRIMETHYL-2-[(3E,7E,11E,15E,19E,23E,27E)-4,8,12,16,20,24,28,32-O CTAMETHYL-3,7,11,15,19,23,27,31-TRITRIACONTAOCTAENYL]-6-CHROMANOL

化学式: C28H42O2 (410.3185)
中文名称: γ-生育三烯酚
谱图信息: 最多检出来源 Homo sapiens(feces) 9.02%

分子结构信息

SMILES: C1C(=C(C(=C2O[C@@](C)(CCC=12)CC/C=C(\C)/CC/C=C(\C)/CC/C=C(/C)\C)C)C)O
InChI: InChI=1S/C28H42O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h11,13,15,19,29H,8-10,12,14,16-18H2,1-7H3/b21-13+,22-15+

描述信息

gamma-Tocotrienol, also known as 7,8-dimethyltocotrienol, belongs to the class of organic compounds known as tocotrienols. These are vitamin E derivatives containing an unsaturated trimethyltrideca-3,7,11-trien-1-yl chain attached to the C6 atom of a benzopyran ring system. They differ from tocopherols that contain a saturated trimethyltridecyl chain. Thus, gamma-tocotrienol is considered to be a quinone lipid molecule. gamma-Tocotrienol is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. gamma-Tocotrienol targets cancer cells by inhibiting Id1, a key cancer-promoting protein. gamma-Tocotrienol was shown to trigger cell apoptosis and well as anti-proliferation of cancer cells. This mechanism was also observed in separate prostate cancer and melanoma cell line studies.
Gamma-tocotrienol is a tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2. A vitamin E family member that has potent anti-cancer properties against a wide-range of cancers. It has a role as an antioxidant, an antineoplastic agent, a plant metabolite, a radiation protective agent, an apoptosis inducer and a hepatoprotective agent. It is a tocotrienol and a vitamin E.
gamma-Tocotrienol is a natural product found in Amaranthus cruentus, Triadica sebifera, and other organisms with data available.
A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2. A vitamin E family member that has potent anti-cancer properties against a wide-range of cancers.
Constituent of palm oil. Nutriceutical with anticancer props. and a positive influence on the blood lipid profile. gamma-Tocotrienol is found in many foods, some of which are rye, corn, rosemary, and common grape.
γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a novel radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment[1][2][3].
γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a novel radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment[1][2][3].

同义名列表

46 个代谢物同义名

2,7,8-TRIMETHYL-2-[(3E,7E,11E,15E,19E,23E,27E)-4,8,12,16,20,24,28,32-O CTAMETHYL-3,7,11,15,19,23,27,31-TRITRIACONTAOCTAENYL]-6-CHROMANOL; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2R)- (9CI); 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-, (2R)-; 2H-1-BENZOPYRAN-6-OL, 3,4-DIHYDRO-2,7,8-TRIMETHYL-2-((3E,7E)-4,8,12-TRIMETHYL-3,7,11-TRIDECATRIEN-1-YL)-, (2R)-; 2H-1-BENZOPYRAN-6-OL, 3,4-DIHYDRO-2,7,8-TRIMETHYL-2-((3E,7E)-4,8,12-TRIMETHYL-3,7,11-TRIDECATRIENYL)-, (2R)-; 2H-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2R)-; (2R)-3,4-Dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-2H-1-benzopyran-6-ol; (2R)-2,7,8-Trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-1-benzopyran-6-ol; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (R-(E,E))-; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, [R-(E,E)]-; (2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-chromen-6-ol; (R-(E,E))-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol; 3,4-Dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol; 2R,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-chromen-6-ol; (2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol; (r)-2,7,8-trimethyl-2-((3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl) chroman-6-ol; (R)-2,7,8-Trimethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chroman-6-ol; 6-Chromanol, 2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)- (7CI,8CI); (2R)-2,7,8-trimethyl-2-(4,8,12-trimethyl-trideca-3,7,11-trienyl)-6-hydroxychroman; 6-Chromanol, 2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-; D-gamma-Tocotrienol, analytical reference material; gamma-Tocotrienol, analytical standard; plastochromanol 8, plastochromanol 3; gammaTocotrienolPlastochromanol; GAMMA TOCOTRIENOL [WHO-DD]; (R)-.gamma.-Tocotrienol; 7,8-Dimethyltocotrienol; D-.gamma.-Tocotrienol; (R)-gamma-Tocotrienol; 2R-gamma-tocotrienol; .gamma.-Tocotrienol; D-gamma-Tocotrienol; tocotrienol, gamma; gamma -Tocotrienol; plastochromanol 8; gamma-Tocotrienol; (R)-Γ-tocotrienol; Plastochromanol 3; gamma Tocotrienol; gammaTocotrienol; Gama-Tocotrienol; Plastochromanol; D-Γ-tocotrienol; g-Tocotrienol; γ-Tocotrienol; J13.903C



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, ANXA5, BCL2, CASP3, CCND1, CDK4, CTNNB1, MAPK8, MTOR, MYC, PIK3CA, PTGS2, STAT3, VEGFA
Peripheral membrane protein 3 ANXA5, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, HMGCR, MTOR, PTGS2
Nucleus 12 AKT1, BCL2, CASP3, CCND1, CDK4, CTNNB1, MAPK8, MKI67, MTOR, MYC, STAT3, VEGFA
cytosol 11 AKT1, ANXA5, BCL2, CASP3, CCND1, CDK4, CTNNB1, MAPK8, MTOR, PIK3CA, STAT3
dendrite 1 MTOR
nuclear body 1 MKI67
phagocytic vesicle 1 MTOR
centrosome 2 CCND1, CTNNB1
nucleoplasm 10 AKT1, CASP3, CCND1, CDK4, CTNNB1, MAPK8, MKI67, MTOR, MYC, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 2 AKT1, CTNNB1
Cytoplasmic side 1 MTOR
lamellipodium 3 AKT1, CTNNB1, PIK3CA
Multi-pass membrane protein 1 HMGCR
Golgi apparatus membrane 1 MTOR
Synapse 2 CTNNB1, MAPK8
cell cortex 2 AKT1, CTNNB1
cell junction 1 CTNNB1
cell surface 1 VEGFA
glutamatergic synapse 3 AKT1, CASP3, CTNNB1
Golgi apparatus 1 VEGFA
Golgi membrane 2 INS, MTOR
lysosomal membrane 2 EGF, MTOR
neuronal cell body 1 CASP3
postsynapse 1 AKT1
presynaptic membrane 1 CTNNB1
sarcolemma 1 ANXA5
Lysosome 1 MTOR
plasma membrane 5 AKT1, CTNNB1, EGF, PIK3CA, STAT3
Membrane 10 AKT1, ANXA5, BCL2, CTNNB1, EGF, HMGCR, MKI67, MTOR, MYC, VEGFA
axon 1 MAPK8
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 3 ANXA5, CTNNB1, EGF
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, HMGCR, PTGS2, VEGFA
extracellular space 5 CSF3, EGF, IL6, INS, VEGFA
lysosomal lumen 1 CSF3
perinuclear region of cytoplasm 2 CTNNB1, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CTNNB1, VEGFA
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 3 CCND1, CDK4, CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 1 BCL2
protein-containing complex 5 AKT1, BCL2, CTNNB1, MYC, PTGS2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 4 CSF3, IL6, INS, VEGFA
extracellular region 6 ANXA5, CSF3, EGF, IL6, INS, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
transcription regulator complex 3 CDK4, CTNNB1, STAT3
Nucleus membrane 3 BCL2, CCND1, CDK4
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CCND1, CDK4
external side of plasma membrane 1 ANXA5
Secreted, extracellular space, extracellular matrix 1 VEGFA
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
nucleolus 3 CDK4, MKI67, MYC
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 ANXA5, CTNNB1
spindle 1 AKT1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 1 VEGFA
peroxisomal membrane 1 HMGCR
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 3 CDK4, MYC, STAT3
cell periphery 1 CTNNB1
Chromosome 1 MKI67
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 2 MKI67, MYC
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 2 MTOR, MYC
Endomembrane system 2 CTNNB1, MTOR
endosome lumen 1 INS
Nucleus, nucleoplasm 1 MYC
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
Peroxisome membrane 1 HMGCR
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
transcription repressor complex 1 CCND1
platelet alpha granule lumen 2 EGF, VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
RNA polymerase II transcription repressor complex 1 MYC
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGF
protein-DNA complex 1 CTNNB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Rough endoplasmic reticulum 1 MYC
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDK4
endocytic vesicle lumen 1 CSF3
Myc-Max complex 1 MYC
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 2 CCND1, CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 1 CDK4
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
nucleoplasmic reticulum 1 MYC


文献列表

  • Hanqing Zhao, Xin Guo, Yunxuan Lei, Wenjie Xia, Feiyang Cai, Dehao Zhu, Yang An, Yebin Xi, Xiaoyin Niu, Zhaojun Wang, Tao Yue, Guangjie Chen. γ-Tocotrienol inhibits T helper 17 cell differentiation via the IL-6/JAK/STAT3 signaling pathway. Molecular immunology. 2022 11; 151(?):126-133. doi: 10.1016/j.molimm.2022.09.007. [PMID: 36126500]
  • Elliot Rosen, Oluseyi O Fatanmi, Stephen Y Wise, V Ashutosh Rao, Vijay K Singh. Gamma-tocotrienol, a radiation countermeasure, reverses proteomic changes in serum following total-body gamma irradiation in mice. Scientific reports. 2022 03; 12(1):3387. doi: 10.1038/s41598-022-07266-5. [PMID: 35233005]
  • Grazyna Nowak, Judit Megyesi. γ-Tocotrienol Protects against Mitochondrial Dysfunction, Energy Deficits, Morphological Damage, and Decreases in Renal Functions after Renal Ischemia. International journal of molecular sciences. 2021 Nov; 22(23):. doi: 10.3390/ijms222312674. [PMID: 34884479]
  • Jerzy Kruk, Renata Szymańska. Singlet oxygen oxidation products of carotenoids, fatty acids and phenolic prenyllipids. Journal of photochemistry and photobiology. B, Biology. 2021 Mar; 216(?):112148. doi: 10.1016/j.jphotobiol.2021.112148. [PMID: 33556703]
  • Mohd Saufi Harun, Tin Wui Wong, Chee Wai Fong. Advancing skin delivery of α-tocopherol and γ-tocotrienol for dermatitis treatment via nanotechnology and microwave technology. International journal of pharmaceutics. 2021 Jan; 593(?):120099. doi: 10.1016/j.ijpharm.2020.120099. [PMID: 33259902]
  • Aleksander Siger, Michał Michalak, Justyna Lembicz, Małgorzata Nogala-Kałucka, Teresa Cegielska-Taras, Laurencja Szała. Genotype × environment interaction on tocochromanol and plastochromanol-8 content in seeds of doubled haploids obtained from F1 hybrid black × yellow seeds of winter oilseed rape (Brassica napus L.). Journal of the science of food and agriculture. 2018 Jul; 98(9):3263-3270. doi: 10.1002/jsfa.8829. [PMID: 29230831]
  • Evan L Pannkuk, Evagelia C Laiakis, Albert J Fornace, Oluseyi O Fatanmi, Vijay K Singh. A Metabolomic Serum Signature from Nonhuman Primates Treated with a Radiation Countermeasure, Gamma-tocotrienol, and Exposed to Ionizing Radiation. Health physics. 2018 07; 115(1):3-11. doi: 10.1097/hp.0000000000000776. [PMID: 29787425]
  • Victoria E Palau, Kanishka Chakraborty, Daniel Wann, Janet Lightner, Keely Hilton, Marianne Brannon, William Stone, Koyamangalath Krishnan. γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport. BMC cancer. 2018 May; 18(1):564. doi: 10.1186/s12885-018-4462-y. [PMID: 29769046]
  • Fei Xu, Janam K Pandya, Cheryl Chung, David Julian McClements, Amanda J Kinchla. Emulsions as delivery systems for gamma and delta tocotrienols: Formation, properties and simulated gastrointestinal fate. Food research international (Ottawa, Ont.). 2018 03; 105(?):570-579. doi: 10.1016/j.foodres.2017.11.033. [PMID: 29433249]
  • Sébastien Pellaud, Alexandre Bory, Valentin Chabert, Joëlle Romanens, Laurie Chaisse-Leal, Anh Vu Doan, Lucas Frey, Andrea Gust, Katharina M Fromm, Laurent Mène-Saffrané. WRINKLED1 and ACYL-COA:DIACYLGLYCEROL ACYLTRANSFERASE1 regulate tocochromanol metabolism in Arabidopsis. The New phytologist. 2018 Jan; 217(1):245-260. doi: 10.1111/nph.14856. [PMID: 29105089]
  • Amrita K Cheema, Khyati Y Mehta, Oluseyi O Fatanmi, Stephen Y Wise, Charles P Hinzman, Josh Wolff, Vijay K Singh. A Metabolomic and Lipidomic Serum Signature from Nonhuman Primates Administered with a Promising Radiation Countermeasure, Gamma-Tocotrienol. International journal of molecular sciences. 2017 Dec; 19(1):. doi: 10.3390/ijms19010079. [PMID: 29283379]
  • Jo Aan Goon, Nor Helwa Ezzah Nor Azman, Siti Madiani Abdul Ghani, Zalina Hamid, Wan Zurinah Wan Ngah. Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults. Clinical nutrition ESPEN. 2017 10; 21(?):1-12. doi: 10.1016/j.clnesp.2017.07.004. [PMID: 30014863]
  • Ahmed Abu-Fayyad, Sami Nazzal. Gemcitabine-vitamin E conjugates: Synthesis, characterization, entrapment into nanoemulsions, and in-vitro deamination and antitumor activity. International journal of pharmaceutics. 2017 Aug; 528(1-2):463-470. doi: 10.1016/j.ijpharm.2017.06.031. [PMID: 28627455]
  • JuHee Song, Mi-Ja Kim, Young-Jun Kim, JaeHwan Lee. Monitoring changes in acid value, total polar material, and antioxidant capacity of oils used for frying chicken. Food chemistry. 2017 Apr; 220(?):306-312. doi: 10.1016/j.foodchem.2016.09.174. [PMID: 27855904]
  • Eva Fleta-Soriano, Sergi Munné-Bosch. Enhanced plastochromanol-8 accumulation during reiterated drought in maize (Zea mays L.). Plant physiology and biochemistry : PPB. 2017 Mar; 112(?):283-289. doi: 10.1016/j.plaphy.2017.01.016. [PMID: 28119116]
  • Yingyi Mao, Jigang Han, Fang Tian, Xue Tang, Yonghong Hu, Yan Guan. Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed. Journal of food science. 2017 Feb; 82(2):553-561. doi: 10.1111/1750-3841.13593. [PMID: 28135396]
  • Chiaki Sato, Saki Kaneko, Ayami Sato, Nantiga Virgona, Kozue Namiki, Tomohiro Yano. Combination Effect of δ-Tocotrienol and γ-Tocopherol on Prostate Cancer Cell Growth. Journal of nutritional science and vitaminology. 2017; 63(5):349-354. doi: 10.3177/jnsv.63.349. [PMID: 29225320]
  • Aleksander Siger, Marta Józefiak, Paweł Górnaś. Cold-pressed and hot-pressed rapeseed oil: The effects of roasting and seed moisture on the antioxi- dant activity, canolol, and tocopherol level. Acta scientiarum polonorum. Technologia alimentaria. 2017 Jan; 16(1):69-81. doi: 10.17306/j.afs.2017.0458. [PMID: 28362474]
  • Daniela Strenkert, Clariss Ann Limso, Abdelhak Fatihi, Stefan Schmollinger, Gilles J Basset, Sabeeha S Merchant. Genetically Programmed Changes in Photosynthetic Cofactor Metabolism in Copper-deficient Chlamydomonas. The Journal of biological chemistry. 2016 09; 291(36):19118-31. doi: 10.1074/jbc.m116.717413. [PMID: 27440043]
  • Teresa Cegielska-Taras, Małgorzata Nogala-Kałucka, Laurencja Szala, Aleksander Siger. Study of variation of tocochromanol and phytosterol contents in black and yellow seeds of Brassica napus L. doubled haploid populations. Acta scientiarum polonorum. Technologia alimentaria. 2016 Jul; 15(3):321-332. doi: 10.17306/j.afs.2016.3.31. [PMID: 28071031]
  • Shuya Yamashita, Kiwako Baba, Akiko Makio, Motofumi Kumazoe, Yuhui Huang, I-Chian Lin, Jaehoon Bae, Motoki Murata, Shuhei Yamada, Hirofumi Tachibana. γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein. Biochemical and biophysical research communications. 2016 05; 473(4):801-807. doi: 10.1016/j.bbrc.2016.03.111. [PMID: 27055589]
  • Ping Tou Gee, Chen Yee Liew, Meng Chil Thong, Melvin C L Gay. Vitamin E analysis by ultra-performance convergence chromatography and structural elucidation of novel α-tocodienol by high-resolution mass spectrometry. Food chemistry. 2016 Apr; 196(?):367-73. doi: 10.1016/j.foodchem.2015.09.073. [PMID: 26593503]
  • Lu Zhao, Xiefan Fang, Maurice R Marshall, Soonkyu Chung. Regulation of Obesity and Metabolic Complications by Gamma and Delta Tocotrienols. Molecules (Basel, Switzerland). 2016 Mar; 21(3):344. doi: 10.3390/molecules21030344. [PMID: 26978344]
  • Yongeun Kim, Wei Wang, Meshail Okla, Inhae Kang, Regis Moreau, Soonkyu Chung. Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes. Journal of lipid research. 2016 Jan; 57(1):66-76. doi: 10.1194/jlr.m062828. [PMID: 26628639]
  • Osama A Alawin, Rayan A Ahmed, Baher A Ibrahim, Karen P Briski, Paul W Sylvester. Antiproliferative effects of γ-tocotrienol are associated with lipid raft disruption in HER2-positive human breast cancer cells. The Journal of nutritional biochemistry. 2016 Jan; 27(?):266-77. doi: 10.1016/j.jnutbio.2015.09.018. [PMID: 26507543]
  • Jolanta Dłużewska, Renata Szymańska, Michal Gabruk, Peter B Kós, Beatrycze Nowicka, Jerzy Kruk. Tocopherol Cyclases-Substrate Specificity and Phylogenetic Relations. PloS one. 2016; 11(7):e0159629. doi: 10.1371/journal.pone.0159629. [PMID: 27462710]
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