Maculosin (BioDeep_00000003847)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Cyclo(L-Pro-L-Tyr)

化学式: C14H16N2O3 (260.1161)
中文名称: 环(脯氨酸一酪氨酸)
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 63.1%

分子结构信息

SMILES: C1CC2C(=O)NC(C(=O)N2C1)CC3=CC=C(C=C3)O
InChI: InChI=1S/C14H16N2O3/c17-10-5-3-9(4-6-10)8-11-14(19)16-7-1-2-12(16)13(18)15-11/h3-6,11-12,17H,1-2,7-8H2,(H,15,18)/t11-,12-/m0/s1

描述信息

A homodetic cyclic peptide that is a dipeptide composed of L-proline and L-tyrosine joined by peptide linkages.
Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC50 of 48.90 μg/mL[1][2][3].
Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC50 of 48.90 μg/mL[1][2][3].

同义名列表

4 个代谢物同义名

Cyclo(L-Pro-L-Tyr); Maculosin; Cyclo(Tyr-Pro); Maculosin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

141 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 BCL2, CASP3, PIK3CA, PTEN, PTGS2
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 4 ACR, BCL2, CASP3, PTEN
cytosol 4 BCL2, CASP3, PIK3CA, PTEN
nucleoplasm 2 CASP3, PTEN
lamellipodium 1 PIK3CA
glutamatergic synapse 1 CASP3
neuronal cell body 1 CASP3
plasma membrane 2 PIK3CA, PTEN
Membrane 1 BCL2
apical plasma membrane 1 PTEN
caveola 1 PTGS2
endoplasmic reticulum 2 BCL2, PTGS2
perinuclear region of cytoplasm 1 PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 1 BCL2
protein-containing complex 3 ACR, BCL2, PTGS2
Microsome membrane 1 PTGS2
postsynaptic density 2 CASP3, PTEN
extracellular region 2 ACR, PTEN
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
dendritic spine 1 PTEN
cytoplasmic vesicle 1 ARL14
Golgi-associated vesicle 1 ACR
pore complex 1 BCL2
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 1 PTEN
PML body 1 PTEN
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, neuron projection 1 PTEN
neuron projection 2 PTEN, PTGS2
cell projection 1 PTEN
myelin sheath 1 BCL2
endoplasmic reticulum lumen 1 PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
Schmidt-Lanterman incisure 1 PTEN
death-inducing signaling complex 1 CASP3
myelin sheath adaxonal region 1 PTEN
acrosomal matrix 1 ACR
BAD-BCL-2 complex 1 BCL2
[Isoform alpha]: Secreted 1 PTEN
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Omar González, Randy Ortíz-Castro, César Díaz-Pérez, Alma L Díaz-Pérez, Viridiana Magaña-Dueñas, José López-Bucio, Jesús Campos-García. Non-ribosomal Peptide Synthases from Pseudomonas aeruginosa Play a Role in Cyclodipeptide Biosynthesis, Quorum-Sensing Regulation, and Root Development in a Plant Host. Microbial ecology. 2017 04; 73(3):616-629. doi: 10.1007/s00248-016-0896-4. [PMID: 27900439]
  • Pakorn Wattana-Amorn, Waranya Charoenwongsa, Christopher Williams, Matthew P Crump, Busaya Apichaisataienchote. Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria. Natural product research. 2016 Sep; 30(17):1980-3. doi: 10.1080/14786419.2015.1095747. [PMID: 26469746]
  • G Puopolo, A Cimmino, M C Palmieri, O Giovannini, A Evidente, I Pertot. Lysobacter capsici AZ78 produces cyclo(L-Pro-L-Tyr), a 2,5-diketopiperazine with toxic activity against sporangia of Phytophthora infestans and Plasmopara viticola. Journal of applied microbiology. 2014 Oct; 117(4):1168-80. doi: 10.1111/jam.12611. [PMID: 25066530]
  • Sílvia C D N Lopes, Aleksander Fedorov, Miguel A R B Castanho. Cholesterol modulates maculosin's orientation in model systems of biological membranes. Relevance towards putative molecular recognition. Steroids. 2004 Dec; 69(13-14):825-30. doi: 10.1016/j.steroids.2004.10.001. [PMID: 15582538]
  • S H Park, G A Strobel. Cellular protein receptors of maculosin, a host specific phytotoxin of spotted knapweed (Centaurea maculosa L.). Biochimica et biophysica acta. 1994 Jan; 1199(1):13-9. doi: 10.1016/0304-4165(94)90090-6. [PMID: 8280748]