Toyomycin (BioDeep_00000003840)

   

Chemicals and Drugs Antibiotics


代谢物信息卡片


chromomycin a3

化学式: C57H82O26 (1182.5094072000002)
中文名称: 色霉素A3
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O
InChI: InChI=1S/C57H82O26/c1-21-34(79-40-19-37(53(26(6)75-40)77-28(8)59)82-38-16-33(61)52(70-11)25(5)74-38)15-31-13-30-14-32(54(71-12)51(68)46(63)22(2)58)55(50(67)44(30)49(66)43(31)45(21)62)83-41-18-35(47(64)24(4)73-41)80-39-17-36(48(65)23(3)72-39)81-42-20-57(10,69)56(27(7)76-42)78-29(9)60/h13,15,22-27,32-33,35-42,46-48,52-56,58,61-66,69H,14,16-20H2,1-12H3

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
D000970 - Antineoplastic Agents > D000903 - Antibiotics, Antineoplastic > D002865 - Chromomycins
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D004396 - Coloring Agents > D005456 - Fluorescent Dyes
Same as: D02062

同义名列表

4 个代谢物同义名

chromomycin a3; Aburamycin B; Toyomycin; Chromomycin A



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yu-Wen Chen, Roshan Satange, Pei-Ching Wu, Cyong-Ru Jhan, Chung-Ke Chang, Kuang-Ren Chung, Michael J Waring, Sheng-Wei Lin, Li-Ching Hsieh, Ming-Hon Hou. CoII(Chromomycin)₂ Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex. International journal of molecular sciences. 2018 Sep; 19(9):. doi: 10.3390/ijms19092796. [PMID: 30227633]
  • Burak Ozkosem, Sheldon I Feinstein, Aron B Fisher, Cristian O'Flaherty. Absence of Peroxiredoxin 6 Amplifies the Effect of Oxidant Stress on Mobility and SCSA/CMA3 Defined Chromatin Quality and Impairs Fertilizing Ability of Mouse Spermatozoa. Biology of reproduction. 2016 Mar; 94(3):68. doi: 10.1095/biolreprod.115.137646. [PMID: 26792942]
  • Laura Chalup, Sergio Sebastián Samoluk, Viviana Solís Neffa, Guillermo Seijo. Karyotype characterization and evolution in South American species of Lathyrus (Notolathyrus, Leguminosae) evidenced by heterochromatin and rDNA mapping. Journal of plant research. 2015 Nov; 128(6):893-908. doi: 10.1007/s10265-015-0756-1. [PMID: 26440502]
  • Mohammad Salehi, Hakimeh Akbari, Mohammad Hassan Heidari, Aidin Molouki, Kavitha Murulitharan, Hassan Moeini, Marefat Ghaffari Novin, Farhang Aabed, Hossein Taheri, Fateme Fadaei, Mehdi Mohsenzadeh, Mohammad Jafari, Aliyar Pirouzi, Reihane Heidari. Correlation between human clusterin in seminal plasma with sperm protamine deficiency and DNA fragmentation. Molecular reproduction and development. 2013 Sep; 80(9):718-24. doi: 10.1002/mrd.22202. [PMID: 23740886]
  • Artur Fonsêca, Andrea Pedrosa-Harand. Karyotype stability in the genus Phaseolus evidenced by the comparative mapping of the wild species Phaseolus microcarpus. Genome. 2013 Jun; 56(6):335-43. doi: 10.1139/gen-2013-0025. [PMID: 23957673]
  • Eliene Mariano Bonifácio, Artur Fonsêca, Cícero Almeida, Karla G B Dos Santos, Andrea Pedrosa-Harand. Comparative cytogenetic mapping between the lima bean (Phaseolus lunatus L.) and the common bean (P. vulgaris L.). TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2012 May; 124(8):1513-20. doi: 10.1007/s00122-012-1806-x. [PMID: 22331139]
  • Jyoti Verma, W S Lakra, B Kushwaha, M Sirajuddin, N S Nagpure, Ravindra Kumar. Characterization of two freshwater silurid catfish using conventional and molecular cytogenetic techniques. Journal of genetics. 2011 Aug; 90(2):319-22. doi: 10.1007/s12041-011-0061-2. [PMID: 21869482]
  • Ana Emília Barros e Silva, André Marques, Karla G B dos Santos, Marcelo Guerra. The evolution of CMA bands in Citrus and related genera. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 2010 Jun; 18(4):503-14. doi: 10.1007/s10577-010-9130-2. [PMID: 20490650]
  • A E Barros e Silva, M Guerra. The meaning of DAPI bands observed after C-banding and FISH procedures. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2010 Apr; 85(2):115-25. doi: 10.1080/10520290903149596. [PMID: 19657781]
  • Nicoletta Tarozzi, Marco Nadalini, Alessandra Stronati, Davide Bizzaro, Luca Dal Prato, Giovanni Coticchio, Andrea Borini. Anomalies in sperm chromatin packaging: implications for assisted reproduction techniques. Reproductive biomedicine online. 2009 Apr; 18(4):486-95. doi: 10.1016/s1472-6483(10)60124-1. [PMID: 19400989]
  • Patrick D Sutphin, Denise A Chan, James M Li, Sandra Turcotte, Adam J Krieg, Amato J Giaccia. Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells. Cancer research. 2007 Jun; 67(12):5896-905. doi: 10.1158/0008-5472.can-07-0604. [PMID: 17575159]
  • A P Moraes, R R Lemos, A C Brasileiro-Vidal, W Dos Santos Soares Filho, M Guerra. Chromosomal markers distinguish hybrids and non-hybrid accessions of mandarin. Cytogenetic and genome research. 2007; 119(3-4):275-81. doi: 10.1159/000112074. [PMID: 18253042]
  • Yong Liu, Hong-Shu Sui, Hui-Li Wang, Ji-Hong Yuan, Ming-Jiu Luo, Ping Xia, Jing-He Tan. Germinal vesicle chromatin configurations of bovine oocytes. Microscopy research and technique. 2006 Oct; 69(10):799-807. doi: 10.1002/jemt.20349. [PMID: 16886230]
  • Junko Noguchi. Homolog pairing and two kinds of bouquets in the meiotic prophase of rye, Secale cereale. Genes & genetic systems. 2002 Feb; 77(1):39-50. doi: 10.1266/ggs.77.39. [PMID: 12036103]
  • C M White, O Heidenreich, A Nordheim, T A Beerman. Evaluation of the effectiveness of DNA-binding drugs to inhibit transcription using the c-fos serum response element as a target. Biochemistry. 2000 Oct; 39(40):12262-73. doi: 10.1021/bi001427l. [PMID: 11015205]
  • E O Punina, Iu A Miakoshina, A M Efimov, A V Rodionov. [Chromosome maps of the plant family Trilliaceae: nucleotide composition of heterochromatin an localization of 18S-26S rRNA-genes of four-leafed paris (Paris quadrifolia L.)]. Genetika. 2000 May; 36(5):673-7. doi: ". [PMID: 10867884]
  • A Cavallini, G Cionini, E Polizzi, L Natali. Cytophotometric determination of heterochromatin base composition in interphase nuclei of plant cells. European journal of histochemistry : EJH. 1996; 40(4):283-8. doi: ". [PMID: 9116335]
  • C J Jeon, R H Masland. Selective accumulation of diamidino yellow and chromomycin A3 by retinal glial cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1993 Nov; 41(11):1651-8. doi: 10.1177/41.11.8409373. [PMID: 8409373]
  • J M Lehman, J Laffin, T D Friedrich. Flow cytometry of DNA increase after simian virus 40 infection of CV-1 cells. In vitro cellular & developmental biology : journal of the Tissue Culture Association. 1992 May; 28A(5):306-8. doi: NULL. [PMID: 1317836]
  • M Ohta, N Hara, Y Ichikawa, T Kanda, K Shima, K Tamura, M Hokama. [Benefits of cisplatin-based polychemotherapy in non-small cell bronchogenic carcinoma. Kyushu Lung Cancer Chemotherapy Study Group]. Gan to kagaku ryoho. Cancer & chemotherapy. 1988 Jun; 15(6):1901-8. doi: . [PMID: 2454615]
  • K Fujiwara, H Nakamura, T Kitagawa. Development of enzyme immunoassay for chromomycin A3 and olivomycin using beta-D-galactosidase as a label. Cancer research. 1985 Nov; 45(11 Pt 1):5442-6. doi: . [PMID: 3931906]
  • K Numasawa, H Kakizaki, A Takamizawa, Y Kubota, K Suzuki. [A study of post-operative chemotherapy for renal pelvic and ureteral tumors]. Gan to kagaku ryoho. Cancer & chemotherapy. 1984 Jul; 11(7):1501-5. doi: . [PMID: 6430245]
  • M A Van Dilla, R G Langlois, D Pinkel, D Yajko, W K Hadley. Bacterial characterization by flow cytometry. Science (New York, N.Y.). 1983 May; 220(4597):620-2. doi: 10.1126/science.6188215. [PMID: 6188215]
  • R S Gupta. Species specific differences in the toxicity of mithramycin, chromomycin A3, and olivomycin towards cultured mammalian cells. Journal of cellular physiology. 1982 Oct; 113(1):11-6. doi: 10.1002/jcp.1041130104. [PMID: 6215417]
  • A Sh Byshevskii, S L Galian. [Effect of protein synthesis inhibitors on the vicasol-induced change in the content of the thermostable antifactor Xa in the blood serum]. Voprosy meditsinskoi khimii. 1980 Jan; 26(1):85-8. doi: NULL. [PMID: 6768192]
  • B Samal, S Jones, R W Brownlee, F Morrison, B Hoogstraten, E Caoili, L Baker. Chromomycin A3 for advanced breast cancer: a Southwest Oncology Group study. Cancer treatment reports. 1978 Jan; 62(1):19-22. doi: . [PMID: 342093]