1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenyl-1-propanone (BioDeep_00000003782)

human metabolite PANOMIX_OTCML-2023

代谢物信息卡片

1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenyl-1-propanone

化学式: C16H16O4 (272.1048536)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(cc(c(c(c1)O)C(=O)CCc1ccccc1)O)OC
InChI: InChI=1S/C16H16O4/c1-20-12-9-14(18)16(15(19)10-12)13(17)8-7-11-5-3-2-4-6-11/h2-6,9-10,18-19H,7-8H2,1H3

描述信息

1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenyl-1-propanone is isolated from Populus balsamifera (balsam poplar) oi
Isolated from Populus balsamifera (balsam poplar) oil.

同义名列表

7 个代谢物同义名

1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenyl-1-propanone; 1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenylpropan-1-one; 2,6-Dihydroxy-4-methoxy-b-phenylpropiophenone; 2,6-Dihydroxy-4-methoxydihydro-chalcone; 2,6-dihydroxy-4-methoxydihydrochalcone; 2,6-Dihydroxy-4-methoxydihydrochalone; 2',6'-Dihydroxy-4'-methoxydihydrochalcone

数据库引用编号

16 个数据库交叉引用编号

ChEBI: CHEBI:28523
KEGG: C09644
PubChem: 169676
HMDB: HMDB0034435
Metlin: METLIN52314
ChEMBL: CHEMBL486009
KNApSAcK: C00007929
foodb: FDB012836
chemspider: 148386
CAS: 35241-55-5
PMhub: MS000011499
PubChem: 11834
LipidMAPS: LMPK12120511
3DMET: B03157
NIKKAJI: J289.946I
KNApSAcK: 28523

分类词条

2'-Hydroxy-dihydrochalcones

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

97729 - Boesenbergia rotunda: 10.1248/CPB.56.956
188496 - Etlingera littoralis: 10.3987/COM-10-12131
377273 - Greyia flanaganii: 10.1016/J.PHYMED.2011.03.013
9606 - Homo sapiens: -
128638 - Licaria triandra: 10.1055/S-2006-958054
128640 - Lindera umbellata:
88853 - Litsea glaucescens: 10.1055/S-2006-958054
1249038 - Miliusa balansae: 10.1016/S0031-9422(02)00374-6
306987 - Mitrella kentii: 10.1021/NP9700331
200954 - Ononis natrix: 10.1021/NP960402D
352187 - Peperomia macrostachya: 10.1016/S0968-0896(03)00406-1
471708 - Persicaria senegalensis: 10.3998/ARK.5550190.0008.904
130377 - Piper aduncum:
130401 - Piper hispidum: 10.1016/S0031-9422(00)81303-5
511544 - Piper hostmannianum:
538297 - Piper longicaudatum: 10.1055/S-2001-11517
538362 - Piper trichoneuron:
164274 - Pityrogramma calomelanos:
92927 - Sarcandra glabra: 10.1016/0031-9422(96)00352-4

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Ana E Gonçalves, Ângela Malheiros, Camila A Casarin, Lara de França, David L Palomino-Salcedo, Leonardo L G Ferreira, Adriano D Andricopulo, María J Dávila-Rodríguez, Leticia C Lacava, Aldo S de Oliveira, Marcia M de Souza. 2',6'-dihydroxy-4'-methoxy Dihydrochalcone Improves the Cognitive Impairment of Alzheimer's Disease: A Structure-activity Relationship Study. Current topics in medicinal chemistry. 2021; 21(13):1167-1185. doi: 10.2174/1568026621666210701114034. [PMID: 34218788]
Murilo Luiz Cerutti, Larissa Benvenutti, Roberta Nunes, Silvia Ramos da Silva, Sara Cristiane Barauna, Márcia Maria de Souza, Ângela Malheiros, Letícia Lacava, Nara Lins Meira Quintão, José Roberto Santin. Effects of 2',6'-dihydroxy-4'-methoxydihidrochalcone on innate inflammatory response. Naunyn-Schmiedeberg's archives of pharmacology. 2020 11; 393(11):2061-2072. doi: 10.1007/s00210-020-01922-1. [PMID: 32548784]
Namrita Lall, Elizabeth Mogapi, Marco Nuno de Canha, Bridget Crampton, Mabatho Nqephe, Ahmed A Hussein, Vivek Kumar. Insights into tyrosinase inhibition by compounds isolated from Greyia radlkoferi Szyszyl using biological activity, molecular docking and gene expression analysis. Bioorganic & medicinal chemistry. 2016 11; 24(22):5953-5959. doi: 10.1016/j.bmc.2016.09.054. [PMID: 27720556]
Billy Joel Cabanillas, Anne-Cécile Le Lamer, Denis Castillo, Jorge Arevalo, Yannick Estevez, Rosario Rojas, Céline Valadeau, Geneviève Bourdy, Michel Sauvain, Nicolas Fabre. Dihydrochalcones and benzoic acid derivatives from Piper dennisii. Planta medica. 2012 Jun; 78(9):914-8. doi: 10.1055/s-0031-1298459. [PMID: 22516933]
M B Mapunya, A A Hussein, B Rodriguez, N Lall. Tyrosinase activity of Greyia flanaganii (Bolus) constituents. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Aug; 18(11):1006-12. doi: 10.1016/j.phymed.2011.03.013. [PMID: 21680165]
João Henrique G Lago, Clécio Sousa Ramos, Diego Campos C Casanova, Andreia de A Morandim, Debora Cristina B Bergamo, Alberto J Cavalheiro, Vanderlan da S Bolzani, Maysa Furlan, Elsie F Guimarães, Maria Claudia M Young, Massuo J Kato. Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum. Journal of natural products. 2004 Nov; 67(11):1783-8. doi: 10.1021/np030530j. [PMID: 15568762]
A S Joshi, X C Li, A C Nimrod, H N elSohly, L A Walker, A M Clark. Dihydrochalcones from Piper longicaudatum. Planta medica. 2001 Mar; 67(2):186-8. doi: 10.1055/s-2001-11517. [PMID: 11301876]
J Orjala, A D Wright, H Behrends, G Folkers, O Sticher, H Rüegger, T Rali. Cytotoxic and antibacterial dihydrochalcones from Piper aduncum. Journal of natural products. 1994 Jan; 57(1):18-26. doi: 10.1021/np50103a003. [PMID: 8158163]