Hocogenin (BioDeep_00000000376)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(1R,2S,4S,5R,6R,7S,8R,9S,12S,13S,16S,18S)-16-hydroxy-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2-oxane]-10-one

化学式: C27H42O4 (430.3083)
中文名称: 番麻皂素, 海柯吉宁, 海柯皂苷元
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1[C@]2(C)[C@@]3([H])CC(=O)[C@]4(C)[C@H]5[C@@H]([C@]6(O[C@H]5C[C@@]4([H])[C@]3([H])CC[C@@]2([H])C[C@@H](O)C1)CC[C@@H](C)CO6)C
InChI: InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)12-21-19-6-5-17-11-18(28)8-9-25(17,3)20(19)13-23(29)26(21,24)4/h15-22,24,28H,5-14H2,1-4H3/t15-,16+,17+,18+,19-,20+,21+,22+,24+,25+,26-,27-/m1/s1

描述信息

Hecogenin is a triterpenoid.
Hecogenin is a natural product found in Yucca gloriosa, Allium rotundum, and other organisms with data available.

同义名列表

31 个代谢物同义名

(1R,2S,4S,5R,6R,7S,8R,9S,12S,13S,16S,18S)-16-hydroxy-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2-oxane]-10-one; Spirostan-12-one, 3-hydroxy-, (3.beta.,5.alpha.,25R)-; Spirostan-12-one, 3-hydroxy-, (3beta,5alpha,25R)-; (22R,25R)-3beta-Hydroxy-5alpha-spirostan-12-one; 5alpha-Spirostan-12-one, 3beta-hydroxy-, (25R)-; (3beta,5alpha,25R)-3-hydroxyspirostan-12-one; (25R)-3beta-hydroxy-5alpha-spirostan-12-one; Spirostan-12-one, 3-hydroxy-, (3b,5a,25R)-; Spirostan-12-one,3-hydroxy-, (3b,5a,25R)-; (3beta,5alpha,25R)-spirostan-3-ol-12-one; 3-beta-Hydroxy-5-alpha-spirostan-12-one; 25(R)-3.BETA.-HYDROXYSPIROSTAN-12-ONE; hecogenin, (3beta,5alpha,25S)-isomer; (25r)-3b-hydroxy-5a-spirostan-12-one; (25R)-12-oxo-spirostan-3beta-ol; QOLRLLFJMZLYQJ-LOBDNJQFSA-N; Prestwick3_000730; 12-OXOTIGOGENIN; UNII-3XP44JJ79F; Tox21_110443_1; HECOGENIN [MI]; BPBio1_000726; (+)-HECOGENIN; Tox21_110443; 3XP44JJ79F; ST 27:3;O4; HEKOGENIN; Hocogenin; gekogenin; Hecogenin; Hecogenin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, AIMP2, CASP3, CASP8, CASP9, MAPK8, NFKB1, PTGS2
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 7 PTGS2, SPP1, UGT1A3, UGT1A4, UGT1A9, UGT2B10, UGT2B7
Nucleus 8 AIMP2, CASP3, CASP8, CASP9, MAPK8, MPO, NFKB1, PPARA
cytosol 6 AIMP2, CASP3, CASP8, CASP9, MAPK8, NFKB1
nucleoplasm 6 CASP3, CASP8, MAPK8, MPO, NFKB1, PPARA
Cell membrane 4 ABCB1, SPP1, TNF, TRPV1
lamellipodium 1 CASP8
Multi-pass membrane protein 4 ABCB1, SLC45A2, SPP1, TRPV1
Synapse 1 MAPK8
cell surface 2 ABCB1, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 CCN2, SPP1
neuronal cell body 3 CASP3, TNF, TRPV1
Cytoplasm, cytosol 1 AIMP2
Lysosome 1 MPO
plasma membrane 5 ABCB1, CCN2, SPP1, TNF, TRPV1
Membrane 8 ABCB1, AIMP2, SLC45A2, TRPV1, UGT1A3, UGT1A4, UGT1A9, UGT2B7
apical plasma membrane 1 ABCB1
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 3 ABCB1, MPO, SPP1
endoplasmic reticulum 4 PTGS2, UGT1A3, UGT1A4, UGT1A9
extracellular space 4 CCN2, MPO, SPP1, TNF
perinuclear region of cytoplasm 1 SPP1
mitochondrion 3 CASP8, CASP9, NFKB1
protein-containing complex 3 CASP8, CASP9, PTGS2
intracellular membrane-bounded organelle 2 CCN2, MPO
Microsome membrane 2 PTGS2, UGT2B10
postsynaptic density 1 CASP3
Secreted 2 CCN2, SPP1
extracellular region 5 CCN2, MPO, NFKB1, SPP1, TNF
Single-pass membrane protein 5 UGT1A3, UGT1A4, UGT1A9, UGT2B10, UGT2B7
mitochondrial outer membrane 1 CASP8
transcription regulator complex 1 NFKB1
external side of plasma membrane 2 TNF, TRPV1
Secreted, extracellular space, extracellular matrix 1 CCN2
Melanosome membrane 1 SLC45A2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 TRPV1
Apical cell membrane 1 ABCB1
Cell projection, lamellipodium 1 CASP8
Membrane raft 1 TNF
GABA-ergic synapse 1 TRPV1
extracellular matrix 1 CCN2
secretory granule 1 MPO
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 TRPV1
Cell projection, neuron projection 1 TRPV1
neuron projection 1 PTGS2
chromatin 2 NFKB1, PPARA
cell projection 1 SPP1
phagocytic cup 1 TNF
cytoskeleton 1 CASP8
cell body 1 CASP8
azurophil granule 1 MPO
secretory granule lumen 1 NFKB1
endoplasmic reticulum lumen 2 PTGS2, SPP1
specific granule lumen 1 NFKB1
azurophil granule lumen 1 MPO
apoptosome 1 CASP9
phagocytic vesicle lumen 1 MPO
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • A Berenice Aguilar-Guadarrama, Mónica Aideé Díaz-Román, Maribel Osorio-García, Myrna Déciga-Campos, María Yolanda Rios. Chemical Constituents from Agave applanata and Its Antihyperglycemic, Anti-inflammatory, and Antimicrobial Activities Associated with Its Tissue Repair Capability. Planta medica. 2024 May; 90(5):397-410. doi: 10.1055/a-2270-5527. [PMID: 38365219]
  • Deepa K Ingawale, Satish K Mandlik, Snehal S Patel. Hecogenin and fluticasone combination attenuates TNBS-induced ulcerative colitis in rats via downregulation of pro-inflammatory mediators and oxidative stress. Immunopharmacology and immunotoxicology. 2021 Apr; 43(2):160-170. doi: 10.1080/08923973.2021.1872617. [PMID: 33435764]
  • Joanie Vaillancourt, Véronique Turcotte, Patrick Caron, Lyne Villeneuve, Louis Lacombe, Frédéric Pouliot, Éric Lévesque, Chantal Guillemette. Glucuronidation of Abiraterone and Its Pharmacologically Active Metabolites by UGT1A4, Influence of Polymorphic Variants and Their Potential as Inhibitors of Steroid Glucuronidation. Drug metabolism and disposition: the biological fate of chemicals. 2020 02; 48(2):75-84. doi: 10.1124/dmd.119.088229. [PMID: 31727674]
  • Rui Yuan, Tong Su, Chao Zhang, Xiao Song, Yao-Hui Yuan, Rui-Teng Li, Yi-Jing Liu. [Study on transformation rules of terrestrosin D in course of Tribuli Fructus stir-frying based on simulated processing technology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Jul; 44(14):3049-3054. doi: 10.19540/j.cnki.cjcmm.20190321.304. [PMID: 31602852]
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  • Yan-liu LU, Yu-qi HE, Miao WANG, Li ZHANG, Li YANG, Zheng-tao WANG, Guang JI. Characterization of nuciferine metabolism by P450 enzymes and uridine diphosphate glucuronosyltransferases in liver microsomes from humans and animals. Acta pharmacologica Sinica. 2010 Dec; 31(12):1635-42. doi: 10.1038/aps.2010.172. [PMID: 21127497]
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  • Bertrand Liagre, Pascale Vergne-Salle, David Y Leger, Jean-Louis Beneytout. Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2. International journal of molecular medicine. 2007 Oct; 20(4):451-60. doi: . [PMID: 17786275]
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