Cupressuflavone (BioDeep_00000003751)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

8-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-8-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

化学式: C30H18O10 (538.0899928)
中文名称: CUPRESSUFLAVONE TRIHYDRATE
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.17%

分子结构信息

SMILES: c1(cc(c2c(c1c1c(cc(c3c1oc(cc3=O)c1ccc(cc1)O)O)O)oc(cc2=O)c1ccc(cc1)O)O)O
InChI: InChI=1S/C30H18O10/c31-15-5-1-13(2-6-15)23-11-21(37)25-17(33)9-19(35)27(29(25)39-23)28-20(36)10-18(34)26-22(38)12-24(40-30(26)28)14-3-7-16(32)8-4-14/h1-12,31-36H

描述信息

Cupressuflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-8 of the two chromene rings respectively. Isolated from Cupressus sempervirens and Juniperus occidentalis, it exhibits free radical scavenging and antielastase activities. It has a role as an EC 3.4.21.37 (leukocyte elastase) inhibitor, a radical scavenger and a metabolite. It is a biflavonoid, a hydroxyflavone and a ring assembly.
Cupressuflavone is a natural product found in Fitzroya cupressoides, Juniperus drupacea, and other organisms with data available.
A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-8 of the two chromene rings respectively. Isolated from Cupressus sempervirens and Juniperus occidentalis, it exhibits free radical scavenging and antielastase activities.

同义名列表

8 个代谢物同义名

8-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-8-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 5,5,7,7-tetrahydroxy-2,2-bis(4-hydroxyphenyl)-4H,4H-8,8-bichromene-4,4-dione; 4,4,5,5,7,7-hexahydroxy-8-8-biflavone; CUPRESSUFLAVONE TRIHYDRATE; CUPRESSUFLAVONETRIHYDRATE; CUPRESSUFLAVONE 3-HYDRATE; Cupressuflavone; 8,8-Biapigenin

数据库引用编号

29 个数据库交叉引用编号

ChEBI: CHEBI:3960
KEGG: C10034
PubChem: 5281609
Metlin: METLIN47522
ChEMBL: CHEMBL1208973
LipidMAPS: LMPK12040010
MeSH: cupressuflavone
KNApSAcK: C00001034
CAS: 3952-18-9
MoNA: VF-NPL-LTQ000748
MoNA: VF-NPL-LTQ000747
MoNA: VF-NPL-LTQ000746
MoNA: VF-NPL-LTQ000745
MoNA: VF-NPL-QEHF001227
MoNA: VF-NPL-QEHF001226
MoNA: VF-NPL-QEHF001225
MoNA: VF-NPL-QEHF001224
MoNA: VF-NPL-QEHF001223
MoNA: VF-NPL-QEHF001222
MoNA: VF-NPL-QEHF001221
MoNA: VF-NPL-QEHF001220
MoNA: VF-NPL-QEHF001219
medchemexpress: HY-N9173
PMhub: MS000059827
PMhub: MS000011256
MetaboLights: MTBLC3960
PubChem: 12220
3DMET: B03477
NIKKAJI: J22.579G

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

39 个相关的物种来源信息

103962 - Callitris acuminata: 10.1016/0031-9422(83)85032-8
214234 - Callitris endlicheri: 10.1016/0031-9422(83)85032-8
214231 - Callitris macleayana: 10.1016/0031-9422(83)85032-8
2250721 - Callitris neocaledonica: 10.1016/0031-9422(83)85032-8
214236 - Callitris oblonga: 10.1016/0031-9422(83)85032-8
89193 - Callitris pancheri: 10.1016/0031-9422(83)85032-8
214228 - Callitris pyramidalis: 10.1016/0031-9422(83)85032-8
214232 - Callitris sulcata: 10.1016/0031-9422(83)85032-8
85954 - Callitropsis nootkatensis: 10.1016/S0031-9422(00)83535-9
13387 - Calocedrus decurrens: 10.1016/S0031-9422(00)83535-9
187464 - Cupressus cashmeriana: 10.1021/NP50051A032
13469 - Cupressus sempervirens:
13497 - Diselma archeri: 10.1016/0031-9422(83)85032-8
103972 - Fitzroya cupressoides: 10.1016/0031-9422(83)85032-8
884032 - Juniperus bermudiana: 10.1016/S0031-9422(00)83535-9
58039 - Juniperus communis:
103973 - Juniperus drupacea:
758917 - Juniperus excelsa: 10.1016/S0031-9422(00)83535-9
669713 - Juniperus horizontalis: 10.1248/CPB.50.1358
114265 - Juniperus occidentalis: 10.1248/CPB.50.1358
69008 - Juniperus oxycedrus: 10.1016/S0031-9422(00)83535-9
61308 - Juniperus phoenicea: 10.1016/S0031-9422(00)85693-9
62753 - Juniperus procera: 10.1016/S0031-9422(00)83535-9
39584 - Juniperus virginiana:
13595 - Libocedrus plumosa: 10.1016/0031-9422(83)85032-8
103975 - Libocedrus yateensis: 10.1016/0031-9422(83)85032-8
13614 - Microbiota decussata: 10.1515/ZNC-2002-11-1208
103977 - Papuacedrus papuana: 10.1016/0031-9422(83)85032-8
123602 - Picea smithiana: 10.1515/ZNC-1988-1-202
103979 - Pilgerodendron uviferum: 10.1016/0031-9422(83)85032-8
58046 - Platycladus orientalis:
28979 - Sciadopitys verticillata: 10.1515/ZNC-1998-11-1202
65409 - Scutellaria baicalensis: 10.1111/J.1600-0609.2009.01365.X
99814 - Sequoiadendron giganteum: 10.1515/ZNC-1998-11-1202
13717 - Tetraclinis articulata: 10.1016/0031-9422(83)85032-8
3317 - Thuja occidentalis: 10.1016/S0031-9422(00)83535-9
13760 - Widdringtonia cedarbergensis: 10.1016/0031-9422(83)85032-8
214229 - Widdringtonia nodiflora: 10.1016/0031-9422(83)85032-8
1075059 - Widdringtonia whytei: 10.1016/0031-9422(83)85032-8

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Sullim Lee, No-June Park, Sim-Kyu Bong, Jonghwan Jegal, Sang-A Park, Su-Nam Kim, Min Hye Yang. Ameliorative effects of Juniperus rigida fruit on oxazolone- and 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice. Journal of ethnopharmacology. 2018 Mar; 214(?):160-167. doi: 10.1016/j.jep.2017.12.022. [PMID: 29258854]
Eman Al-Sayed, Haidy A Gad, Mohamed El-Shazly, Mohamed M Abdel-Daim, Abdel Nasser Singab. Anti-inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro-inflammatory mediators. Drug development research. 2018 02; 79(1):22-28. doi: 10.1002/ddr.21417. [PMID: 29130540]
Phi-Hung Nguyen, Da-Jung Ji, Yu-Ran Han, Jae-Sue Choi, Dong-Young Rhyu, Byung-Sun Min, Mi-Hee Woo. Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects. Bioorganic & medicinal chemistry. 2015 Jul; 23(13):3730-7. doi: 10.1016/j.bmc.2015.04.007. [PMID: 25907369]
Eman Al-Sayed, Mohamed M Abdel-Daim. Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride-induced hepato- and nephrotoxicity in mice. Planta medica. 2014 Dec; 80(18):1665-71. doi: 10.1055/s-0034-1383211. [PMID: 25338212]
K M Sakthivel, C Guruvayoorappan. Biophytum sensitivum: Ancient medicine, modern targets. Journal of advanced pharmaceutical technology & research. 2012 Apr; 3(2):83-91. doi: 10.4103/2231-4040.97279. [PMID: 22837955]
A M Freitas, M T R Almeida, C R Andrighetti-Fröhner, F T G S Cardozo, C R M Barardi, M R Farias, C M O Simões. Antiviral activity-guided fractionation from Araucaria angustifolia leaves extract. Journal of ethnopharmacology. 2009 Dec; 126(3):512-7. doi: 10.1016/j.jep.2009.09.005. [PMID: 19761825]
Nabaweya Ali Ibrahim, Hesham Rushdey El-Seedi, Magdy Mostafa Desoky Mohammed. Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt. Natural product research. 2007 Aug; 21(10):857-66. doi: 10.1080/14786410601132477. [PMID: 17680494]
Mirosława Krauze-Baranowska, Marek Mardarowicz, Marian Wiwart. The chemical composition of Microbiota decussata. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2002 Nov; 57(11-12):998-1003. doi: 10.1515/znc-2002-11-1208. [PMID: 12562084]
Tsutomu Nakanishi, Yuka Inatomi, Hiroko Murata, Naoki Iida, Akira Inada, Frank A Lang, Jin Murata. Phytochemical study on American plants I. Two new phenol glucosides, together with known biflavones and diterpene, from leaves of Juniperus occidentalis Hook. Chemical & pharmaceutical bulletin. 2002 Oct; 50(10):1358-61. doi: 10.1248/cpb.50.1358. [PMID: 12372862]