Cyclic cmp (BioDeep_00000003529)
natural product
代谢物信息卡片
CYTIDINE 3:5-CYCLIC MONOPHOSPHATE
化学式: C9H12N3O7P (305.0413)
中文名称: 胞苷-3’,5’-环一磷酸
谱图信息:
最多检出来源 Viridiplantae(plant) 21.37%
分子结构信息
SMILES: C1C2C(C(C(O2)N3C=CC(=NC3=O)N)O)OP(=O)(O1)O
InChI: InChI=1S/C9H12N3O7P/c10-5-1-2-12(9(14)11-5)8-6(13)7-4(18-8)3-17-20(15,16)19-7/h1-2,4,6-8,13H,3H2,(H,15,16)(H2,10,11,14)/t4-,6-,7-,8-/m1/s1
描述信息
Acquisition and generation of the data is financially supported in part by CREST/JST.
同义名列表
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:17065
- KEGG: C00941
- PubChem: 19236
- PubChem: 3632205
- Metlin: METLIN3436
- ChEMBL: CHEMBL72442
- MeSH: Cyclic CMP
- CAS: 3616-08-8
- MoNA: PR100118
- MoNA: PS018902
- MoNA: PS018901
- MoNA: PR100537
- MoNA: PS018906
- MoNA: PS018907
- MoNA: PS018908
- MoNA: PS018903
- MoNA: PR100117
- MoNA: PS018909
- MoNA: PS018905
- MoNA: PS018904
- MoNA: PS018910
- PMhub: MS000009919
- PubChem: 4193
- PDB-CCD: CC7
- 3DMET: B01353
- NIKKAJI: J413.990I
- RefMet: cyclic CMP
- KNApSAcK: 17065
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 3888 - Pisum sativum: 10.1016/S0031-9422(00)97962-7
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Arvand Akbari, Giovanni Battista Pipitone, Zahra Anvar, Mojtaba Jaafarinia, Maurizio Ferrari, Paola Carrera, Mehdi Totonchi. ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria.
Human reproduction (Oxford, England).
2019 06; 34(6):1155-1164. doi:
10.1093/humrep/dez048. [PMID: 31119281] - Yan Liu, Hong Xu, Yucong Geng, Dingjie Xu, Lijuan Zhang, Yi Yang, Zhongqiu Wei, Bonan Zhang, Shifeng Li, Xuemin Gao, Ruimin Wang, Xianghong Zhang, Darrell Brann, Fang Yang. Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis.
Respiratory research.
2017 02; 18(1):38. doi:
10.1186/s12931-017-0523-z. [PMID: 28222740] - Donghyun Lee, Adel R Moawad, Tania Morielli, Maria C Fernandez, Cristian O'Flaherty. Peroxiredoxins prevent oxidative stress during human sperm capacitation.
Molecular human reproduction.
2017 02; 23(2):106-115. doi:
10.1093/molehr/gaw081. [PMID: 28025393] - Rui Peng, Guang-Xi Zhao, Jing Li, Yu Zhang, Xi-Zhong Shen, Ji-Yao Wang, Jian-Yong Sun. Auphen and dibutyryl cAMP suppress growth of hepatocellular carcinoma by regulating expression of aquaporins 3 and 9 in vivo.
World journal of gastroenterology.
2016 Mar; 22(12):3341-54. doi:
10.3748/wjg.v22.i12.3341. [PMID: 27022216] - Witold Korytowski, Katarzyna Wawak, Pawel Pabisz, Jared C Schmitt, Alexandra C Chadwick, Daisy Sahoo, Albert W Girotti. Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress.
Arteriosclerosis, thrombosis, and vascular biology.
2015 Oct; 35(10):2104-13. doi:
10.1161/atvbaha.115.306210. [PMID: 26315403] - Heike Bähre, Christina Hartwig, Antje Munder, Sabine Wolter, Tane Stelzer, Bastian Schirmer, Ulrike Beckert, Dara W Frank, Burkhard Tümmler, Volkhard Kaever, Roland Seifert. cCMP and cUMP occur in vivo.
Biochemical and biophysical research communications.
2015 May; 460(4):909-14. doi:
10.1016/j.bbrc.2015.03.115. [PMID: 25838203] - Seong Min Lee, Kathleen A Bishop, Joseph J Goellner, Charles A O'Brien, J Wesley Pike. Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype.
Endocrinology.
2014 Jun; 155(6):2064-76. doi:
10.1210/en.2014-1107. [PMID: 24693968] - Ina Nemet, Guilian Tian, Yoshikazu Imanishi. Organization of cGMP sensing structures on the rod photoreceptor outer segment plasma membrane.
Channels (Austin, Tex.).
2014; 8(6):528-35. doi:
10.4161/19336950.2014.973776. [PMID: 25616687] - Tomohisa Hirobe, Kiyotaka Hasegawa, Rikako Furuya, Rumiko Fujiwara, Kiyoshi Sato. Effects of fibroblast-derived factors on the proliferation and differentiation of human melanocytes in culture.
Journal of dermatological science.
2013 Jul; 71(1):45-57. doi:
10.1016/j.jdermsci.2013.03.012. [PMID: 23726358] - Eduardo N Maldonado, Jyoti Patnaik, Matthew R Mullins, John J Lemasters. Free tubulin modulates mitochondrial membrane potential in cancer cells.
Cancer research.
2010 Dec; 70(24):10192-201. doi:
10.1158/0008-5472.can-10-2429. [PMID: 21159641] - Janice M W Taylor, Faye Borthwick, Chris Bartholomew, Annette Graham. Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI.
Cardiovascular research.
2010 Jun; 86(3):526-34. doi:
10.1093/cvr/cvq015. [PMID: 20083572] - WenChieh Chen, Shaw-Jenq Tsai, Hamm-Ming Sheu, Jih-Chien Tsai, Christos C Zouboulis. Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone.
Experimental dermatology.
2010 May; 19(5):470-2. doi:
10.1111/j.1600-0625.2009.00996.x. [PMID: 20337700] - Randa Hilal-Dandan, Huaping He, Jody L Martin, Laurence L Brunton, Wolfgang H Dillmann. Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP.
American journal of physiology. Heart and circulatory physiology.
2009 Mar; 296(3):H728-34. doi:
10.1152/ajpheart.00584.2008. [PMID: 19151257] - Anne-Sophie Morisset, Céline Huot, Denis Légaré, André Tchernof. Circulating IL-6 concentrations and abdominal adipocyte isoproterenol-stimulated lipolysis in women.
Obesity (Silver Spring, Md.).
2008 Jul; 16(7):1487-92. doi:
10.1038/oby.2008.242. [PMID: 18451782] - Hiroto Tsujikawa, Yumei Song, Makino Watanabe, Haruko Masumiya, Sachin A Gupte, Rikuo Ochi, Takao Okada. Cholesterol depletion modulates basal L-type Ca2+ current and abolishes its -adrenergic enhancement in ventricular myocytes.
American journal of physiology. Heart and circulatory physiology.
2008 Jan; 294(1):H285-92. doi:
10.1152/ajpheart.00824.2007. [PMID: 17982015] - Maryanne Borsick, Trivikram Rajkhowa, Mary Taub. Evidence for post-transcriptional regulation of Na,K-ATPase by prostaglandin E1.
Biochemical and biophysical research communications.
2006 Jun; 345(2):739-45. doi:
10.1016/j.bbrc.2006.04.158. [PMID: 16701566] - F A van Gaalen, H Visser, T W J Huizinga. A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis.
Annals of the rheumatic diseases.
2005 Oct; 64(10):1510-2. doi:
10.1136/ard.2004.035089. [PMID: 15800005] - Keizo Kasono, Tomoyuki Saito, Takako Saito, Hiroyuki Tamemoto, Chieko Yanagidate, Shinichi Uchida, Masanobu Kawakami, Sei Sasaki, San-e Ishikawa. Hypertonicity regulates the aquaporin-2 promoter independently of arginine vasopressin.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2005 Mar; 20(3):509-15. doi:
10.1093/ndt/gfh677. [PMID: 15671070] - Shun-Fen Tzeng, May J Tsai, Shih-Chieh Hung, Henrich Cheng. Neuronal morphological change of size-sieved stem cells induced by neurotrophic stimuli.
Neuroscience letters.
2004 Aug; 367(1):23-8. doi:
10.1016/j.neulet.2004.05.117. [PMID: 15308290] - Takayuki Negishi, Yoshiyuki Ishii, Shigeru Kyuwa, Yoichiro Kuroda, Yasuhiro Yoshikawa. Primary culture of cortical neurons, type-1 astrocytes, and microglial cells from cynomolgus monkey (Macaca fascicularis) fetuses.
Journal of neuroscience methods.
2003 Dec; 131(1-2):133-40. doi:
10.1016/j.jneumeth.2003.08.006. [PMID: 14659833] - R P Newton, B J Salvage, N A Hakeem. Cytidylate cyclase: development of assay and determination of kinetic properties of a cytidine 3',5'-cyclic monophosphate-synthesizing enzyme.
The Biochemical journal.
1990 Jan; 265(2):581-6. doi:
10.1042/bj2650581. [PMID: 2154193] - R P Newton, N A Hakeem, B J Salvage, G Wassenaar, E E Kingston. Cytidylate cyclase activity: identification of cytidine 3',5'-cyclic monophosphate and four novel cytidine cyclic phosphates as biosynthetic products from cytidine triphosphate.
Rapid communications in mass spectrometry : RCM.
1988 Jun; 2(6):118-26. doi:
10.1002/rcm.1290020606. [PMID: 2577847] - P P Schnetkamp, M D Bownds. Na+- and cGMP-induced Ca2+ fluxes in frog rod photoreceptors.
The Journal of general physiology.
1987 Mar; 89(3):481-500. doi:
10.1085/jgp.89.3.481. [PMID: 3031199] - R P Newton, S G Salih, B J Salvage, E E Kingston. Extraction, purification and identification of cytidine 3',5'-cyclic monophosphate from rat tissues.
The Biochemical journal.
1984 Aug; 221(3):665-73. doi:
10.1042/bj2210665. [PMID: 6089744] - L M Houdebine. [Recent data on the mechanism of action of prolactin].
Annales d'endocrinologie.
1983 Mar; 44(2):85-100. doi:
NULL. [PMID: 6311073] - R Horstmann, R Hammers, P Clarenbach, H Cramer. The effects of probenecid on cyclic adenosine 3',5'-monophosphate levels in cerebrospinal fluid and on brain phosphodiesterase activity in the rat.
Archiv fur Psychiatrie und Nervenkrankheiten.
1983; 233(1):71-6. doi:
10.1007/bf00540038. [PMID: 6305307] - Y Carcassonne. Urine cyclic nucleotides in cancer and other conditions.
Journal of clinical pathology.
1983 Jan; 36(1):116. doi:
10.1136/jcp.36.1.116-a. [PMID: 6296203] - T R Anderson. Cyclic cytidine 3',5'-monophosphate (cCMP) in cell regulation.
Molecular and cellular endocrinology.
1982 Nov; 28(3):373-85. doi:
10.1016/0303-7207(82)90134-4. [PMID: 6295841] - I Yamamoto, T Takai, J Tsuji. Enzyme immunoassay for cytidine 3',5'-cyclic monophosphate (cyclic CMP).
Immunopharmacology.
1982 Aug; 4(4):331-40. doi:
10.1016/0162-3109(82)90054-6. [PMID: 6288621] - T Sato, A Kuninaka, H Yoshino. A practically sensitive radioimmunoassay for cyclic CMP by 2'-O-acetylation.
Analytical biochemistry.
1982 Jun; 123(1):208-18. doi:
10.1016/0003-2697(82)90646-7. [PMID: 6287882] - R G Andersson, J F Kuo, K Norrby, J Wikberg. Changes in cyclic nucleotide levels and phosphodiesterase and protein kinase activities in mitogenically stimulated 3T3 fibroblasts.
Virchows Archiv. B, Cell pathology including molecular pathology.
1981; 37(3):245-50. doi:
10.1007/bf02892573. [PMID: 6117970] - R W Wrenn, D M Biddulph. Correlation between cyclic AMP levels and calcium efflux in isolated renal cortical tubules.
Journal of cyclic nucleotide research.
1979; 5(3):239-50. doi:
. [PMID: 225358]
