Methysergide (BioDeep_00000003470)

 

Secondary id: BioDeep_00000408859

human metabolite blood metabolite


代谢物信息卡片


(4R,7R)-N-(1-hydroxybutan-2-yl)-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(15),2,9,12(16),13-pentaene-4-carboxamide

化学式: C21H27N3O2 (353.2103162)
中文名称: 美西麦角
谱图信息: 最多检出来源 Homo sapiens(blood) 17.74%

分子结构信息

SMILES: CCC(CO)NC(=O)C(C4)C=C(C(N(C)4)1)c(c3)c(c(cc3)2)c(cn(C)2)C1
InChI: InChI=1S/C21H27N3O2/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26)

描述信息

An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome. [PubChem]
N - Nervous system > N02 - Analgesics > N02C - Antimigraine preparations > N02CA - Ergot alkaloids
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
KEIO_ID M156; [MS2] KO009047
KEIO_ID M156

同义名列表

23 个代谢物同义名

(4R,7R)-N-(1-hydroxybutan-2-yl)-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(15),2,9,12(16),13-pentaene-4-carboxamide; (+)-9,10-Didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethylergoline-8beta-carboxamide; (+)-9,10-Didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethylergoline-8β-carboxamide; (+)-9,10-Didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethylergoline-8b-carboxamide; 9,10-Didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethylergoline-8-carboxamide; 1-Methyllysergic acid butanolamide tartrate, (R-(r*,r*))-(8beta)-isomer; N-(1-(Hydroxymethyl)propyl)-1-methyl-dextro-(+)-lysergamide; N-(alpha-(Hydroxymethyl)propyl)-1-methyl-dextro-lysergamide; 1-Methyl-dextro-lysergic acid (+)-1-hydroxy-2-butylamide; (+)-N-(1-(Hydroxymethyl)propyl)-1-methyl-D-lysergamide; 1-Methyl-dextro-lysergate (+)-1-hydroxy-2-butylamide; 1-Methyl-D-lysergic acid butanolamide; 1-Methyllysergic acid butanolamide; 1-Methyl-D-lysergate butanolamide; Methyllysergic acid butanolamide; 1-Methyllysergate butanolamide; 1-Methylmethylergonovine; Methysergidum; methysergide; Metisergide; Metisergida; Methysergid; Deseril



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yi Kuang, Bin Li, Jingran Fan, Xue Qiao, Min Ye. Antitussive and expectorant activities of licorice and its major compounds. Bioorganic & medicinal chemistry. 2018 01; 26(1):278-284. doi: 10.1016/j.bmc.2017.11.046. [PMID: 29224994]
  • Pollyana S Siqueira-Lima, Renan G Brito, Heitor G Araújo-Filho, Priscila L Santos, Angélica Lucchesi, Adriano A S Araújo, Paula P Menezes, Luciana Scotti, Marcus T Scotti, Irwin R A Menezes, Henrique D M Coutinho, Gokhan Zengin, Abdurrahman Aktumsek, Angelo R Antoniolli, Lucindo J Quintans-Júnior, Jullyana S S Quintans. Anti-hyperalgesic effect of Lippia grata leaf essential oil complexed with β-cyclodextrin in a chronic musculoskeletal pain animal model: Complemented with a molecular docking and antioxidant screening. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jul; 91(?):739-747. doi: 10.1016/j.biopha.2017.05.009. [PMID: 28499245]
  • Richard B David, Camila F Roncari, Mariana R Lauar, Regina C Vendramini, José Antunes-Rodrigues, José V Menani, Laurival A De Luca. Sodium intake, brain c-Fos protein and gastric emptying in cell-dehydrated rats treated with methysergide into the lateral parabrachial nucleus. Physiology & behavior. 2015 Nov; 151(?):111-20. doi: 10.1016/j.physbeh.2015.07.014. [PMID: 26171591]
  • L O Margatho, C Y Porcari, A F Macchione, G D da Silva Souza, X E Caeiro, J Antunes-Rodrigues, L Vivas, A Godino. Temporal dissociation between sodium depletion and sodium appetite appearance: Involvement of inhibitory and stimulatory signals. Neuroscience. 2015 Jun; 297(?):78-88. doi: 10.1016/j.neuroscience.2015.03.059. [PMID: 25841323]
  • Jochen Frederick Hernekamp, S Hu, K Schmidt, A Walther, M Lehnhardt, Thomas Kremer. Methysergide attenuates systemic burn edema in rats. Microvascular research. 2013 Sep; 89(?):115-21. doi: 10.1016/j.mvr.2013.03.002. [PMID: 23669653]
  • Yu-Shang Lee, Ching-Yi Lin, Hai-Hong Jiang, Marc Depaul, Vernon W Lin, Jerry Silver. Nerve regeneration restores supraspinal control of bladder function after complete spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Jun; 33(26):10591-606. doi: 10.1523/jneurosci.1116-12.2013. [PMID: 23804083]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Yong Chen, Florian Palm, Klaus-Peter Lesch, Manfred Gerlach, Rainald Moessner, Claudia Sommer. 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice. Molecular pain. 2011 Mar; 7(?):21. doi: 10.1186/1744-8069-7-21. [PMID: 21447193]
  • Haihua Shu, Hideko Arita, Masakazu Hayashida, Liang Zhang, Ke An, Wenqi Huang, Kazuo Hanaoka. Anti-hypersensitivity effects of Shu-jing-huo-xue-tang, a Chinese herbal medicine, in CCI-neuropathic rats. Journal of ethnopharmacology. 2010 Sep; 131(2):464-70. doi: 10.1016/j.jep.2010.07.004. [PMID: 20633621]
  • Katharina Heimes, Björn Feistel, Eugen J Verspohl. Impact of the 5-HT3 receptor channel system for insulin secretion and interaction of ginger extracts. European journal of pharmacology. 2009 Dec; 624(1-3):58-65. doi: 10.1016/j.ejphar.2009.09.049. [PMID: 19818348]
  • Sanjeev Bhattacharyya, Anthony H Schapira, Dimitri P Mikhailidis, Joseph Davar. Drug-induced fibrotic valvular heart disease. Lancet (London, England). 2009 Aug; 374(9689):577-85. doi: 10.1016/s0140-6736(09)60252-x. [PMID: 19683643]
  • Sebastian Rinaldi, Davi O Silva, Fabiana Bello, Celuta S Alviano, Daniela S Alviano, Maria Eline Matheus, Patricia D Fernandes. Characterization of the antinociceptive and anti-inflammatory activities from Cocos nucifera L. (Palmae). Journal of ethnopharmacology. 2009 Apr; 122(3):541-6. doi: 10.1016/j.jep.2009.01.024. [PMID: 19429325]
  • L L Hernandez, C M Stiening, J B Wheelock, L H Baumgard, A M Parkhurst, R J Collier. Evaluation of serotonin as a feedback inhibitor of lactation in the bovine. Journal of dairy science. 2008 May; 91(5):1834-44. doi: 10.3168/jds.2007-0766. [PMID: 18420614]
  • C Lima, V M O Souza, A L Soares, M S Macedo, W Tavares-de-Lima, B B Vargaftig. Interference of methysergide, a specific 5-hydroxytryptamine receptor antagonist, with airway chronic allergic inflammation and remodelling in a murine model of asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2007 May; 37(5):723-34. doi: 10.1111/j.1365-2222.2007.02700.x. [PMID: 17456220]
  • Lisandra Oliveira Margatho, Alexandre Giusti-Paiva, Jose Vanderlei Menani, Lucila Leico Kagohara Elias, Laura M Vivas, Jose Antunes-Rodrigues. Serotonergic mechanisms of the lateral parabrachial nucleus in renal and hormonal responses to isotonic blood volume expansion. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 Mar; 292(3):R1190-7. doi: 10.1152/ajpregu.00351.2006. [PMID: 17138727]
  • Erik Hedner, Martin Sjögren, Per-Anders Frändberg, Tobias Johansson, Ulf Göransson, Mia Dahlström, Per Jonsson, Fred Nyberg, Lars Bohlin. Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. Journal of natural products. 2006 Oct; 69(10):1421-4. doi: 10.1021/np0601760. [PMID: 17067154]
  • David B Wainscott, Joseph H Krushinski, James E Audia, John M Schaus, John M Zgombick, Virginia L Lucaites, David L Nelson. [3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties. Naunyn-Schmiedeberg's archives of pharmacology. 2005 Mar; 371(3):169-77. doi: 10.1007/s00210-005-1035-9. [PMID: 15900510]
  • Frankie H M Cheng, Paul L R Andrews, Benoit Moreaux, Man-P Ngan, John A Rudd, Tasia S W Sam, Man-K Wai, Christina Wan. Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew). European journal of pharmacology. 2005 Jan; 508(1-3):231-8. doi: 10.1016/j.ejphar.2004.12.022. [PMID: 15680276]
  • Raffaele Capasso, Francesca Borrelli, Francesco Capasso, Nicola Mascolo, Angelo A Izzo. Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro. Urology. 2004 Jul; 64(1):168-72. doi: 10.1016/j.urology.2004.02.021. [PMID: 15245964]
  • Sheikh Arshad Saeed, Huma Rasheed, Anwar-ul-Hassan Gilani. Synergism interaction between arachidonic acid by 5-hydroxytryptamine in human platelet aggregation is mediated through multiple signalling pathways. Acta pharmacologica Sinica. 2003 Oct; 24(10):958-64. doi: . [PMID: 14531936]
  • Lorraine A Fitzpatrick. Alternatives to estrogen. The Medical clinics of North America. 2003 Sep; 87(5):1091-113, x. doi: 10.1016/s0025-7125(03)00116-0. [PMID: 14621333]
  • Tatiana R Lavich, Renato S B Cordeiro, João B Calixto, Patrícia M R e Silva, Marco A Martins. Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats. European journal of pharmacology. 2003 Feb; 462(1-3):185-92. doi: 10.1016/s0014-2999(02)02947-3. [PMID: 12591112]
  • Seong-Soo Choi, Eun-Jung Han, Tae-Hee Lee, Jin-Koo Lee, Ki-Jung Han, Han-Kyu Lee, Hong-Won Suh. Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse. Planta medica. 2002 Sep; 68(9):794-8. doi: 10.1055/s-2002-34396. [PMID: 12357389]
  • Bryan C Hains, Alex W Everhart, Steven D Fullwood, Claire E Hulsebosch. Changes in serotonin, serotonin transporter expression and serotonin denervation supersensitivity: involvement in chronic central pain after spinal hemisection in the rat. Experimental neurology. 2002 Jun; 175(2):347-62. doi: 10.1006/exnr.2002.7892. [PMID: 12061865]
  • John D Connor, Amr Rostom, Eyasu Makonnen. Comparison of effects of khat extract and amphetamine on motor behaviors in mice. Journal of ethnopharmacology. 2002 Jun; 81(1):65-71. doi: 10.1016/s0378-8741(02)00035-1. [PMID: 12020929]
  • Andreas Walther, Christoph Peter, Andreas Secchi, Martha Maria Gebhard, Eike Martin, Heinfried Schmidt. Selective serotonin receptor antagonism and leukocyte-independent plasma extravasation during endotoxemia. Microvascular research. 2002 Jan; 63(1):135-8. doi: 10.1006/mvre.2001.2370. [PMID: 11749080]
  • K N Lapner, S F Perry. The role of angiotensin II in regulating catecholamine secretion during hypoxia in rainbow trout Oncorhynchus mykiss. The Journal of experimental biology. 2001 Dec; 204(Pt 23):4169-76. doi: 10.1242/jeb.204.23.4169. [PMID: 11809790]
  • A Walther, N Yilmaz, W Schmidt, A Bach, M M Gebhard, E Martin, H Schmidt. Methysergide attenuates leukocyte-independent plasma extravasation during endotoxemia. Journal of critical care. 2001 Sep; 16(3):121-6. doi: 10.1053/jcrc.2001.28975. [PMID: 11689769]
  • K Hayashi, H Sato, T Kaise, K Ohmori, A Ishii, J Sano, A Karasawa. Roles of mast cells and sensory nerves in cutaneous vascular hyperpermeability and scratching behavior induced by poly-L-arginine in rats. European journal of pharmacology. 2001 Aug; 425(3):219-27. doi: 10.1016/s0014-2999(01)01177-3. [PMID: 11513841]
  • S K Costa, L C Esquisatto, E Camargo, A Gambero, S D Brain, G De Nucci, E Antunes. Comparative effect of Phoneutria nigriventer spider venom and capsaicin on the rat paw oedema. Life sciences. 2001 Aug; 69(13):1573-85. doi: 10.1016/s0024-3205(01)01234-6. [PMID: 11554618]
  • C Y Lee, P F Yang, H S Zou. Serotonergic regulation of crustacean hyperglycemic hormone secretion in the crayfish, Procambarus clarkii. Physiological and biochemical zoology : PBZ. 2001 May; 74(3):376-82. doi: 10.1086/320430. [PMID: 11331509]
  • J P Hannon, B Tigani, I Williams, L Mazzoni, J R Fozard. Mechanism of airway hyperresponsiveness to adenosine induced by allergen challenge in actively sensitized Brown Norway rats. British journal of pharmacology. 2001 Apr; 132(7):1509-23. doi: 10.1038/sj.bjp.0703961. [PMID: 11264245]
  • R E Garfield, E Bytautiene, Y P Vedernikov, J S Marshall, R Romero. Modulation of rat uterine contractility by mast cells and their mediators. American journal of obstetrics and gynecology. 2000 Jul; 183(1):118-25. doi: 10.1067/mob.2000.105741. [PMID: 10920318]
  • G Campiani, E Morelli, S Gemma, V Nacci, S Butini, M Hamon, E Novellino, G Greco, A Cagnotto, M Goegan, L Cervo, F Dalla Valle, C Fracasso, S Caccia, T Mennini. Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies. Journal of medicinal chemistry. 1999 Oct; 42(21):4362-79. doi: 10.1021/jm990151g. [PMID: 10543880]
  • G A Lambert, T Shimomura, P M Boers, V Gordon, C Donaldson, A S Zagami. Serotonin infusions inhibit sensory input from the dural vasculature. Cephalalgia : an international journal of headache. 1999 Sep; 19(7):639-50. doi: 10.1046/j.1468-2982.1999.019007639.x. [PMID: 10524657]
  • A V Amelin, V E Ivanov, Iu D Ignatov, B Ch Tumelevich, A A Pushkarev, N I Usachev. [The effect of tropoxin on the neurogenic and vasogenic inflammation of the dura mater vessels]. Eksperimental'naia i klinicheskaia farmakologiia. 1999 Jul; 62(4):14-7. doi: NULL. [PMID: 10513329]
  • Y Ohta, T Kobayashi, I Ishiguro. Role of endogenous serotonin and histamine in the pathogenesis of gastric mucosal lesions in unanaesthetised rats with a single treatment of compound 48/80, a mast cell degranulator. Pharmacological research. 1999 Apr; 39(4):261-7. doi: 10.1006/phrs.1998.0403. [PMID: 10208755]
  • J Yamada, Y Sugimoto, T Yoshikawa. p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors. European journal of pharmacology. 1998 Oct; 359(2-3):185-90. doi: 10.1016/s0014-2999(98)00639-6. [PMID: 9832390]
  • A MaassenVanDenBrink, M Reekers, W A Bax, M D Ferrari, P R Saxena. Coronary side-effect potential of current and prospective antimigraine drugs. Circulation. 1998 Jul; 98(1):25-30. doi: 10.1161/01.cir.98.1.25. [PMID: 9665056]
  • G D Withers, P Kubes, G Ibbotson, R B Scott. Anaphylaxis-induced mesenteric vascular permeability, granulocyte adhesion, and platelet aggregates in rat. The American journal of physiology. 1998 07; 275(1):H274-84. doi: 10.1152/ajpheart.1998.275.1.h274. [PMID: 9688924]
  • K E Scrogin, R Veelken, A K Johnson. Central methysergide prevents renal sympathoinhibition and bradycardia during hypotensive hemorrhage. The American journal of physiology. 1998 Jan; 274(1 Pt 2):H43-51. doi: 10.1152/ajpheart.1998.274.1.h43. [PMID: 9458850]
  • J A Bucci, A Manoharan. Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features. Mayo Clinic proceedings. 1997 Dec; 72(12):1148-50. doi: 10.4065/72.12.1148. [PMID: 9413296]
  • F G Boess, F J Monsma, V Meyer, C Zwingelstein, A J Sleight. Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-hydroxytryptamine6 receptor. Molecular pharmacology. 1997 Sep; 52(3):515-23. doi: 10.1124/mol.52.3.515. [PMID: 9284367]
  • S Taleisnik, B Haymal. Dual effect of electrochemical stimulation of the medial preoptic area on the release of LH: possible neurotransmitter involvement. Neuroendocrinology. 1997 Aug; 66(2):114-21. doi: 10.1159/000127227. [PMID: 9263208]
  • T F Meert, W Melis, N Aerts, G Clincke. Antagonism of meta-chlorophenylpiperazine-induced inhibition of exploratory activity in an emergence procedure, the open field test, in rats. Behavioural pharmacology. 1997 Aug; 8(4):353-63. doi: 10.1097/00008877-199708000-00008. [PMID: 9832994]
  • P Kubes, J P Gaboury. Rapid mast cell activation causes leukocyte-dependent and -independent permeability alterations. The American journal of physiology. 1996 Dec; 271(6 Pt 2):H2438-46. doi: 10.1152/ajpheart.1996.271.6.h2438. [PMID: 8997303]
  • J E Leysen, W Gommeren, L Heylen, W H Luyten, I Van de Weyer, P Vanhoenacker, G Haegeman, A Schotte, P Van Gompel, R Wouters, A S Lesage. Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Molecular pharmacology. 1996 Dec; 50(6):1567-80. doi: . [PMID: 8967979]
  • J Damas, V Bourdon, J F Liégeois, W H Simmons. Influence of several peptidase inhibitors on the pro-inflammatory effects of substance P, capsaicin and collagenase. Naunyn-Schmiedeberg's archives of pharmacology. 1996 Nov; 354(5):662-9. doi: 10.1007/bf00170843. [PMID: 8938667]
  • R T Palframan, S K Costa, P Wilsoncroft, E Antunes, G de Nucci, S D Brain. The effect of a tachykinin NK1 receptor antagonist, SR140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider. British journal of pharmacology. 1996 May; 118(2):295-8. doi: 10.1111/j.1476-5381.1996.tb15402.x. [PMID: 8735630]
  • J D Silva, M T Nunes. Facilitatory role of serotonin (5-HT) in the control of thyrotropin releasing hormone/thyrotropin (TRH/TSH) secretion in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 1996 May; 29(5):677-83. doi: . [PMID: 9033822]
  • Y Asari, M Majima, K Sugimoto, M Katori, T Ohwada. Release site of TNF alpha after intravenous and intraperitoneal injection of LPS from Escherichia coli in rats. Shock (Augusta, Ga.). 1996 Mar; 5(3):208-12. doi: 10.1097/00024382-199603000-00007. [PMID: 8696985]
  • J J Ferrara, C L Westervelt, E L Kukuy, E W Franklin, E U Choe, K K Mercurio, H L Lippton, L M Flint. Burn edema reduction by methysergide is not due to control of regional vasodilation. The Journal of surgical research. 1996 Feb; 61(1):11-6. doi: 10.1006/jsre.1996.0073. [PMID: 8769935]
  • P R Germonpré, G F Joos, E Everaert, J C Kips, R A Pauwels. Characterization of neurogenic inflammation in the airways of two highly inbred rat strains. American journal of respiratory and critical care medicine. 1995 Dec; 152(6 Pt 1):1796-804. doi: 10.1164/ajrccm.152.6.8520739. [PMID: 8520739]
  • R A Pauwels, P R Germonpré, J C Kips, G F Joos. Genetic control of indirect airway responsiveness in the rat. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1995 Nov; 25 Suppl 2(?):55-60. doi: 10.1111/j.1365-2222.1995.tb00423.x. [PMID: 8590345]
  • B Seletti, C Benkelfat, P Blier, L Annable, F Gilbert, C de Montigny. Serotonin1A receptor activation by flesinoxan in humans. Body temperature and neuroendocrine responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 1995 Oct; 13(2):93-104. doi: 10.1016/0893-133x(95)00025-9. [PMID: 8597527]
  • M E el Halawani, O M Youngren, I Rozenboim, G R Pitts, J L Silsby, R E Phillips. Serotonergic stimulation of prolactin secretion is inhibited by vasoactive intestinal peptide immunoneutralization in the turkey. General and comparative endocrinology. 1995 Jul; 99(1):69-74. doi: 10.1006/gcen.1995.1086. [PMID: 7657159]
  • M C Rho, N Nakahata, H Nakamura, A Murai, Y Ohizumi. Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca(2+)-dependent manner by zooxanthellatoxin-A, a novel polyol. British journal of pharmacology. 1995 Jun; 115(3):433-40. doi: 10.1111/j.1476-5381.1995.tb16352.x. [PMID: 7582454]
  • J C Souza Pinto, G Remacle-Volon, C A Sampaio, J Damas. Collagenase-induced oedema in the rat paw and the kinin system. European journal of pharmacology. 1995 Feb; 274(1-3):101-7. doi: 10.1016/0014-2999(94)00723-k. [PMID: 7768261]
  • J P Wang, S L Raung, L C Chang, S C Kuo. Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. European journal of pharmacology. 1995 Jan; 272(1):87-95. doi: 10.1016/0014-2999(94)00627-j. [PMID: 7536160]
  • J J Ferrara, E W Franklin, E U Choe, H L Lippton, A L Hyman, L M Flint. Effects of methysergide administration on edema formation at the site of scald. Journal of applied physiology (Bethesda, Md. : 1985). 1995 Jan; 78(1):191-7. doi: 10.1152/jappl.1995.78.1.191. [PMID: 7713811]
  • J Bugajski, A J Bugajski, Z Chłap, J Borycz. Effect of compound 48/80 on the thalamic mast cells, serotonin level and corticosterone secretion in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 1994 Dec; 45(4):583-92. doi: NULL. [PMID: 7727800]
  • A Kawabata, S Manabe, H Takagi. Comparison of antinociception induced by supraspinally administered L-arginine and kyotorphin. British journal of pharmacology. 1994 Jul; 112(3):817-22. doi: 10.1111/j.1476-5381.1994.tb13152.x. [PMID: 7921607]
  • C Takeshige, T Aoki. Effect of artificial and human external qigong on electroencephalograms in rabbit and spontaneous electrical activity of the rat pineal gland. Acupuncture & electro-therapeutics research. 1994 Jun; 19(2-3):89-106. doi: 10.3727/036012994816357303. [PMID: 7863841]
  • N A Abdullah, M Hirata, K Matsumoto, H Aizawa, R Inoue, S Hamano, S Ikeda, Z Xie, N Hara, Y Ito. Contraction and depolarization induced by fetal bovine serum in airway smooth muscle. The American journal of physiology. 1994 May; 266(5 Pt 1):L528-35. doi: 10.1152/ajplung.1994.266.5.l528. [PMID: 8203546]
  • C H Cho, Q B Mei, S K Kaan. The intraperitoneal effects of 5-hydroxytryptamine on haemodynamics, gastric mucosal blood flow and platelet aggregation. European journal of pharmacology. 1994 Apr; 256(1):9-15. doi: 10.1016/0014-2999(94)90609-2. [PMID: 8026564]
  • K Sugimoto, M Kawamura, M Katori, M Shindo, T Ohwada. Transmigration routes and a delayed systemic hypotension in rats after intraperitoneal injection of endotoxin from Escherichia coli. Circulatory shock. 1993 Nov; 41(3):185-96. doi: NULL. [PMID: 8269648]
  • N P Kerezoudis, L Olgart, L Edwall. Evans blue extravasation in rat dental pulp and oral tissues induced by electrical stimulation of the inferior alveolar nerve. Archives of oral biology. 1993 Oct; 38(10):893-901. doi: 10.1016/0003-9969(93)90099-8. [PMID: 8279994]
  • S Matzen, N H Secher, U Knigge, J Pawelczyk, G Perko, H Iversen, F W Bach, J Warberg. Effect of serotonin receptor blockade on endocrine and cardiovascular responses to head-up tilt in humans. Acta physiologica Scandinavica. 1993 Oct; 149(2):163-76. doi: 10.1111/j.1748-1716.1993.tb09609.x. [PMID: 8266806]
  • Y Shen, F J Monsma, M A Metcalf, P A Jose, M W Hamblin, D R Sibley. Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. The Journal of biological chemistry. 1993 Aug; 268(24):18200-4. doi: . [PMID: 8394362]
  • C Dean, J P Kampine. A role for serotonin in the elaboration of a differential pattern of activity in sympathetic nerves to kidney and skeletal muscle vasculature. Journal of the autonomic nervous system. 1993 Aug; 44(2-3):207-15. doi: 10.1016/0165-1838(93)90033-q. [PMID: 8227956]
  • S Le Corre, P Chemineau. Serotonergic 5HT2 receptors mediate the inhibitory action of serotonin on luteinizing hormone secretion in ovariectomized, estradiol-treated ewes that are refractory to short days. Biology of reproduction. 1993 Jul; 49(1):140-7. doi: 10.1095/biolreprod49.1.140. [PMID: 8353180]
  • L Oosterbosch, M von der Ohe, M A Valdovinos, L J Kost, S F Phillips, M Camilleri. Effects of serotonin on rat ileocolonic transit and fluid transfer in vivo: possible mechanisms of action. Gut. 1993 Jun; 34(6):794-8. doi: 10.1136/gut.34.6.794. [PMID: 8100206]
  • N Adham, H T Kao, L E Schecter, J Bard, M Olsen, D Urquhart, M Durkin, P R Hartig, R L Weinshank, T A Branchek. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 1993 Jan; 90(2):408-12. doi: 10.1073/pnas.90.2.408. [PMID: 8380639]
  • J Yamada, Y Sugimoto, I Kimura, Y Watanabe, N Takeuchi, K Horisaka. Peripherally administered serotonin induces hyperglucagonemia in mice. Life sciences. 1993; 52(23):1845-9. doi: 10.1016/0024-3205(93)90004-m. [PMID: 8502121]
  • D Collado, E Aguilar. Further evidence that prolactin secretion in adult female rats is differently modified after neonatal estrogenization or androgenization: responses to methysergide, quipazine, and pizotifen. Physiology & behavior. 1993 Jan; 53(1):161-5. doi: 10.1016/0031-9384(93)90025-b. [PMID: 8434056]
  • K J Kellar, B A Hulihan-Giblin, S E Mulroney, M D Lumpkin, C M Flores. Stimulation of serotonin1A receptors increases release of prolactin in the rat. Neuropharmacology. 1992 Jul; 31(7):643-7. doi: 10.1016/0028-3908(92)90142-c. [PMID: 1357574]
  • G McAllister, A Charlesworth, C Snodin, M S Beer, A J Noble, D N Middlemiss, L L Iversen, P Whiting. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proceedings of the National Academy of Sciences of the United States of America. 1992 Jun; 89(12):5517-21. doi: 10.1073/pnas.89.12.5517. [PMID: 1608964]
  • C M Flores, B A Hulihan-Giblin, P J Hornby, M D Lumpkin, K J Kellar. Partial characterization of a neurotransmitter pathway regulating the in vivo release of prolactin. Neuroendocrinology. 1992 May; 55(5):519-28. doi: 10.1159/000126176. [PMID: 1350068]
  • C M Teng, M F Hsu, J P Wang. Comparison of kinin-forming and amidolytic activities of four trimucases, oedema-producing and kinin-releasing enzymes, from Trimeresurus mucrosquamatus venom. The Journal of pharmacy and pharmacology. 1992 Apr; 44(4):306-10. doi: 10.1111/j.2042-7158.1992.tb03611.x. [PMID: 1355541]
  • H Jørgensen, U Knigge, J Warberg. Involvement of 5-HT1, 5-HT2, and 5-HT3 receptors in the mediation of the prolactin response to serotonin and 5-hydroxytryptophan. Neuroendocrinology. 1992 Mar; 55(3):336-43. doi: 10.1159/000126134. [PMID: 1386914]
  • T Takahashi, H Hisa, S Satoh. Serotonin-induced vasoconstriction in dog kidney. Journal of cardiovascular pharmacology. 1992; 20(5):779-84. doi: NULL. [PMID: 1280741]
  • C Z Amorim, M G Henriques, V B Weg, R S Cordeiro, B B Vargaftig. Effect of PAF-acether antagonists on active anaphylactic mouse paw edema. Lipids. 1991 Dec; 26(12):1396-9. doi: 10.1007/bf02536574. [PMID: 1668123]
  • V B Weg, M L Watson, R S Cordeiro, T J Williams. Histamine, leukotriene D4 and platelet-activating factor in guinea pig passive cutaneous anaphylaxis. European journal of pharmacology. 1991 Nov; 204(2):157-63. doi: 10.1016/0014-2999(91)90700-z. [PMID: 1687219]
  • P Mullaney, B Curren, L Collum, S Kilfeather. Fibroblast and endothelial outgrowth from human Tenon's explants: inhibition of fibroblast growth by 5HT receptor antagonism. Research communications in chemical pathology and pharmacology. 1991 Nov; 74(2):201-13. doi: NULL. [PMID: 1811281]
  • S Jancar, M G Sirois, J Carrier, P Braquet, P Sirois. PAF induces rat plasma extravasation and releases eicosanoids during anaphylaxis. Inflammation. 1991 Oct; 15(5):347-54. doi: 10.1007/bf00917351. [PMID: 1757122]
  • J H Johnson, C S Kitts. Analysis of neurotransmitter receptors mediating changes in LH release induced by electrical stimulation of the dorsal raphe nucleus in the rat. Journal of neuroscience research. 1991 Aug; 29(4):520-6. doi: 10.1002/jnr.490290412. [PMID: 1665188]
  • L Chen. [Roles of oxytocin, serotonin and norepinephrine in regulation of prolactin release during stress]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 1991 Aug; 13(4):288-92. doi: NULL. [PMID: 1839525]
  • P Lavaud, F Rodrigue, C Carré, C Touvay, J M Mencia-Huerta, P Braquet. Pharmacologic modulation of picryl chloride-induced contact dermatitis in the mouse. The Journal of investigative dermatology. 1991 Jul; 97(1):101-5. doi: 10.1111/1523-1747.ep12478438. [PMID: 2056180]
  • J Damas. Involvement of platelet-activating factor in the hypotensive response to zymosan in rats. Journal of lipid mediators. 1991 May; 3(3):333-44. doi: NULL. [PMID: 1773031]
  • T Takahashi, H Hisa, S Satoh. Serotonin-induced renin release in the dog kidney. European journal of pharmacology. 1991 Feb; 193(3):315-20. doi: 10.1016/0014-2999(91)90145-g. [PMID: 1905236]
  • F Y Lam, W R Ferrell. Mediators of substance P-induced inflammation in the rat knee joint. Agents and actions. 1990 Nov; 31(3-4):298-307. doi: 10.1007/bf01997623. [PMID: 1707585]
  • H Takada, H Hirai, T Fujiwara, T Koga, T Ogawa, S Hamada. Bacteroides lipopolysaccharides (LPS) induce anaphylactoid and lethal reactions in LPS-responsive and -nonresponsive mice primed with muramyl dipeptide. The Journal of infectious diseases. 1990 Aug; 162(2):428-34. doi: 10.1093/infdis/162.2.428. [PMID: 2197336]
  • U Bredberg, L Paalzow. Pharmacokinetics of methysergide and its metabolite methylergometrine in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1990 May; 18(3):338-43. doi: NULL. [PMID: 1974196]
  • M Scheinin, M Koulu, S Karhuvaara, R H Zimmer. Evidence that the reversible MAO-A inhibitor moclobemide increases prolactin secretion by a serotonergic mechanism in healthy male volunteers. Life sciences. 1990; 47(16):1491-9. doi: 10.1016/0024-3205(90)90529-z. [PMID: 2250565]
  • A Watanabe, H Hayashi. Allergen-induced biphasic bronchoconstriction in rats. International archives of allergy and applied immunology. 1990; 93(1):26-34. doi: 10.1159/000235275. [PMID: 2128296]
  • A A Norris, M E Leeson, D M Jackson, M C Holroyde. Modulation of neurogenic inflammation in rat trachea. Pulmonary pharmacology. 1990; 3(4):180-4. doi: 10.1016/0952-0600(90)90014-a. [PMID: 2135222]
  • T Sasaki, S Shimura, K Ikeda, H Sasaki, T Takishima. Platelet-activating factor increases platelet-dependent glycoconjugate secretion from tracheal submucosal gland. The American journal of physiology. 1989 Dec; 257(6 Pt 1):L373-8. doi: 10.1152/ajplung.1989.257.6.l373. [PMID: 2692465]