Methysergide (BioDeep_00000003470)
Secondary id: BioDeep_00000408859
human metabolite blood metabolite
代谢物信息卡片
(4R,7R)-N-(1-hydroxybutan-2-yl)-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(15),2,9,12(16),13-pentaene-4-carboxamide
化学式: C21H27N3O2 (353.2103)
中文名称: 美西麦角
谱图信息:
最多检出来源 Homo sapiens(blood) 16.7%
分子结构信息
SMILES: CCC(CO)NC(=O)C(C4)C=C(C(N(C)4)1)c(c3)c(c(cc3)2)c(cn(C)2)C1
InChI: InChI=1S/C21H27N3O2/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26)
描述信息
An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome. [PubChem]
N - Nervous system > N02 - Analgesics > N02C - Antimigraine preparations > N02CA - Ergot alkaloids
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
KEIO_ID M156; [MS2] KO009047
KEIO_ID M156
同义名列表
24 个代谢物同义名
(4R,7R)-N-(1-hydroxybutan-2-yl)-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(15),2,9,12(16),13-pentaene-4-carboxamide; (+)-9,10-Didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethylergoline-8beta-carboxamide; (+)-9,10-Didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethylergoline-8β-carboxamide; (+)-9,10-Didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethylergoline-8b-carboxamide; 9,10-Didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethylergoline-8-carboxamide; 1-Methyllysergic acid butanolamide tartrate, (R-(r*,r*))-(8beta)-isomer; N-(1-(Hydroxymethyl)propyl)-1-methyl-dextro-(+)-lysergamide; N-(alpha-(Hydroxymethyl)propyl)-1-methyl-dextro-lysergamide; 1-Methyl-dextro-lysergic acid (+)-1-hydroxy-2-butylamide; (+)-N-(1-(Hydroxymethyl)propyl)-1-methyl-D-lysergamide; 1-Methyl-dextro-lysergate (+)-1-hydroxy-2-butylamide; 1-Methyl-D-lysergic acid butanolamide; 1-Methyllysergic acid butanolamide; 1-Methyl-D-lysergate butanolamide; Methyllysergic acid butanolamide; 1-Methyllysergate butanolamide; 1-Methylmethylergonovine; Methysergidum; methysergide; Metisergide; Metisergida; Methysergid; Deseril; Methysergide
数据库引用编号
33 个数据库交叉引用编号
- ChEBI: CHEBI:584020
- ChEBI: CHEBI:91995
- ChEBI: CHEBI:92629
- KEGG: C07199
- KEGGdrug: D02357
- PubChem: 6540428
- PubChem: 9408
- PubChem: 4163
- PubChem: 9681
- HMDB: HMDB0014392
- Metlin: METLIN1242
- DrugBank: DB00247
- ChEMBL: CHEMBL485253
- ChEMBL: CHEMBL1065
- Wikipedia: Methysergide
- MeSH: Methysergide
- chemspider: 5022813
- CAS: 220756-57-0
- CAS: 361-37-5
- MoNA: KO009049
- MoNA: KO003561
- MoNA: KO009047
- MoNA: KO009048
- MoNA: KO003558
- MoNA: KO003559
- MoNA: KO003557
- MoNA: KO003560
- MoNA: KO009050
- PMhub: MS000009724
- PDB-CCD: H8J
- NIKKAJI: J76.430B
- RefMet: Methysergide
- KNApSAcK: 584020
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
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European journal of pharmacology.
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1994 Dec; 45(4):583-92. doi:
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British journal of pharmacology.
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Acupuncture & electro-therapeutics research.
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