Guanethidine (BioDeep_00000003461)

 

Secondary id: BioDeep_00001868086

human metabolite blood metabolite


代谢物信息卡片


((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine

化学式: C10H22N4 (198.1844)
中文名称: 依斯美林
谱图信息: 最多检出来源 Homo sapiens(blood) 61.46%

分子结构信息

SMILES: C1CCCN(CCC1)CCN=C(N)N
InChI: InChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13)

描述信息

An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem]
C - Cardiovascular system > C02 - Antihypertensives > C02C - Antiadrenergic agents, peripherally acting > C02CC - Guanidine derivatives
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
KEIO_ID I063

同义名列表

24 个代谢物同义名

((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine; 2-(1-N,N-Heptamethyleneimino)ethylguanidine; (2-(Octahydro-1-azocinyl)ethyl)guanidine; Guanethidine sulfate (2:1), 14C-labeled; N-(2-Perhydroazocin-1-ylethyl)guanidine; 2-(1-Azacyclooctyl)ethylguanidine; 2-[2-(azocan-1-yl)ethyl]guanidine; Guanethidine sulfate (1:1); Guanethidine sulfate (1:2); Guanethidine sulfate (2:1); monoSulfate, guanethidine; Guanethidine monosulphate; Guanethidine monosulfate; Sulfate, guanethidine; Guanethidine sulphae; Guanethidine sulfate; Guanethidinum; GUANETHIDINE; Guanetidina; Octadine; Isobarin; Ismelin; Oktadin; Guanethidine



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AXIN2, CALCA, CHAT, DBH, EDN1, GAL, TH
Peripheral membrane protein 1 ACHE
Nucleus 4 ACHE, AXIN2, CHAT, TH
cytosol 5 AXIN2, CHAT, NGF, SST, TH
dendrite 3 NGF, TACR1, TH
centrosome 1 AXIN2
Cell membrane 5 ACHE, ADRB3, GAL, TACR1, TNF
Cell projection, axon 1 TH
Multi-pass membrane protein 2 ADRB3, TACR1
Synapse 4 ACHE, CHAT, DBH, TAC1
cell surface 3 ACHE, TACR1, TNF
Golgi apparatus 2 ACHE, NPY
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
neuronal cell body 5 CALCA, GAL, SST, TAC1, TNF
smooth endoplasmic reticulum 1 TH
synaptic vesicle 2 NGF, TH
Cytoplasmic vesicle, secretory vesicle 1 NTS
plasma membrane 8 ACHE, ADRB3, AXIN2, GAL, KNG1, REN, TACR1, TNF
terminal bouton 2 CALCA, TH
Membrane 3 ACHE, DBH, REN
axon 3 NGF, TAC1, TH
extracellular exosome 1 KNG1
endoplasmic reticulum 1 DBH
extracellular space 13 ACHE, CALCA, DBH, EDN1, GAL, INS, KNG1, NGF, NPY, REN, SST, TAC1, TNF
perinuclear region of cytoplasm 2 ACHE, TH
mitochondrion 1 TH
intracellular membrane-bounded organelle 2 DBH, NTS
Secreted 12 ACHE, CALCA, DBH, EDN1, GAL, INS, NGF, NPY, NTS, REN, SST, VIP
extracellular region 15 ACHE, CALCA, DBH, EDN1, GAL, INS, KNG1, NGF, NPY, NTS, REN, SST, TAC1, TNF, VIP
cytoplasmic side of plasma membrane 1 TH
basal part of cell 1 EDN1
hippocampal mossy fiber to CA3 synapse 1 CALCA
Extracellular side 1 ACHE
centriolar satellite 1 DBH
external side of plasma membrane 1 TNF
perikaryon 1 TH
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 TH
Melanosome membrane 1 TH
apical part of cell 1 REN
recycling endosome 1 TNF
Single-pass type II membrane protein 2 DBH, TNF
postsynaptic membrane 1 TACR1
Cytoplasm, perinuclear region 1 TH
Membrane raft 1 TNF
GABA-ergic synapse 2 NPY, SST
basement membrane 1 ACHE
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 GAL
receptor complex 1 ADRB3
neuron projection 3 CHAT, TH, VIP
phagocytic cup 1 TNF
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
sperm midpiece 1 TACR1
Lipid-anchor, GPI-anchor 1 ACHE
sperm flagellum 1 TACR1
endosome lumen 2 INS, NGF
cell body 1 TACR1
side of membrane 1 ACHE
secretory granule lumen 2 DBH, INS
secretory granule membrane 1 DBH
Golgi lumen 2 INS, NGF
endoplasmic reticulum lumen 2 INS, KNG1
platelet alpha granule lumen 1 KNG1
axon terminus 1 NTS
transport vesicle 3 EDN1, INS, NTS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 3 CALCA, NPY, SST
synaptic cleft 1 ACHE
Cytoplasmic vesicle, secretory vesicle membrane 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
transport vesicle membrane 1 DBH
rough endoplasmic reticulum lumen 1 EDN1
sperm head 1 TACR1
Weibel-Palade body 1 EDN1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
[Isoform H]: Cell membrane 1 ACHE
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Anna Vavřínová, Michal Behuliak, Michal Bencze, Martin Vodička, Peter Ergang, Ivana Vaněčková, Josef Zicha. Sympathectomy-induced blood pressure reduction in adult normotensive and hypertensive rats is counteracted by enhanced cardiovascular sensitivity to vasoconstrictors. Hypertension research : official journal of the Japanese Society of Hypertension. 2019 12; 42(12):1872-1882. doi: 10.1038/s41440-019-0319-2. [PMID: 31527789]
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  • Younes Filali-Zegzouti, Jean-Louis Rouanet, Toufiq Fechtali, Damien Roussel. Mitochondrial oxidative energy metabolism in guanethidine-induced sympathectomized ducklings. General physiology and biophysics. 2014; 33(1):91-7. doi: 10.4149/gpb_2013072. [PMID: 24334534]
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