Guanethidine (BioDeep_00000003461)
Secondary id: BioDeep_00001868086
human metabolite blood metabolite
代谢物信息卡片
((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine
化学式: C10H22N4 (198.1844372)
中文名称: 依斯美林
谱图信息:
最多检出来源 Homo sapiens(blood) 64.52%
分子结构信息
SMILES: C1CCCN(CCC1)CCN=C(N)N
InChI: InChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13)
描述信息
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem]
C - Cardiovascular system > C02 - Antihypertensives > C02C - Antiadrenergic agents, peripherally acting > C02CC - Guanidine derivatives
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
KEIO_ID I063
同义名列表
23 个代谢物同义名
((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine; 2-(1-N,N-Heptamethyleneimino)ethylguanidine; (2-(Octahydro-1-azocinyl)ethyl)guanidine; Guanethidine sulfate (2:1), 14C-labeled; N-(2-Perhydroazocin-1-ylethyl)guanidine; 2-(1-Azacyclooctyl)ethylguanidine; 2-[2-(azocan-1-yl)ethyl]guanidine; Guanethidine sulfate (1:1); Guanethidine sulfate (1:2); Guanethidine sulfate (2:1); monoSulfate, guanethidine; Guanethidine monosulphate; Guanethidine monosulfate; Sulfate, guanethidine; Guanethidine sulphae; Guanethidine sulfate; Guanethidinum; GUANETHIDINE; Guanetidina; Octadine; Isobarin; Ismelin; Oktadin
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:5557
- KEGG: C07036
- KEGGdrug: D08030
- PubChem: 3518
- HMDB: HMDB0015301
- Metlin: METLIN515
- DrugBank: DB01170
- ChEMBL: CHEMBL765
- Wikipedia: Guanethidine
- MeSH: Guanethidine
- chemspider: 3398
- CAS: 55-65-2
- MoNA: KO003244
- MoNA: KO003242
- MoNA: KO003246
- MoNA: KO003245
- MoNA: KO003243
- PMhub: MS000009711
- PubChem: 9248
- NIKKAJI: J4.562D
- RefMet: Guanethidine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anna Vavřínová, Michal Behuliak, Michal Bencze, Martin Vodička, Peter Ergang, Ivana Vaněčková, Josef Zicha. Sympathectomy-induced blood pressure reduction in adult normotensive and hypertensive rats is counteracted by enhanced cardiovascular sensitivity to vasoconstrictors.
Hypertension research : official journal of the Japanese Society of Hypertension.
2019 12; 42(12):1872-1882. doi:
10.1038/s41440-019-0319-2. [PMID: 31527789] - Tod Turner, Xian Chen, Matthew Zahner, Alan Opsahl, George DeMarco, Magalie Boucher, Bryan Goodwin, Mylène Perreault. FGF21 increases water intake, urine output and blood pressure in rats.
PloS one.
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Journal of pharmacological and toxicological methods.
2017 Nov; 88(Pt 1):64-71. doi:
10.1016/j.vascn.2017.06.002. [PMID: 28658603] - Patrick Freyhardt, Ricardo Donners, Alex Riemert, Jörg Schnorr, Nicola Stolzenburg, Jan L Rinnenthal, Ulrich Bernhardt, Bernd Hamm, Rolf W Günther, Florian Streitparth. Renal denervation by CT-guided periarterial injection of hyperosmolar saline, vincristine, paclitaxel and guanethidine in a pig model.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
2017 Apr; 12(18):e2262-e2270. doi:
10.4244/eij-d-15-00354. [PMID: 27890860] - Matthew R Zahner, Chang-Ning Liu, Carlin V Okerberg, Alan C Opsahl, Walter F Bobrowski, Chris J Somps. Neurophysiological assessment of sympathetic cardiovascular activity after loss of postganglionic neurons in the anesthetized rat.
Journal of pharmacological and toxicological methods.
2016 Jul; 80(?):59-67. doi:
10.1016/j.vascn.2016.04.010. [PMID: 27085835] - Rafik Hachani, Houcine Dab, Anouar Feriani, Sami Saber, Mohsen Sakly, Eric Vicaut, Jacques Callebert, Richard Sercombe, Kamel Kacem. Hypercholesterolemic diet induces vascular smooth muscle cell apoptosis in sympathectomized rats via intrinsic pathway.
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General physiology and biophysics.
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Muscle & nerve.
2008 Aug; 38(2):1027-35. doi:
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2008 Jul; 179(3):118-23. doi:
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2007 Feb; 579(Pt 1):247-54. doi:
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Journal of hypertension.
2004 Nov; 22(11):2103-9. doi:
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Brain research.
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