Dimethyl malate (BioDeep_00000003446)

   


代谢物信息卡片


(3S)-2-hydroxy-2,3-dimethylbutanedioic acid

化学式: C6H10O5 (162.0528)
中文名称: L-苹果酸二甲酯, DL-苹果酸二甲酯, D-苹果酸二甲酯, 苹果酸二甲酯
谱图信息: 最多检出来源 Viridiplantae(plant) 20.85%

分子结构信息

SMILES: CC(C(=O)O)C(C)(C(=O)O)O
InChI: InChI=1S/C6H10O5/c1-3(4(7)8)6(2,11)5(9)10/h3,11H,1-2H3,(H,7,8)(H,9,10)/t3-,6-/m1/s1



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ELANE, GCK, ME1, MLXIPL, MLYCD, PCK1, PIK3CA, PTEN
Peripheral membrane protein 1 GCK
Mitochondrion membrane 1 SLC25A1
Nucleus 4 GCK, MLXIPL, PTEN, SLC25A1
cytosol 9 ACACA, ELANE, GCK, ME1, MLXIPL, MLYCD, PCK1, PIK3CA, PTEN
phagocytic vesicle 1 ELANE
nucleoplasm 4 ATP2B1, GCK, MLXIPL, PTEN
Cell membrane 1 ATP2B1
lamellipodium 1 PIK3CA
Multi-pass membrane protein 2 ATP2B1, SLC25A1
Golgi apparatus membrane 1 GCK
Synapse 1 ATP2B1
cell surface 1 ELANE
glutamatergic synapse 1 ATP2B1
Golgi membrane 2 GCK, INS
mitochondrial inner membrane 1 SLC25A1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 2 ACACA, PCK1
plasma membrane 5 ATP2B1, ME1, ME2, PIK3CA, PTEN
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ATP2B1, ME1, ME2, SLC25A1
apical plasma membrane 1 PTEN
basolateral plasma membrane 2 ATP2B1, GCK
extracellular exosome 4 ATP2B1, ELANE, PCK1, SLC25A1
endoplasmic reticulum 1 PCK1
extracellular space 2 ELANE, INS
perinuclear region of cytoplasm 1 PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 6 ACACA, GCK, ME1, ME2, MLYCD, SLC25A1
intracellular membrane-bounded organelle 2 ATP2B1, ME2
postsynaptic density 1 PTEN
Secreted 1 INS
extracellular region 3 ELANE, INS, PTEN
cytoplasmic side of plasma membrane 1 PTEN
Single-pass membrane protein 2 ME1, ME2
Mitochondrion matrix 2 ME2, MLYCD
mitochondrial matrix 2 ME2, MLYCD
transcription regulator complex 1 MLXIPL
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
actin cytoskeleton 1 ACACA
dendritic spine 1 PTEN
Mitochondrion inner membrane 1 SLC25A1
Peroxisome 1 MLYCD
Peroxisome matrix 1 MLYCD
peroxisomal matrix 1 MLYCD
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 1 PTEN
PML body 1 PTEN
collagen-containing extracellular matrix 1 ELANE
secretory granule 1 ELANE
lateral plasma membrane 1 ATP2B1
Cell projection, neuron projection 1 PTEN
neuron projection 1 PTEN
chromatin 1 MLXIPL
cell projection 2 ATP2B1, PTEN
Basolateral cell membrane 2 ATP2B1, GCK
fibrillar center 1 ACACA
endosome lumen 1 INS
Presynaptic cell membrane 1 ATP2B1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transcription repressor complex 1 ELANE
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 ELANE
transport vesicle 1 INS
Schmidt-Lanterman incisure 1 PTEN
azurophil granule lumen 1 ELANE
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
Cytoplasmic vesicle, phagosome 1 ELANE
myelin sheath adaxonal region 1 PTEN
photoreceptor ribbon synapse 1 ATP2B1
[Isoform alpha]: Secreted 1 PTEN
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Chen Chen, Qihong Sun, Buvaneswari Narayanan, Donald L Nuss, Osnat Herzberg. Structure of oxalacetate acetylhydrolase, a virulence factor of the chestnut blight fungus. The Journal of biological chemistry. 2010 Aug; 285(34):26685-96. doi: 10.1074/jbc.m110.117804. [PMID: 20558740]
  • Chia-Chuan Chang, Angela Fay Ku, Yun-Yu Tseng, Wen-Bin Yang, Jim-Min Fang, Chi-Huey Wong. 6,8-Di-C-glycosyl flavonoids from Dendrobium huoshanense. Journal of natural products. 2010 Feb; 73(2):229-32. doi: 10.1021/np900252f. [PMID: 20055483]
  • Toshiyuki Akachi, Yasuyuki Shiina, Takumi Kawaguchi, Hirokazu Kawagishi, Tatsuya Morita, Kimio Sugiyama. 1-methylmalate from camu-camu (Myrciaria dubia) suppressed D-galactosamine-induced liver injury in rats. Bioscience, biotechnology, and biochemistry. 2010; 74(3):573-8. doi: 10.1271/bbb.90775. [PMID: 20208347]
  • Anne Boucher, Danhong Lu, Shawn C Burgess, Sabine Telemaque-Potts, Mette V Jensen, Hindrik Mulder, May-Yun Wang, Roger H Unger, A Dean Sherry, Christopher B Newgard. Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue. The Journal of biological chemistry. 2004 Jun; 279(26):27263-71. doi: 10.1074/jbc.m401167200. [PMID: 15073188]
  • H S Ballard, A J Marcus. Platelet aggregation in portal cirrhosis. Archives of internal medicine. 1976 Mar; 136(3):316-9. doi: . [PMID: 4041]