Blasticidin S (BioDeep_00000003361)
Secondary id: BioDeep_00001028330
human metabolite Endogenous
代谢物信息卡片
(2S,3S,6R)-3-{[(3R)-3-amino-1-hydroxy-5-(N-methylcarbamimidamido)pentylidene]amino}-6-(2-hydroxy-4-imino-1,4-dihydropyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylate
化学式: C17H26N8O5 (422.2026)
中文名称: 布拉叶斯
谱图信息:
最多检出来源 Homo sapiens(viridiplantae) 22.77%
分子结构信息
SMILES: CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N
InChI: InChI=1S/C17H26N8O5/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29)
描述信息
Contact fungicide used against rice blast disease in Japan Blasticidin S is an antibiotic used to select transformed cells in genetic engineering. In short, DNA of interest is fused to DNA encoding a resistance gene, and then is transformed into cells. After allowing time for recovery and for cells to begin transcribing and translating their new DNA, blasticidin is added. Now only the cells that have the new DNA can grow
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
KEIO_ID B019; [MS3] KO008877
KEIO_ID B019; [MS2] KO008876
D004791 - Enzyme Inhibitors
KEIO_ID B019
同义名列表
18 个代谢物同义名
(2S,3S,6R)-3-{[(3R)-3-amino-1-hydroxy-5-(N-methylcarbamimidamido)pentylidene]amino}-6-(2-hydroxy-4-imino-1,4-dihydropyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylate; (2S,3S,6R)-6-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-[(3R)-3-amino-5-(1-methylcarbamimidamido)pentanamido]-3,6-dihydro-2H-pyran-2-carboxylic acid; (2S,3S,6R)-3-[[3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid; (2S,3S,6R)-6-(4-amino-2-oxopyrimidin-1-yl)-3-[(3R)-3-amino-5-(1-methylcarbamimidamido)pentanamido]-3,6-dihydro-2H-pyran-2-carboxylic acid; Blasticidin S, monohydrochloride, (S)-isomer; Blasticidin S, carbamodithioate, (S)-isomer; Blasticidin S, dodecyl sulfate, (S)-isomer; Blasticidin S, methyl sulfate, (S)-isomer; Blasticidin S, hydrochloride, (S)-isomer; Antibiotic a 83094C; Antibiotic 21544; blasticidin-S; Blasticidin S; NSC 91770; Cytovirin; a 83094C; Bla-S; Blasticidin S
数据库引用编号
35 个数据库交叉引用编号
- ChEBI: CHEBI:182497
- KEGG: C02010
- PubChem: 439625
- PubChem: 5106
- PubChem: 258
- HMDB: HMDB0030452
- Metlin: METLIN65700
- ChEMBL: CHEMBL1622944
- Wikipedia: Blasticidin S
- KNApSAcK: C00016063
- foodb: FDB002319
- chemspider: 21615450
- CAS: 2079-00-7
- MoNA: KO008878
- MoNA: KO002469
- MoNA: KO000346
- MoNA: KO008876
- MoNA: KO000350
- MoNA: KO000349
- MoNA: KO000348
- MoNA: KO008880
- MoNA: KO008881
- MoNA: KO002471
- MoNA: KO002468
- MoNA: KO002470
- MoNA: KO008877
- MoNA: KO002472
- MoNA: KO000347
- MoNA: KO008879
- PMhub: MS000009542
- ChEBI: CHEBI:15353
- PDB-CCD: BLS
- NIKKAJI: J9.250I
- RefMet: Blasticidin S
- KNApSAcK: 15353
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 1886 - Streptomyces albidoflavus: 10.7164/ANTIBIOTICS.51.570
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiahua Guo, Yi Bai, Zhi Chen, Jiezhang Mo, Qi Li, Haotian Sun, Qiang Zhang. Transcriptomic analysis suggests the inhibition of DNA damage repair in green alga Raphidocelis subcapitata exposed to roxithromycin.
Ecotoxicology and environmental safety.
2020 Sep; 201(?):110737. doi:
10.1016/j.ecoenv.2020.110737. [PMID: 32505758] - Abdelghani Mahmoudi, Mihaela Tertiş, Laura-Mihaela Simon, Ann Van Schepdael, Silvia De Francia, Lia-Monica Junie, Robert Săndulescu. Correlated quantification using microbiological and electrochemical assays for roxithromycin determination in biological and pharmaceutical samples.
Talanta.
2020 May; 211(?):120703. doi:
10.1016/j.talanta.2019.120703. [PMID: 32070606] - Xiang Liu, Chen Chen, Xiaoying Zhang. Drug-drug interaction of acetaminophen and roxithromycin with the cocktail of cytochrome P450 and hepatotoxicity in rats.
International journal of medical sciences.
2020; 17(3):414-421. doi:
10.7150/ijms.38527. [PMID: 32132876] - X F Gu, X M Chen, H J Chen, T T Xu, Z W Qiu, D D Sun, X T Ge, S M Ying, Y R Dai. [The role of S100A8/RAGE and Caveolin-1 and the effect of roxithromycin on their expression in a rat model of neutrophilic asthma].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2019 Nov; 42(11):845-851. doi:
10.3760/cma.j.issn.1001-0939.2019.11.012. [PMID: 31694095] - X F Gu, H J Chen, X M Chen, T T Xu, Z W Qiu, L Q Wu, W Dai, S M Ying, Y R Dai. [Expression of RAGE in asthmatic rats and the intervention of Roxithromycin].
Zhonghua yi xue za zhi.
2019 Aug; 99(32):2542-2546. doi:
10.3760/cma.j.issn.0376-2491.2019.32.015. [PMID: 31484284] - Syed Faheem Askari Rizvi, Saleha Tariq, Muhammad Mehdi, Ahmad Junaid Hassan. Synthesis of 99m Tc-roxithromycin: A novel diagnostic agent to discriminate between septic and aseptic inflammation.
Chemical biology & drug design.
2019 06; 93(6):1166-1174. doi:
10.1111/cbdd.13412. [PMID: 30370631] - Yu Ke, Xiaoye Zhang, Caikun Liu, Meng Xiao, Hong Li, Jiachen Fan, Pengcheng Fu, Shuhao Wang, Fei Zan, Gang Wu. Polypseudorotaxane functionalized magnetic nanoparticles as a dual responsive carrier for roxithromycin delivery.
Materials science & engineering. C, Materials for biological applications.
2019 Jun; 99(?):159-170. doi:
10.1016/j.msec.2019.01.078. [PMID: 30889688] - Qian Xiong, Li-Xin Hu, You-Sheng Liu, Tuan-Tuan Wang, Guang-Guo Ying. New insight into the toxic effects of chloramphenicol and roxithromycin to algae using FTIR spectroscopy.
Aquatic toxicology (Amsterdam, Netherlands).
2019 Feb; 207(?):197-207. doi:
10.1016/j.aquatox.2018.12.017. [PMID: 30584953] - C Behr, S Sperber, X Jiang, V Strauss, H Kamp, T Walk, M Herold, K Beekmann, I M C M Rietjens, B van Ravenzwaay. Microbiome-related metabolite changes in gut tissue, cecum content and feces of rats treated with antibiotics.
Toxicology and applied pharmacology.
2018 09; 355(?):198-210. doi:
10.1016/j.taap.2018.06.028. [PMID: 30008377] - Yixin Ge, Jae Hoon Lee, Baishi Hu, Youfu Zhao. Loss-of-Function Mutations in the Dpp and Opp Permeases Render Erwinia amylovora Resistant to Kasugamycin and Blasticidin S.
Molecular plant-microbe interactions : MPMI.
2018 08; 31(8):823-832. doi:
10.1094/mpmi-01-18-0007-r. [PMID: 29474798] - Giuseppe Maiolino, Giulio Ceolotto, Michele Battistel, Giulio Barbiero, Maurizio Cesari, Laurence Amar, Brasilina Caroccia, Roberto Padrini, Michel Azizi, Gian Paolo Rossi. Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism.
Blood pressure.
2018 08; 27(4):200-205. doi:
10.1080/08037051.2018.1436961. [PMID: 29409357] - Mengling Xia, Hui Xu, Wei Dai, Cong Zhu, Liqin Wu, Sunshun Yan, Xiangting Ge, Wangfeng Zhou, Cuicui Chen, Yuanrong Dai. The role of HDAC2 in cigarette smoke-induced airway inflammation in a murine model of asthma and the effect of intervention with roxithromycin.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2018 04; 55(4):337-344. doi:
10.1080/02770903.2017.1337788. [PMID: 28960099] - Zhenhua Yan, Guanghua Lu, Hongwei Sun, Binni Ma. Influence of multi-walled carbon nanotubes on the effects of roxithromycin in crucian carp (Carassius auratus) in the presence of natural organic matter.
Chemosphere.
2017 Jul; 178(?):165-172. doi:
10.1016/j.chemosphere.2017.03.043. [PMID: 28324838] - Jack R Davison, Katheryn M Lohith, Xiaoning Wang, Kostyantyn Bobyk, Sivakoteswara R Mandadapu, Su-Lin Lee, Regina Cencic, Justin Nelson, Scott Simpkins, Karen M Frank, Jerry Pelletier, Chad L Myers, Jeff Piotrowski, Harold E Smith, Carole A Bewley. A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter.
Antimicrobial agents and chemotherapy.
2017 06; 61(6):. doi:
10.1128/aac.02635-16. [PMID: 28373194] - Qing-Mei Pei, Ping Jiang, Min Yang, Xue-Jiao Qian, Jiang-Bo Liu, Sung-Ho Kim. Roxithromycin inhibits VEGF-induced human airway smooth muscle cell proliferation: Opportunities for the treatment of asthma.
Experimental cell research.
2016 10; 347(2):378-84. doi:
10.1016/j.yexcr.2016.08.024. [PMID: 27587274] - Anthony L Shiver, Hendrik Osadnik, George Kritikos, Bo Li, Nevan Krogan, Athanasios Typas, Carol A Gross. A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S.
PLoS genetics.
2016 06; 12(6):e1006124. doi:
10.1371/journal.pgen.1006124. [PMID: 27355376] - Jie Ding, Fengshuang Zhang, Xiaopan Zhang, Long Wang, Changjia Wang, Qi Zhao, Yang Xu, Lan Ding, Nanqi Ren. Determination of roxithromycin from human plasma samples based on magnetic surface molecularly imprinted polymers followed by liquid chromatography-tandem mass spectromer.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 May; 1021(?):221-228. doi:
10.1016/j.jchromb.2015.08.001. [PMID: 26300321] - Qing Yan, Guozhong Feng, Xu Gao, Chengxiao Sun, Jin-song Guo, Zhiwei Zhu. Removal of pharmaceutically active compounds (PhACs) and toxicological response of Cyperus alternifolius exposed to PhACs in microcosm constructed wetlands.
Journal of hazardous materials.
2016 Jan; 301(?):566-75. doi:
10.1016/j.jhazmat.2015.08.057. [PMID: 26465971] - Shohei Sakuda, Tomoya Yoshinari, Tomohiro Furukawa, Usuma Jermnak, Keiko Takagi, Kurin Iimura, Toshiyoshi Yamamoto, Michio Suzuki, Hiromichi Nagasawa. Search for aflatoxin and trichothecene production inhibitors and analysis of their modes of action.
Bioscience, biotechnology, and biochemistry.
2016; 80(1):43-54. doi:
10.1080/09168451.2015.1086261. [PMID: 26376763] - Hanna Wosicka-Frąckowiak, Krzysztof Cal, Justyna Stefanowska, Eliza Główka, Magdalena Nowacka, Wiktoria Struck-Lewicka, Biljana Govedarica, Monika Pasikowska, Renata Dębowska, Teofil Jesionowski, Stane Srčič, Michał Jan Markuszewski. Roxithromycin-loaded lipid nanoparticles for follicular targeting.
International journal of pharmaceutics.
2015 Nov; 495(2):807-15. doi:
10.1016/j.ijpharm.2015.09.068. [PMID: 26456292] - Inna Galvidis, Gennady Lapa, Maksim Burkin. Group determination of 14-membered macrolide antibiotics and azithromycin using antibodies against common epitopes.
Analytical biochemistry.
2015 01; 468(?):75-82. doi:
10.1016/j.ab.2014.09.009. [PMID: 25256165] - Henrik Svanström, Björn Pasternak, Anders Hviid. Use of clarithromycin and roxithromycin and risk of cardiac death: cohort study.
BMJ (Clinical research ed.).
2014 Aug; 349(?):g4930. doi:
10.1136/bmj.g4930. [PMID: 25139799] - Y Gong, J Lu, X Ding, Y Yu. Effect of adjunctive roxithromycin therapy on interleukin-1β, transforming growth factor-β1 and vascular endothelial growth factor in gingival crevicular fluid of cyclosporine A-treated patients with gingival overgrowth.
Journal of periodontal research.
2014 Aug; 49(4):448-57. doi:
10.1111/jre.12123. [PMID: 23947915] - Clarissa C Lee, Elizaveta Freinkman, David M Sabatini, Hidde L Ploegh. The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D.
The Journal of biological chemistry.
2014 Jun; 289(24):17124-31. doi:
10.1074/jbc.m114.571257. [PMID: 24782309] - Sheng-Na Han, Song-Hua Yang, Yu Zhang, Yan-Yan Duan, Xiao-Yan Sun, Qiu Chen, Tian-Li Fan, Zhen-Kun Ye, Chen-Zheng Huang, Xiang-Jie Hu, Zhao Zhang, Li-Rong Zhang. Blockage of hERG current and the disruption of trafficking as induced by roxithromycin.
Canadian journal of physiology and pharmacology.
2013 Dec; 91(12):1112-8. doi:
10.1139/cjpp-2012-0456. [PMID: 24289083] - Joo Hyun Lee, Young Ju Park, Ju-Hee Oh, Young-Joo Lee. Decrease in gastrointestinal absorption of roxithromycin in bile duct cannulated rats due to depletion of bile salts.
Biopharmaceutics & drug disposition.
2013 Sep; 34(6):360-4. doi:
10.1002/bdd.1845. [PMID: 23703541] - Keiji Kuroda, Radha Venkatakrishnan, Madhuri S Salker, Emma S Lucas, Fozia Shaheen, Masako Kuroda, Andrew Blanks, Mark Christian, Siobhan Quenby, Jan J Brosens. Induction of 11β-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells.
Molecular endocrinology (Baltimore, Md.).
2013 Feb; 27(2):192-202. doi:
10.1210/me.2012-1247. [PMID: 23275455] - Xijuan Tan, Zhenghua Song. Continuous, quantitative monitoring of roxithromycin in human saliva by flow injection chemiluminescence analysis.
Applied spectroscopy.
2013 Jan; 67(1):54-8. doi:
10.1366/12-06644. [PMID: 23317671] - X Wang, Y F Tao, L L Huang, D M Chen, S Z Yin, A Ihsan, W Zhou, S J Su, Z L Liu, Y H Pan, Z H Yuan. Pharmacokinetics of tulathromycin and its metabolite in swine administered with an intravenous bolus injection and a single gavage.
Journal of veterinary pharmacology and therapeutics.
2012 Jun; 35(3):282-9. doi:
10.1111/j.1365-2885.2011.01322.x. [PMID: 21749408] - Anuruk Choemunng, Kesara Na-Bangchang. An alternative liquid chromatography-mass spectrometric method for the determination of azithromycin in human plasma and its application to pharmacokinetic study of patients with malaria.
The Southeast Asian journal of tropical medicine and public health.
2010 Sep; 41(5):1048-58. doi:
NULL. [PMID: 21073024] - Christoph Ort, Michael G Lawrence, Julien Reungoat, Geoff Eaglesham, Steve Carter, Jurg Keller. Determining the fraction of pharmaceutical residues in wastewater originating from a hospital.
Water research.
2010 Jan; 44(2):605-15. doi:
10.1016/j.watres.2009.08.002. [PMID: 19717180] - Li Zheng, Yongping Qin, Feng Nan, Ying Wang, Nan Xu, Maozhi Liang. [Pharmacokinetics and relative bioavailability study of roxithromycin tablet in Chinese healthy volunteers by LC-MS/MS].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.
2009 Dec; 26(6):1315-9. doi:
NULL. [PMID: 20095494] - Mesut Ogrendik. Efficacy of roxithromycin in adult patients with rheumatoid arthritis who had not received disease-modifying antirheumatic drugs: a 3-month, randomized, double-blind, placebo-controlled trial.
Clinical therapeutics.
2009 Aug; 31(8):1754-64. doi:
10.1016/j.clinthera.2009.08.014. [PMID: 19808134] - Cheng Li, Cheul-Seol Kim, Jeong-Yeol Yang, Yeong-Jin Park, Jun-Shik Choi. Effects of roxithromycin on the pharmacokinetics of loratadine after oral and intravenous administration of loratadine in rats.
European journal of drug metabolism and pharmacokinetics.
2008 Oct; 33(4):231-6. doi:
10.1007/bf03190877. [PMID: 19230596] - Jingwu Wang, Zhiming Yang, Xiaoxia Wang, Nianjun Yang. Capillary electrophoresis with gold nanoparticles enhanced electrochemiluminescence for the detection of roxithromycin.
Talanta.
2008 Jun; 76(1):85-90. doi:
10.1016/j.talanta.2008.02.006. [PMID: 18585245] - S A P Condé, F M Aarestrup, B J Vieira, M G Bastos. Roxithromycin reduces cyclosporine-induced gingival hyperplasia in renal transplant patients.
Transplantation proceedings.
2008 Jun; 40(5):1435-8. doi:
10.1016/j.transproceed.2008.04.012. [PMID: 18589124] - Constantinos Kousoulos, Georgia Tsatsou, Yannis Dotsikas, Constantinos Apostolou, Yannis L Loukas. Validation of a fully automated high throughput liquid chromatographic/tandem mass spectrometric method for roxithromycin quantification in human plasma. Application to a bioequivalence study.
Biomedical chromatography : BMC.
2008 May; 22(5):494-501. doi:
10.1002/bmc.958. [PMID: 18059078] - J M Branley, B Roy, D E Dwyer, T C Sorrell. Real-time PCR detection and quantitation of Chlamydophila psittaci in human and avian specimens from a veterinary clinic cluster.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2008 Apr; 27(4):269-73. doi:
10.1007/s10096-007-0431-0. [PMID: 18183441] - Ines Glojnaric, Snjezana Cuzic, Vesna Erakovic-Haber, Michael J Parnham. The serum amyloid A response to sterile silver nitrate in mice and its inhibition by dexamethasone and macrolide antibiotics.
International immunopharmacology.
2007 Dec; 7(12):1544-51. doi:
10.1016/j.intimp.2007.07.031. [PMID: 17920531] - Tai-Jun Hang, Meng Zhang, Min Song, Jian-Ping Shen, Yin-di Zhang. Simultaneous determination and pharmacokinetic study of roxithromycin and ambroxol hydrochloride in human plasma by LC-MS/MS.
Clinica chimica acta; international journal of clinical chemistry.
2007 Jul; 382(1-2):20-4. doi:
10.1016/j.cca.2007.03.015. [PMID: 17462615] - Franciszek K Główka, Marta Karaźniewicz-Łada. Determination of roxithromycin in human plasma by HPLC with fluorescence and UV absorbance detection: application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 852(1-2):669-73. doi:
10.1016/j.jchromb.2007.02.022. [PMID: 17329175] - Yasuki Yasuda, Kei Kasahara, Fumiko Mizuno, Kazuyuki Nishi, Keiichi Mikasa, Eiji Kita. Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model.
Antimicrobial agents and chemotherapy.
2007 May; 51(5):1741-52. doi:
10.1128/aac.01459-06. [PMID: 17353244] - Hiroshi Tamagawa, Takachika Hiroi, Tsunekazu Mizushima, Toshinori Ito, Hikaru Matsuda, Hiroshi Kiyono. Therapeutic effects of roxithromycin in interleukin-10-deficient colitis.
Inflammatory bowel diseases.
2007 May; 13(5):547-56. doi:
10.1002/ibd.20093. [PMID: 17245768] - Ting Huang, Tongling Li, Lan Yang, Xiaohong Xu, Pengcheng Zheng, Tingting Zhang, Jie Zheng, Shuye Chen. [Relative bioavailability of roxithromycin dispersive tablets in healthy volunteers].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.
2007 Apr; 24(2):376-8. doi:
NULL. [PMID: 17591264] - J-H Lim, B-K Park, H-I Yun. Pharmacokinetic/pharmacodynamic modelling of roxithromycin for the inhibitory effect of tumour necrosis factor-alpha and interleukin-6 production in dogs.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine.
2006 Oct; 53(8):394-8. doi:
10.1111/j.1439-0442.2006.00852.x. [PMID: 16970627] - Nawal El-Rabbat, Hassan F Askal, Pakinaz Y Khashaba, Noha N Attia. A validated spectrofluorometric assay for the determination of certain macrolide antibiotics in pharmaceutical formulations and spiked biological fluids.
Journal of AOAC International.
2006 Sep; 89(5):1276-87. doi:
. [PMID: 17042176] - Zhenghua Song, Yanhong Liu, Xiaofeng Xie. In vitro monitoring picogram roxithromycin in human urine using flow injection chemiluminescence procedure.
Current drug metabolism.
2006 May; 7(4):389-95. doi:
10.2174/138920006776873481. [PMID: 16724928] - Wei Zhang, Bingren Xiang, Yanwei Wu, Erxin Shang. Stochastic resonance is applied to quantitative analysis for weak chromatographic signal of roxithromycin in beagle dog plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Feb; 831(1-2):307-12. doi:
10.1016/j.jchromb.2005.12.014. [PMID: 16386967] - Yasuyo Urasaki, Mamoru Nori, Satoshi Iwata, Takahiro Sasaki, Osamu Hosono, Hiroshi Kawasaki, Hirotoshi Tanaka, Nam H Dang, Eiji Ikeda, Chikao Morimoto. Roxithromycin specifically inhibits development of collagen induced arthritis and production of proinflammatory cytokines by human T cells and macrophages.
The Journal of rheumatology.
2005 Sep; 32(9):1765-74. doi:
. [PMID: 16142877] - Hirofumi Tomita, Tomohiro Osanai, Tsutomu Toki, Naotaka Maeda, Reiichi Murakami, Zhaoning Chen, Hideaki Yamabe, Hiroshi Osawa, Minoru Yasujima, Ken Okumura. Roxithromycin is an inhibitor of human coronary artery smooth muscle cells proliferation: a potential ability to prevent coronary heart disease.
Atherosclerosis.
2005 Sep; 182(1):87-95. doi:
10.1016/j.atherosclerosis.2005.02.007. [PMID: 16115478] - B Barrett, V Borek-Dohalský, P Fejt, S Vaingátová, J Huclová, B Nemec, I Jelínek. Validated HPLC-MS-MS method for determination of azithromycin in human plasma.
Analytical and bioanalytical chemistry.
2005 Sep; 383(2):210-7. doi:
10.1007/s00216-005-0018-5. [PMID: 16091946] - Shinichi Ueno, Dai Aoki, Fumitake Kubo, Kiyokazu Hiwatashi, Kenji Matsushita, Tohru Oyama, Ikuro Maruyama, Takashi Aikou. Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2005 Aug; 11(15):5645-50. doi:
10.1158/1078-0432.ccr-05-0652. [PMID: 16061884] - Jin Sun, Tianhong Zhang, Feng Qiu, Yu Liu, Jingling Tang, Haihua Huang, Zhonggui He. Impact of pharmaceutical dosage forms on the pharmacokinetics of roxithromycin in healthy human volunteers.
The Journal of antimicrobial chemotherapy.
2005 May; 55(5):796-9. doi:
10.1093/jac/dki082. [PMID: 15761061] - Nathalie Marissal-Arvy, Pierre Mormède. Excretion of electrolytes in Brown Norway and Fischer 344 rats: effects of adrenalectomy and of mineralocorticoid and glucocorticoid receptor ligands.
Experimental physiology.
2004 Nov; 89(6):753-65. doi:
10.1113/expphysiol.2004.028621. [PMID: 15364879] - Pietro Vandoni, Benedetto Morelli, Liliana Lazzati, Roberto Citterio, Arnaldo Poli, Raffaela Fetiveau, Maurizio D'Urbano, Francesco Cafiero, Enrico Viganò, Stefano De Servi. Effect of a short antibiotic treatment with roxithromycin on circulating adhesion molecules after coronary stenting: a single-center pilot trial.
Italian heart journal : official journal of the Italian Federation of Cardiology.
2004 Sep; 5(9):667-72. doi:
. [PMID: 15568594] - Ali Akcay, Mehmet Kanbay, Siren Sezer, Fatma N Ozdemir. Acute renal failure and hepatotoxicity associated with roxithromycin.
The Annals of pharmacotherapy.
2004 Apr; 38(4):721-2. doi:
10.1345/aph.1d421. [PMID: 14766998] - Mario Cazzola, Maria Gabriella Matera, Francesco Blasi. Macrolide and occult infection in asthma.
Current opinion in pulmonary medicine.
2004 Jan; 10(1):7-14. doi:
10.1097/00063198-200401000-00003. [PMID: 14749600] - Lorinczi Lilla, Székely Edit, Kiss Eva. [Detection of Mycoplasma species in urinary tract infections in children].
Bacteriologia, virusologia, parazitologia, epidemiologia (Bucharest, Romania : 1990).
2004 Jan; 49(1-2):33-6. doi:
NULL. [PMID: 16752749] - Norifumi Ogawa, Yoko Sugawara, Yukiko Fujiwara, Takeshi Noma. Roxithromycin promotes lymphocyte apoptosis in Dermatophagoides-sensitive asthma patients.
European journal of pharmacology.
2003 Aug; 474(2-3):273-81. doi:
10.1016/s0014-2999(03)01998-8. [PMID: 12921874] - Xiao-hong Liu, An-cun Hou, De-li Xin. [Effect of zhidan huayu oral liquid on mycoplasmal pneumonia in mice].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2003 Jun; 23(6):441-4. doi:
". [PMID: 12872398] - Jong-hwan Lim, Byung-kwon Park, Hyo-in Yun. Determination of roxithromycin by liquid chromatography/mass spectrometry after multiple-dose oral administration in broilers.
Journal of veterinary science.
2003 Apr; 4(1):35-9. doi:
10.4142/jvs.2003.4.1.35. [PMID: 12819363] - Maria-José González de la Huebra, Guy Bordin, Adela R Rodríguez. Comparative study of coulometric and amperometric detection for the determination of macrolides in human urine using high-performance liquid chromatography.
Analytical and bioanalytical chemistry.
2003 Apr; 375(8):1031-7. doi:
10.1007/s00216-003-1801-9. [PMID: 12733015] - Clarissa Prazeres da Costa, Franz-Josef Neumann, Adnan Kastrati, Ingrid Stallforth, Manuela Schmid, Nader Joghetai, Sigrid Prebeck, Hermann Wagner, Thomas Miethke. Role of IgG-seropositivity to Chlamydia pneumoniae in early thrombotic events after coronary stent placement.
Atherosclerosis.
2003 Jan; 166(1):171-6. doi:
10.1016/s0021-9150(02)00326-x. [PMID: 12482564] - Xiu-Sheng Miao, Chris D Metcalfe. Determination of pharmaceuticals in aqueous samples using positive and negative voltage switching microbore liquid chromatography/electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS.
2003 Jan; 38(1):27-34. doi:
10.1002/jms.394. [PMID: 12526003] - Shinya Katsuta, Hirotaka Osafune, Rumi Takita, Masao Sugamata. [Therapeutic effect of roxithromycin on chronic sinusitis with nasal -- polyps clinical, computed tomography, and electron microscopy analysis].
Nihon Jibiinkoka Gakkai kaiho.
2002 Dec; 105(12):1189-97. doi:
10.3950/jibiinkoka.105.1189. [PMID: 12607280] - Wilfried Hauke, Gert Köhler, Hans-Heinrich Henneicke-Von Zepelin, Johannes Freudenstein. Esberitox N as supportive therapy when providing standard antibiotic treatment in subjects with a severe bacterial infection (acute exacerbation of chronic bronchitis). A multicentric, prospective, double-blind, placebo-controlled study.
Chemotherapy.
2002 Dec; 48(5):259-66. doi:
10.1159/000066763. [PMID: 12476043] - T Huynh, D Cordato, F Yang, T Choy, K Johnstone, F Bagnall, N Hitchens, R Dunn. HMG CoA reductase-inhibitor-related myopathy and the influence of drug interactions.
Internal medicine journal.
2002 Sep; 32(9-10):486-90. doi:
10.1046/j.1445-5994.2002.00264.x. [PMID: 12380704] - Denny G Mellersh, Inge V Foulds, Verna J Higgins, Michele C Heath. H2O2 plays different roles in determining penetration failure in three diverse plant-fungal interactions.
The Plant journal : for cell and molecular biology.
2002 Feb; 29(3):257-68. doi:
10.1046/j.0960-7412.2001.01215.x. [PMID: 11844104] - Makoto Kimura, Makio Furuichi, Masaki Yamamoto, Takashi Kumasaka, Hiroshi Mizuno, Masashi Miyano, Isamu Yamaguchi. The flexible C-terminal region of Aspergillus terreus blasticidin S deaminase: identification of its functional roles with deletion enzymes.
Biochemical and biophysical research communications.
2002 Jan; 290(1):421-6. doi:
10.1006/bbrc.2001.6184. [PMID: 11779186] - M Bucher, G Mair, F Kees. Effect of roxithromycin on the pharmacokinetics of lovastatin in volunteers.
European journal of clinical pharmacology.
2002 Jan; 57(11):787-91. doi:
10.1007/s00228-001-0385-6. [PMID: 11868800] - Alexander A Firsov, Stephen H Zinner, Sergey N Vostrov, Olga V Kononenko, Yury A Portnoy, Larissa V Shustova, Igor B Kadenatsi. Comparative pharmacodynamics of azithromycin and roxithromycin with S. pyogenes and S. pneumoniae in a model that simulates in vitro pharmacokinetics in human tonsils.
The Journal of antimicrobial chemotherapy.
2002 Jan; 49(1):113-9. doi:
10.1093/jac/49.1.113. [PMID: 11751774] - Y Qin, Y Zou, M Liang, Y Huang, Q Yu, P Feng. [Determination of roxithromycin in serum by high-performance liquid chromatography with ultraviolet detection].
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao.
2001 Dec; 32(4):612-4. doi:
NULL. [PMID: 12528565] - H Akamatsu, M Yamawaki, T Horio. Effects of roxithromycin on adhesion molecules expressed on endothelial cells of the dermal microvasculature.
The Journal of international medical research.
2001 Nov; 29(6):523-7. doi:
10.1177/147323000102900609. [PMID: 11803737] - D Zhong, X Chen, J Gu, X Li, J Guo. Applications of liquid chromatography-tandem mass spectrometry in drug and biomedical analyses.
Clinica chimica acta; international journal of clinical chemistry.
2001 Nov; 313(1-2):147-50. doi:
10.1016/s0009-8981(01)00667-2. [PMID: 11694253] - S Yamamoto, K Asano, T Shimane, T Hisamitsu, H Suzaki. Enhancement of endogenous corticosterone levels by a macrolide antibiotic, roxithromycin in mice.
Life sciences.
2001 Jul; 69(10):1115-21. doi:
10.1016/s0024-3205(01)01199-7. [PMID: 11508344] - K L Easton-Carter, W Hardikar, A L Smith. Possible roxithromycin-induced fulminant hepatic failure in a child.
Pharmacotherapy.
2001 Jul; 21(7):867-70. doi:
10.1592/phco.21.9.867.34552. [PMID: 11444584] - F Neumann, A Kastrati, T Miethke, G Pogatsa-Murray, J Mehilli, C Valina, N Jogethaei, C P da Costa, H Wagner, A Schömig. Treatment of Chlamydia pneumoniae infection with roxithromycin and effect on neointima proliferation after coronary stent placement (ISAR-3): a randomised, double-blind, placebo-controlled trial.
Lancet (London, England).
2001 Jun; 357(9274):2085-9. doi:
10.1016/s0140-6736(00)05181-3. [PMID: 11445102] - C Frangié, D Morel, G Sassoust, J L Pariente, N Grenier, J Y Lacut, L Potaux. A rare infection in a renal transplant recipient.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2001 Jun; 16(6):1285-7. doi:
10.1093/ndt/16.6.1285. [PMID: 11390736] - A Pappa-Louisi, A Papageorgiou, A Zitrou, S Sotiropoulos, E Georgarakis, F Zougrou. Study on the electrochemical detection of the macrolide antibiotics clarithromycin and roxithromycin in reversed-phase high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
2001 May; 755(1-2):57-64. doi:
10.1016/s0378-4347(00)00614-9. [PMID: 11393733] - H Ohtani, C Taninaka, E Hanada, H Kotaki, H Sato, Y Sawada, T Iga. Comparative pharmacodynamic analysis of Q-T interval prolongation induced by the macrolides clarithromycin, roxithromycin, and azithromycin in rats.
Antimicrobial agents and chemotherapy.
2000 Oct; 44(10):2630-7. doi:
10.1128/aac.44.10.2630-2637.2000. [PMID: 10991836] - D Zhong, X Li, A Wang, Y Xu, S Wu. Identification of the metabolites of roxithromycin in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2000 May; 28(5):552-9. doi:
. [PMID: 10772634] - H Suzuki, K Ikeda, R Honma, S Gotoh, T Oshima, M Furukawa, T Takasaka. Prognostic factors of chronic rhinosinusitis under long-term low-dose macrolide therapy.
ORL; journal for oto-rhino-laryngology and its related specialties.
2000 May; 62(3):121-7. doi:
10.1159/000027731. [PMID: 10810255] - L Drago, M C Fassina, E De Vecchi, B Mombelli, A Lombardi, M R Gismondo. Lack of in vitro and in vivo selection of bacterial resistance by roxithromycin.
Chemotherapy.
2000 May; 46(3):160-5. doi:
10.1159/000007272. [PMID: 10765029] - F Kees, A Holstege, K P Ittner, M Zimmermann, G Lock, J Schölmerich, H Grobecker. Pharmacokinetic interaction between proton pump inhibitors and roxithromycin in volunteers.
Alimentary pharmacology & therapeutics.
2000 Apr; 14(4):407-12. doi:
10.1046/j.1365-2036.2000.00731.x. [PMID: 10759619] - H Yoshida, T Furuta. [Tissue penetration properties of macrolide antibiotics--comparative tissue distribution of erythromycin-stearate, clarithromycin, roxithromycin and azithromycin in rats].
The Japanese journal of antibiotics.
1999 Jul; 52(7):497-503. doi:
. [PMID: 10516929] - T Shoji, S Yoshida, H Sakamoto, H Hasegawa, H Nakagawa, H Amayasu. Anti-inflammatory effect of roxithromycin in patients with aspirin-intolerant asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1999 Jul; 29(7):950-6. doi:
10.1046/j.1365-2222.1999.00551.x. [PMID: 10383596] - H Nakamura, S Fujishima, T Inoue, Y Ohkubo, K Soejima, Y Waki, M Mori, T Urano, F Sakamaki, S Tasaka, A Ishizaka, M Kanazawa, K Yamaguchi. Clinical and immunoregulatory effects of roxithromycin therapy for chronic respiratory tract infection.
The European respiratory journal.
1999 Jun; 13(6):1371-9. doi:
10.1183/09031936.99.13613809. [PMID: 10445614] - D Bhowmik, S C Dash, A K Dinda, S C Tiwari, S K Agarwal, S Gupta, R P Mathur. Recurrent granulomatous acute interstitial nephritis induced by commonly used antibiotics.
The Journal of the Association of Physicians of India.
1999 Jun; 47(6):635-6. doi:
NULL. [PMID: 10999166] - J Macek, P Ptácek, J Klíma. Determination of roxithromycin in human plasma by high-performance liquid chromatography with spectrophotometric detection.
Journal of chromatography. B, Biomedical sciences and applications.
1999 Feb; 723(1-2):233-8. doi:
10.1016/s0378-4347(98)00533-7. [PMID: 10080650] - M Motta, W Ribeiro, D R Ifa, M E Moares, M O Moraes, A P Corrado, G De Nucci. Bioequivalence evaluation of two roxithromycin formulations in healthy human volunteers by high performance liquid cromatography coupled to tandem mass spectrometry.
Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia.
1999; 49(4):233-41. doi:
NULL. [PMID: 10797866] - H Yamazaki, T Shimada. Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin.
Drug metabolism and disposition: the biological fate of chemicals.
1998 Nov; 26(11):1053-7. doi:
. [PMID: 9806945] - K Arimori, S Miyamoto, K Fukuda, C Nakamura, M Nakano. Characteristic difference in gastrointestinal excretion of clarithromycin and roxithromycin.
Biopharmaceutics & drug disposition.
1998 Oct; 19(7):433-8. doi:
10.1002/(sici)1099-081x(199810)19:7<433::aid-bdd122>3.0.co;2-z. [PMID: 9818709] - H Yamazaki, T Shimada. Formation in vitro of an inhibitory cytochrome P450 x Fe2+-metabolite complex with roxithromycin and its decladinosyl, O-dealkyl and N-demethyl metabolites in rat liver microsomes.
Xenobiotica; the fate of foreign compounds in biological systems.
1998 Oct; 28(10):995-1004. doi:
10.1080/004982598239056. [PMID: 9849646] - D Zhong, H Huang, A Wang, L Tian, X Lei, J Zhang. [Comparison of roxithromycin bioavailability of a conventional and a dispersible tablet formulation].
Yao xue xue bao = Acta pharmaceutica Sinica.
1998 Aug; 33(8):621-5. doi:
NULL. [PMID: 12016904] - M Brett, P Short, S Beatson. The comparative in-vitro activity of roxithromycin and other antibiotics against Bordetella pertussis.
The Journal of antimicrobial chemotherapy.
1998 Mar; 41 Suppl B(?):23-7. doi:
10.1093/jac/41.suppl_2.23. [PMID: 9579709] - F Scaglione, G Rossoni. Comparative anti-inflammatory effects of roxithromycin, azithromycin and clarithromycin.
The Journal of antimicrobial chemotherapy.
1998 Mar; 41 Suppl B(?):47-50. doi:
10.1093/jac/41.suppl_2.47. [PMID: 9579712] - R Piccolomini, G Di Bonaventura, G Catamo, C Picciani, M Paolantonio. In vitro antimicrobial susceptibility of periodontopathic Actinobacillus actinomycetemcomitans to roxithromycin and erythromycin.
Oral microbiology and immunology.
1997 Dec; 12(6):366-71. doi:
10.1111/j.1399-302x.1997.tb00740.x. [PMID: 9573812] - S Nakashio, H Iwasawa, S Iino, J Shimada. [Comparative antimicrobial activity of RP 59,500 (quinupristin-dalfopristin), the first semisynthetic injectable streptgramin, against gram-positive cocci and other recent clinical pathogens].
The Japanese journal of antibiotics.
1997 Oct; 50(10):844-53. doi:
NULL. [PMID: 9412874] - J Gaillat. [Antibiotic strategy in bronchial infections. Role of roxithromycin].
Presse medicale (Paris, France : 1983).
1997 Mar; 26 Suppl 2(?):16-21. doi:
. [PMID: 9113048]
