Methadyl Acetate (BioDeep_00000033335)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(3R,6R)-3-Acetoxy-6-dimethylamino-4,4-diphenylheptane
化学式: C23H31NO2 (353.2355)
中文名称: 醋美沙朵
谱图信息:
最多检出来源 Homo sapiens(blood) 19.55%
分子结构信息
SMILES: CCC(C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)OC(=O)C
InChI: InChI=1S/C23H31NO2/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21/h7-16,18,22H,6,17H2,1-5H3
描述信息
Methadyl Acetate is only found in individuals that have used or taken this drug. It is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]Methadyl Acetate is primarily a mu-type opioid receptor agonist. It functions similarily to methadone.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
21 个代谢物同义名
(3R,6R)-3-Acetoxy-6-dimethylamino-4,4-diphenylheptane; [6-(dimethylamino)-4,4-diphenylheptan-3-yl] acetate; 6-(dimethylamino)-4,4-diphenylheptan-3-yl acetate; 6-(Dimethylamino)-4,4-diphenyl-3-heptanol acetate; Levomethadyl acetate hydrochloride; Levo-alpha-acetylmethadol; Levo alpha acetylmethadol; Methadyl acetic acid; Levomethadyl Acetate; Alphacetylmethadol; Levoacetylmethadol; Methadyl acetate; Acetylmethadol; Amidolacetate; Dimepheptanol; Acemethadone; Levomethadyl; Betamethadol; Methadol; Orlaam; LAAM
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:135491
- PubChem: 10517
- HMDB: HMDB0015502
- DrugBank: DB01433
- ChEMBL: CHEMBL170179
- Wikipedia: Acetylmethadol
- MeSH: Methadyl Acetate
- chemspider: 10080
- CAS: 509-74-0
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- David A L Newcombe, Andrew A Somogyi, Felix Bochner, Jason M White. Impaired psychomotor function and plasma methadone and levo-alpha-acetylmethadol (LAAM) concentrations in opioid-substitution patients.
Experimental and clinical psychopharmacology.
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10.1037/pha0000114. [PMID: 28414496] - Silvia Minozzi, Laura Amato, Cristina Bellisario, Marina Davoli. Maintenance treatments for opiate -dependent adolescents.
The Cochrane database of systematic reviews.
2014 Jun; ?(6):CD007210. doi:
10.1002/14651858.cd007210.pub3. [PMID: 24957634] - B Michel-Lauter, C Maier, A Schwarzer. [Accidental levomethadone intoxication in a palliative patient].
Schmerz (Berlin, Germany).
2012 Dec; 26(6):721-3. doi:
10.1007/s00482-012-1229-2. [PMID: 23093298] - Michael J Mancino, Janette McGaugh, Zachary Feldman, James Poling, Alison Oliveto. Effect of PTSD diagnosis and contingency management procedures on cocaine use in dually cocaine- and opioid-dependent individuals maintained on LAAM: a retrospective analysis.
The American journal on addictions.
2010 Mar; 19(2):169-77. doi:
10.1111/j.1521-0391.2009.00025.x. [PMID: 20163389] - Silvia Minozzi, Laura Amato, Marina Davoli. Maintenance treatments for opiate dependent adolescent.
The Cochrane database of systematic reviews.
2009 Apr; ?(2):CD007210. doi:
10.1002/14651858.cd007210.pub2. [PMID: 19370679] - Bradley T Conner, M Douglas Anglin, Jeffery Annon, Douglas Longshore. Effect of religiosity and spirituality on drug treatment outcomes.
The journal of behavioral health services & research.
2009 Apr; 36(2):189-98. doi:
10.1007/s11414-008-9145-z. [PMID: 18770043] - H Wieneke, H Conrads, J Wolstein, F Breuckmann, M Gastpar, R Erbel, Norbert Scherbaum. Levo-alpha-acetylmethadol (LAAM) induced QTc-prolongation - results from a controlled clinical trial.
European journal of medical research.
2009 Jan; 14(1):7-12. doi:
10.1186/2047-783x-14-1-7. [PMID: 19258204] - J Wolstein, M Gastpar, T Finkbeiner, C Heinrich, R Heitkamp, T Poehlke, N Scherbaum. A randomized, open-label trial comparing methadone and Levo-Alpha-Acetylmethadol (LAAM) in maintenance treatment of opioid addiction.
Pharmacopsychiatry.
2009 Jan; 42(1):1-8. doi:
10.1055/s-0028-1083818. [PMID: 19153939] - Séverine Crettol, Patricia Digon, Kerry Powell Golay, Marlyse Brawand, Chin B Eap. In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites.
Pharmacology.
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Drug and alcohol dependence.
2005 Aug; 79(2):157-65. doi:
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2005; 44(7):731-51. doi:
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2004 Oct; 76(1):63-72. doi:
10.1016/j.drugalcdep.2004.04.004. [PMID: 15380290] - David E Moody, Sharon L Walsh, Douglas E Rollins, Jennifer A Neff, Wei Huang. Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individuals.
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2004 Aug; 76(2):154-66. doi:
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2004 Jun; 805(1):141-6. doi:
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2003 Jul; 306(1):205-12. doi:
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2003 Jan; 24(1):67-74. doi:
10.1016/s0740-5472(02)00343-4. [PMID: 12646332] - Wei Huang, Paul A Bemis, Matthew H Slawson, David E Moody. Determination of l-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in clinical and in vitro samples using liquid chromatography with electrospray ionization and tandem mass spectrometry.
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2003 Jan; 92(1):10-20. doi:
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International journal of toxicology.
2002 Mar; 21(2):147-59. doi:
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The New England journal of medicine.
2000 Nov; 343(18):1290-7. doi:
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1999 Oct; 23(6):500-5. doi:
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The American journal on addictions.
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JAMA.
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1995 Oct; 19(6):343-51. doi:
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1977 Feb; 16(2):251-63. doi:
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1977 Jan; 237(2):138-42. doi:
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1977 Jan; 21(1):16-25. doi:
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NIDA research monograph.
1976 Jul; ?(8):54. doi:
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NIDA research monograph.
1976 Jul; ?(8):64-5. doi:
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NIDA research monograph.
1976 Jul; ?(8):61. doi:
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1976 Jul; ?(8):94-102. doi:
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1976 Apr; 28(4):316-8. doi:
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1976 Mar; 19(3):371-4. doi:
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1975 Jul; 18(1):96-103. doi:
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