Ceftazidime (BioDeep_00000003324)
Secondary id: BioDeep_00000397837
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
化学式: C22H22N6O7S2 (546.0991342)
中文名称: 头孢他啶
谱图信息:
最多检出来源 Homo sapiens(blood) 64%
分子结构信息
SMILES: CC(C)(C(=O)O)O/N=C(/c1csc(N)n1)\C(=O)N[C@@H]1C(=O)N2C(=C(C[n+]3ccccc3)CS[C@H]12)C(=O)[O-]
InChI: InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1
描述信息
Ceftazidime is only found in individuals that have used or taken this drug. It is a semisynthetic, broad-spectrum antibacterial derived from cephaloridine and used especially for Pseudomonas and other gram-negative infections in debilitated patients. [PubChem]The bactericidal activity of ceftazidime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DD - Third-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
同义名列表
15 个代谢物同义名
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 1-{[(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}pyridin-1-ium; Pentahydrate, ceftazidime; Ceftazidime Pentahydrate; Anhydrous, ceftazidime; Ceftazidime anhydrous; Ceftazidimum; Ceftazidime; Ceftazidima; Tazidime; Fortaz; Fortum; Ceptaz; CAZ
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:3508
- KEGG: C06889
- KEGGdrug: D07654
- PubChem: 76552301
- PubChem: 5481173
- HMDB: HMDB0014582
- Metlin: METLIN1619
- DrugBank: DB00438
- ChEMBL: CHEMBL44354
- Wikipedia: Ceftazidime
- MeSH: Ceftazidime
- chemspider: 4587145
- CAS: 72558-82-8
- PMhub: MS000009287
- PubChem: 9106
- NIKKAJI: J117.701J
- RefMet: Ceftazidime
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dongying Li, Yueyi Li, Jingyi Wang, Weifeng Yang, Kaiyu Cui, Renjing Su, Lu Li, Xing Ren, Xianyu Li, Yi Wang. In-depth analysis of the treatment effect and synergistic mechanism of TanReQing injection on clinical multi-drug resistant Pseudomonas aeruginosa.
Microbiology spectrum.
2024 Apr; 12(4):e0272623. doi:
10.1128/spectrum.02726-23. [PMID: 38415603] - Iñaki Deza-Cruz, María J Vilar, Martina Velasova, Manal AbuOun, Muna F Anjum, Richard P Smith. Antimicrobial resistance of Escherichia coli in the UK: comparison of single vs. pooled samples from healthy pigs.
Letters in applied microbiology.
2023 Nov; ?(?):. doi:
10.1093/lambio/ovad123. [PMID: 37942558] - Maytham Hussein, Rafah Allobawi, Jinxin Zhao, Heidi Yu, Stephanie L Neville, Jonathan Wilksch, Labell J M Wong, Mark Baker, Christopher A McDevitt, Gauri G Rao, Jian Li, Tony Velkov. Integrated Transcriptomic and Metabolomic Mapping Reveals the Mechanism of Action of Ceftazidime/Avibactam against Pan-Drug-Resistant Klebsiella pneumoniae.
ACS infectious diseases.
2023 Oct; ?(?):. doi:
10.1021/acsinfecdis.3c00264. [PMID: 37878861] - Murugan Thulasi Meenu, Grace Kaul, Abdul Akhir, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Developing the Natural Prenylflavone Artocarpin from Artocarpus hirsutus as a Potential Lead Targeting Pathogenic, Multidrug-Resistant Staphylococcus aureus, Persisters and Biofilms with No Detectable Resistance.
Journal of natural products.
2022 10; 85(10):2413-2423. doi:
10.1021/acs.jnatprod.2c00621. [PMID: 36222797] - Wenliang Feng, Xuebin Jiang, Rujiang Zhang, Zhendong Guo, Daiquan Gao. Diagnosis of an Acinetobacter pittii from a patient in China with a multiplex PCR-based targeted gene sequencing platform of the cerebrospinal fluid: A case report with literature review.
Medicine.
2022 Oct; 101(42):e31130. doi:
10.1097/md.0000000000031130. [PMID: 36281177] - Muriel Masi, Julia Vergalli, Ishan Ghai, Andrea Barba-Bon, Thérèse Schembri, Werner M Nau, Daniel Lafitte, Mathias Winterhalter, Jean-Marie Pagès. Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane.
Communications biology.
2022 10; 5(1):1059. doi:
10.1038/s42003-022-04035-y. [PMID: 36198902] - Kaoru Yamabe, Yukio Arakawa, Masaki Shoji, Katsushiro Miyamoto, Takahiro Tsuchiya, Katsuhiko Minoura, Yukihiro Akeda, Kazunori Tomono, Mitsuko Onda. Enhancement of Acinetobacter baumannii biofilm growth by cephem antibiotics via enrichment of protein and extracellular DNA in the biofilm matrices.
Journal of applied microbiology.
2022 Sep; 133(3):2002-2013. doi:
10.1111/jam.15712. [PMID: 35818769] - Nabih A Baeshen, Abdulaziz O Albeshri, Naseebh N Baeshen, Roba Attar, Alaa Karkashan, Basma Abbas, Thamer A Bouback, Abdullah A Aljaddawi, Mohammed Y Refai, Hayam S Abdelkader, Abdullah Al Tamim, Abdullah Alowaifeer, Firoz Ahmed, Mohammed N Baeshen. In silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19.
Scientific reports.
2022 Jul; 12(1):11120. doi:
10.1038/s41598-022-15288-2. [PMID: 35778482] - Nikhil Sadashiv Shetty, Arvind Karikal, Sharanya Menon Radhakrishnan. Melioidosis: an unusual diagnosis for deep temporal and masticatory space infection following trauma.
BMJ case reports.
2022 Jun; 15(6):. doi:
10.1136/bcr-2022-248866. [PMID: 35732363] - Fernando L Gordillo Altamirano, Xenia Kostoulias, Dinesh Subedi, Denis Korneev, Anton Y Peleg, Jeremy J Barr. Phage-antibiotic combination is a superior treatment against Acinetobacter baumannii in a preclinical study.
EBioMedicine.
2022 Jun; 80(?):104045. doi:
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Journal of pharmacy practice.
2022 Jun; 35(3):482-487. doi:
10.1177/0897190021989931. [PMID: 33517818] - Petr Tůma, Martin Jaček, Blanka Sommerová, Pavel Dlouhý, Radka Jarošíková, Jitka Husáková, Veronika Wosková, Vladimíra Fejfarová. Monitoring of amoxicilline and ceftazidime in the microdialysate of diabetic foot and serum by capillary electrophoresis with contactless conductivity detection.
Electrophoresis.
2022 06; 43(11):1129-1139. doi:
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Journal of global antimicrobial resistance.
2022 Jun; 29(?):141-146. doi:
10.1016/j.jgar.2022.02.018. [PMID: 35257971] - Ben Vaknin, Nancy Bishouty, Amos Adler. Microbiological and clinical changes following the transition to the 2010 revised CLSI breakpoints for extended-spectrum cephalosporin in Enterobacterales.
Diagnostic microbiology and infectious disease.
2022 May; 103(1):115654. doi:
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European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2022 Apr; 41(4):573-580. doi:
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Expert opinion on drug metabolism & toxicology.
2022 Apr; 18(4):277-284. doi:
10.1080/17425255.2022.2080052. [PMID: 35583387] - G Bianco, M Boattini, A Bondi, S Comini, T Zaccaria, R Cavallo, C Costa. Outbreak of ceftazidime-avibactam resistant Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae in a COVID-19 intensive care unit, Italy: urgent need for updated diagnostic protocols of surveillance cultures.
The Journal of hospital infection.
2022 04; 122(?):217-219. doi:
10.1016/j.jhin.2022.02.001. [PMID: 35139426] - Gabriele Arcari, Alessandra Oliva, Federica Sacco, Federica Maria Di Lella, Giammarco Raponi, Dario Tomolillo, Ambrogio Curtolo, Mario Venditti, Alessandra Carattoli. Interplay between Klebsiella pneumoniae producing KPC-31 and KPC-3 under treatment with high dosage meropenem: a case report.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2022 Mar; 41(3):495-500. doi:
10.1007/s10096-021-04388-y. [PMID: 34988712] - Yu-Hsin Tang, Po-Liang Lu, Ho-Yin Huang, Ying-Chi Lin. Clinical effectiveness of beta-lactams versus fluoroquinolones as empirical therapy in patients with diabetes mellitus hospitalized for urinary tract infections: A retrospective cohort study.
PloS one.
2022; 17(3):e0266416. doi:
10.1371/journal.pone.0266416. [PMID: 35358291] - Tian Wei, Chengyun Zou, Jie Qin, Jianmin Tao, Li Yan, Jiangjun Wang, Hong Du, Fang Shen, Yanqin Zhao, Haiying Wang. Emergence of Hypervirulent ST11-K64 Klebsiella pneumoniae Poses a Serious Clinical Threat in Older Patients.
Frontiers in public health.
2022; 10(?):765624. doi:
10.3389/fpubh.2022.765624. [PMID: 35309213] - D Chen, L Xiao, D Hong, Y Zhao, X Hu, S Shi, F Chen. Epidemiology of resistance of carbapenemase-producing Klebsiella pneumoniae to ceftazidime-avibactam in a Chinese hospital.
Journal of applied microbiology.
2022 Jan; 132(1):237-243. doi:
10.1111/jam.15166. [PMID: 34053144] - Mustafa Sadek, Laurent Poirel, Manuel Dominguez Pino, Fernando D'Emidio, Stefano Pomponio, Patrice Nordmann. Evaluation of SuperCAZ/AVI® Medium for Screening Ceftazidime-avibactam Resistant Gram-negative Isolates.
Diagnostic microbiology and infectious disease.
2021 Dec; 101(4):115475. doi:
10.1016/j.diagmicrobio.2021.115475. [PMID: 34419742] - Ammar A Hasnie, Mauricio Kahn, Robert Centor. Ur-Ine Trouble: A Case of Nephrolithiasis in A Patient with End-Stage Renal Disease.
The American journal of medicine.
2021 11; 134(11):e553-e554. doi:
10.1016/j.amjmed.2021.05.017. [PMID: 34197788] - Murugan Thulasi Meenu, Grace Kaul, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Cudraflavone C from Artocarpus hirsutus as a Promising Inhibitor of Pathogenic, Multidrug-Resistant S. aureus, Persisters, and Biofilms: A New Insight into a Rational Explanation of Traditional Wisdom.
Journal of natural products.
2021 10; 84(10):2700-2708. doi:
10.1021/acs.jnatprod.1c00578. [PMID: 34546736] - Kun Feng, Nan Jia, Peijuan Zhu, Serubbabel Sy, Yanfei Liu, Dandan Dong, Shixing Zhu, Jiayuan Zhang, Yuwei Liu, Frederico S Martins, Hugh Gong, Zhihua Lv, Mingming Yu, Sherwin K B Sy, Yuanqi Zhu. Aztreonam/avibactam effect on pharmacodynamic indices for mutant selection of Escherichia coli and Klebsiella pneumoniae harbouring serine- and New Delhi metallo-β-lactamases.
The Journal of antimicrobial chemotherapy.
2021 10; 76(11):2875-2883. doi:
10.1093/jac/dkab292. [PMID: 34383928] - Johanna Berkhout, Maria J Melchers, Anita C van Mil, Claudia M Lagarde, Wright W Nichols, Johan W Mouton. Evaluation of the post-antibiotic effect in vivo for the combination of a β-lactam antibiotic and a β-lactamase inhibitor: ceftazidime-avibactam in neutropenic mouse thigh and lung infections.
Journal of chemotherapy (Florence, Italy).
2021 Oct; 33(6):400-408. doi:
10.1080/1120009x.2021.1892365. [PMID: 33682636] - Anil R Maharaj, Huali Wu, Kanecia O Zimmerman, William J Muller, Janice E Sullivan, Catherine M T Sherwin, Julie Autmizguine, Mobeen H Rathore, Chi D Hornik, Amira Al-Uzri, Elizabeth H Payne, Daniel K Benjamin, Christoph P Hornik. Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity.
Paediatric drugs.
2021 Sep; 23(5):499-513. doi:
10.1007/s40272-021-00460-4. [PMID: 34302290] - Véronique Goncette, Nathalie Layios, Julie Descy, Frédéric Frippiat. Continuous infusion, therapeutic drug monitoring and outpatient parenteral antimicrobial therapy with ceftazidime/avibactam: a retrospective cohort study.
Journal of global antimicrobial resistance.
2021 09; 26(?):15-19. doi:
10.1016/j.jgar.2021.04.015. [PMID: 33989847] - Elham Isaei, Shahla Mansouri, Maryam Rahmani, Fariba Sharififar, Atefeh Salary. Novel Synergistic Activity of Quercus infectoria Gall Extract with Ceftazidime Against Standard and Multiple Drug Resistant Pseudomonas aeruginosa and Escherichia coli Isolates.
Archives of Iranian medicine.
2021 09; 24(9):684-688. doi:
10.34172/aim.2021.98. [PMID: 34816684] - Punit J Shah, Thuytram Tran, Francis Emelogu, Farheen Tariq. Aztreonam, Ceftazidime/Avibactam, and Colistin Combination for the Management of Carbapenemase-Producing Klebsiella Pneumoniae Bacteremia: A Case Report.
Journal of pharmacy practice.
2021 Aug; 34(4):653-657. doi:
10.1177/0897190019882262. [PMID: 31698984] - Joan Bergman, Lainey Harvill, Shawna Hawkins, Kurt Sladky, Sherry Cox. Determination of ceftazidime in plasma by RP-HPLC and ultraviolet detection.
Biomedical chromatography : BMC.
2021 Jul; 35(7):e5104. doi:
10.1002/bmc.5104. [PMID: 33629742] - Shawna J Hawkins, Sherry K Cox, Kurt K Sladky. Pharmacokinetics of ceftazidime in Northern leopard frogs (Lithobates pipiens) at two different doses and administration routes.
American journal of veterinary research.
2021 Jul; 82(7):560-565. doi:
10.2460/ajvr.82.7.560. [PMID: 34166088] - Christina D McNeal, Clare A Ryan, Londa J Berghaus, Brenton C Credille, Chih-Ping Lo, Virginia R Fajt. Plasma disposition of ceftazidime in healthy neonatal foals following intravenous and intramuscular administration.
Journal of veterinary pharmacology and therapeutics.
2021 Jul; 44(4):560-567. doi:
10.1111/jvp.12947. [PMID: 33511670] - Marianna Meschiari, Iacopo Franconi, Erica Bacca, Vincenzo Bianco, Gabriella Orlando, Gianluca Cuomo, Andrea Bedini, Cristina Mussini. Ceftazidime/avibactam and ceftolozane/tazobactam for the treatment of extensively drug-resistant Pseudomonas aeruginosa post-neurosurgical infections: three cases and a review of the literature.
Infection.
2021 Jun; 49(3):549-553. doi:
10.1007/s15010-020-01539-9. [PMID: 33074365] - ChangDong Lin, Yue Li, YueBin Zhang, ZhaoYuan Liu, Xia Mu, Chenjian Gu, Jing Liu, Yutang Li, GuoHui Li, JianFeng Chen. Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein-ACE2 interaction.
Signal transduction and targeted therapy.
2021 05; 6(1):198. doi:
10.1038/s41392-021-00619-y. [PMID: 34006835] - Zhengwu Shen, Wei Xu, Jingfeng Yu, Lixia Chen, Jinghua Zhang, Sihan Sheng, Xun Dong, Hongzhu Bian. Synthesis and in vitro antibacterial activity of new aminothiazole-oximepiperidone cephalosporins.
Bioorganic & medicinal chemistry letters.
2021 05; 40(?):127928. doi:
10.1016/j.bmcl.2021.127928. [PMID: 33705899] - Francesco Perrotta, Marco Paolo Perrini. Successful Treatment of Klebsiella pneumoniae NDM Sepsis and Intestinal Decolonization with Ceftazidime/Avibactam Plus Aztreonam Combination in a Patient with TTP Complicated by SARSCoV-2 Nosocomial Infection.
Medicina (Kaunas, Lithuania).
2021 Apr; 57(5):. doi:
10.3390/medicina57050424. [PMID: 33924769] - Raja Amarendra Muthina, Naveen Kumar Koppara, Maria Bethasaida Manuel, Alekhya Naga Bommu, Sunnesh Reddy Anapalli, Sangeetha Lakshmi Boju, Ram Rapur, Siva Kumar Vishnubotla. Cerebral abscess and calvarial osteomyelitis caused by Burkholderia pseudomallei in a renal transplant recipient.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Apr; 23(2):e13530. doi:
10.1111/tid.13530. [PMID: 33248011] - Jie Zhou, Xiang You, Meng Ke, Lingling Ye, Wanhong Wu, Pinfang Huang, Cuihong Lin. Dosage Adjustment for Ceftazidime in Pediatric Patients With Renal Impairment Using Physiologically Based Pharmacokinetic Modeling.
Journal of pharmaceutical sciences.
2021 04; 110(4):1853-1862. doi:
10.1016/j.xphs.2021.02.001. [PMID: 33556385] - Kari E Musgrave, Christopher S Hanley, Mark G Papich. POPULATION PHARMACOKINETICS OF CEFTAZIDIME AFTER A SINGLE SUBCUTANEOUS INJECTION AND NORMAL ORAL AND CLOACAL BACTERIAL FLORA SURVEY IN EASTERN HELLBENDERS (CRYPTOBRANCHUS ALLEGANIENSIS ALLEGANIENSIS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2021 Apr; 52(1):90-96. doi:
10.1638/2020-0145. [PMID: 33827165] - Selina Schießer, Florian Hitzenbichler, Martin G Kees, Alexander Kratzer, Matthias Lubnow, Bernd Salzberger, Frieder Kees, Christoph Dorn. Measurement of Free Plasma Concentrations of Beta-Lactam Antibiotics: An Applicability Study in Intensive Care Unit Patients.
Therapeutic drug monitoring.
2021 04; 43(2):264-270. doi:
10.1097/ftd.0000000000000827. [PMID: 33086362] - Ying Wang, Zhichao Du, Yongdong Chen, Yugang Liu, Zhitang Yang. Meta-analysis: combination of meropenem vs ceftazidime and amikacin for empirical treatment of cancer patients with febrile neutropenia.
Medicine.
2021 Feb; 100(8):e24883. doi:
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 02; 72(4):611-621. doi:
10.1093/cid/ciaa061. [PMID: 32107536] - Zana Rubic, Silvija Soprek, Marko Jelic, Anita Novak, Ivana Goic-Barisic, Marina Radic, Arjana Tambic-Andrasevic, Marija Tonkic. Molecular Characterization of β-Lactam Resistance and Antimicrobial Susceptibility to Possible Therapeutic Options of AmpC-Producing Multidrug-Resistant Proteus mirabilis in a University Hospital of Split, Croatia.
Microbial drug resistance (Larchmont, N.Y.).
2021 Feb; 27(2):162-169. doi:
10.1089/mdr.2020.0002. [PMID: 32429775] - Calvina E L Estaleva, Tomas F Zimba, John Osei Sekyere, Usha Govinden, Hafizah Y Chenia, Gunnar S Simonsen, Bjørg Haldorsen, Sabiha Y Essack, Arnfinn Sundsfjord. High prevalence of multidrug resistant ESBL- and plasmid mediated AmpC-producing clinical isolates of Escherichia coli at Maputo Central Hospital, Mozambique.
BMC infectious diseases.
2021 Jan; 21(1):16. doi:
10.1186/s12879-020-05696-y. [PMID: 33407206] - Worapong Nasomsong, Parnrada Nulsopapon, Dhitiwat Changpradub, Manat Pongchaidecha, Supanun Pungcharoenkijkul, Piraporn Juntanawiwat, Waristha Simsiriporn, Wichai Santimaleeworagun. The Potential Use of Ceftazidime-Avibactam Against Carbapenem Resistant Klebsiella pneumoniae Clinical Isolates Harboring Different Carbapenemase Types in a Thai University Hospital.
Drug design, development and therapy.
2021; 15(?):3095-3104. doi:
10.2147/dddt.s321147. [PMID: 34295150] - Feng Xie, Shengwang Dai, Yu Zhao, Pei Huang, Shen Yu, Biao Ren, Qiushui Wang, Zengchun Ji, Gil Alterovitz, Qi Zhang, Jingyu Zhang, Xiangyin Chen, Lan Jiang, Fuhang Song, Hongwei Liu, Frederick M Ausubel, Xueting Liu, Huanqin Dai, Lixin Zhang. Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis.
Cell chemical biology.
2020 12; 27(12):1532-1543.e6. doi:
10.1016/j.chembiol.2020.10.009. [PMID: 33186541] - Dennis Kühn, Carlos Metz, Frederik Seiler, Holger Wehrfritz, Sophie Roth, Mohammad Alqudrah, André Becker, Hendrik Bracht, Stefan Wagenpfeil, Mathias Hoffmann, Robert Bals, Ulrich Hübner, Jürgen Geisel, Philipp M Lepper, Sören L Becker. Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observational single-center study.
Critical care (London, England).
2020 11; 24(1):664. doi:
10.1186/s13054-020-03397-1. [PMID: 33239110] - Zhiqiang Wang, Ke Ma, Zhongju Chen, Zhiliang Guo, Guangyuan Zhao, Hui Guo, Lan Zhu, Gang Chen. Successful Treatment of Early Post-Transplant Bloodstream and Pulmonary Infection Caused by Carbapenem-Resistant Klebsiella pneumoniae With a Combination of Ceftazidime-Avibactam and Carbapenem: A Case Report.
Transplantation proceedings.
2020 Nov; 52(9):2742-2746. doi:
10.1016/j.transproceed.2020.08.006. [PMID: 32861482] - Rachelle E Beattie, Troy Skwor, Krassimira R Hristova. Survivor microbial populations in post-chlorinated wastewater are strongly associated with untreated hospital sewage and include ceftazidime and meropenem resistant populations.
The Science of the total environment.
2020 Oct; 740(?):140186. doi:
10.1016/j.scitotenv.2020.140186. [PMID: 32569917] - Ting Li, Guang-Shing Cheng, Sudhakar N J Pipavath, Gregory A Kicska, Liangjin Liu, Paul E Kinahan, Wei Wu. The novel coronavirus disease (COVID-19) complicated by pulmonary embolism and acute respiratory distress syndrome.
Journal of medical virology.
2020 10; 92(10):2205-2208. doi:
10.1002/jmv.26068. [PMID: 32470156] - Yesim Coskun, Serkan Atici. Successful Treatment of Pandrug-resistant Klebsiella pneumoniae Infection With Ceftazidime-avibactam in a Preterm Infant: A Case Report.
The Pediatric infectious disease journal.
2020 09; 39(9):854-856. doi:
10.1097/inf.0000000000002807. [PMID: 32804464] - S Bui, A Facchin, P Ha, S Bouchet, S Leroux, F Nacka, M Fayon, E Jacqz-Aigrain. Population pharmacokinetics of ceftazidime in critically ill children: impact of cystic fibrosis.
The Journal of antimicrobial chemotherapy.
2020 08; 75(8):2232-2239. doi:
10.1093/jac/dkaa170. [PMID: 32457995] - Upendo O Kibwana, Mtebe Majigo, Doreen Kamori, Joel Manyahi. High fecal carriage of extended Beta Lactamase producing Enterobacteriaceae among adult patients admitted in referral hospitals in Dar es Salaam, Tanzania.
BMC infectious diseases.
2020 Jul; 20(1):557. doi:
10.1186/s12879-020-05272-4. [PMID: 32736605] - Martina Paldrychová, Eva Vaňková, Petra Kašparová, Eliška Sembolová, Olga Maťátková, Jan Masák, Vladimír Scholtz, Jaroslav Julák. Use of non-thermal plasma pre-treatment to enhance antibiotic action against mature Pseudomonas aeruginosa biofilms.
World journal of microbiology & biotechnology.
2020 Jul; 36(8):108. doi:
10.1007/s11274-020-02891-6. [PMID: 32656596] - Arash Ghaffari-Rafi, Anthony C Netzel, Madeline Prat, Daniel T Miles. Cerebellar Parieto-occipital Posterior Reversible Encephalopathy Syndrome and Cerebral Metamorphopsia Associated with Asymptomatic Atrial Septum Vegetation and Renal Disease: Case Report.
The American journal of case reports.
2020 Jun; 21(?):e923441. doi:
10.12659/ajcr.923441. [PMID: 32516303] - Ling Song, Zhiheng Yu, Yifan Xu, Xiaobei Li, Xuanlin Liu, Dongyang Liu, Tianyan Zhou. Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women.
Biopharmaceutics & drug disposition.
2020 Jun; 41(6):248-267. doi:
10.1002/bdd.2243. [PMID: 32520400] - Romy D Zwittink, Diny van Zoeren-Grobben, Ingrid B Renes, Richard A van Lingen, Obbe F Norbruis, Rocio Martin, Liesbeth J Groot Jebbink, Jan Knol, Clara Belzer. Dynamics of the bacterial gut microbiota in preterm and term infants after intravenous amoxicillin/ceftazidime treatment.
BMC pediatrics.
2020 05; 20(1):195. doi:
10.1186/s12887-020-02067-z. [PMID: 32380969] - Vikas Gautam, Johan W Mouton, Marian T Ten Kate, Irma A J M Bakker-Woudenberg, Sebastian van Burgh, Nikolaos Strepis, Corné H W Klaassen, Wil Goessens. Cefpirome Treatment Results in Limited Selection of Stable Derepressed Enterobacter cloacae Mutants in the Intestinal Flora of Rats Treated for an Experimental Klebsiella pneumoniae Pulmonary Infection.
Microbial drug resistance (Larchmont, N.Y.).
2020 Apr; 26(4):341-348. doi:
10.1089/mdr.2018.0473. [PMID: 31657651] - Tommaso Giani, Alberto Antonelli, Samanta Sennati, Vincenzo Di Pilato, Adriana Chiarelli, Antonio Cannatelli, Christopher Gatsch, Francesco Luzzaro, Teresa Spanu, Stefania Stefani, Gian Maria Rossolini. Results of the Italian infection-Carbapenem Resistance Evaluation Surveillance Trial (iCREST-IT): activity of ceftazidime/avibactam against Enterobacterales isolated from urine.
The Journal of antimicrobial chemotherapy.
2020 04; 75(4):979-983. doi:
10.1093/jac/dkz547. [PMID: 31958125] - Pan Gao, Zonglai Liu, Han Yang, Ziqiu He, Zhi Zhang, Xiong Guo, Hongbo Zhang, Wei Ai, Dan Du. Ceftazidime-related urinary calculi in a young boy: a case report.
The Journal of international medical research.
2020 Apr; 48(4):300060520921667. doi:
10.1177/0300060520921667. [PMID: 32351152] - Ruta Petraitiene, Vidmantas Petraitis, Povilas Kavaliauskas, Bo Bo W Maung, Farehin Khan, Ethan Naing, Thein Aung, Vilma Zigmantaite, Ramune Grigaleviciute, Audrius Kucinskas, Rimantas Stakauskas, Benjamin N Georgiades, Chase A Mazur, Joshua A Hayden, Michael J Satlin, Thomas J Walsh. Pharmacokinetics and Efficacy of Ceftazidime-Avibactam in the Treatment of Experimental Pneumonia Caused by Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae in Persistently Neutropenic Rabbits.
Antimicrobial agents and chemotherapy.
2020 03; 64(4):. doi:
10.1128/aac.02157-19. [PMID: 32015048] - Marco Coppi, Vincenzo Di Pilato, Francesco Monaco, Tommaso Giani, Pier Giulio Conaldi, Gian Maria Rossolini. Ceftazidime-Avibactam Resistance Associated with Increased bla KPC-3 Gene Copy Number Mediated by pKpQIL Plasmid Derivatives in Sequence Type 258 Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy.
2020 03; 64(4):. doi:
10.1128/aac.01816-19. [PMID: 31964792] - L Zhao, X Li, X He, L Jian. Levofloxacin-ceftazidime administration regimens combat Pseudomonas aeruginosa in the hollow-fiber infection model simulating abnormal renal function in critically ill patients.
BMC pharmacology & toxicology.
2020 03; 21(1):20. doi:
10.1186/s40360-020-0396-5. [PMID: 32131897] - Pinpongsarn Triyawatanyu, Pajaree Chariyavilaskul, Weeraya Phaisal, Sadudee Peerapornratana, Talerngsak Kanjanabuch, Kearkiat Praditpornsilpa, Pisut Katavetin. Intraperitoneal cefazolin and ceftazidime during short-dwell exchange in peritoneal dialysis patients with peritonitis.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2020 03; 40(2):179-184. doi:
10.1177/0896860819893820. [PMID: 32063189] - Shampa Das, Diansong Zhou, Wright W Nichols, Andy Townsend, Paul Newell, Jianguo Li. Selecting the dosage of ceftazidime-avibactam in the perfect storm of nosocomial pneumonia.
European journal of clinical pharmacology.
2020 Mar; 76(3):349-361. doi:
10.1007/s00228-019-02804-z. [PMID: 31836928] - Wenxia Zhang, Yan Guo, Yang Yang, Dong Dong, Yonggui Zheng, Demei Zhu, Fupin Hu. Study of In Vitro Synergistic Bactericidal Activity of Dual β-Lactam Antibiotics Against KPC-2-Producing Klebsiella pneumoniae.
Microbial drug resistance (Larchmont, N.Y.).
2020 Mar; 26(3):204-210. doi:
10.1089/mdr.2019.0126. [PMID: 31553260] - Hasan Cenk Mirza, Elvan Hortaç, Aylin Altay Koçak, M Hamiyet Demirkaya, Buket Yayla, Aylin Üsküdar Güçlü, Ahmet Başustaoğlu. In vitro activity of ceftolozane-tazobactam and ceftazidime-avibactam against clinical isolates of meropenem-non-susceptible Pseudomonas aeruginosa: A two-centre study.
Journal of global antimicrobial resistance.
2020 03; 20(?):334-338. doi:
10.1016/j.jgar.2019.09.016. [PMID: 31568882] - Julie A Lawrence, Zhongping Huang, Sivaprakash Rathinavelu, Jin-Feng Hu, Eliane Garo, Michael Ellis, Vanessa L Norman, Ronald Buckle, Russell B Williams, Courtney M Starks, Gary R Eldridge. Optimized plant compound with potent anti-biofilm activity across gram-negative species.
Bioorganic & medicinal chemistry.
2020 03; 28(5):115229. doi:
10.1016/j.bmc.2019.115229. [PMID: 32033878] - Paige Soukup, Andrew C Faust, Vindhya Edpuganti, William C Putnam, James A McKinnell. Steady-State Ceftazidime-Avibactam Serum Concentrations and Dosing Recommendations in a Critically Ill Patient Being Treated for Pseudomonas aeruginosa Pneumonia and Undergoing Continuous Venovenous Hemodiafiltration.
Pharmacotherapy.
2019 12; 39(12):1216-1222. doi:
10.1002/phar.2338. [PMID: 31596506] - Ashley Ferro, Meryl Griffiths, Rona Smith, Andrew Fry. Acute kidney injury as the presenting complaint of ceftazidime-induced immune-mediated haemolysis.
BMJ case reports.
2019 Nov; 12(11):. doi:
10.1136/bcr-2019-232884. [PMID: 31732539] - Carolina Saffioti, Sebastiano Barco, Giuliana Cangemi, Alessio Mesini, Rosaria Casciaro, Federico Cresta, Carlo Castellani, Roberto Bandettini, Patrizia Morelli, Elio Castagnola. Ceftazidime plasma concentration in a patient with cystic fibrosis treated with ceftazidime/avibactam plus trimethoprim/sulfametoxazole for Bulkholderia cepacia reacutization.
Journal of chemotherapy (Florence, Italy).
2019 Nov; 31(7-8):436-438. doi:
10.1080/1120009x.2019.1671654. [PMID: 31583970] - Muthana Al Sahlawi, Adrian Liew, Jeffrey Perl. Cefepime as Empirical Peritoneal Dialysis-Associated Peritonitis Treatment: Something to Dwell On?.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2019 11; 74(5):579-582. doi:
10.1053/j.ajkd.2019.06.008. [PMID: 31515138] - Thidarat Kitrungphaiboon, Pongpratch Puapatanakul, Piyatida Chuengsaman, Krittaya Tiskajornsiri, Guttiga Halue, Monchai Siribamrungwong, Saraporn Matayart, Kamonrat Chongthanakorn, Ussanee Poonvivatchaikarn, Chanchana Boonyakrai, Wanida Somboonsilp, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, David W Johnson, Talerngsak Kanjanabuch. Intraperitoneal Cefepime Monotherapy Versus Combination Therapy of Cefazolin Plus Ceftazidime for Empirical Treatment of CAPD-Associated Peritonitis: A Multicenter, Open-Label, Noninferiority, Randomized, Controlled Trial.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2019 11; 74(5):601-609. doi:
10.1053/j.ajkd.2019.05.011. [PMID: 31331757] - Temilolu Idowu, Derek Ammeter, Gilbert Arthur, George G Zhanel, Frank Schweizer. Potentiation of β-lactam antibiotics and β-lactam/β-lactamase inhibitor combinations against MDR and XDR Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates.
The Journal of antimicrobial chemotherapy.
2019 09; 74(9):2640-2648. doi:
10.1093/jac/dkz228. [PMID: 31139830] - Paul B Eckburg, Troy Lister, Susannah Walpole, Tim Keutzer, Luke Utley, John Tomayko, Ellen Kopp, Nicholas Farinola, Scott Coleman. Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects.
Antimicrobial agents and chemotherapy.
2019 09; 63(9):. doi:
10.1128/aac.00892-19. [PMID: 31262767] - Li Zhou, Xiao Tong, Pradeep Sharma, Hongmei Xu, Nidal Al-Huniti, Diansong Zhou. Physiologically based pharmacokinetic modelling to predict exposure differences in healthy volunteers and subjects with renal impairment: Ceftazidime case study.
Basic & clinical pharmacology & toxicology.
2019 Aug; 125(2):100-107. doi:
10.1111/bcpt.13209. [PMID: 30739396] - Janni S Mortensen, Berit P Jensen, Mei Zhang, Matthew Doogue. Preanalytical Stability of Piperacillin, Tazobactam, Meropenem, and Ceftazidime in Plasma and Whole Blood Using Liquid Chromatography-Tandem Mass Spectrometry.
Therapeutic drug monitoring.
2019 08; 41(4):538-543. doi:
10.1097/ftd.0000000000000650. [PMID: 31306394] - Valentina Viaggi, Beatrice Pini, Silvia Tonolo, Francesco Luzzaro, Luigi Principe. In vitro activity of ceftazidime/avibactam against clinical isolates of ESBL-producing Enterobacteriaceae in Italy.
Journal of chemotherapy (Florence, Italy).
2019 Jul; 31(4):195-201. doi:
10.1080/1120009x.2019.1620406. [PMID: 31130090] - Pier Giorgio Cojutti, Natalia Maximova, Giulia Schillani, William Hope, Federico Pea. Population pharmacokinetics of continuous-infusion ceftazidime in febrile neutropenic children undergoing HSCT: implications for target attainment for empirical treatment against Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy.
2019 06; 74(6):1648-1655. doi:
10.1093/jac/dkz065. [PMID: 30838391] - Valeria Daccò, Laura Claut, Stefania Piconi, Luca Castellazzi, Francesca Garbarino, Antonio Teri, Carla Colombo. Successful ceftazidime-avibactam treatment of post-surgery Burkholderia multivorans genomovar II bacteremia and brain abscesses in a young lung transplanted woman with cystic fibrosis.
Transplant infectious disease : an official journal of the Transplantation Society.
2019 Jun; 21(3):e13082. doi:
10.1111/tid.13082. [PMID: 30892778] - Jamie L Miller, Peter N Johnson, Bryan P White, Stephen B Neely, Hala Chaaban, Netsanet Kassa, Robert C Welliver. Impact of Ceftazidime Use on Susceptibility Patterns in the Neonatal Intensive Care Unit.
The Pediatric infectious disease journal.
2019 06; 38(6):605-607. doi:
10.1097/inf.0000000000002255. [PMID: 30489466] - G Spoletini, C Etherington, N Shaw, I J Clifton, M Denton, P Whitaker, D G Peckham. Use of ceftazidime/avibactam for the treatment of MDR Pseudomonas aeruginosa and Burkholderia cepacia complex infections in cystic fibrosis: a case series.
The Journal of antimicrobial chemotherapy.
2019 05; 74(5):1425-1429. doi:
10.1093/jac/dky558. [PMID: 30649419] - Poonam Giri, Harilal Patel, Nuggehally R Srinivas. Review of Clinical Pharmacokinetics of Avibactam, A Newly Approved non-β lactam β-lactamase Inhibitor Drug, In Combination Use With Ceftazidime.
Drug research.
2019 May; 69(5):245-255. doi:
10.1055/a-0748-5548. [PMID: 30296806] - Nicola Peruzzu, Silvio Borrelli, Antonella Netti, Toni De Stefano, Carlo Vita, Maria Sabatino, Michela Salzano, Giuseppe Conte, Luca De Nicola, Roberto Minutolo, Carlo Garofalo. [Infected hepatic cyst in ADPKD patient in peritoneal dialysis].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2019 Apr; 36(2):. doi:
NULL. [PMID: 30983178] - Jianguo Li, Mark Lovern, Michelle L Green, Joannellyn Chiu, Diansong Zhou, Craig Comisar, Yuan Xiong, Jeremy Hing, Merran MacPherson, James G Wright, Todd Riccobene, Timothy J Carrothers, Shampa Das. Ceftazidime-Avibactam Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Across Adult Indications and Patient Subgroups.
Clinical and translational science.
2019 03; 12(2):151-163. doi:
10.1111/cts.12585. [PMID: 30221827] - Bela Kocsis, Akos Toth, Daniel Gulyas, Balazs Ligeti, Katalin Katona, Laszlo Rokusz, Dora Szabo. Acquired qnrVC1 and blaNDM-1 resistance markers in an international high-risk Pseudomonas aeruginosa ST773 clone.
Journal of medical microbiology.
2019 Mar; 68(3):336-338. doi:
10.1099/jmm.0.000927. [PMID: 30667355] - George G Zhanel, Alyssa R Golden, Sheryl Zelenitsky, Karyn Wiebe, Courtney K Lawrence, Heather J Adam, Temilolu Idowu, Ronald Domalaon, Frank Schweizer, Michael A Zhanel, Philippe R S Lagacé-Wiens, Andrew J Walkty, Ayman Noreddin, Joseph P Lynch Iii, James A Karlowsky. Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.
Drugs.
2019 Feb; 79(3):271-289. doi:
10.1007/s40265-019-1055-2. [PMID: 30712199] - Jason M Pogue, Robert A Bonomo, Keith S Kaye. Ceftazidime/Avibactam, Meropenem/Vaborbactam, or Both? Clinical and Formulary Considerations.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2019 01; 68(3):519-524. doi:
10.1093/cid/ciy576. [PMID: 30020449] - Gary E Stein, Curtis L Smith, Amy Scharmen, James M Kidd, Christopher Cooper, Joseph Kuti, Subhashis Mitra, David P Nicolau, Daniel H Havlichek. Pharmacokinetic and Pharmacodynamic Analysis of Ceftazidime/Avibactam in Critically Ill Patients.
Surgical infections.
2019 Jan; 20(1):55-61. doi:
10.1089/sur.2018.141. [PMID: 30351195] - Dejenie Shiferaw Teklu, Abebe Aseffa Negeri, Melese Hailu Legese, Tesfaye Legesse Bedada, Hiwot Ketema Woldemariam, Kassu Desta Tullu. Extended-spectrum beta-lactamase production and multi-drug resistance among Enterobacteriaceae isolated in Addis Ababa, Ethiopia.
Antimicrobial resistance and infection control.
2019; 8(?):39. doi:
10.1186/s13756-019-0488-4. [PMID: 30815254] - Tiago J Carvalho, Patrícia Quadros Branco, Ana Rita Martins, Augusta Gaspar. Chryseobacterium indologenes peritonitis in a peritoneal dialysis patient.
BMJ case reports.
2018 Dec; 11(1):. doi:
10.1136/bcr-2018-227713. [PMID: 30567209] - Monique R Bidell, Thomas P Lodise. Suboptimal Clinical Response Rates with Newer Antibiotics Among Patients with Moderate Renal Impairment: Review of the Literature and Potential Pharmacokinetic and Pharmacodynamic Considerations for Observed Findings.
Pharmacotherapy.
2018 12; 38(12):1205-1215. doi:
10.1002/phar.2184. [PMID: 30289995] - Richard Dimelow, James G Wright, Merran MacPherson, Paul Newell, Shampa Das. Population Pharmacokinetic Modelling of Ceftazidime and Avibactam in the Plasma and Epithelial Lining Fluid of Healthy Volunteers.
Drugs in R&D.
2018 Sep; 18(3):221-230. doi:
10.1007/s40268-018-0241-0. [PMID: 30054895] - A J Cerreta, G A Lewbart, D R Dise, M G Papich. Population pharmacokinetics of ceftazidime after a single intramuscular injection in wild turtles.
Journal of veterinary pharmacology and therapeutics.
2018 Aug; 41(4):495-501. doi:
10.1111/jvp.12500. [PMID: 29517112] - Honghong Wang, Xingang Li, Shusen Sun, Guifu Mao, Ping Xiao, Chan Fu, Zhuoxin Liang, Min Zheng, Yuling Huang, Haihong Tang, Renhao Ou, Ni Yang, Xi Ling, Zhigang Zhao. Population Pharmacokinetics and Dosing Simulations of Ceftazidime in Chinese Neonates.
Journal of pharmaceutical sciences.
2018 05; 107(5):1416-1422. doi:
10.1016/j.xphs.2017.12.018. [PMID: 29274818] - Eris Cani, Farzad Moussavi, Eric Ocheretyaner, Roopali Sharma, Clinton Brown, Brandon Eilertson. Carbapenem-resistant Klebsiella pneumoniae vertebral osteomyelitis in a renal transplant recipient treated with ceftazidime-avibactam.
Transplant infectious disease : an official journal of the Transplantation Society.
2018 Apr; 20(2):e12837. doi:
10.1111/tid.12837. [PMID: 29359842] - María García-Castillo, Sergio García-Fernández, Rosa Gómez-Gil, Cristina Pitart, Marina Oviaño, Irene Gracia-Ahufinger, Jazmín Díaz-Regañón, Marta Tato, Rafael Cantón. Activity of ceftazidime-avibactam against carbapenemase-producing Enterobacteriaceae from urine specimens obtained during the infection-carbapenem resistance evaluation surveillance trial (iCREST) in Spain.
International journal of antimicrobial agents.
2018 Mar; 51(3):511-515. doi:
10.1016/j.ijantimicag.2018.01.011. [PMID: 29371104] - Marco Falcone, Pierluigi Viale, Giusy Tiseo, Manjunath Pai. Pharmacokinetic drug evaluation of avibactam + ceftazidime for the treatment of hospital-acquired pneumonia.
Expert opinion on drug metabolism & toxicology.
2018 Mar; 14(3):331-340. doi:
10.1080/17425255.2018.1434142. [PMID: 29373935]