Oxymetholone (BioDeep_00000003273)

   


代谢物信息卡片


17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one, (2E,5alpha,17beta)-

化学式: C21H32O3 (332.23513219999995)
中文名称: 康复龙
谱图信息: 最多检出来源 Viridiplantae(plant) 96.3%

分子结构信息

SMILES: CC12CC(=CO)C(=O)CC1CCC1C2CCC2(C)C1CCC2(C)O
InChI: InChI=1S/C21H32O3/c1-19-11-13(12-22)18(23)10-14(19)4-5-15-16(19)6-8-20(2)17(15)7-9-21(20,3)24/h12,14-17,22,24H,4-11H2,1-3H3/b13-12-

描述信息

A - Alimentary tract and metabolism > A14 - Anabolic agents for systemic use > A14A - Anabolic steroids > A14AA - Androstan derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D045930 - Anabolic Agents
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D000728 - Androgens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid

同义名列表

4 个代谢物同义名

Oxymetholone; 17-beta-Hydroxy-2-(hydroxymethylene)-17-methyl-5-alpha-androstan-3-one; 17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one, (2E,5alpha,17beta)-; 434-07-1



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jinge Feng, Hongbo Gao, Lin Yang, Yu Xie, Ayman E El-Kenawy, Attalla F El-Kott. Renoprotective and hepatoprotective activity of Lepidium draba L. extracts on oxymetholone-induced oxidative stress in rat. Journal of food biochemistry. 2022 09; 46(9):e14250. doi: 10.1111/jfbc.14250. [PMID: 35633194]
  • Yanbo Wang, Liang Bai, Huiting Li, Wenjun Yang, Min Li. Protective effects of Lepidium draba L. leaves extract on testis histopathology, oxidative stress indicators, serum reproductive hormones and inflammatory signalling in oxymetholone-treated rat. Andrologia. 2021 Dec; 53(11):e14239. doi: 10.1111/and.14239. [PMID: 34520070]
  • Mohsen Akbari Bazm, Nader Goodarzi, Seyed Reza Shahrokhi, Mozafar Khazaei. The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone-induced testicular toxicity in mouse. Andrologia. 2020 Apr; 52(3):e13522. doi: 10.1111/and.13522. [PMID: 32012329]
  • Mohsen Akbari Bazm, Mozafar Khazaei, Fatemeh Khazaei, Leila Naseri. Nasturtium Officinale L. hydroalcoholic extract improved oxymetholone-induced oxidative injury in mouse testis and sperm parameters. Andrologia. 2019 Aug; 51(7):e13294. doi: 10.1111/and.13294. [PMID: 31025410]
  • Yen-Ping Lin, Ying-Lin Lee, Chien-Ya Hung, Chuan-Fa Chang, Yi Chen. Detection of adulterated drugs in traditional Chinese medicine and dietary supplements using hydrogen as a carrier gas. PloS one. 2018; 13(10):e0205371. doi: 10.1371/journal.pone.0205371. [PMID: 30304050]
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  • Tayyebeh Madrakian, Abbas Afkhami, Mohammad Rahimi, Mazaher Ahmadi, Mohammad Soleimani. Preconcentration and spectrophotometric determination of oxymetholone in the presence of its main metabolite (mestanolone) using modified maghemite nanoparticles in urine sample. Talanta. 2013 Oct; 115(?):468-73. doi: 10.1016/j.talanta.2013.05.056. [PMID: 24054620]
  • Tim Sobolevsky, Grigory Rodchenkov. Mass spectrometric description of novel oxymetholone and desoxymethyltestosterone metabolites identified in human urine and their importance for doping control. Drug testing and analysis. 2012 Sep; 4(9):682-91. doi: 10.1002/dta.1407. [PMID: 22945829]
  • Cornelia Fürstenberger, Anna Vuorinen, Thierry Da Cunha, Denise V Kratschmar, Martial Saugy, Daniela Schuster, Alex Odermatt. The anabolic androgenic steroid fluoxymesterone inhibits 11β-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicological sciences : an official journal of the Society of Toxicology. 2012 Apr; 126(2):353-61. doi: 10.1093/toxsci/kfs022. [PMID: 22273746]
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  • Carla Rodrigues Cardoso, Marlice A Sípoli Marques, Ricardo Carvalho Caminha, Maria Christina Maioli, Francisco R Aquino Neto. Validation of the determination of oxymetholone in human plasma analysis using gas chromatography-mass spectrometry. Application to pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Jul; 775(1):1-8. doi: 10.1016/s1570-0232(02)00243-x. [PMID: 12101054]
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