Clobenpropit (BioDeep_00000003112)
Secondary id: BioDeep_00000405783
human metabolite blood metabolite
代谢物信息卡片
化学式: C14H17ClN4S (308.0862)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 9.87%
分子结构信息
SMILES: C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl
InChI: InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
同义名列表
21 个代谢物同义名
N-[(4-chlorophenyl)methyl]{[3-(1H-imidazol-5-yl)propyl]sulfanyl}methanimidamide; S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea; clobenpropit; Clobenpropit; 3-(1~{H}-imidazol-4-yl)propyl ~{N}'-[(4-chlorophenyl)methyl]carbamimidothioate; 3-(1H-imidazol-4-yl)propyl ((4-chlorophenyl)methyl)carbamimidothioate; 3-(1H-imidazol-4-yl)propyl 4-chlorobenzylcarbamimidothioate; 3-(1H-imidazol-4-yl)propyl N-(4-chlorobenzyl)carbamimidothioate; 3-(1H-Imidazol-5-yl)propyl 4-chlorobenzylcarbamimidothioate; 3-(1H-imidazol-5-yl)propyl N'-[(4-chlorophenyl)methyl]carbamimidothioate; Carbamimidothioic acid, ((4-chlorophenyl)methyl)-, 3-(1H-imidazol-4-yl)propyl ester; CARBAMIMIDOTHIOIC ACID, N-((4-CHLOROPHENYL)METHYL)-, 3-(1H-IMIDAZOL-5-YL)PROPYL ESTER; Carbamimidothioic acid, N-[(4-chlorophenyl)methyl]-, 3-(1H-imidazol-5-yl)propyl ester; Carbamimidothioic acid,N-[(4-chlorophenyl)methyl]-, 3-(1H-imidazol-5-yl)propyl ester; Clobenpropit free base; N'-((4-chlorophenyl)methyl)-1-(3-(3H-imidazol-4-yl)propylsulfanyl)methanimidamide; N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylsulfanyl]methanimidamide; N''''-[(4-chlorophenyl)methyl]{[3-(1H-imidazol-5-yl)propyl]sulfanyl}methanimidamide; PDSP1_000537; PDSP2_000535; UCAIEVHKDLMIFL-UHFFFAOYSA-N
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:64177
- KEGG: C17934
- PubChem: 2790
- HMDB: HMDB0250329
- ChEMBL: CHEMBL14690
- Wikipedia: Clobenpropit
- PMhub: MS000008104
- PubChem: 96024155
- CAS: 145231-45-4
- PDB-CCD: VCL
- NIKKAJI: J506.353A
- KNApSAcK: 64177
- MeSH: clobenpropit
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anca D Buzoianu, Aruna Sharma, Dafin F Muresanu, Lianyuan Feng, Hongyun Huang, Lin Chen, Z Ryan Tian, Ala Nozari, José Vicente Lafuente, Lars Wiklund, Hari Shanker Sharma. Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein Reduces Brain Pathology in Parkinson's Disease.
Advances in neurobiology.
2023; 32(?):55-96. doi:
10.1007/978-3-031-32997-5_2. [PMID: 37480459] - Anca D Buzoianu, Aruna Sharma, Dafin F Muresanu, Lianyuan Feng, Hongyun Huang, Lin Chen, Z Ryan Tian, Ala Nozari, José Vicente Lafuente, Per-Ove Sjöqvist, Lars Wiklund, Hari Shanker Sharma. Nanodelivery of histamine H3 receptor inverse agonist BF-2649 with H3 receptor antagonist and H4 receptor agonist clobenpropit induced neuroprotection is potentiated by antioxidant compound H-290/51 in spinal cord injury.
International review of neurobiology.
2023; 172(?):37-77. doi:
10.1016/bs.irn.2023.06.003. [PMID: 37833018] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Minkui Zhang, Li Tang, Liu Jiang, Jun Wei, Yongzhou Hu, Rong Sheng. Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H3 receptor antagonists and β-amyloid aggregation inhibitors for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2021 Feb; 212(?):113096. doi:
10.1016/j.ejmech.2020.113096. [PMID: 33395621] - Elvia Mena-Avila, Ricardo Márquez-Gómez, Guillermo Aquino-Miranda, Gustavo Nieto-Alamilla, José-Antonio Arias-Montaño. Clobenpropit, a histamine H3 receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes.
Pharmacological reports : PR.
2018 Feb; 70(1):146-155. doi:
10.1016/j.pharep.2017.08.007. [PMID: 29414147] - Yuji Sugata, Mitsuhiro Okano, Tazuko Fujiwara, Rie Matsumoto, Hisashi Hattori, Miki Yamamoto, Masahiro Nishibori, Kazunori Nishizaki. Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses.
Immunology.
2007 Jun; 121(2):266-75. doi:
10.1111/j.1365-2567.2007.02574.x. [PMID: 17346280] - Jacob Raber. Role of apolipoprotein E in anxiety.
Neural plasticity.
2007; 2007(?):91236. doi:
10.1155/2007/91236. [PMID: 17710250] - F C Shenton, P L Chazot. Probing the importance of N-glycosylation for [(3)H] clobenpropit binding to human H (3) receptors expressed in HEK 293 cells . 3. Molecular and chemical aspects of the histamine receptors.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2006 Apr; 55 Suppl 1(?):S40-1. doi:
10.1007/s00011-005-0033-1. [PMID: 16547815] - Kathleen M Krueger, David G Witte, Lynne Ireland-Denny, Thomas R Miller, John L Baranowski, Steve Buckner, Ivan Milicic, Timothy A Esbenshade, Arthur A Hancock. G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations.
The Journal of pharmacology and experimental therapeutics.
2005 Jul; 314(1):271-81. doi:
10.1124/jpet.104.078865. [PMID: 15821027] - H E Badenhorst, D S Maharaj, S F Malan, S Daya, S van Dyk. Histamine-3 receptor antagonists reduce superoxide anion generation and lipid peroxidation in rat brain homogenates.
The Journal of pharmacy and pharmacology.
2005 Jun; 57(6):781-5. doi:
10.1211/0022357056064. [PMID: 15969934] - Jingcai Chen, Changlu Liu, Timothy W Lovenberg. Molecular and pharmacological characterization of the mouse histamine H3 receptor.
European journal of pharmacology.
2003 Apr; 467(1-3):57-65. doi:
10.1016/s0014-2999(03)01635-2. [PMID: 12706455] - Dirk Gründemann, Ann-Cathrin Koschker, Christine Haag, Cornelius Honold, Tim Zimmermann, Edgar Schömig. Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells.
British journal of pharmacology.
2002 Nov; 137(6):910-8. doi:
10.1038/sj.bjp.0704926. [PMID: 12411423] - Mark O'Reilly, Robbin Alpert, Stephen Jenkinson, Ronald P Gladue, Shane Foo, Steven Trim, Beate Peter, Mike Trevethick, Mark Fidock. Identification of a histamine H4 receptor on human eosinophils--role in eosinophil chemotaxis.
Journal of receptor and signal transduction research.
2002 Feb; 22(1-4):431-48. doi:
10.1081/rrs-120014612. [PMID: 12503632] - H Stark, B Sadek, M Krause, A Hüls, X Ligneau, C R Ganellin, J M Arrang, J C Schwartz, W Schunack. Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds.
Journal of medicinal chemistry.
2000 Oct; 43(21):3987-94. doi:
10.1021/jm000966l. [PMID: 11052804] - W Fischer, H van der Goot. Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice.
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