4-Hydroxyquinoline (BioDeep_00000003088)

 

Secondary id: BioDeep_00001868681

human metabolite blood metabolite natural product


代谢物信息卡片


1,4-dihydroquinolin-4-one

化学式: C9H7NO (145.0528)
中文名称: 喹啉-4(1H)-酮, 4-羟基喹啉
谱图信息: 最多检出来源 Homo sapiens(plant) 16.46%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=O)C=CN2
InChI: InChI=1S/C9H7NO/c11-9-5-6-10-8-4-2-1-3-7(8)9/h1-6H,(H,10,11)

描述信息

CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 53
CONFIDENCE standard compound; INTERNAL_ID 2492
KEIO_ID H139

同义名列表

10 个代谢物同义名

1,4-dihydroquinolin-4-one; 4-Hydroxyquinoline; 4(1H)-Quinolinone; Quinolin-4-ol; 4-Quinolinol; 4-Chinolinol; 4-quinolone; Kynurine; 4-Hydroxyquinoline; 4-Hydroxyquinoline



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ABCB1, AKR1B1, ANXA5, CNR1, CNR2, ELANE, MAPK8, MAPK9, METAP1, PDGFRB, SOS1
Peripheral membrane protein 2 ANXA5, CYP1B1
Endoplasmic reticulum membrane 1 CYP1B1
Mitochondrion membrane 1 ALPL
Nucleus 4 MAPK8, MAPK9, MET, PDGFRB
cytosol 7 AKR1B1, ANXA5, ELANE, MAPK8, MAPK9, METAP1, SOS1
dendrite 1 CNR2
mitochondrial membrane 1 ALPL
nuclear body 1 MET
phagocytic vesicle 1 ELANE
nucleoplasm 5 AKR1B1, CD2, MAPK8, MAPK9, MET
Cell membrane 7 ABCB1, ALPI, ALPL, CD2, CNR1, KIT, PROKR2
Cell projection, axon 1 CNR1
Multi-pass membrane protein 4 ABCB1, CNR1, MT-CYB, PROKR2
Synapse 1 MAPK8
cell surface 4 ABCB1, CD2, ELANE, MET
glutamatergic synapse 2 CNR1, SOS1
Golgi apparatus 2 CD2, PDGFRB
growth cone 1 CNR1
mitochondrial inner membrane 1 MT-CYB
neuronal cell body 1 SOS1
postsynapse 1 MET
presynaptic membrane 1 CNR1
sarcolemma 1 ANXA5
Presynapse 1 CNR1
acrosomal vesicle 1 KIT
plasma membrane 12 ABCB1, ALPI, ALPL, CD2, CNR1, CNR2, KIT, MAPK9, MET, PDGFRB, PROKR2, SOS1
Membrane 8 ABCB1, ALPL, ANXA5, CYP1B1, KIT, MET, MT-CYB, PDGFRB
apical plasma membrane 2 ABCB1, PDGFRB
axon 2 CNR1, MAPK8
extracellular exosome 5 ABCB1, AKR1B1, ALPL, ANXA5, ELANE
endoplasmic reticulum 1 CNR2
extracellular space 3 AKR1B1, ELANE, KIT
lysosomal lumen 1 PDGFRB
Schaffer collateral - CA1 synapse 1 MAPK9
mitochondrion 4 AKR1B1, CYP1B1, MAPK9, MT-CYB
protein-containing complex 1 CD2
intracellular membrane-bounded organelle 2 CYP1B1, PDGFRB
Microsome membrane 1 CYP1B1
postsynaptic density 1 SOS1
Single-pass type I membrane protein 2 CD2, KIT
extracellular region 6 ALPI, ALPL, ANXA5, CD2, ELANE, MET
cytoplasmic side of plasma membrane 2 CD2, KIT
Mitochondrion outer membrane 1 CNR1
Single-pass membrane protein 1 MET
mitochondrial outer membrane 1 CNR1
external side of plasma membrane 3 ANXA5, CD2, KIT
actin cytoskeleton 1 CNR1
perikaryon 1 CNR2
cytoplasmic vesicle 1 PDGFRB
cell-cell junction 2 CD2, KIT
postsynaptic membrane 1 CNR2
Apical cell membrane 1 ABCB1
Mitochondrion inner membrane 1 MT-CYB
Membrane raft 1 CNR1
focal adhesion 2 ANXA5, PDGFRB
GABA-ergic synapse 1 CNR1
extracellular matrix 1 ALPL
Mitochondrion intermembrane space 1 ALPL
mitochondrial intermembrane space 1 ALPL
collagen-containing extracellular matrix 2 ANXA5, ELANE
secretory granule 1 ELANE
nuclear speck 1 MAPK9
receptor complex 3 KIT, MET, PDGFRB
Zymogen granule membrane 1 ANXA5
Lipid-anchor, GPI-anchor 2 ALPI, ALPL
fibrillar center 1 KIT
Cell projection, dendrite 1 CNR2
side of membrane 2 ALPI, ALPL
basal plasma membrane 1 MET
[Isoform 3]: Cytoplasm 1 KIT
transcription repressor complex 1 ELANE
specific granule lumen 1 ELANE
azurophil granule lumen 1 ELANE
vesicle membrane 1 ANXA5
respiratory chain complex III 1 MT-CYB
extrinsic component of cytoplasmic side of plasma membrane 1 CNR2
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
nucleosome 1 SOS1
Cytoplasmic vesicle, phagosome 1 ELANE
cytosolic ribosome 1 METAP1
GTPase complex 1 SOS1
Extracellular vesicle membrane 1 ALPL
endothelial microparticle 1 ANXA5


文献列表

  • Kenichi Onda, Fumie Narazaki, Naoki Ishibashi, Keita Nakanishi, Yuki Sawada, Ken-ichiro Imamura, Kazuhiro Momose, Shigetada Furukawa, Yoshiaki Shimada, Hiroyuki Moriguchi, Masamichi Yuda, Hiroshi Kayakiri, Mitsuaki Ohta. Identification of 4-quinolone derivatives as inhibitors of reactive oxygen species production from human umbilical vein endothelial cells. Bioorganic & medicinal chemistry letters. 2011 Nov; 21(22):6861-6. doi: 10.1016/j.bmcl.2011.09.015. [PMID: 21963985]
  • Alessandra Gaeta, John Woodcraft, Stuart Plant, Julian Goggi, Paul Jones, Mark Battle, William Trigg, Sajinder K Luthra, Matthias Glaser. Use of 2-[(18)F]fluoroethylazide for the Staudinger ligation - Preparation and characterisation of GABA(A) receptor binding 4-quinolones. Bioorganic & medicinal chemistry letters. 2010 Aug; 20(15):4649-52. doi: 10.1016/j.bmcl.2010.05.106. [PMID: 20579877]
  • Giordano Rampioni, Christian Pustelny, Matthew P Fletcher, Victoria J Wright, Mary Bruce, Kendra P Rumbaugh, Stephan Heeb, Miguel Cámara, Paul Williams. Transcriptomic analysis reveals a global alkyl-quinolone-independent regulatory role for PqsE in facilitating the environmental adaptation of Pseudomonas aeruginosa to plant and animal hosts. Environmental microbiology. 2010 Jun; 12(6):1659-73. doi: 10.1111/j.1462-2920.2010.02214.x. [PMID: 20406282]
  • Durk Fekkes, Arthur R Van Gool, Marjolein Bannink, Stefan Sleijfer, Wim H J Kruit, Bronno van der Holt, Alexander M M Eggermont, Michiel W Hengeveld, Gerrit Stoter. Nitric oxide production and monoamine oxidase activity in cancer patients during interferon-alpha therapy. Amino acids. 2009 Oct; 37(4):703-8. doi: 10.1007/s00726-008-0191-x. [PMID: 18953681]
  • Ashraf M Mahmoud, Nasr Y Khalil, Ibrahim A Darwish, Tarek Aboul-Fadl. Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate. International journal of analytical chemistry. 2009; 2009(?):810104. doi: 10.1155/2009/810104. [PMID: 20140080]
  • Vanessa Gressler, Caroline Z Stüker, Gilvan de O C Dias, Ionara I Dalcol, Robert A Burrow, Juergen Schmidt, Ludger Wessjohann, Ademir F Morel. Quinolone alkaloids from Waltheria douradinha. Phytochemistry. 2008 Feb; 69(4):994-9. doi: 10.1016/j.phytochem.2007.10.018. [PMID: 18076957]
  • Hoi-Seon Lee. Acaricidal effects of quinone and its congeners and color alteration of Dermatophagoides spp. with quinone. Journal of microbiology and biotechnology. 2007 Aug; 17(8):1394-8. doi: ". [PMID: 18051611]
  • Thomas D Harris, Edward Cheesman, Anthony R Harris, Richard Sachleben, D Scott Edwards, Shuang Liu, Judit Bartis, Charles Ellars, Dave Onthank, Padmaja Yalamanchili, Stuart Heminway, Paula Silva, Simon Robinson, Joel Lazewatsky, Milind Rajopadhye, John Barrett. Radiolabeled divalent peptidomimetic vitronectin receptor antagonists as potential tumor radiotherapeutic and imaging agents. Bioconjugate chemistry. 2007 Jul; 18(4):1266-79. doi: 10.1021/bc070002+. [PMID: 17579472]
  • Amal M El-Shennawy, Amira H Mohamed, Mohamed Abass. Studies on parasitologic and haematologic activities of an enaminone derivative of 4-hydroxyquinolin-2(1H)-one against murine schistosomiasis mansoni. MedGenMed : Medscape general medicine. 2007 Jan; 9(1):15. doi: . [PMID: 17435624]
  • Thomas D Harris, Shirley Kalogeropoulos, Tiffany Nguyen, Gregory Dwyer, D Scott Edwards, Shuang Liu, Judit Bartis, Charles Ellars, Dave Onthank, Padmaja Yalamanchili, Stuart Heminway, Simon Robinson, Joel Lazewatsky, John Barrett. Structure-activity relationships of 111In- and 99mTc-labeled quinolin-4-one peptidomimetics as ligands for the vitronectin receptor: potential tumor imaging agents. Bioconjugate chemistry. 2006 Sep; 17(5):1294-313. doi: 10.1021/bc060063s. [PMID: 16984141]
  • Donghui Yang, Shaoqing Cai, Hongyu Liu, Xinxin Guo, Changling Li, Mingying Shang, Xuan Wang, Yuying Zhao. On-line identification of the constituents of Buyang Huanwu decoction in pig serum using combined HPLC-DAD-MS techniques. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Feb; 831(1-2):288-302. doi: 10.1016/j.jchromb.2005.12.032. [PMID: 16406846]
  • T P T Cushnie, A J Lamb. Assessment of the antibacterial activity of galangin against 4-quinolone resistant strains of Staphylococcus aureus. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2006 Feb; 13(3):187-91. doi: 10.1016/j.phymed.2004.07.003. [PMID: 16428027]
  • Kathrin Dittmann, Ulrike Riese, Matthias Hamburger. HPLC-based bioactivity profiling of plant extracts: a kinetic assay for the identification of monoamine oxidase-A inhibitors using human recombinant monoamine oxidase-A. Phytochemistry. 2004 Nov; 65(21):2885-91. doi: 10.1016/j.phytochem.2004.07.024. [PMID: 15501256]
  • Zai-Qun Liu, Kun Han, Ying-Jie Lin, Xu-Yang Luo. Antioxidative or prooxidative effect of 4-hydroxyquinoline derivatives on free-radical-initiated hemolysis of erythrocytes is due to its distributive status. Biochimica et biophysica acta. 2002 Mar; 1570(2):97-103. doi: 10.1016/s0304-4165(02)00159-9. [PMID: 11985893]
  • M Rizk, F Belal, F Ibrahim, S Ahmed, Z A Sheribah. Derivative spectrophotometric analysis of 4-quinolone antibacterials in formulations and spiked biological fluids by their Cu(II) complexes. Journal of AOAC International. 2001 Mar; 84(2):368-75. doi: . [PMID: 11324600]