N6-Methyl-2-deoxyadenosine (BioDeep_00000003065)

   

Antitumor activity


代谢物信息卡片


n6-methyl-2-deoxy-adenosine

化学式: C11H15N5O3 (265.117484)
中文名称: N6-甲基-2-脱氧腺苷
谱图信息: 最多检出来源 Viridiplantae(plant) 66.67%

分子结构信息

SMILES: CNC1=C2C(=NC=N1)N(C=N2)C3CC(C(O3)CO)O
InChI: InChI=1S/C11H15N5O3/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(18)7(3-17)19-8/h4-8,17-18H,2-3H2,1H3,(H,12,13,14)/t6-,7+,8+/m0/s1

描述信息

KEIO_ID M110; [MS2] KO009042
KEIO_ID M110
N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

同义名列表

4 个代谢物同义名

n6-methyl-2-deoxy-adenosine; N6-Methyl-2-deoxyadenosine; Adenosine,2-deoxy-N-methyl-; N-6-Methyl-2-deoxyadenosine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Elizabeth Tran, Haiyan Sun, Ye Fang. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors. Assay and drug development technologies. 2012 Feb; 10(1):37-45. doi: 10.1089/adt.2011.0392. [PMID: 22066912]
  • Taras Lyubchenko, Heather Woodward, Kristopher D Veo, Nana Burns, Hala Nijmeh, Ganna A Liubchenko, Kurt R Stenmark, Evgenia V Gerasimovskaya. P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells. American journal of physiology. Cell physiology. 2011 Feb; 300(2):C266-75. doi: 10.1152/ajpcell.00237.2010. [PMID: 20962269]
  • Zhiyun Wang, Pao-Lin Che, Jian Du, Barbara Ha, Kevin J Yarema. Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385. PloS one. 2010 Nov; 5(11):e13883. doi: 10.1371/journal.pone.0013883. [PMID: 21079735]
  • Andrés Norambuena, M Inés Poblete, M Verónica Donoso, C Sofía Espinoza, Alfonso González, J Pablo Huidobro-Toro. P2Y1 receptor activation elicits its partition out of membrane rafts and its rapid internalization from human blood vessels: implications for receptor signaling. Molecular pharmacology. 2008 Dec; 74(6):1666-77. doi: 10.1124/mol.108.048496. [PMID: 18799799]
  • Jing-Jun Sun, Ying Liu, Zhu-Rong Ye. Effects of P2Y1 receptor on glial fibrillary acidic protein and glial cell line-derived neurotrophic factor production of astrocytes under ischemic condition and the related signaling pathways. Neuroscience bulletin. 2008 Aug; 24(4):231-43. doi: 10.1007/s12264-008-0430-x. [PMID: 18668152]
  • Sandra M Penz, Armin J Reininger, Orsolya Toth, Hans Deckmyn, Richard Brandl, Wolfgang Siess. Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques. Thrombosis and haemostasis. 2007 Mar; 97(3):435-43. doi: . [PMID: 17334511]
  • Liaman K Mamedova, Zhan-Guo Gao, Kenneth A Jacobson. Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors. Biochemical pharmacology. 2006 Oct; 72(8):1031-41. doi: 10.1016/j.bcp.2006.07.017. [PMID: 16934758]
  • Kerstin Wirkner, Attila Köfalvi, Wolfgang Fischer, Albrecht Günther, Heike Franke, Helke Gröger-Arndt, Wolfgang Nörenberg, Emília Madarász, E Sylvester Vizi, Dietmar Schneider, Beáta Sperlágh, Peter Illes. Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia. Journal of neurochemistry. 2005 Dec; 95(5):1421-37. doi: 10.1111/j.1471-4159.2005.03465.x. [PMID: 16313518]
  • Ricardo J Rodrigues, Teresa Almeida, Peter J Richardson, Catarina R Oliveira, Rodrigo A Cunha. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Jul; 25(27):6286-95. doi: 10.1523/jneurosci.0628-05.2005. [PMID: 16000618]
  • Lingwei Wang, Göran Olivecrona, Matthias Götberg, Martin L Olsson, Maria Sörhede Winzell, David Erlinge. ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells. Circulation research. 2005 Feb; 96(2):189-96. doi: 10.1161/01.res.0000153670.07559.e4. [PMID: 15604418]
  • L Guerra, M Favia, T Fanelli, G Calamita, M Svetlo, A Bagorda, K A Jacobson, S J Reshkin, V Casavola. Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells. Pflugers Archiv : European journal of physiology. 2004 Oct; 449(1):66-75. doi: 10.1007/s00424-004-1293-2. [PMID: 15235914]
  • Catherine Leon, Catherine Ravanat, Monique Freund, Jean-Pierre Cazenave, Christian Gachet. Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity. Arteriosclerosis, thrombosis, and vascular biology. 2003 Oct; 23(10):1941-7. doi: 10.1161/01.atv.0000092127.16125.e6. [PMID: 12933533]
  • C Léon, M Freund, C Ravanat, A Baurand, J P Cazenave, C Gachet. Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist. Circulation. 2001 Feb; 103(5):718-23. doi: 10.1161/01.cir.103.5.718. [PMID: 11156884]
  • J C Rogers, S W Rogers. Comparison of the effects of N6-methyldeoxyadenosine and N5-methyldeoxycytosine on transcription from nuclear gene promoters in barley. The Plant journal : for cell and molecular biology. 1995 Feb; 7(2):221-33. doi: 10.1046/j.1365-313x.1995.7020221.x. [PMID: 7704046]