Medroxyprogesteroneacetate (BioDeep_00000003062)

 

Secondary id: BioDeep_00000399087

PANOMIX_OTCML-2023


代谢物信息卡片


Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6.alpha.)-

化学式: C24H34O4 (386.2457)
中文名称: 安宫黄体酮
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 20.79%

分子结构信息

SMILES: CC(=O)OC1(C(C)=O)CCC2C3CC(C)C4=CC(=O)CCC4(C)C3CCC21C
InChI: InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
CONFIDENCE standard compound; INTERNAL_ID 8749
CONFIDENCE standard compound; INTERNAL_ID 2813
D000970 - Antineoplastic Agents
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].

同义名列表

6 个代谢物同义名

Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6.alpha.)-; Medroxyprogesterone 17-acetate; Medroxyprogesterone acetate; Medroxyprogesteroneacetate; Farlutin; Medroxyprogesterone acetate



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AKT1, BCL2, CCND1, CDKN1A, ESR1, PGR, PRL, TBX20, VEGFA
Peripheral membrane protein 1 ESR1
Endoplasmic reticulum membrane 2 BCL2, CYP19A1
Nucleus 10 AKT1, BCL2, CCND1, CDKN1A, ESR1, PCNA, PGR, PRL, TBX20, VEGFA
cytosol 6 AKT1, BCL2, CCND1, CDKN1A, ESR1, PGR
nuclear body 2 CDKN1A, PCNA
centrosome 2 CCND1, PCNA
nucleoplasm 7 AKT1, CCND1, CDKN1A, ESR1, PCNA, PGR, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 3 AKT1, ESR1, TNF
Cytoplasmic side 1 ESR1
lamellipodium 1 AKT1
Multi-pass membrane protein 1 CYP19A1
cell cortex 1 AKT1
cell surface 3 PLG, TNF, VEGFA
glutamatergic synapse 2 AKT1, PLG
Golgi apparatus 2 ESR1, VEGFA
neuronal cell body 1 TNF
postsynapse 1 AKT1
plasma membrane 7 AKT1, ESR1, F2, F7, PGR, PLG, TNF
Membrane 5 AKT1, BCL2, CYP19A1, ESR1, VEGFA
extracellular exosome 4 F2, PCNA, PLG, SHBG
endoplasmic reticulum 3 BCL2, CYP19A1, VEGFA
extracellular space 10 CXCL8, F2, F7, GNRH1, IGF1, IL6, PLG, PRL, TNF, VEGFA
perinuclear region of cytoplasm 1 CDKN1A
Schaffer collateral - CA1 synapse 1 PLG
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
mitochondrion 1 BCL2
protein-containing complex 4 AKT1, BCL2, CDKN1A, ESR1
Microsome membrane 1 CYP19A1
Secreted 9 CXCL8, F2, F7, IGF1, IL6, PLG, PRL, SHBG, VEGFA
extracellular region 11 CXCL8, F2, F7, GNRH1, IGF1, IL6, PLG, PRL, SHBG, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, PGR
transcription regulator complex 1 ESR1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 2 PLG, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
nucleolus 1 CDKN1A
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, F7
Membrane raft 1 TNF
pore complex 1 BCL2
spindle 1 AKT1
extracellular matrix 1 VEGFA
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 3 F2, F7, PLG
secretory granule 1 VEGFA
ciliary basal body 1 AKT1
chromatin 5 ESR1, PCNA, PGR, PRL, TBX20
phagocytic cup 1 TNF
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
blood microparticle 2 F2, PLG
endosome lumen 1 PRL
euchromatin 1 ESR1
replication fork 1 PCNA
myelin sheath 1 BCL2
exocytic vesicle 1 IGF1
Golgi lumen 2 F2, F7
endoplasmic reticulum lumen 3 F2, F7, IL6
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 3 IGF1, PLG, VEGFA
nuclear lamina 1 PCNA
[Isoform 1]: Nucleus 1 ESR1
cyclin-dependent protein kinase holoenzyme complex 3 CCND1, CDKN1A, PCNA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
interleukin-6 receptor complex 1 IL6
[Isoform 4]: Mitochondrion outer membrane 1 PGR
serine-type peptidase complex 1 F7
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 2 CDKN1A, PCNA
replisome 1 PCNA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Li Feng, Le Wang, Benjamin Hernández-Wolters, Kousalya Prabahar, Periyannan Velu, Hamed Kord-Varkaneh. The impact of medroxyprogesterone acetate on lipid profiles in Women: A time and dose-response meta-analysis of randomized controlled trials. Diabetes research and clinical practice. 2023 Dec; ?(?):111073. doi: 10.1016/j.diabres.2023.111073. [PMID: 38142749]
  • Awel Turki, Almaz Ayalew, Andualem Mossie, Shimelis Mitiku. Effects of hormonal contraceptives on lipid profile among women attending family planning unit in Goba Town Public Health Facilities, Bale, Southeast Ethiopia: a comparative cross-sectional study. Reproductive health. 2023 Dec; 20(1):185. doi: 10.1186/s12978-023-01727-4. [PMID: 38115027]
  • Qi Li, Zhao-di Kong, Huan Wang, Hong-Hui Gu, Zhong Chen, Shi-Guang Li, Yi-Qi Chen, Yu Cai, Zhen-Jiang Yang. Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by Directly Inhibiting E3 Ubiquitin Ligase. Chinese journal of integrative medicine. 2023 Aug; ?(?):. doi: 10.1007/s11655-023-3702-4. [PMID: 37612478]
  • Hikaru Murakami, Masami Hayashi, Shinichi Terada, Masahide Ohmichi. Medroxyprogesterone acetate-resistant endometrial cancer cells are susceptible to ferroptosis inducers. Life sciences. 2023 Jul; 325(?):121753. doi: 10.1016/j.lfs.2023.121753. [PMID: 37160245]
  • Bryan P Brown, Colin Feng, Ramla F Tanko, Shameem Z Jaumdally, Rubina Bunjun, Smritee Dabee, Anna-Ursula Happel, Melanie Gasper, Donald D Nyangahu, Maricianah Onono, Gonasagrie Nair, Thesla Palanee-Phillips, Caitlin W Scoville, Kate Heller, Jared M Baeten, Steven E Bosinger, Adam Burgener, Jo-Ann S Passmore, Renee Heffron, Heather B Jaspan. Copper intrauterine device increases vaginal concentrations of inflammatory anaerobes and depletes lactobacilli compared to hormonal options in a randomized trial. Nature communications. 2023 01; 14(1):499. doi: 10.1038/s41467-023-36002-4. [PMID: 36717556]
  • Endang Sri Wahyuni, Maryatun Maryatun, Nora Veri, Elly Susilawati, Lely Firrahmawati, Endah Sri Wahyuni, Riyani Wulandari. Green Tea Extract has a Protective Effect on Leptin and Lipid Profile Levels Due to the Induction of Depot Medroxyprogesterone Acetate. Medical archives (Sarajevo, Bosnia and Herzegovina). 2023; 77(3):173-177. doi: 10.5455/medarh.2023.77.173-177. [PMID: 37700918]
  • Rubina Bunjun, Tanko F Ramla, Shameem Z Jaumdally, Laura Noël-Romas, Hossaena Ayele, Bryan P Brown, Hoyam Gamieldien, Rushil Harryparsad, Smritee Dabee, Gonasagrie Nair, Maricianah Onono, Thesla Palanee-Phillips, Catilin W Scoville, Kate B Heller, Jared M Baeten, Steven E Bosinger, Adam Burgener, Jo-Ann S Passmore, Heather Jaspan, Renee Heffron. Initiating Intramuscular Depot Medroxyprogesterone Acetate Increases Frequencies of Th17-like Human Immunodeficiency Virus Target Cells in the Genital Tract of Women in South Africa: A Randomized Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 11; 75(11):2000-2011. doi: 10.1093/cid/ciac284. [PMID: 35941737]
  • Ramla F Tanko, Rubina Bunjun, Smritee Dabee, Shameem Z Jaumdally, Maricianah Onono, Gonasagrie Nair, Thesla Palanee-Phillips, Rushil Harryparsad, Anna Ursula Happel, Hoyam Gamieldien, Yamkela Qumbelo, Musalula Sinkala, Caitlin W Scoville, Kate Heller, Jared M Baeten, Steven E Bosinger, Adam Burgener, Renee Heffron, Heather B Jaspan, Jo Ann S Passmore. The Effect of Contraception on Genital Cytokines in Women Randomized to Copper Intrauterine Device, Depot Medroxyprogesterone Acetate, or Levonorgestrel Implant. The Journal of infectious diseases. 2022 09; 226(5):907-919. doi: 10.1093/infdis/jiac084. [PMID: 35263421]
  • Wenjing Gu, Akira Mitsuhashi, Tatsuya Kobayashi, Makio Shozu. Metformin attenuates the production and proliferative effects of prolactin induced by medroxyprogesterone acetate during fertility-sparing treatment for endometrial cancer. BMC cancer. 2022 Jul; 22(1):753. doi: 10.1186/s12885-022-09858-w. [PMID: 35820883]
  • Janice E Rowell, John E Blake, Kathleen M Roth, Courtney M Sutton, Colleen C Sachse, Andrea S Cupp, Thomas W Geary, Abigail L Zezeski, Brenda M Alexander, Robert L Ziegler, Milan P Shipka. Medroxyprogesterone acetate in reindeer bulls: testes histology, cfos activity in the brain, breeding success, and semen quality. Journal of animal science. 2022 Jun; 100(6):. doi: 10.1093/jas/skac106. [PMID: 35648129]
  • Gabriella Edfeldt, Julie Lajoie, Maria Röhl, Julius Oyugi, Alexandra Åhlberg, Behnaz Khalilzadeh-Binicy, Frideborg Bradley, Matthias Mack, Joshua Kimani, Kenneth Omollo, Carolina Wählby, Keith R Fowke, Kristina Broliden, Annelie Tjernlund. Regular Use of Depot Medroxyprogesterone Acetate Causes Thinning of the Superficial Lining and Apical Distribution of Human Immunodeficiency Virus Target Cells in the Human Ectocervix. The Journal of infectious diseases. 2022 04; 225(7):1151-1161. doi: 10.1093/infdis/jiaa514. [PMID: 32780807]
  • Yao Jiang, Andrew D Southam, Sandro Trova, Flavio Beke, Bader Alhazmi, Thomas Francis, Anshul Radotra, Alessandro di Maio, Mark T Drayson, Chris M Bunce, Farhat L Khanim. Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing. British journal of cancer. 2022 02; 126(2):275-286. doi: 10.1038/s41416-021-01570-z. [PMID: 34686779]
  • Intan Sofia Omar, Amira Hajirah Abd Jamil, Noor Azmi Mat Adenan, Ivy Chung. MPA alters metabolic phenotype of endometrial cancer-associated fibroblasts from obese women via IRS2 signaling. PloS one. 2022; 17(7):e0270830. doi: 10.1371/journal.pone.0270830. [PMID: 35816477]
  • Chih-Chen Chen, Chun-Yen Huang, Li-Yen Shiu, Ya-Chun Yu, Jui-Chi Lai, Chi-Chang Chang, Chi-Feng Fu, S Joseph Huang. Combinatory effects of current regimens and Guizhi Fuling Wan on the development of endometriosis. Taiwanese journal of obstetrics & gynecology. 2022 Jan; 61(1):70-74. doi: 10.1016/j.tjog.2021.11.013. [PMID: 35181049]
  • David W Haas, Rosie Mngqibisa, Jose Francis, Helen McIlleron, Jennifer A Robinson, Michelle A Kendall, Paxton Baker, Sajeeda Mawlana, Sharlaa Badal-Faesen, Francis Angira, Ayotunde Omoz-Oarhe, Wadzanai P Samaneka, Paolo Denti, Susan E Cohn. Pharmacogenetics of interaction between depot medroxyprogesterone acetate and efavirenz, rifampicin, and isoniazid during treatment of HIV and tuberculosis. Pharmacogenetics and genomics. 2022 01; 32(1):24-30. doi: 10.1097/fpc.0000000000000448. [PMID: 34369424]
  • Jose Francis, Rosie Mngqibisa, Helen McIlleron, Michelle A Kendall, Xingye Wu, Kelly E Dooley, Cynthia Firnhaber, Catherine Godfrey, Susan E Cohn, Paolo Denti. A Semimechanistic Pharmacokinetic Model for Depot Medroxyprogesterone Acetate and Drug-Drug Interactions With Antiretroviral and Antituberculosis Treatment. Clinical pharmacology and therapeutics. 2021 10; 110(4):1057-1065. doi: 10.1002/cpt.2324. [PMID: 34151439]
  • Audrey M Burlando, Anne N Flynn, Sarah Gutman, Arden McAllister, Andrea H Roe, Courtney A Schreiber, Sarita Sonalkar. The Role of Subcutaneous Depot Medroxyprogesterone Acetate in Equitable Contraceptive Care: A Lesson From the Coronavirus Disease 2019 (COVID-19) Pandemic. Obstetrics and gynecology. 2021 10; 138(4):574-577. doi: 10.1097/aog.0000000000004524. [PMID: 34623069]
  • Ruihong Cai, Beihong Zheng, Qiupin Lin, Jie Deng, Xiaoping Zeng, Wei Lin, Daohua Shi. A meta-analysis of the efficacy of progestin-primed ovarian stimulation with medroxyprogesterone acetate in ovulation induction in poor ovarian responders. Journal of gynecology obstetrics and human reproduction. 2021 Sep; 50(7):102049. doi: 10.1016/j.jogoh.2020.102049. [PMID: 33387677]
  • Juan Giles, Pilar Alama, Pilar Gamiz, Carmen Vidal, Paloma Badia, Antonio Pellicer, Ernesto Bosch. Medroxyprogesterone acetate is a useful alternative to a gonadotropin-releasing hormone antagonist in oocyte donation: a randomized, controlled trial. Fertility and sterility. 2021 08; 116(2):404-412. doi: 10.1016/j.fertnstert.2021.02.036. [PMID: 33814126]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Zhenni Mu, Yuanhong Sa, Zhengao Sun, Yang Yi. Ovulation induction with high progesterone levels may be more suitable for elderly patients with low ovarian response. Journal of gynecology obstetrics and human reproduction. 2021 Feb; 50(2):101661. doi: 10.1016/j.jogoh.2019.101661. [PMID: 31809957]
  • Jonathan J Sheard, Andrew D Southam, Hannah L MacKay, Max A Ellington, Martyn D Snow, Farhat L Khanim, Christopher M Bunce, William E Johnson. Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells. Bioscience reports. 2021 01; 41(1):. doi: 10.1042/bsr20202505. [PMID: 33289496]
  • Mulu Shiferaw, Woldeteklehaymanot Kassahun, Belay Zawdie. Anthropometric indices, blood pressure, and lipid profile status among women using progestin-only contraceptives: comparative cross-sectional study. BMC women's health. 2021 01; 21(1):34. doi: 10.1186/s12905-021-01178-8. [PMID: 33485353]
  • G M Bragança, R I T P Batista, J M G Souza-Fabjan, V A P Alfradique, E K N Arashiro, P H N Pinto, J D R Santos, L S A Camargo, A Menchaca, J F da Fonseca, F Z Brandão. Exogenous progestogens differentially alter gene expression of immature cumulus-oocyte complexes in sheep. Domestic animal endocrinology. 2021 01; 74(?):106518. doi: 10.1016/j.domaniend.2020.106518. [PMID: 32711283]
  • Smritee Dabee, Ramla F Tanko, Bryan P Brown, Rubina Bunjun, Christina Balle, Colin Feng, Iyaloo N Konstantinus, Shameem Z Jaumdally, Maricianah Onono, Gonasagrie Nair, Thesla Palanee-Phillips, Katherine Gill, Jared M Baeten, Linda-Gail Bekker, Jo-Ann S Passmore, Renee Heffron, Heather B Jaspan, Anna-Ursula Happel. Comparison of Female Genital Tract Cytokine and Microbiota Signatures Induced by Initiation of Intramuscular DMPA and NET-EN Hormonal Contraceptives - a Prospective Cohort Analysis. Frontiers in immunology. 2021; 12(?):760504. doi: 10.3389/fimmu.2021.760504. [PMID: 34956191]
  • Micah Katz, Rebecca L Newmark, Alison Aronstam, Niamh O'Grady, Sara Strome, Sally Rafie, Jennifer Karlin. An implementation project to expand access to self-administered depot medroxyprogesterone acetate (DMPA). Contraception. 2020 12; 102(6):392-395. doi: 10.1016/j.contraception.2020.09.001. [PMID: 32931811]
  • Jessica Tarleton, Beatrice A Chen, Leslie A Meyn, Craig W Hendrix, Mark A Marzinke, Sharon L Achilles. Pharmacokinetic and Pharmacodynamic Impacts of Depot Medroxyprogesterone Acetate Use on HIV Pre-exposure Prophylaxis in Women. Journal of acquired immune deficiency syndromes (1999). 2020 10; 85(2):182-188. doi: 10.1097/qai.0000000000002421. [PMID: 32568766]
  • Juliana Dantas Rodrigues Santos, Rodolfo Ungerfeld, Mário Felipe Alvarez Balaro, Joanna Maria Gonçalves Souza-Fabjan, Isabel Oliveira Cosentino, Viviane Lopes Brair, Clara Vieira de Souza, Pedro Henrique Nicolau Pinto, Ana Luiza Cunha Bade, Jeferson Ferreira da Fonseca, Felipe Zandonadi Brandão. Transcervical vs. laparotomy embryo collection in ewes: The effectiveness and welfare implications of each technique. Theriogenology. 2020 Sep; 153(?):112-121. doi: 10.1016/j.theriogenology.2020.05.004. [PMID: 32450469]
  • Daniela Bispo, Victoria Fabris, Caroline A Lamb, Claudia Lanari, Luisa A Helguero, Ana M Gil. Hormone-Independent Mouse Mammary Adenocarcinomas with Different Metastatic Potential Exhibit Different Metabolic Signatures. Biomolecules. 2020 08; 10(9):. doi: 10.3390/biom10091242. [PMID: 32867141]
  • Nirk E Quispe Calla, Rodolfo D Vicetti Miguel, Linda Fritts, Christopher J Miller, Kristen M Aceves, Thomas L Cherpes. Exogenous sex steroids regulate genital epithelial barrier function in female rhesus macaques. Biology of reproduction. 2020 08; 103(2):310-317. doi: 10.1093/biolre/ioaa105. [PMID: 32542371]
  • Eva Lundström, Ivana Virijevic, Gunnar Söderqvist. Progestogen addition with low-dose levonorgestrel intrauterine system in menopausal hormone treatment gives less normal breast tissue proliferation than oral norethisterone acetate or medroxyprogesterone acetate. Hormone molecular biology and clinical investigation. 2020 Jul; 41(3):. doi: 10.1515/hmbci-2019-0051. [PMID: 32735552]
  • Rosie Mngqibisa, Michelle A Kendall, Kelly Dooley, Xingye Shirley Wu, Cynthia Firnhaber, Helen Mcilleron, Jennifer Robinson, Yoninah Cramer, Susan L Rosenkranz, Jhoanna Roa, Kristine Coughlin, Sajeeda Mawlana, Sharlaa Badal-Faesen, David Schnabel, Ayotunde Omoz-Oarhe, Wadzanai Samaneka, Catherine Godfrey, Susan E Cohn. Pharmacokinetics and Pharmacodynamics of Depot Medroxyprogesterone Acetate in African Women Receiving Treatment for Human Immunodeficiency Virus and Tuberculosis: Potential Concern for Standard Dosing Frequency. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 07; 71(3):517-524. doi: 10.1093/cid/ciz863. [PMID: 31504342]
  • Yang Chen, Yunxia Cui, Xiao Sun, Huiwen Wu, Manjiao Ou, Yunzhe Tang, Shuaishuai Ni, Xiaokang Li, Jin Zhu, Fei Mao, Yudong Wang, Jian Li. Repurposing of antipsychotics perphenazine for the treatment of endometrial cancer. Bioorganic & medicinal chemistry letters. 2020 07; 30(14):127239. doi: 10.1016/j.bmcl.2020.127239. [PMID: 32527541]
  • Osita U Ezenwosu, Barth F Chukwu, Ndubuisi A Uwaezuoke, Ifeyinwa L Ezenwosu, Anthony N Ikefuna, Ifeoma J Emodi. Glanzmann's thrombasthenia: a rare bleeding disorder in a Nigerian girl. African health sciences. 2020 Jun; 20(2):753-757. doi: 10.4314/ahs.v20i2.27. [PMID: 33163040]
  • Bijay K Sah, Sarathi Kundu. Behaviour of protein (BSA)-lipid (DMPA) mixed monolayer on the spreading order of the individual component. Chemistry and physics of lipids. 2019 12; 225(?):104810. doi: 10.1016/j.chemphyslip.2019.104810. [PMID: 31415733]
  • Nirk E Quispe Calla, Rodolfo D Vicetti Miguel, Kristen M Aceves, Angelo Torres, Thomas L Cherpes. Depot-medroxyprogesterone acetate reduces genital cell-cell adhesion molecule expression and increases genital herpes simplex virus type 2 infection susceptibility in a dose-dependent fashion. Contraception. 2019 11; 100(5):397-401. doi: 10.1016/j.contraception.2019.07.003. [PMID: 31302121]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Hiroyo Hashimoto, Hideaki Miyachi, Koki Kataoka, Yugo Maru, Yaei Togawa, Hiroyuki Matsue. Case of fertility treatment-induced Stevens-Johnson syndrome with a severe ocular complication. The Journal of dermatology. 2019 Nov; 46(11):1042-1045. doi: 10.1111/1346-8138.15072. [PMID: 31489686]
  • Rafael da Rosa Ulguim, André Luis Mallmann, Bernardo Garziera Gasperin, Mari Lourdes Bernardi, Ivo Wentz, Ana Paula Gonçalves Mellagi, Fernando Pandolfo Bortolozzo. Effects of intravaginal devices containing different dosages of medroxyprogesterone acetate for the control of the estrous cycle in gilts. Animal reproduction science. 2019 Nov; 210(?):106200. doi: 10.1016/j.anireprosci.2019.106200. [PMID: 31635772]
  • Jocelyn M Wessels, Julie Lajoie, Maeve I J Hay Cooper, Kenneth Omollo, Allison M Felker, Danielle Vitali, Haley A Dupont, Philip V Nguyen, Kristen Mueller, Fatemeh Vahedi, Joshua Kimani, Julius Oyugi, Juliana Cheruiyot, John N Mungai, Alexandre Deshiere, Michel J Tremblay, Tony Mazzulli, Jennifer C Stearns, Ali A Ashkar, Keith R Fowke, Michael G Surette, Charu Kaushic. Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice. Disease models & mechanisms. 2019 10; 12(10):. doi: 10.1242/dmm.039669. [PMID: 31537512]
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