Pregnanolone (BioDeep_00000002965)
Main id: BioDeep_00000028302
Secondary id: BioDeep_00000055252, BioDeep_00000864738
代谢物信息卡片
(3alpha,5beta)-3-hydroxypregnan-20-one
化学式: C21H34O2 (318.2558664)
中文名称: 孕烷醇酮
谱图信息:
最多检出来源 Homo sapiens(blood) 39.88%
分子结构信息
SMILES: C1C[C@@H](O)C[C@@]2([H])CC[C@]3([H])[C@@]([H])([C@]21C)CC[C@]1(C)[C@@]([H])(C(=O)C)CC[C@]13[H]
InChI: InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:1712
- KEGG: C05480
- PubChem: 31402
- Metlin: METLIN41891
- Metlin: METLIN57869
- DrugBank: DB12308
- ChEMBL: CHEMBL210952
- LipidMAPS: LMST02030175
- MeSH: Pregnanolone
- MetaCyc: 3-BETA-HYDROXY-5-ALPHA-PREGNANE-20-ONE
- CAS: 110350-90-8
- CAS: 128-20-1
- PMhub: MS000007548
- PubChem: 7840
- PDB-CCD: P9N
- 3DMET: B05054
- NIKKAJI: J6.567F
- RefMet: 3alpha-Hydroxy-5beta-pregnane-20-one
- KNApSAcK: 1712
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Julia V Bukanova, Elena I Solntseva, Vladimir G Skrebitsky. Factors promoting the release of picrotoxin from the trap in the GABA(A) receptor pore.
Neurochemistry international.
2024 May; 175(?):105703. doi:
10.1016/j.neuint.2024.105703. [PMID: 38395151] - Shaimaa Nasr Amin, Sherif Ahmed Shaltout, Walaa Bayoumie El Gazzar, Noha Samir Abdel Latif, Ghadah Nazar Al-Jussani, Yasmeen Jamal Alabdallat, Khaled Anwer Albakri, Dalia Azmy Elberry. Impact of NMDA receptors block versus GABA-A receptors modulation on synaptic plasticity and brain electrical activity in metabolic syndrome.
Advances in medical sciences.
2024 Mar; 69(1):176-189. doi:
10.1016/j.advms.2024.03.008. [PMID: 38561071] - Meiyue Dong, Yanyan Wang, Ping Li, Zinuo Chen, Varada Anirudhan, Qinghua Cui, Lijun Rong, Ruikun Du. Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor.
Virologica Sinica.
2023 Dec; 38(6):931-939. doi:
10.1016/j.virs.2023.09.003. [PMID: 37741571] - Hao Zhang, Mingqi Qiao, Dongmei Gao, Jieqiong Wang, Chunyan Sun, Ya Sun, Yang Zhang, Huayuan Liu, Zhen Zhang, Mingzhou Gao. Shuyu capsule alleviates premenstrual depression via allopregnanolone metabolic pathway targeting GABA (A) receptors δ subunit in the hippocampus.
Asian journal of psychiatry.
2023 Oct; 90(?):103800. doi:
10.1016/j.ajp.2023.103800. [PMID: 37898099] - Ya Sun, Mingzhou Gao, Dongmei Gao, Dan Chen, Jieqiong Wang. Allopregnanolone-mediated GABAA-Rα4 function in amygdala and hippocampus of PMDD liver qi-invasion syndrome model rats.
Aging.
2023 Feb; 15(?):. doi:
10.18632/aging.204541. [PMID: 36842096] - Veronica Antipova, Lisa-Marie Steinhoff, Carsten Holzmann, Arndt Rolfs, Carlos Junior Hempel, Martin Witt, Andreas Wree. Organ Weights in NPC1 Mutant Mice Partly Normalized by Various Pharmacological Treatment Approaches.
International journal of molecular sciences.
2022 Dec; 24(1):. doi:
10.3390/ijms24010573. [PMID: 36614015] - Mingzhou Gao, Hao Zhang, Ya Sun, Zhan Gao, Chunyan Sun, Fengqin Wei, Dongmei Gao. Gabrb2 knock-out mice exhibit double-directed PMDD-like symptoms: GABAAR subunits, neurotransmitter metabolism disruption, and allopregnanolone binding.
Aging.
2022 10; 14(20):8437-8447. doi:
10.18632/aging.204351. [PMID: 36287173] - Johanna Molin, Eszter Vanky, Tone S Løvvik, Eva Dehlin, Marie Bixo. Gestational weight gain, appetite regulating hormones, and metformin treatment in polycystic ovary syndrome: A longitudinal, placebo-controlled study.
BJOG : an international journal of obstetrics and gynaecology.
2022 06; 129(7):1112-1121. doi:
10.1111/1471-0528.17042. [PMID: 34865304] - Irene Vuu, Edward E Patterson, Chun-Yi Wu, Dorota Zolkowska, Ilo E Leppik, Michael A Rogawski, Gregory A Worrell, Vaclav Kremen, James C Cloyd, Lisa D Coles. Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs.
The Journal of pharmacology and experimental therapeutics.
2022 02; 380(2):104-113. doi:
10.1124/jpet.121.000736. [PMID: 34862270] - Torbjörn Bäckström, Roshni Das, Marie Bixo. Positive GABAA receptor modulating steroids and their antagonists: Implications for clinical treatments.
Journal of neuroendocrinology.
2022 02; 34(2):e13013. doi:
10.1111/jne.13013. [PMID: 34337790] - Silvia Diviccaro, Valentina Caputi, Lucia Cioffi, Silvia Giatti, Joshua M Lyte, Donatella Caruso, Siobhain M O'Mahony, Roberto Cosimo Melcangi. Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212551. [PMID: 34830433] - Gabrielle K Crombie, Hannah K Palliser, Julia C Shaw, Deborah M Hodgson, David W Walker, Jonathan J Hirst. Neurosteroid-based intervention using Ganaxolone and Emapunil for improving stress-induced myelination deficits and neurobehavioural disorders.
Psychoneuroendocrinology.
2021 11; 133(?):105423. doi:
10.1016/j.psyneuen.2021.105423. [PMID: 34601389] - G Mayne, E De Bloois, D Dabelea, U Christians. Development and validation of an LC-MS/MS assay for the quantification of allopregnanolone and its progesterone-derived isomers, precursors, and cortisol/cortisone in pregnancy.
Analytical and bioanalytical chemistry.
2021 Sep; 413(21):5427-5438. doi:
10.1007/s00216-021-03523-0. [PMID: 34279681] - Bo Qian, Zeng Zen, Zhaoxuan Zheng, Chengqiang Wang, Jiale Song. A preliminary study on the mechanism of the neurosteroid-mediated ionotropic receptor dysfunction in neurodevelopmental toxicity induced by decabromodiphenyl ether.
Ecotoxicology and environmental safety.
2021 Jul; 217(?):112198. doi:
10.1016/j.ecoenv.2021.112198. [PMID: 33862428] - Donna Elizabeth Sunny, Elke Hammer, Till Ittermann, Elisabeth Luise Krüger, Stephanie Hübner, Michaela Friederike Hartmann, Stefan Alexander Wudy, Uwe Völker, Matthias Heckmann. Fetal Zone Steroids and Estrogen Show Sex Specific Effects on Oligodendrocyte Precursor Cells in Response to Oxidative Damage.
International journal of molecular sciences.
2021 Jun; 22(12):. doi:
10.3390/ijms22126586. [PMID: 34205405] - Melanie H Jacobson, Cheryl R Stein, Mengling Liu, Marra G Ackerman, Jennifer K Blakemore, Sara E Long, Graziano Pinna, Raquel Romay-Tallon, Kurunthachalam Kannan, Hongkai Zhu, Leonardo Trasande. Prenatal Exposure to Bisphenols and Phthalates and Postpartum Depression: The Role of Neurosteroid Hormone Disruption.
The Journal of clinical endocrinology and metabolism.
2021 06; 106(7):1887-1899. doi:
10.1210/clinem/dgab199. [PMID: 33792735] - Sahruh Turkmen, Torbjörn Bäckström, Yvonne Kangas Flodin, Marie Bixo. Neurosteroid involvement in threatened preterm labour.
Endocrinology, diabetes & metabolism.
2021 04; 4(2):e00216. doi:
10.1002/edm2.216. [PMID: 33855217] - Cecilia Rustichelli, Elisa Bellei, Stefania Bergamini, Emanuela Monari, Flavia Lo Castro, Carlo Baraldi, Aldo Tomasi, Anna Ferrari. Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study.
The journal of headache and pain.
2021 Mar; 22(1):13. doi:
10.1186/s10194-021-01231-9. [PMID: 33757421] - Valérie Jolivel, Susana Brun, Fabien Binamé, Jérémie Benyounes, Omar Taleb, Dominique Bagnard, Jérôme De Sèze, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan. Microglial Cell Morphology and Phagocytic Activity Are Critically Regulated by the Neurosteroid Allopregnanolone: A Possible Role in Neuroprotection.
Cells.
2021 03; 10(3):. doi:
10.3390/cells10030698. [PMID: 33801063] - Giorgia Boero, Ryan E Tyler, Caroline A Todd, Todd K O'Buckley, Irina Balan, Joyce Besheer, A Leslie Morrow. (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) regulation of hypothalamic and extrahypothalamic corticotropin releasing factor (CRF): Sexual dimorphism and brain region specificity in Sprague Dawley rats.
Neuropharmacology.
2021 03; 186(?):108463. doi:
10.1016/j.neuropharm.2021.108463. [PMID: 33460689] - Gabrielle K Crombie, Hannah K Palliser, Julia C Shaw, Deborah M Hodgson, David W Walker, Jonathan J Hirst. Effects of prenatal stress on behavioural and neurodevelopmental outcomes are altered by maternal separation in the neonatal period.
Psychoneuroendocrinology.
2021 02; 124(?):105060. doi:
10.1016/j.psyneuen.2020.105060. [PMID: 33333379] - Leila Chew, Kevin L Sun, Wenchao Sun, Zhe Wang, Jayakumar Rajadas, Ryan E Flores, Emily Arnold, Booil Jo, Lawrence K Fung. Association of serum allopregnanolone with restricted and repetitive behaviors in adult males with autism.
Psychoneuroendocrinology.
2021 01; 123(?):105039. doi:
10.1016/j.psyneuen.2020.105039. [PMID: 33161257] - Graziano Pinna. Sex and COVID-19: A Protective Role for Reproductive Steroids.
Trends in endocrinology and metabolism: TEM.
2021 01; 32(1):3-6. doi:
10.1016/j.tem.2020.11.004. [PMID: 33229187] - Kristina M Deligiannidis, Aimee R Kroll-Desrosiers, Yanglan Tan, Michelle L Dubuke, Scott A Shaffer. Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.
Psychoneuroendocrinology.
2020 11; 121(?):104827. doi:
10.1016/j.psyneuen.2020.104827. [PMID: 32828068] - Michael Schumacher, Philippe Liere, Abdelmoumen Ghoumari. Progesterone and fetal-neonatal neuroprotection.
Best practice & research. Clinical obstetrics & gynaecology.
2020 Nov; 69(?):50-61. doi:
10.1016/j.bpobgyn.2020.09.001. [PMID: 33039311] - Cecilia Rustichelli, Elisa Bellei, Stefania Bergamini, Emanuela Monari, Carlo Baraldi, Flavia Lo Castro, Aldo Tomasi, Anna Ferrari. Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study.
Cephalalgia : an international journal of headache.
2020 10; 40(12):1355-1362. doi:
10.1177/0333102420937742. [PMID: 32588652] - Eileen E Parks, Sreemathi Logan, Alexander Yeganeh, Julie A Farley, Daniel B Owen, William E Sonntag. Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.
Journal of lipid research.
2020 10; 61(10):1308-1319. doi:
10.1194/jlr.ra119000479. [PMID: 32669383] - Antonella Rosario Ramona Cáceres, Adriana Soledad Vega Orozco, Ricardo Jorge Cabrera, Myriam Raquel Laconi. "Rapid actions of the neurosteroid allopregnanolone on ovarian and hypothalamic steroidogenesis: Central and peripheral modulation".
Journal of neuroendocrinology.
2020 03; 32(3):e12836. doi:
10.1111/jne.12836. [PMID: 32062869] - Chao Shang, Ying Guo, Jun-Qi Yao, Xin-Xin Fang, Li-Jun Sun, Xiang-Yun Jiang, Zhen-Chun Ding, Yu-Hua Ran, Heng-Lin Wang, Li-Ming Zhang, Yun-Feng Li. Rapid anti-PTSD-like activity of the TSPO agonist YL-IPA08: Emphasis on brain GABA, neurosteroids and HPA axis function.
Behavioural brain research.
2020 02; 379(?):112320. doi:
10.1016/j.bbr.2019.112320. [PMID: 31669345] - Allison Kimball, Laura E Dichtel, Maren B Nyer, David Mischoulon, Lauren B Fisher, Cristina Cusin, Christina M Dording, Nhi-Ha Trinh, Albert Yeung, Melanie S Haines, Joshua C Sung, Graziano Pinna, Ann M Rasmusson, Linda L Carpenter, Maurizio Fava, Anne Klibanski, Karen Klahr Miller. The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause.
Psychoneuroendocrinology.
2020 02; 112(?):104512. doi:
10.1016/j.psyneuen.2019.104512. [PMID: 31780185] - Tomasz Misztal, Patrycja Młotkowska, Elżbieta Marciniak, Anna Misztal. Allopregnanolone reduces neuroendocrine response to acute stressful stimuli in sheep.
The Journal of endocrinology.
2020 01; 244(1):201-211. doi:
10.1530/joe-19-0376. [PMID: 31600724] - Tian Wang, Jia Yao, Shuhua Chen, Zisu Mao, Roberta Diaz Brinton. Allopregnanolone Reverses Bioenergetic Deficits in Female Triple Transgenic Alzheimer's Mouse Model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2020 01; 17(1):178-188. doi:
10.1007/s13311-019-00793-6. [PMID: 31664643] - Li Ren, Qing Song, Yunhuan Liu, Lihua Zhang, Zhiming Hao, Wenke Feng. Probiotic Lactobacillus rhamnosus GG prevents progesterone metabolite epiallaopregnanolone sulfate-induced hepatic bile acid accumulation and liver injury.
Biochemical and biophysical research communications.
2019 11; 520(1):67-72. doi:
10.1016/j.bbrc.2019.09.103. [PMID: 31575408] - Wei Zheng, Dong-Bin Cai, Wei Zheng, Kang Sim, Gabor S Ungvari, Xiao-Jiang Peng, Yu-Ping Ning, Gang Wang, Yu-Tao Xiang. Brexanolone for postpartum depression: A meta-analysis of randomized controlled studies.
Psychiatry research.
2019 09; 279(?):83-89. doi:
10.1016/j.psychres.2019.07.006. [PMID: 31323375] - Anna-Maria Neßlauer, Anne Gläser, Markus Gräler, Robby Engelmann, Brigitte Müller-Hilke, Marcus Frank, Christine Burstein, Arndt Rolfs, John Neidhardt, Andreas Wree, Martin Witt, Anja U Bräuer. A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1.
Lipids in health and disease.
2019 Jun; 18(1):146. doi:
10.1186/s12944-019-1088-2. [PMID: 31248418] - Zhiyi Yu, David C Chiara, Pavel Y Savechenkov, Karol S Bruzik, Jonathan B Cohen. A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.
The Journal of biological chemistry.
2019 05; 294(19):7892-7903. doi:
10.1074/jbc.ra118.007172. [PMID: 30923128] - Eleonora Napoli, Andrea Schneider, Jun Yi Wang, Aditi Trivedi, Nika Roa Carrillo, Flora Tassone, Michael Rogawski, Randi J Hagerman, Cecilia Giulivi. Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study.
Molecular neurobiology.
2019 May; 56(5):3702-3713. doi:
10.1007/s12035-018-1330-3. [PMID: 30187385] - Doodipala Samba Reddy, Chase Matthew Carver, Bryan Clossen, Xin Wu. Extrasynaptic γ-aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures.
Epilepsia.
2019 04; 60(4):730-743. doi:
10.1111/epi.14693. [PMID: 30895610] - Ariela Frieder, Madeleine Fersh, Rachel Hainline, Kristina M Deligiannidis. Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development.
CNS drugs.
2019 03; 33(3):265-282. doi:
10.1007/s40263-019-00605-7. [PMID: 30790145] - Kristina M Deligiannidis, Christina L Fales, Aimee R Kroll-Desrosiers, Scott A Shaffer, Vanessa Villamarin, Yanglan Tan, Janet E Hall, Blaise B Frederick, Elif M Sikoglu, Richard A Edden, Anthony J Rothschild, Constance M Moore. Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2019 02; 44(3):546-554. doi:
10.1038/s41386-018-0242-2. [PMID: 30327498] - Imane Lejri, Anastasia Agapouda, Amandine Grimm, Anne Eckert. Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence.
Oxidative medicine and cellular longevity.
2019; 2019(?):9695412. doi:
10.1155/2019/9695412. [PMID: 31214285] - Qing-Yun Guo, Ken Ebihara, Takafumi Shimodaira, Hironori Fujiwara, Kazufumi Toume, Dya Fita Dibwe, Suresh Awale, Ryota Araki, Takeshi Yabe, Kinzo Matsumoto. Kami-shoyo-san improves ASD-like behaviors caused by decreasing allopregnanolone biosynthesis in an SKF mouse model of autism.
PloS one.
2019; 14(1):e0211266. doi:
10.1371/journal.pone.0211266. [PMID: 30703109] - Ying Sze, Andrew C Gill, Paula J Brunton. Sex-dependent changes in neuroactive steroid concentrations in the rat brain following acute swim stress.
Journal of neuroendocrinology.
2018 11; 30(11):e12644. doi:
10.1111/jne.12644. [PMID: 30194779] - Dorota Zolkowska, Chun-Yi Wu, Michael A Rogawski. Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus.
Epilepsia.
2018 10; 59 Suppl 2(?):220-227. doi:
10.1111/epi.13999. [PMID: 29453777] - S L Pineles, Y I Nillni, G Pinna, J Irvine, A Webb, K A Arditte Hall, R Hauger, M W Miller, P A Resick, S P Orr, A M Rasmusson. PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma.
Psychoneuroendocrinology.
2018 07; 93(?):133-141. doi:
10.1016/j.psyneuen.2018.04.024. [PMID: 29727810] - Maja Johansson, Maria Månsson, Lars-Eric Lins, Bruce Scharschmidt, Magnus Doverskog, Torbjörn Bäckström. GR3027 reversal of neurosteroid-induced, GABA-A receptor-mediated inhibition of human brain function: an allopregnanolone challenge study.
Psychopharmacology.
2018 05; 235(5):1533-1543. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
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International journal of molecular sciences.
2018 Mar; 19(4):. doi:
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Physiology & behavior.
2018 02; 184(?):172-178. doi:
10.1016/j.physbeh.2017.11.027. [PMID: 29179996] - Radoslaw Slopien, Nicola Pluchino, Alina Warenik-Szymankiewicz, Stefan Sajdak, Michele Luisi, Panagiotis Drakopoulos, Andrea R Genazzani. Correlation between allopregnanolone levels and depressive symptoms during late menopausal transition and early postmenopause.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2018 Feb; 34(2):144-147. doi:
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Frontiers in neuroendocrinology.
2018 01; 48(?):70-77. doi:
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Alcoholism, clinical and experimental research.
2018 Jan; 42(1):12-20. doi:
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Biochimica et biophysica acta. Molecular basis of disease.
2017 12; 1863(12):3016-3027. doi:
10.1016/j.bbadis.2017.09.007. [PMID: 28899788] - Brittany L Mason, Erin Van Enkevort, Francesca Filbey, Christine E Marx, John Park, Alyson Nakamura, Prabha Sunderajan, E Sherwood Brown. Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders.
Journal of clinical psychopharmacology.
2017 Dec; 37(6):684-688. doi:
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The Biochemical journal.
2017 11; 474(23):3985-3999. doi:
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The Journal of steroid biochemistry and molecular biology.
2017 11; 174(?):201-216. doi:
10.1016/j.jsbmb.2017.09.015. [PMID: 28951257] - Antonio G Gomes de Mello Martins, Giuseppe Allegretta, Gerhard Unteregger, Jörg Haupenthal, Jens Eberhard, Michael Hoffmann, Jill A van der Zee, Kerstin Junker, Michael Stöckle, Rolf Müller, Rolf W Hartmann, Carsten-H Ohlmann. CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone.
The Journal of steroid biochemistry and molecular biology.
2017 11; 174(?):183-191. doi:
10.1016/j.jsbmb.2017.09.006. [PMID: 28890368] - Greer A Bennett, Hannah K Palliser, Julia C Shaw, Kerrin L Palazzi, David W Walker, Jonathan J Hirst. Maternal stress in pregnancy affects myelination and neurosteroid regulatory pathways in the guinea pig cerebellum.
Stress (Amsterdam, Netherlands).
2017 11; 20(6):580-588. doi:
10.1080/10253890.2017.1378637. [PMID: 28969480] - A L Cumberland, H K Palliser, P Rani, D W Walker, J J Hirst. Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal guinea pig model.
Journal of developmental origins of health and disease.
2017 Oct; 8(5):584-596. doi:
10.1017/s2040174417000307. [PMID: 28502262] - Maria Giuseppina Pisu, Giorgia Boero, Francesca Biggio, Anna Garau, Daniela Corda, Mauro Congiu, Alessandra Concas, Patrizia Porcu, Mariangela Serra. Juvenile social isolation affects maternal care in rats: involvement of allopregnanolone.
Psychopharmacology.
2017 Sep; 234(17):2587-2596. doi:
10.1007/s00213-017-4661-2. [PMID: 28623385] - Jeremiah P Jensen, Michelle A Nipper, Melinda L Helms, Matthew M Ford, John C Crabbe, David J Rossi, Deborah A Finn. Ethanol withdrawal-induced dysregulation of neurosteroid levels in plasma, cortex, and hippocampus in genetic animal models of high and low withdrawal.
Psychopharmacology.
2017 Sep; 234(18):2793-2811. doi:
10.1007/s00213-017-4671-0. [PMID: 28664280] - Charlotte Hellgren, Erika Comasco, Alkistis Skalkidou, Inger Sundström-Poromaa. Allopregnanolone levels and depressive symptoms during pregnancy in relation to single nucleotide polymorphisms in the allopregnanolone synthesis pathway.
Hormones and behavior.
2017 08; 94(?):106-113. doi:
10.1016/j.yhbeh.2017.06.008. [PMID: 28666923] - Sabrina K Syan, Luciano Minuzzi, Dustin Costescu, Mara Smith, Olivia R Allega, Marg Coote, Geoffrey B C Hall, Benicio N Frey. Influence of endogenous estradiol, progesterone, allopregnanolone, and dehydroepiandrosterone sulfate on brain resting state functional connectivity across the menstrual cycle.
Fertility and sterility.
2017 05; 107(5):1246-1255.e4. doi:
10.1016/j.fertnstert.2017.03.021. [PMID: 28476183] - Anja Meyer, Andreas Wree, René Günther, Carsten Holzmann, Oliver Schmitt, Arndt Rolfs, Martin Witt. Increased Regenerative Capacity of the Olfactory Epithelium in Niemann-Pick Disease Type C1.
International journal of molecular sciences.
2017 Apr; 18(4):. doi:
10.3390/ijms18040777. [PMID: 28383485] - Matthew C Beattie, Antoniette M Maldonado-Devincci, Patrizia Porcu, Todd K O'Buckley, James B Daunais, Kathleen A Grant, A Leslie Morrow. Voluntary ethanol consumption reduces GABAergic neuroactive steroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) in the amygdala of the cynomolgus monkey.
Addiction biology.
2017 Mar; 22(2):318-330. doi:
10.1111/adb.12326. [PMID: 26625954] - Luana Lionetto, Fernando De Andrés, Matilde Capi, Martina Curto, Donata Sabato, Maurizio Simmaco, Paola Bossù, Eleonora Sacchinelli, Maria Donata Orfei, Federica Piras, Nerisa Banaj, Gianfranco Spalletta. LC-MS/MS simultaneous analysis of allopregnanolone, epiallopregnanolone, pregnanolone, dehydroepiandrosterone and dehydroepiandrosterone 3-sulfate in human plasma.
Bioanalysis.
2017 Mar; 9(6):527-539. doi:
10.4155/bio-2016-0262. [PMID: 28207286] - Yuyong Ke, Renaud Gonthier, Fernand Labrie. A sensitive and accurate LC-MS/MS assay with the derivatization of 1-Amino-4-methylpiperazine applied to serum allopregnanolone, pregnenolone and androsterone in pre- and postmenopausal women.
Steroids.
2017 02; 118(?):25-31. doi:
10.1016/j.steroids.2016.11.007. [PMID: 27913096] - Stefano Meletti, Chiara Lucchi, Giulia Monti, Giada Giovannini, Roberta Bedin, Tommaso Trenti, Cecilia Rustichelli, Giuseppe Biagini. Decreased allopregnanolone levels in cerebrospinal fluid obtained during status epilepticus.
Epilepsia.
2017 02; 58(2):e16-e20. doi:
10.1111/epi.13625. [PMID: 27888513] - Arif-Ullah Khan, Shamsher Ali, Anwarul-Hassan Gilani, Manzoor Ahmed, Muhammad Iqbal Choudhary. Antispasmodic, bronchodilator, vasorelaxant and cardiosuppressant effects of Buxus papillosa.
BMC complementary and alternative medicine.
2017 Jan; 17(1):54. doi:
10.1186/s12906-017-1558-x. [PMID: 28100216] - Narender Kumar, Jerôme Fagart, Philippe Liere, Scott J Mitchell, Alanah R Knibb, Isabelle Petit-Topin, Marion Rame, Martine El-Etr, Michael Schumacher, Jeremy J Lambert, Marie-Edith Rafestin-Oblin, Regine Sitruk-Ware. Nestorone® as a Novel Progestin for Nonoral Contraception: Structure-Activity Relationships and Brain Metabolism Studies.
Endocrinology.
2017 01; 158(1):170-182. doi:
10.1210/en.2016-1426. [PMID: 27824503] - Zhi-Kun Qiu, Jia-Li He, Xu Liu, Guan-Hua Zhang, Jia Zeng, Hong Nie, Yong-Gang Shen, Ji-Sheng Chen. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus.
Scientific reports.
2016 11; 6(?):37345. doi:
10.1038/srep37345. [PMID: 27886206] - Maria Claudia Gonzalez Deniselle, Philippe Liere, Antoine Pianos, Maria Meyer, Fanny Aprahamian, Annie Cambourg, Noelia P Di Giorgio, Michael Schumacher, Alejandro F De Nicola, Rachida Guennoun. Steroid Profiling in Male Wobbler Mouse, a Model of Amyotrophic Lateral Sclerosis.
Endocrinology.
2016 Nov; 157(11):4446-4460. doi:
10.1210/en.2016-1244. [PMID: 27571131] - Kristina M Deligiannidis, Aimee R Kroll-Desrosiers, Shunyan Mo, Hien P Nguyen, Abby Svenson, Nina Jaitly, Janet E Hall, Bruce A Barton, Anthony J Rothschild, Scott A Shaffer. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
Psychoneuroendocrinology.
2016 08; 70(?):98-107. doi:
10.1016/j.psyneuen.2016.05.010. [PMID: 27209438] - Greer A Bennett, Hannah K Palliser, David Walker, Jonathan Hirst. Severity and timing: How prenatal stress exposure affects glial developmental, emotional behavioural and plasma neurosteroid responses in guinea pig offspring.
Psychoneuroendocrinology.
2016 08; 70(?):47-57. doi:
10.1016/j.psyneuen.2016.04.011. [PMID: 27155257] - Mary Kimmel, Makena Clive, Fiona Gispen, Jerry Guintivano, Tori Brown, Olivia Cox, Matthias W Beckmann, Johannes Kornhuber, Peter A Fasching, Lauren M Osborne, Elisabeth Binder, Jennifer L Payne, Zachary Kaminsky. Oxytocin receptor DNA methylation in postpartum depression.
Psychoneuroendocrinology.
2016 07; 69(?):150-60. doi:
10.1016/j.psyneuen.2016.04.008. [PMID: 27108164] - Li-Ming Zhang, Zhi-Kun Qiu, Xiao-Fei Chen, Nan Zhao, Hong-Xia Chen, Rui- Xue, You-Zhi Zhang, Ri-Fang Yang, Yun-Feng Li. Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.
Journal of psychopharmacology (Oxford, England).
2016 05; 30(5):474-81. doi:
10.1177/0269881115625115. [PMID: 26783231] - M G Pisu, A Garau, G Boero, F Biggio, V Pibiri, R Dore, V Locci, E Paci, P Porcu, M Serra. Sex differences in the outcome of juvenile social isolation on HPA axis function in rats.
Neuroscience.
2016 Apr; 320(?):172-82. doi:
10.1016/j.neuroscience.2016.02.009. [PMID: 26868968] - Erin L Legacki, Elizabeth L Scholtz, Barry A Ball, Scott D Stanley, Trish Berger, Alan J Conley. The dynamic steroid landscape of equine pregnancy mapped by mass spectrometry.
Reproduction (Cambridge, England).
2016 Apr; 151(4):421-30. doi:
10.1530/rep-15-0547. [PMID: 26814209] - Verica Milivojevic, Helen C Fox, Mehmet Sofuoglu, Jonathan Covault, Rajita Sinha. Effects of progesterone stimulated allopregnanolone on craving and stress response in cocaine dependent men and women.
Psychoneuroendocrinology.
2016 Mar; 65(?):44-53. doi:
10.1016/j.psyneuen.2015.12.008. [PMID: 26716877] - Pedro E Martinez, David R Rubinow, Lynnette K Nieman, Deloris E Koziol, A Leslie Morrow, Crystal E Schiller, Dahima Cintron, Karla D Thompson, Khursheed K Khine, Peter J Schmidt. 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2016 Mar; 41(4):1093-102. doi:
10.1038/npp.2015.246. [PMID: 26272051] - Sahruh Turkmen, Alebtekin Ahangari, Torbjörn Bäckstrom. Roux-en-Y Gastric Bypass Surgery in Patients with Polycystic Ovary Syndrome and Metabolic Syndrome.
Obesity surgery.
2016 Jan; 26(1):111-8. doi:
10.1007/s11695-015-1729-0. [PMID: 25975201] - Zhuo-Wei Gao, Jing-Bin Huang, Qing Lin, Qiang Qin, Yao-Jun Liang, Lu Zhou, Min Luo. The effects of PK11195 on meningioma was associated with allopregnanolone biosynthesis, which was mediated by translocator protein 18 KDa.
Cancer biomarkers : section A of Disease markers.
2016; 16(1):65-9. doi:
10.3233/cbm-150541. [PMID: 26835706] - Helena Hedström, Torbjörn Bäckström, Marie Bixo, Sigrid Nyberg, Mingde Wang, Ida Gideonsson, Sahruh Turkmen. Women with polycystic ovary syndrome have elevated serum concentrations of and altered GABA(A) receptor sensitivity to allopregnanolone.
Clinical endocrinology.
2015 Nov; 83(5):643-50. doi:
10.1111/cen.12809. [PMID: 25929428] - Torbjörn Bäckström, Marie Bixo, Jessica Strömberg. GABAA Receptor-Modulating Steroids in Relation to Women's Behavioral Health.
Current psychiatry reports.
2015 Nov; 17(11):92. doi:
10.1007/s11920-015-0627-4. [PMID: 26396092] - Christopher D Schmoutz, Glenn F Guerin, Scott P Runyon, Suraj Dhungana, Nicholas E Goeders. A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats.
Behavioural brain research.
2015 Sep; 291(?):108-111. doi:
10.1016/j.bbr.2015.05.019. [PMID: 26003946] - Rivka Ben Dor, Christine E Marx, Lawrence J Shampine, David R Rubinow, Peter J Schmidt. DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action.
Psychopharmacology.
2015 Sep; 232(18):3375-83. doi:
10.1007/s00213-015-3991-1. [PMID: 26105109] - Zhi-Kun Qiu, Guan-Hua Zhang, Jia-Li He, Jian-Chun Ma, Jia Zeng, Dong Shen, Yong-Gang Shen, Ji-Sheng Chen, Cheng-Yong Liu. Free and Easy Wanderer Plus (FEWP) improves behavioral deficits in an animal model of post-traumatic stress disorder by stimulating allopregnanolone biosynthesis.
Neuroscience letters.
2015 Aug; 602(?):162-6. doi:
10.1016/j.neulet.2015.06.055. [PMID: 26160034] - Giorgio Dimastrogiovanni, Denise Fernandes, Marta Bonastre, Cinta Porte. Progesterone is actively metabolized to 5α-pregnane-3,20-dione and 3β-hydroxy-5α-pregnan-20-one by the marine mussel Mytilus galloprovincialis.
Aquatic toxicology (Amsterdam, Netherlands).
2015 Aug; 165(?):93-100. doi:
10.1016/j.aquatox.2015.05.018. [PMID: 26026673] - M Pallarès, A Llidó, L Mòdol, M Vallée, S Darbra. Finasteride administration potentiates the disruption of prepulse inhibition induced by forced swim stress.
Behavioural brain research.
2015 Aug; 289(?):55-60. doi:
10.1016/j.bbr.2015.04.023. [PMID: 25913832] - H K Palliser, M A Kelleher, M Tolcos, D W Walker, J J Hirst. Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs.
Journal of developmental origins of health and disease.
2015 Aug; 6(4):350-61. doi:
10.1017/s2040174415001075. [PMID: 25907069] - Chitra Bhatia, Stephanie Oerum, James Bray, Kathryn L Kavanagh, Naeem Shafqat, Wyatt Yue, Udo Oppermann. Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships.
Chemico-biological interactions.
2015 Jun; 234(?):114-25. doi:
10.1016/j.cbi.2014.12.013. [PMID: 25526675] - Ken'ichi Yamaguchi. Evaluation for roles of neurosteroids in modulating forebrain mechanisms controlling vasopressin secretion and related phenomena in conscious rats.
Neuroscience research.
2015 Jun; 95(?):38-50. doi:
10.1016/j.neures.2015.01.002. [PMID: 25598212] - Zhi-Kun Qiu, Jia-Li He, Xu Liu, Sha Lai, Jian-Chun Ma, Jia Zeng, Yan Li, Hong-Wei Wu, Yong Chen, Yong-Gang Shen, Ji-Sheng Chen, Min Luo. The role of allopregnanolone in the anxiolytic-like effect of free and easy wanderer plus (FEWP), a polyherbal preparation.
Neuroscience letters.
2015 May; 595(?):94-8. doi:
10.1016/j.neulet.2015.03.039. [PMID: 25800108] - Daniel Balleza, Mattia Sacchi, Giulia Vena, Debora Galloni, Giulia Puia, Paolo Facci, Andrea Alessandrini. Effects of neurosteroids on a model membrane including cholesterol: A micropipette aspiration study.
Biochimica et biophysica acta.
2015 May; 1848(5):1268-76. doi:
10.1016/j.bbamem.2015.01.017. [PMID: 25660752] - Mattia Sacchi, Daniel Balleza, Giulia Vena, Giulia Puia, Paolo Facci, Andrea Alessandrini. Effect of neurosteroids on a model lipid bilayer including cholesterol: An Atomic Force Microscopy study.
Biochimica et biophysica acta.
2015 May; 1848(5):1258-67. doi:
10.1016/j.bbamem.2015.01.002. [PMID: 25620773] - Alain Y Dury, Yuyong Ke, Renaud Gonthier, Maxim Isabelle, Jean-Nicolas Simard, Fernand Labrie. Validated LC-MS/MS simultaneous assay of five sex steroid/neurosteroid-related sulfates in human serum.
The Journal of steroid biochemistry and molecular biology.
2015 May; 149(?):1-10. doi:
10.1016/j.jsbmb.2015.01.006. [PMID: 25595042] - Paula J Brunton, Marcio V Donadio, Song T Yao, Mike Greenwood, Jonathan R Seckl, David Murphy, John A Russell. 5α-Reduced neurosteroids sex-dependently reverse central prenatal programming of neuroendocrine stress responses in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Jan; 35(2):666-77. doi:
10.1523/jneurosci.5104-13.2015. [PMID: 25589761] - Adam J Devall, Julia M Santos, Jonathan P Fry, John W Honour, Marcus L Brandão, Thelma A Lovick. Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2015 Jan; 25(1):113-23. doi:
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