Yangambin (BioDeep_00000002926)

 

Secondary id: BioDeep_00000230249

PANOMIX_OTCML-2023


代谢物信息卡片


1H,3H-Furo(3,4-c)furan, tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-, (1S-(1alpha,3aalpha,4beta,6aalpha))-

化学式: C24H30O8 (446.1941)
中文名称: 鹅掌楸树脂酚B二甲醚
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 87.5%

分子结构信息

SMILES: COC1=CC(=CC(=C1OC)OC)C2C3COC(C3CO2)C4=CC(=C(C(=C4)OC)OC)OC
InChI: InChI=1S/C24H30O8/c1-25-17-7-13(8-18(26-2)23(17)29-5)21-15-11-32-22(16(15)12-31-21)14-9-19(27-3)24(30-6)20(10-14)28-4/h7-10,15-16,21-22H,11-12H2,1-6H3/t15-,16-,21+,22+/m0/s1

描述信息

Epiyangambin is a natural product found in Hernandia ovigera, Achillea holosericea, and other organisms with data available.

同义名列表

21 个代谢物同义名

(1S,3aR,4S,6aR)-1,4-bis(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[4,3-c]furan; ZINC04098936; 13060-14-5; Yangambin; C10894; 1H,3H-Furo(3,4-c)furan, tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-, (1S-(1alpha,3aalpha,4beta,6aalpha))-; (3R,3aR,6S,6aR)-3,6-bis(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan; 1H,3H-Furo[3,4-c]furan, tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-, (1R,3aR,4S,6aR)-; 1,4-Bis(3,4,5-trimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan; (1S-(1alpha,3aalpha,4alpha,6aalpha))-isomer of epiyangambin; Lirioresinol A, O,O-dimethyl-; Lirioresinol A dimethyl ether; O,O-Dimethyllirioresinol A; Lirioresinol A, dimethyl-; MEGxp0_001363; epi-yangambin; epiyangambin; ACon1_001856; Lirioresinol-B dimethyl ether; MLS000877028; Yangambin



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

42 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, MAPK8, MYD88, PTGS2, PTHLH, TNFSF11, TUBB4B
Peripheral membrane protein 2 CTSK, PTGS2
Endosome membrane 1 MYD88
Endoplasmic reticulum membrane 6 PTGS2, UGT1A1, UGT1A3, UGT1A4, UGT1A9, UGT2B7
Nucleus 6 ALB, JUND, MAPK8, MYD88, PTHLH, TUBB4B
cytosol 5 ALB, MAPK8, MYD88, PTHLH, TUBB4B
centrosome 1 ALB
nucleoplasm 4 CTSK, JUND, MAPK8, PTHLH
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 4 CTSK, PTAFR, TNF, TNFSF11
Multi-pass membrane protein 1 PTAFR
Synapse 1 MAPK8
cell surface 2 MYD88, TNF
Golgi apparatus 2 ALB, PTHLH
neuronal cell body 1 TNF
Lysosome 1 CTSK
plasma membrane 9 CTSK, F2, KNG1, MYD88, PTAFR, TNF, TNFRSF11B, TNFSF11, UGT1A1
Membrane 7 PTAFR, TNFSF11, UGT1A1, UGT1A3, UGT1A4, UGT1A9, UGT2B7
apical plasma membrane 1 CTSK
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 4 ALB, F2, KNG1, TUBB4B
endoplasmic reticulum 6 ALB, PTGS2, UGT1A1, UGT1A3, UGT1A4, UGT1A9
extracellular space 9 ALB, CTSK, F2, IL10, KNG1, PTHLH, TNF, TNFRSF11B, TNFSF11
lysosomal lumen 1 CTSK
perinuclear region of cytoplasm 1 UGT1A1
protein-containing complex 3 ALB, MYD88, PTGS2
intracellular membrane-bounded organelle 1 CTSK
Microsome membrane 1 PTGS2
Secreted 7 ALB, CTSK, F2, IL10, PTHLH, TNFRSF11B, TNFSF11
extracellular region 10 ALB, CTSK, F2, IL10, KNG1, PTHLH, TNF, TNFRSF11B, TNFSF11, TUBB4B
Single-pass membrane protein 5 UGT1A1, UGT1A3, UGT1A4, UGT1A9, UGT2B7
Extracellular side 1 CTSK
anchoring junction 1 ALB
transcription regulator complex 1 JUND
external side of plasma membrane 2 CTSK, TNF
Extracellular vesicle 1 TUBB4B
microtubule cytoskeleton 1 TUBB4B
recycling endosome 1 TNF
Single-pass type II membrane protein 2 TNF, TNFSF11
Apical cell membrane 1 CTSK
Cytoplasm, perinuclear region 1 UGT1A1
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 TUBB4B
microtubule 1 TUBB4B
extracellular matrix 1 TNFRSF11B
collagen-containing extracellular matrix 2 F2, KNG1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 TNFRSF11B
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 1 JUND
phagocytic cup 1 TNF
mitotic spindle 1 TUBB4B
cytoskeleton 1 TUBB4B
centriole 1 ALB
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
blood microparticle 3 ALB, F2, KNG1
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
axonemal microtubule 1 TUBB4B
tertiary granule membrane 1 PTAFR
secretory granule membrane 1 PTAFR
Golgi lumen 1 F2
endoplasmic reticulum lumen 4 ALB, F2, KNG1, PTGS2
transcription repressor complex 1 JUND
platelet alpha granule lumen 2 ALB, KNG1
azurophil granule lumen 1 TUBB4B
[Isoform 2]: Cytoplasm 1 TNFSF11
[Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted 1 TNFSF11
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
basal dendrite 1 MAPK8
extrinsic component of plasma membrane 1 MYD88
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
endoplasmic reticulum chaperone complex 1 UGT1A1
endolysosome lumen 1 CTSK
cytochrome complex 1 UGT1A1
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jéssica Rebouças-Silva, Gabriel Farias Santos, José Maria Barbosa Filho, Andresa A Berretta, Franciane Marquele-Oliveira, Valéria M Borges. In vitro leishmanicidal effect of Yangambin and Epi-yangambin lignans isolated from Ocotea fasciculata (Nees) Mez. Frontiers in cellular and infection microbiology. 2022; 12(?):1045732. doi: 10.3389/fcimb.2022.1045732. [PMID: 36704104]
  • María Y Rios, Yordin D Ocampo-Acuña, M Ángeles Ramírez-Cisneros, María E Salazar-Rios. Furofuranone Lignans from Leucophyllum ambiguum. Journal of natural products. 2020 05; 83(5):1424-1431. doi: 10.1021/acs.jnatprod.9b00759. [PMID: 32239935]
  • Júlia Martins, Joana Coelho, Maraine Catarina Tadini, Rebeca Oliveira de Souza, Sonia Aparecida Figueiredo, Maria José Vieira Fonseca, Nayara Cristina Perez de Albuquerque, Norberto Peporine Lopes, Andresa Berretta, Franciane Marquele-Oliveira, Anderson Rodrigo Moraes de Oliveira. Yangambin and Epi-yangambin Isomers: New Purification Method from Ocotea fasciculata and First Cytotoxic Aspects Focusing on In Vivo Safety. Planta medica. 2020 Apr; 86(6):415-424. doi: 10.1055/a-1118-3828. [PMID: 32126582]
  • Adeeb Shehzad, Shagufta Rehmat, Salman Ul-Islam, Rizwan Ahmad, Meneerah Aljafary, Noor A Alrushaid, Ebtesam A Al-Suhaimi. Lirioresinol B dimethyl ether inhibits NF-κB and COX-2 and activates IκBα expression in CCl4-induced hepatic fibrosis. BMC complementary medicine and therapies. 2020 Feb; 20(1):49. doi: 10.1186/s12906-020-2839-3. [PMID: 32046692]
  • Ramesh Kumar Santhanam, Syahida Ahmad, Faridah Abas, Intan Safinar Ismail, Yaya Rukayadi, Muhammad Tayyab Akhtar, Khozirah Shaari. Bioactive Constituents of Zanthoxylum rhetsa Bark and Its Cytotoxic Potential against B16-F10 Melanoma Cancer and Normal Human Dermal Fibroblast (HDF) Cell Lines. Molecules (Basel, Switzerland). 2016 May; 21(6):. doi: 10.3390/molecules21060652. [PMID: 27231889]
  • Rubens L Monte Neto, Louisa M A Sousa, Celidarque S Dias, José M Barbosa Filho, Márcia R Oliveira, Regina C B Q Figueiredo. Morphological and physiological changes in Leishmania promastigotes induced by yangambin, a lignan obtained from Ocotea duckei. Experimental parasitology. 2011 Jan; 127(1):215-21. doi: 10.1016/j.exppara.2010.07.020. [PMID: 20691682]
  • Jae Yeon Kim, Hyo Jin Lim, Da Yeon Lee, Ji Sun Kim, Do Hee Kim, Hwa Jin Lee, Hee Doo Kim, Raok Jeon, Jae-Ha Ryu. In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii. Bioorganic & medicinal chemistry letters. 2009 Feb; 19(3):937-40. doi: 10.1016/j.bmcl.2008.11.103. [PMID: 19110419]
  • Rubens L Monte Neto, Louisa M A Sousa, Celidarque S Dias, José M Barbosa Filho, Márcia R Oliveira. Yangambin cytotoxicity: a pharmacologically active lignan obtained from Ocotea duckei vattimo (Lauraceae). Zeitschrift fur Naturforschung. C, Journal of biosciences. 2008 Sep; 63(9-10):681-6. doi: 10.1515/znc-2008-9-1012. [PMID: 19040107]
  • Rubens L Neto Monte, José M Filho Barbosa, Louisa M A Sousa, Petrônio F Filho Athayde, Celidarque S Dias, Márcia R Oliveira. Crude ethanolic extract, lignoid fraction and yangambin from Ocotea duckei (Lauraceae) show antileishmanial activity. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2007 May; 62(5-6):348-52. doi: 10.1515/znc-2007-5-605. [PMID: 17708438]
  • Marise Maleck de Oliveira Cabral, Paloma Martins Mendonça, Celma Marinho da Silva Gomes, José Maria Barbosa-Filho, Celidarque da Silva Dias, Maurilio José Soares, Margareth Maria de Carvalho Queiroz. Biological activity of yangambin on the postembryonic development of Chrysomya megacephala (Diptera: Calliphoridae). Journal of medical entomology. 2007 Mar; 44(2):249-55. doi: 10.1603/0022-2585(2007)44[249:baoyot]2.0.co;2. [PMID: 17427693]
  • Regina Célia Pereira Marques, Sílvia Regina Batistuzzo de Medeiros, Celidarque da Silva Dias, José Maria Barbosa-Filho, Lucymara Fassarella Agnez-Lima. Evaluation of the mutagenic potential of yangambin and of the hydroalcoholic extract of Ocotea duckei by the Ames test. Mutation research. 2003 Apr; 536(1-2):117-20. doi: 10.1016/s1383-5718(03)00040-8. [PMID: 12694751]
  • C V Araújo, J M Barbosa-Filho, R S Cordeiro, E Tibiriçá. Protective effects of yangambin on cardiovascular hyporeactivity to catecholamines in rats with endotoxin-induced shock. Naunyn-Schmiedeberg's archives of pharmacology. 2001 Mar; 363(3):267-75. doi: 10.1007/s002100000350. [PMID: 11284440]
  • E Tibiriçá. Cardiovascular properties of yangambin, a lignan isolated from Brazilian plants. Cardiovascular drug reviews. 2001; 19(4):313-28. doi: 10.1111/j.1527-3466.2001.tb00073.x. [PMID: 11830750]
  • C M Jesus-Morais, E F Assis, R S Cordeiro, J M Barbosa-Filho, W T Lima, Z L Silva, P T Bozza, H C Castro-Faria-Neto. Yangambin, a lignan obtained from Ocotea duckei, differentiates putative PAF receptor subtypes in the gastrointestinal tract of rats. Planta medica. 2000 Apr; 66(3):211-6. doi: 10.1055/s-2000-8556. [PMID: 10821044]
  • S Cailleaux, R A Lopes-Martins, F Aimbire, R S Cordeiro, E Tibiriçá. Involvement of platelet-activating factor in the modulation of vascular tone in the isolated perfused rabbit kidney. Naunyn-Schmiedeberg's archives of pharmacology. 1999 Jun; 359(6):505-11. doi: 10.1007/pl00005383. [PMID: 10431763]
  • J M Herbert, H C Castro-Faria-Neto, J M Barbosa-Filho, R S Cordeiro, E Tibiriça. Pharmacological evidence for the putative existence of two different subtypes of PAF receptors on platelets and leukocytes; studies with yangambin. Journal of lipid mediators and cell signalling. 1997 Sep; 17(1):1-14. doi: 10.1016/s0929-7855(97)00011-4. [PMID: 9302650]
  • M F Serra, B L Diaz, E O Barreto, A P Pereira, M C Lima, J M Barbosa-Filho, R S Cordeiro, M A Martins, P M de Silva. Anti-allergic properties of the natural PAF antagonist yangambin. Planta medica. 1997 Jun; 63(3):207-12. doi: 10.1055/s-2006-957654. [PMID: 9225600]
  • H C Castro-Faria-Neto, C V Araújo, S Moreira, P T Bozza, G Thomas, J M Barbosa-Filho, R S Cordeiro, E V Tibiriçá. Yangambin: a new naturally-occurring platelet-activating factor receptor antagonist: in vivo pharmacological studies. Planta medica. 1995 Apr; 61(2):106-12. doi: 10.1055/s-2006-958026. [PMID: 7753914]
  • H C Castro-Faria-Neto, P T Bozza, H N Cruz, C L Silva, F A Violante, J M Barbosa-Filho, G Thomas, M A Martins, E V Tibiriçá, F Noel. Yangambin: a new naturally-occurring platelet-activating factor receptor antagonist: binding and in vitro functional studies. Planta medica. 1995 Apr; 61(2):101-5. doi: 10.1055/s-2006-958025. [PMID: 7753913]
  • H C Castro-Faria-Neto, M A Martins, P M Silva, P T Bozza, H N Cruz, M de Queiroz-Paulo, M A Kaplan, R S Cordeiro. Pharmacological profile of epiyangambin: a furofuran lignan with PAF antagonist activity. Journal of lipid mediators. 1993 May; 7(1):1-9. doi: . [PMID: 8358020]