Nalbuphine (BioDeep_00000002835)
Secondary id: BioDeep_00000405953
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1S,5R,13R,14S,17S)-4-(cyclobutylmethyl)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7,9,11(18)-triene-10,14,17-triol
化学式: C21H27NO4 (357.194)
中文名称: 纳布啡
谱图信息:
最多检出来源 Homo sapiens(blood) 24.21%
分子结构信息
SMILES: C1CC(C1)CN1CC[C@]23c4c5ccc(c4O[C@H]2[C@H](CC[C@]3([C@H]1C5)O)O)O
InChI: InChI=1S/C21H27NO4/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12/h4-5,12,15-16,19,23-25H,1-3,6-11H2/t15-,16+,19-,20-,21+/m0/s1
描述信息
Nalbuphine is only found in individuals that have used or taken this drug. It is a narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. [PubChem]The exact mechanism of action is unknown, but is believed to interact with an opiate receptor site in the CNS (probably in or associated with the limbic system). The opiate antagonistic effect may result from competitive inhibition at the opiate receptor, but may also be a result of other mechanisms. Nalbuphine is thought primarily to be a kappa agonist. It is also a partial mu antagonist analgesic, with some binding to the delta receptor and minimal agonist activity at the sigma receptor.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
N - Nervous system > N02 - Analgesics > N02A - Opioids > N02AF - Morphinan derivatives
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
17 个代谢物同义名
(1S,5R,13R,14S,17S)-4-(cyclobutylmethyl)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7,9,11(18)-triene-10,14,17-triol; N-Cyclobutylmethyl-4,5alpha-epoxy-3,6alpha,14-morphinantriol; N-Cyclobutylmethyl-4,5α-epoxy-3,6α,14-morphinantriol; N-Cyclobutylmethyl-4,5a-epoxy-3,6a,14-morphinantriol; N-Cyclobutylmethyl-14-hydroxydihydronormorphine; Hydrochloride, nalbuphine; SERB brand OF nalbuphine; Nalbuphine Hydrochloride; Nalbuphine serb brand; Serb, nalbuphine; Nalbuphine serb; Nalbuphinum; nalbuphine; Nalbufina; Intapan; Nubain; Nalbuphine
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:7454
- KEGG: C07251
- KEGGdrug: D08246
- PubChem: 5311304
- PubChem: 4419
- HMDB: HMDB0014982
- Metlin: METLIN1399
- DrugBank: DB00844
- ChEMBL: CHEMBL895
- Wikipedia: Nalbuphine
- MeSH: Nalbuphine
- chemspider: 4470813
- CAS: 20594-83-6
- PMhub: MS000006395
- PubChem: 9460
- NIKKAJI: J14.212C
- RefMet: Nalbuphine
- KNApSAcK: 7454
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shylo R Johnson, Christine K Ellis, Chad K Wickham, Molly R Selleck, Amy T Gilbert. Comparison of Ketamine-Xylazine, Butorphanol-Azaperone-Medetomidine, and Nalbuphine-Medetomidine-Azaperone for Raccoon (Procyon Lotor) Immobilization.
Journal of wildlife diseases.
2023 Nov; ?(?):. doi:
10.7589/jwd-d-23-00060. [PMID: 37924235] - Wei Shi, Jing Dong, Jian-Feng Chen, Hai Yu. A meta-analysis showing the quantitative evidence base of perineural nalbuphine for wound pain from upper-limb orthopaedic trauma surgery.
International wound journal.
2023 May; 20(5):1476-1490. doi:
10.1111/iwj.14002. [PMID: 36330591] - Meng-Si Luo. Nalbuphine reduces the incidence of emergence agitation in children undergoing adenotonsillectomy.
Journal of clinical anesthesia.
2023 Apr; 87(?):111115. doi:
10.1016/j.jclinane.2023.111115. [PMID: 37018929] - Bingxu Ren, Jiannan Zhang, Xiaohu Yang, Dapeng Sun, Duanyang Sheng, Qiang Fang, Zhonghua Ji. Co-Administration of nalbuphine to improve morphine tolerance in mice with bone cancer pain.
Molecular pain.
2023 Jan; 19(?):17448069231178741. doi:
10.1177/17448069231178741. [PMID: 37226458] - Chenran Wang, Shen Sun, Jing Jiao, Xinhua Yu, Shaoqiang Huang. Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats.
Fundamental & clinical pharmacology.
2022 Oct; 36(5):811-817. doi:
10.1111/fcp.12778. [PMID: 35373856] - Dijiao Ruan, Yuanyuan Wang, Sisi Li, Chao Zhang, Wenwen Zheng, Cong Yu. Nalbuphine alleviates inflammation by down-regulating NF-κB in an acute inflammatory visceral pain rat model.
BMC pharmacology & toxicology.
2022 06; 23(1):34. doi:
10.1186/s40360-022-00573-7. [PMID: 35642022] - Jing Dong, Yi-Feng Ren, Meng-Ling Wei, Xin Ye, Xiao-Yun Peng, Long-Fei Zhang, Fang Li, Wei Shi. Re-evaluating the clinical efficacy of intrathecal nalbuphine: Based on minimal clinically important difference and statistical threshold correction.
Pain practice : the official journal of World Institute of Pain.
2022 04; 22(4):497-499. doi:
10.1111/papr.13104. [PMID: 35178877] - Mahmoud Agami, Rasha A Shaalan, Saied F Belal, Marwa A A Ragab. LC-MS bioanalysis of targeted nasal galantamine bound chitosan nanoparticles in rats' brain homogenate and plasma.
Analytical and bioanalytical chemistry.
2021 Aug; 413(20):5181-5191. doi:
10.1007/s00216-021-03487-1. [PMID: 34173038] - Kun He, Wei Ji, Hengli Zhao, Yilin Wei, Shaomei Yang, Qing Wen. Pharmacokinetic comparison of nalbuphine with single injection and patient-controlled analgesia mimic method in healthy Chinese volunteers.
Journal of clinical pharmacy and therapeutics.
2021 Aug; 46(4):1166-1172. doi:
10.1111/jcpt.13421. [PMID: 33942343] - Xingfeng Sun, Qun Zhou, Min Zhou, Rong Cao, Zuolei Chen, Songjiang Tang, Shaoqiang Huang. The Effect of Epidural Nalbuphine Combined With Ropivacaine on Epidural Analgesia During Labor: A Multicenter, Randomized, Double-blind, Controlled Study.
The Clinical journal of pain.
2021 06; 37(6):437-442. doi:
10.1097/ajp.0000000000000928. [PMID: 33758132] - Shang-Wen Lin, Yan-Jye Shyong, Ping-Chung Kuo, Jui-Chen Tsai. Topical application of sebacoyl dinalbuphine ester-loaded nanostructured lipid carriers alleviate pruritus in scratching mouse model.
International journal of pharmaceutics.
2021 May; 600(?):120400. doi:
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2021 05; 236(?):105060. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Apr; 159(?):105734. doi:
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2021 02; 48(2):170-176. doi:
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2021 01; 322(?):207-210. doi:
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2020 Sep; 43(5):134-138. doi:
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2020 Jul; 9(4):1556-1563. doi:
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Journal of wildlife diseases.
2018 04; 54(2):362-365. doi:
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BMC neuroscience.
2002 Nov; 3(?):19. doi:
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2002 Aug; 168(2):694-7. doi:
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Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2002 Feb; 49(2):137-43. doi:
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2001 Jun; 220(1-2):91-9. doi:
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2000 Sep; 746(2):241-7. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2000 Jun; 67(1):1-8. doi:
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1999 Jul; 290(1):259-65. doi:
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The American journal of physiology.
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1997 Mar; 690(1-2):89-97. doi:
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Fundamental & clinical pharmacology.
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European journal of clinical pharmacology.
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Clinical pharmacology and therapeutics.
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Laboratory animals.
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Annales francaises d'anesthesie et de reanimation.
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1988 Dec; 38(12):1768-71. doi:
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Arzneimittel-Forschung.
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Circulatory shock.
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British journal of clinical pharmacology.
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1988 Feb; 68(2):254-60. doi:
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British journal of clinical pharmacology.
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Anesthesia and analgesia.
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Anesthesia and analgesia.
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