Phenytoin (BioDeep_00000002807)

 

Secondary id: BioDeep_00000399082

human metabolite blood metabolite


代谢物信息卡片


5,5-Diphenyltetrahydro-1H-2,4-imidazoledione

化学式: C15H12N2O2 (252.0898732)
中文名称: 苯妥英
谱图信息: 最多检出来源 Homo sapiens(blood) 0.37%

分子结构信息

SMILES: C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
InChI: InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)

描述信息

An anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [PubChem]
CONFIDENCE standard compound; INTERNAL_ID 827; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3943; ORIGINAL_PRECURSOR_SCAN_NO 3941
CONFIDENCE standard compound; INTERNAL_ID 920; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3971; ORIGINAL_PRECURSOR_SCAN_NO 3969
CONFIDENCE standard compound; INTERNAL_ID 920; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3970; ORIGINAL_PRECURSOR_SCAN_NO 3969
CONFIDENCE standard compound; INTERNAL_ID 827; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3970; ORIGINAL_PRECURSOR_SCAN_NO 3969
CONFIDENCE standard compound; INTERNAL_ID 920; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3951; ORIGINAL_PRECURSOR_SCAN_NO 3950
CONFIDENCE standard compound; INTERNAL_ID 920; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3943; ORIGINAL_PRECURSOR_SCAN_NO 3941
CONFIDENCE standard compound; INTERNAL_ID 827; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3985; ORIGINAL_PRECURSOR_SCAN_NO 3983
CONFIDENCE standard compound; INTERNAL_ID 827; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3971; ORIGINAL_PRECURSOR_SCAN_NO 3969
CONFIDENCE standard compound; INTERNAL_ID 827; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3951; ORIGINAL_PRECURSOR_SCAN_NO 3950
CONFIDENCE standard compound; INTERNAL_ID 920; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3953; ORIGINAL_PRECURSOR_SCAN_NO 3948
CONFIDENCE standard compound; INTERNAL_ID 827; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3953; ORIGINAL_PRECURSOR_SCAN_NO 3948
CONFIDENCE standard compound; INTERNAL_ID 920; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3985; ORIGINAL_PRECURSOR_SCAN_NO 3983
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AB - Hydantoin derivatives
D065693 - Cytochrome P-450 Enzyme Inducers > D065694 - Cytochrome P-450 CYP1A2 Inducers
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3319
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

31 个代谢物同义名

5,5-Diphenyltetrahydro-1H-2,4-imidazoledione; 5,5-Diphenyl-imidazolidine-2,4-dione; 5,5-Diphenylimidazolidine-2,4-dione; Park davis brand OF phenytoin; Diphenylhydantoinate, sodium; Sodium diphenylhydantoinate; Pfizer brand OF phenytoin; Phizer brand OF phenytoin; 5,5-Dwufenylohydantoina; Phenytoin phizer brand; Phenytoin pfizer brand; 5,5-Diphenylhydantoin; Diphenylhydatanoin; Diphenylhydantoin; Diphenylan sodium; Phenytoin sodium; Phenytoinum; Dihydantoin; PHENTYTOIN; Phenytoine; Fenitoina; phenytoin; Antisacer; Hydantol; silantin; Epanutin; Fenitoin; DILANTIN; Dihydan; Difenin; Epamin



数据库引用编号

40 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

53 个相关的代谢反应过程信息。

Reactome(50)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(3)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shaimaa M Azzam, Marwa Refaat Abdel Khalek, Amina A S Abdel Rahman, Amany Abdelhameid Osman, Heba Mohammed Refat M Selim, Asmaa Fady Sharif, Yomna Ahmad El-Khattib, Sameh Rabea, Sahar K Ali, Alshaymaa Darwish. Revealing how phenytoin triggers liver damage and the potential protective effects of Balanites Aegyptiaca fruit extracts: Exploring Nrf2/MAPK/ Beclin-1 signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 165(?):115265. doi: 10.1016/j.biopha.2023.115265. [PMID: 37541174]
  • Samson Sahile Salile, Hamin John Lee, Paul Sewes Frederick Alberts, Teferra Abula, Joseph Valentino Raimondo, Gary Ivan Stafford. In vitro and in vivo anti-seizure activity of hydromethanolic extract and fractions of Pterolobium stellatum. Journal of ethnopharmacology. 2023 Mar; 304(?):116073. doi: 10.1016/j.jep.2022.116073. [PMID: 36543277]
  • Davood Nasiry, Ali Reza Khalatbary, Alireza Ghaemi, Mohammad Ali Ebrahimzadeh, Mohammad Hossein Hosseinzadeh. Topical administration of Juglans regia L. leaf extract accelerates diabetic wound healing. BMC complementary medicine and therapies. 2022 Oct; 22(1):255. doi: 10.1186/s12906-022-03735-6. [PMID: 36192711]
  • Amir Siahpoosh, Alireza Malayeri, Anayatollah Salimi, Layasadat Khorsandi, Zeinab Zaheri Abdevand. Determination of the effectiveness of Dorema ammoniacum gum on wound healing: an experimental study. Journal of wound care. 2022 Oct; 31(Sup10):S16-S27. doi: 10.12968/jowc.2022.31.sup10.s16. [PMID: 36240871]
  • Jesús Daniel Cardoso-Vera, Leobardo Manuel Gómez-Oliván, Hariz Islas-Flores, Sandra García-Medina, Gustavo Axel Elizalde-Velázquez, José Manuel Orozco-Hernández, Gerardo Heredia-García, Karina Elisa Rosales-Pérez, Marcela Galar-Martínez. Multi-biomarker approach to evaluate the neurotoxic effects of environmentally relevant concentrations of phenytoin on adult zebrafish Danio rerio. The Science of the total environment. 2022 Aug; 834(?):155359. doi: 10.1016/j.scitotenv.2022.155359. [PMID: 35460791]
  • Faezeh Ghaderi, Elham Ebrahimi, Fatemeh Sari Aslani, Omid Koohi-Hosseinabadi, Farhad Koohpeyma, Cambyz Irajie, Nader Tanideh, Aida Iraji. The effect of hydroalcoholic extract of Psidium guajava L. on experimentally induced oral mucosal wound in rat. BMC complementary medicine and therapies. 2022 Jul; 22(1):201. doi: 10.1186/s12906-022-03655-5. [PMID: 35906612]
  • Maor Wanounou, Chanan Shaul, Zahi Abu Ghosh, Shoshana Alamia, Yoseph Caraco. The Impact of CYP2C9*11 Allelic Variant on the Pharmacokinetics of Phenytoin and (S)-Warfarin. Clinical pharmacology and therapeutics. 2022 07; 112(1):156-163. doi: 10.1002/cpt.2613. [PMID: 35426132]
  • Shamir N Kalaria, Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V Gobburu, Mathangi Gopalakrishnan. Development and Use of an Ex-Vivo In-Vivo Correlation to Predict Antiepileptic Drug Clearance in Patients Undergoing Continuous Renal Replacement Therapy. Pharmaceutical research. 2022 May; 39(5):827-836. doi: 10.1007/s11095-022-03287-x. [PMID: 35552966]
  • Yannick Lipecki, Ekkehard Haen. Simultaneous Quantification of 11 Antiseizure Medications and Metabolites in Serum for Therapeutic Drug Monitoring Using High-Performance Liquid Chromatography with Ultraviolet Detection: A Short Communication. Therapeutic drug monitoring. 2022 04; 44(2):345-350. doi: 10.1097/ftd.0000000000000908. [PMID: 35292610]
  • Naga Chalasani, Herbert L Bonkovsky, Jonathan G Stine, Jiezhun Gu, Huiman Barnhart, Elin Jacobsen, Einar Björnsson, Robert J Fontana, David E Kleiner, Jay H Hoofnagle. Clinical characteristics of antiepileptic-induced liver injury in patients from the DILIN prospective study. Journal of hepatology. 2022 Apr; 76(4):832-840. doi: 10.1016/j.jhep.2021.12.013. [PMID: 34953957]
  • Jesús Daniel Cardoso-Vera, Leobardo Manuel Gómez-Oliván, Hariz Islas-Flores, Sandra García-Medina, José Manuel Orozco-Hernández, Gerardo Heredia-García, Gustavo Axel Elizalde-Velázquez, Marcela Galar-Martínez, Nely SanJuan-Reyes. Acute exposure to environmentally relevant concentrations of phenytoin damages early development and induces oxidative stress in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Mar; 253(?):109265. doi: 10.1016/j.cbpc.2021.109265. [PMID: 34990834]
  • Shuhei Fukuno, Katsuhito Nagai, Shizuka Yamaoka, Fuka Yamada, Haruna Mizumoto, Takuya Ito, Hiroki Konishi. Doxorubicin alters the disposition of phenytoin by reducing its metabolic elimination and binding affinity to serum albumin in rats. The Journal of pharmacy and pharmacology. 2022 Feb; 74(2):200-207. doi: 10.1093/jpp/rgab169. [PMID: 34923583]
  • Alexander Walker, Arashdeep Rupal, Chinmay Jani, Omar Al Omari, Harpreet Singh, Dipesh Patel, Carmen Perrino, Jessica McCannon. Longstanding Phenytoin Use as a Cause of Progressive Dyspnea. Chest. 2022 02; 161(2):e91-e96. doi: 10.1016/j.chest.2021.08.079. [PMID: 35131079]
  • Zhen Wang, Xiaoyu Wang, Zhe Wang, Xin Lv, Hang Yin, Wei Li, Wenli Li, Lili Jiang, Yong Liu. Potential herb-drug interaction risk of thymoquinone and phenytoin. Chemico-biological interactions. 2022 Feb; 353(?):109801. doi: 10.1016/j.cbi.2022.109801. [PMID: 34998822]
  • Younus Mohammad, Richard N Prentice, Ben J Boyd, Shakila B Rizwan. Comparison of cubosomes and hexosomes for the delivery of phenytoin to the brain. Journal of colloid and interface science. 2022 Jan; 605(?):146-154. doi: 10.1016/j.jcis.2021.07.070. [PMID: 34311309]
  • Zuryat Ashraf, Samina Farhat, Mohd Younis Rather. Use of Saliva as an Alternative Matrix to Serum/Plasma for Therapeutic Drug Monitoring Using Reverse-Phase HPLC. Clinical therapeutics. 2021 12; 43(12):2127-2135. doi: 10.1016/j.clinthera.2021.10.012. [PMID: 34794834]
  • Shusaku Noro, Yoshinobu Seo, Kaori Honjo, Masahiro Okuma, Bunsho Asayama, Yuki Amano, Masanori Kyono, Kazuya Sako, Hirohiko Nakamura. Intravenous fosphenytoin therapy for rescue of acute trigeminal neuralgia crisis in patients awaiting neurosurgical procedures: A cross-sectional study. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2021 Dec; 94(?):59-64. doi: 10.1016/j.jocn.2021.09.040. [PMID: 34863463]
  • Amal Yousfan, Noelia Rubio, Mohammad Al-Ali, Abdul Hakim Nattouf, Houmam Kafa. Intranasal delivery of phenytoin-loaded nanoparticles to the brain suppresses pentylenetetrazol-induced generalized tonic clonic seizures in an epilepsy mouse model. Biomaterials science. 2021 Nov; 9(22):7547-7564. doi: 10.1039/d1bm01251g. [PMID: 34652351]
  • Agathe Béranger, Carine Farkh, Samira Ahmed Elie, Delphine Callot, Isabelle Desguerre, Nicolas Pallet, Mehdi Oualha, Pascal Houzé, Jean-Sébastien Diana, Sylvain Renolleau, Laurent Chouchana, Fabrice Lesage. Efficiency of continuous venous-venous hemodiafiltration in a life-threatening phenytoin poisoning: A case report. Therapie. 2021 Nov; 76(6):751-754. doi: 10.1016/j.therap.2021.02.005. [PMID: 33743990]
  • Abhishek Juneja, Kuljeet S Anand. Cerebellar Ataxia in Epilepsy Patient with Normal Serum Phenytoin Levels? Suspect Hyperammonemia. Neurology India. 2021 Nov; 69(6):1869. doi: 10.4103/0028-3886.333518. [PMID: 34979716]
  • Giovanni Mastroianni, Luigi Francesco Iannone, Roberta Roberti, Sara Gasparini, Michele Ascoli, Vittoria Cianci, Giovambattista De Sarro, Antonio Gambardella, Angelo Labate, Francesco Brigo, Emilio Russo, Umberto Aguglia, Edoardo Ferlazzo. Management of status epilepticus in patients with liver or kidney disease: a narrative review. Expert review of neurotherapeutics. 2021 11; 21(11):1251-1264. doi: 10.1080/14737175.2021.1862649. [PMID: 33297776]
  • Ingrid Fricke-Galindo, Helgi Jung-Cook, Iris E Martínez-Juárez, Nancy Monroy-Jaramillo, Alberto Ortega-Vázquez, Irma S Rojas-Tomé, Pedro Dorado, Eva Peñas-Lledó, Adrián Llerena, Marisol López-López. Relevance of NR1I2 variants on carbamazepine therapy in Mexican Mestizos with epilepsy at a tertiary-care hospital. Pharmacogenomics. 2021 10; 22(15):983-996. doi: 10.2217/pgs-2021-0081. [PMID: 34612084]
  • Ana Ferreira, Márcio Rodrigues, Sara Meirinho, Ana Fortuna, Amílcar Falcão, Gilberto Alves. Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats. Drug and chemical toxicology. 2021 Sep; 44(5):458-469. doi: 10.1080/01480545.2019.1601736. [PMID: 31020859]
  • Orlando Salinas-Jaramillo, Alejandra Monroy-Arreola, Sebastian Herrera-Noreña, Ana L Guzmán-Ortiz, Abrahan Hernández-Hernández, Silvia Méndez-Flores, Judith Domínguez-Cherit, Noe V Duran-Figueroa, Dean J Naisbitt, Pedro Cortes-Reynosa, Eduardo Perez Salazar, Héctor Quezada, J Luis Castrejón-Flores. Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions. Chemical research in toxicology. 2021 07; 34(7):1738-1748. doi: 10.1021/acs.chemrestox.1c00047. [PMID: 34142820]
  • Wei Li, Zhen Wang, Xiaoyu Wang, Xiaowei Cao, Caili Bi, Lili Jiang, Shuna Cui, Yong Liu. Risk prediction of drug-drug interaction potential of phenytoin and miconazole topical formulations. Chemico-biological interactions. 2021 Jul; 343(?):109498. doi: 10.1016/j.cbi.2021.109498. [PMID: 33961833]
  • Juntip Kanjanasilp, Ratree Sawangjit, Sirikhwan Phanthaisong, Wongvaruth Borihanthanawuth. A meta-analysis of effects of CYP2C9 and CYP2C19 polymorphisms on phenytoin pharmacokinetic parameters. Pharmacogenomics. 2021 07; 22(10):629-640. doi: 10.2217/pgs-2020-0151. [PMID: 34060344]
  • Ryohei Otani, Ryoji Yamada, Kei Kawaguchi, Miyu Kikuchi, Yoshihiro Kushihara, Nobusada Shinoura. Utility of monitoring the serum levetiracetam concentration for intraoperative seizure control during awake craniotomy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2021 Jul; 89(?):279-282. doi: 10.1016/j.jocn.2021.05.028. [PMID: 34119281]
  • Brian L Erstad. Serum Albumin Levels: Who Needs Them?. The Annals of pharmacotherapy. 2021 06; 55(6):798-804. doi: 10.1177/1060028020959348. [PMID: 32909438]
  • Abhishek G Sathe, Usha Mishra, Vijay Ivaturi, Richard C Brundage, James C Cloyd, Jordan J Elm, James M Chamberlain, Robert Silbergleit, Jaideep Kapur, Daniel H Lowenstein, Shlomo Shinnar, Hannah R Cock, Nathan B Fountain, Lynn Babcock, Lisa D Coles. Early Exposure of Fosphenytoin, Levetiracetam, and Valproic Acid After High-Dose Intravenous Administration in Young Children With Benzodiazepine-Refractory Status Epilepticus. Journal of clinical pharmacology. 2021 06; 61(6):763-768. doi: 10.1002/jcph.1801. [PMID: 33336359]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ritesh Kumar, Renu Arora, Sudhir Chandra Sarangi, Shankar Ganeshan N, Amit Agarwal, Thomas Kaleekal, Yogendra Kumar Gupta. Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. Journal of ethnopharmacology. 2021 Apr; 270(?):113784. doi: 10.1016/j.jep.2021.113784. [PMID: 33429032]
  • Amanda Z Wiebe, Kimberly Terry, John Skaggs. Phenytoin Serum Concentrations in Patients With Left Ventricular Support Devices: A Case Series. Journal of pharmacy practice. 2021 Apr; 34(2):325-328. doi: 10.1177/0897190019894424. [PMID: 31868073]
  • Pooja Sudarsan, Resia Varghese, Aneena Suresh, Arun Radhakrishnan. Phenytoin-Induced Paradoxical Seizures and Blood Dyscrasias in a Patient Receiving Rapid Intravenous Infusion: A Case Report. Journal of pharmacy practice. 2021 Apr; 34(2):306-308. doi: 10.1177/0897190019894868. [PMID: 31875759]
  • M Kathiravan, S Kavitha, R Shanthi. To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients. Scientific reports. 2021 02; 11(1):4393. doi: 10.1038/s41598-021-83312-y. [PMID: 33623072]
  • Koichiro Hotta, Tomomi Ishida, Ken-Ichi Noritake, Kenji Kita, Yuji Mano. Quantitative and qualitative application of a novel capillary microsampling device, Microsampling Wing™ (MSW), using antiepileptic drugs in rats. Journal of pharmaceutical and biomedical analysis. 2021 Feb; 194(?):113788. doi: 10.1016/j.jpba.2020.113788. [PMID: 33281005]
  • R Raftopoulos, J Kuhle, D Grant, S J Hickman, D R Altmann, D Leppert, K Blennow, H Zetterberg, R Kapoor, G Giovannoni, S Gnanapavan. Neurofilament results for the phase II neuroprotection study of phenytoin in optic neuritis. European journal of neurology. 2021 02; 28(2):587-594. doi: 10.1111/ene.14591. [PMID: 33058438]
  • Sampada Jangam, Meenakshi Deodhar, Sagar Wankhede. Synthesis and Biological Evaluation of Amino Acid Based Mutual Amide Prodrugs of Phenytoin as Anticonvulsant Agents. Central nervous system agents in medicinal chemistry. 2021; 21(1):53-72. doi: 10.2174/1871524920666201109152344. [PMID: 33167845]
  • Yang Lv, Hongyu Liang, Jun Li, Xiuxiu Li, Xiaohui Tang, Songyu Gao, Hao Zou, Jing Zhang, Mei Wang, Liang Xiao. Central inhibition prevents the in vivo acute toxicity of harmine in mice. The Journal of toxicological sciences. 2021; 46(6):289-301. doi: 10.2131/jts.46.289. [PMID: 34078836]
  • Behrouz Seyfinejad, Maryam Khoubnasabjafari, Saba Eivaz Ziaei, Sibel A Ozkan, Abolghasem Jouyban. Electromembrane extraction as a new approach for determination of free concentration of phenytoin in plasma using capillary electrophoresis. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2020 Dec; 28(2):615-624. doi: 10.1007/s40199-020-00366-5. [PMID: 32803689]
  • Yoshiaki Yamamoto, Yuka Shiratani, Shoko Asai, Naotaka Usui, Takuji Nishida, Katsumi Imai, Yoshiyuki Kagawa, Yukitoshi Takahashi. Pharmacokinetics, tolerability, and clinical effectiveness of perampanel in Japanese patients with epilepsy. Seizure. 2020 Dec; 83(?):181-186. doi: 10.1016/j.seizure.2020.10.017. [PMID: 33171342]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Atiwat Soontornpun, Natthakarn Manoyana, Nattayaporn Apaijai, Kanokporn Pinyopornpanish, Kanokwan Pinyopornpanish, Angkana Nadsasarn, Surat Tanprawate, Nipon Chattipakorn, Siriporn C Chattipakorn. Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy. Epilepsy research. 2020 11; 167(?):106471. doi: 10.1016/j.eplepsyres.2020.106471. [PMID: 33007725]
  • Sheng Feng, Brandi Bridgewater, Erin C Strickland, Gregory McIntire. A Rapid LC-MS-MS Method for the Quantitation of Antiepileptic Drugs in Urine. Journal of analytical toxicology. 2020 Oct; 44(7):688-696. doi: 10.1093/jat/bkaa095. [PMID: 32744607]
  • S Nishida, Y Hayashi, K Hirai, A Takekoshi, Y Yamada, R Kobayashi, S Shimizu, T Niwa, H Hayashi, T Shimohata, T Sugiyama, A Suzuki. Effect of therapeutic plasma exchange on phenytoin plasma concentration in patients receiving intravenous fosphenytoin therapy. Die Pharmazie. 2020 10; 75(10):488-490. doi: 10.1691/ph.2020.0525. [PMID: 33305722]
  • Juanhong Zhang, Mingxia Zhang, Junmin Zhang, Rong Wang. Enhanced P-glycoprotein expression under high-altitude hypoxia contributes to increased phenytoin levels and reduced clearance in rats. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Oct; 153(?):105490. doi: 10.1016/j.ejps.2020.105490. [PMID: 32721527]
  • Yoshiaki Yamamoto, Kiyohito Terada, Yasukiyo Araki, Yutaro Fukushima, Katsumi Imai, Yoshiyuki Kagawa, Yukitoshi Takahashi. Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range. Therapeutic drug monitoring. 2020 10; 42(5):754-759. doi: 10.1097/ftd.0000000000000764. [PMID: 32941398]
  • Wan-Chun Chang, Shuen-Iu Hung, Bruce C Carleton, Wen-Hung Chung. An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects. Expert opinion on drug metabolism & toxicology. 2020 Aug; 16(8):723-734. doi: 10.1080/17425255.2020.1780209. [PMID: 32510242]
  • Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics. 2020 Aug; 35(4):389-396. doi: 10.1016/j.dmpk.2020.05.004. [PMID: 32690433]
  • Linda Xu, Wonhye Lee, Alexander Rotenberg, Mark Böhlke, Kyungho Yoon, Seung-Schik Yoo. Localized Disruption of Blood Albumin-Phenytoin Binding Using Transcranial Focused Ultrasound. Ultrasound in medicine & biology. 2020 08; 46(8):1986-1997. doi: 10.1016/j.ultrasmedbio.2020.04.011. [PMID: 32402673]
  • Oguzhan Fırat, Nadir Yalçın, Kutay Demirkan. COVID-19 & antiepileptic drugs: Should we pay attention?. Seizure. 2020 08; 80(?):240-241. doi: 10.1016/j.seizure.2020.07.005. [PMID: 32663783]
  • Aditi Sharma, Krista A Wahby, Mohammed Inany, Sarah J Lee. Use of phenytoin for treatment of tacrolimus toxicity with superimposed sepsis. BMJ case reports. 2020 Jul; 13(7):. doi: 10.1136/bcr-2020-234839. [PMID: 32690569]
  • Taylor M Harkness, Elizabeth A Cohen, William S Asch, Kristen D Belfield. Clinical Implications of Unique Drug Interaction Between Extended Release Tacrolimus and Phenytoin. Progress in transplantation (Aliso Viejo, Calif.). 2020 06; 30(2):177-178. doi: 10.1177/1526924820913500. [PMID: 32233829]
  • Edilene Gadelha de Oliveira, Rafaela Santos de Oliveira, Kelly Cristine Zatta, Ana Flávia Furian, Mauro Schneider Oliveira, Adriana Raffin Pohlmann, Sílvia Stanisçuaski Guterres, Ruy Carlos Ruver Beck. Phenytoin-loaded lipid-core nanocapsules improve the technological properties and in vivo performance of fluidised bed granules. Materials science & engineering. C, Materials for biological applications. 2020 Jun; 111(?):110753. doi: 10.1016/j.msec.2020.110753. [PMID: 32279762]
  • Neha Dhir, Savita Verma Attri, Smita Pattanaik, M Praveen Kumar, Navjit Kaur Gill, Ajay Patial, Nidhi Rathore, Lekha Saha, Sandeep Mohindra. Aneurysmal Subarachnoid Hemorrhage: Impact on Phenytoin Permeability across the Blood-Brain Barrier. Neurology India. 2020 May; 68(3):588-592. doi: 10.4103/0028-3886.288987. [PMID: 32643669]
  • Anne Hagemann, Dennis Klimpel, Christian G Bien, Christian Brandt, Theodor W May. Influence of dose and antiepileptic comedication on brivaracetam serum concentrations in patients with epilepsy. Epilepsia. 2020 05; 61(5):e43-e48. doi: 10.1111/epi.16500. [PMID: 32304097]
  • Michelle Knecht, Joseph LaRochelle, Brian Barkemeyer, Raegan Gupta, Michael Brumund, Christy Mumphrey. Cardiac Collapse Secondary to Phenytoin Toxicity in a Neonate Treated with Extracorporeal Membrane Oxygenation Support (ECMO). Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2020 04; 16(2):230-235. doi: 10.1007/s13181-019-00742-x. [PMID: 31773636]
  • A Ashna, D F van Helden, C Dos Remedios, P Molenaar, D R Laver. Phenytoin Reduces Activity of Cardiac Ryanodine Receptor 2; A Potential Mechanism for Its Cardioprotective Action. Molecular pharmacology. 2020 04; 97(4):250-258. doi: 10.1124/mol.119.117721. [PMID: 32015008]
  • Kavita Srivastava, Shirish Bhartiya, Vrushabh Gavli, Rahul Patil, Surekha Rajadhyaksha. Efficacy, Tolerability and Serum Phenytoin Levels after Intravenous Fosphenytoin Loading Dose in Children with Status Epilepticus. Indian pediatrics. 2020 03; 57(3):218-221. doi: 10.1007/s13312-020-1754-5. [PMID: 32198860]
  • Vinayagamoorthy Vignesh, Ramachandran Rameshkumar, Subramanian Mahadevan. Comparison of Phenytoin, Valproate and Levetiracetam in Pediatric Convulsive Status Epilepticus: A Randomized Double-blind Controlled Clinical Trial. Indian pediatrics. 2020 03; 57(3):222-227. doi: . [PMID: 32198861]
  • Chitra Rawat, Shivangi, Suman Kushwaha, Sangeeta Sharma, Achal K Srivastava, Ritushree Kukreti. Altered plasma prostaglandin E2 levels in epilepsy and in response to antiepileptic drug monotherapy. Prostaglandins, leukotrienes, and essential fatty acids. 2020 02; 153(?):102056. doi: 10.1016/j.plefa.2020.102056. [PMID: 32007745]
  • Neeraj Kumar Sharma, Sukhdeep Kaur, Rajesh Kumar Goel. Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. Epilepsy & behavior : E&B. 2020 02; 103(Pt A):106862. doi: 10.1016/j.yebeh.2019.106862. [PMID: 31917144]
  • C Rawat, S Kukal, S Kushwaha, R Agarwal, S Sharma, A K Srivastava, R Kukreti. Elevated serum alkaline phosphatase in epilepsy: effect of age and treatment. British journal of biomedical science. 2020 Jan; 77(1):44-47. doi: 10.1080/09674845.2019.1663781. [PMID: 31483219]
  • Yusuke Marikawa, Hong-Ru Chen, Mark Menor, Youping Deng, Vernadeth B Alarcon. Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reproductive toxicology (Elmsford, N.Y.). 2020 01; 91(?):74-91. doi: 10.1016/j.reprotox.2019.10.004. [PMID: 31711903]
  • Hamidreza Mohammadi, Amir Shamshirian, Shafagh Eslami, Danial Shamshirian, Mohammad Ali Ebrahimzadeh. Magnesium Sulfate Attenuates Lethality and Oxidative Damage Induced by Different Models of Hypoxia in Mice. BioMed research international. 2020; 2020(?):2624734. doi: 10.1155/2020/2624734. [PMID: 33381544]
  • Daniel Muñoz-Pichuante, Lorenzo Villa Zapata, Salvador Cabrera, Ximena Lagos, Juan Grandjean. Dosage of phenytoin in neurocritical patients using Bayesian algorithms: a pilot study. Drug metabolism and personalized therapy. 2019 12; 34(4):. doi: 10.1515/dmpt-2019-0015. [PMID: 31981450]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Kanae Higuchi, Daiki Yamashita, Yushi Kashihara, Makoto Kakara, Takeshi Hirota, Masaaki Hirakawa, Ichiro Ieiri. Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients. Therapeutic drug monitoring. 2019 10; 41(5):674-680. doi: 10.1097/ftd.0000000000000651. [PMID: 31095070]
  • Rob Ter Heine, Sean P Kane, Alwin D R Huitema, Matthew D Krasowski, Erik M van Maarseveen. Nonlinear protein binding of phenytoin in clinical practice: Development and validation of a mechanistic prediction model. British journal of clinical pharmacology. 2019 10; 85(10):2360-2368. doi: 10.1111/bcp.14053. [PMID: 31269540]
  • Caroline Moerke, Isabel Jaco, Christin Dewitz, Tammo Müller, Annette V Jacobsen, Jérémie Gautheron, Jürgen Fritsch, Jessica Schmitz, Jan Hinrich Bräsen, Claudia Günther, James M Murphy, Ulrich Kunzendorf, Pascal Meier, Stefan Krautwald. The anticonvulsive Phenhydan® suppresses extrinsic cell death. Cell death and differentiation. 2019 09; 26(9):1631-1645. doi: 10.1038/s41418-018-0232-2. [PMID: 30442947]
  • Y Urashima, K Urashima, M Ohnishi, K Matsushita, K Suzuki, K Kurachi, M Nishihara, T Katsumata, M Myotoku, K Ikeda, Y Hirotani. Interaction between phenytoin and enteral nutrients and its influence on gastrointestinal absorption. Die Pharmazie. 2019 09; 74(9):559-562. doi: 10.1691/ph.2019.9532. [PMID: 31484597]
  • Amira Motawea, Abd El-Gawad H Abd El-Gawad, Thanaa Borg, Mohamad Motawea, Manal Tarshoby. The impact of topical phenytoin loaded nanostructured lipid carriers in diabetic foot ulceration. Foot (Edinburgh, Scotland). 2019 Sep; 40(?):14-21. doi: 10.1016/j.foot.2019.03.007. [PMID: 30999080]
  • Saeed Alqahtani, Norah Alandas, Abdullah Alsultan. Estimation of apparent clearance of valproic acid in adult Saudi patients. International journal of clinical pharmacy. 2019 Aug; 41(4):1056-1061. doi: 10.1007/s11096-019-00864-w. [PMID: 31222537]
  • Margaret C Montgomery, Jennifer W Chou, Thomas O McPharlin, Geoffrey S Baird, Gail D Anderson. Predicting Unbound Phenytoin Concentrations: Effects of Albumin Concentration and Kidney Dysfunction. Pharmacotherapy. 2019 07; 39(7):756-766. doi: 10.1002/phar.2273. [PMID: 31067355]
  • Maryam Khoubnasabjafari, Azam Samadi, Abolghasem Jouyban. In-situ microscale spectrophotometric determination of phenytoin by using branched gold nanoparticles. Mikrochimica acta. 2019 06; 186(7):422. doi: 10.1007/s00604-019-3546-y. [PMID: 31187298]
  • Nobutsune Ishikawa, Yuichi Tateishi, Hiroo Tani, Yoshiyuki Kobayashi, Masao Kobayashi. Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy. Epilepsy & behavior : E&B. 2019 05; 94(?):82-86. doi: 10.1016/j.yebeh.2019.02.004. [PMID: 30897534]
  • S Osorio, V Escudero-Vilaplana, I Gómez-Centurión, E González-Arias, X García-González, J L Díez. Inadequate response to imatinib treatment in chronic myeloid leukemia due to a drug interaction with phenytoin. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2019 Apr; 25(3):694-698. doi: 10.1177/1078155217743565. [PMID: 29199506]
  • Yubin Xu, Na Zhang, Shanshan Xu, Hongyan Xu, Saizhen Chen, Zhelin Xia. Effects of phenytoin on serum levels of homocysteine, vitamin B12, folate in patients with epilepsy: A systematic review and meta-analysis (PRISMA-compliant article). Medicine. 2019 Mar; 98(12):e14844. doi: 10.1097/md.0000000000014844. [PMID: 30896627]
  • Naoki Yoshikawa, Tomoya Tazaki, Mari Hatanaka, Yasuharu Oda, Nobuhiro Matsumoto, Junichiro Sonoda, Ryuji Ikeda. Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report. Journal of clinical pharmacy and therapeutics. 2019 Feb; 44(1):119-121. doi: 10.1111/jcpt.12764. [PMID: 30311244]
  • Barry E Gidal, Jim Ferry, Antonio Laurenza, Takashi Ueno. Potential protein-binding displacement interactions with perampanel: An in vitro analysis. Epilepsy research. 2019 01; 149(?):102-106. doi: 10.1016/j.eplepsyres.2018.12.003. [PMID: 30580179]
  • Saeed Alqahtani, Thuraya Alzaidi, Mashal Alotaibi, Abdullah Alsultan. Estimation of Phenytoin Pharmacokinetic Parameters in Saudi Epileptic Patients. Pharmacology. 2019; 104(1-2):60-66. doi: 10.1159/000500314. [PMID: 31067540]
  • Zhongdong Li, Chuan Wang, Shuangmin Ji, Hao Jin, Guiqin Song. The Evolution of Population Pharmacokinetic Model of Oral Phenytoin for Early Seizure Prophylaxis Post-Craniotomy. Current drug metabolism. 2019; 20(9):756-764. doi: 10.2174/1389200220666190913115837. [PMID: 31518217]
  • Dhruvkumar M Patel, Jayanti K Gurumukhani, Mukundkumar V Patel, Greshaben R Patel. Phenytoin Induced Chorea: A Rare Adverse Effect of the Drug. Current drug safety. 2019; 14(1):51-52. doi: 10.2174/1574886313666181031161215. [PMID: 30381086]
  • Yoshiaki Yamamoto, Yukitoshi Takahashi, Asako Horino, Naotaka Usui, Takuji Nishida, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Influence of Inflammation on the Pharmacokinetics of Perampanel. Therapeutic drug monitoring. 2018 12; 40(6):725-729. doi: 10.1097/ftd.0000000000000556. [PMID: 30086086]
  • Moisés Hamoy, Luiz Dos Santos Batista, Vanessa Joia de Mello, Walace Gomes-Leal, Rômulo Augusto Feio Farias, Pedro Dos Santos Batista, José Luiz Martins do Nascimento, Helcio Casemiro Marcondes, Jason G Taylor, William D Hutchison, Marcelo Ferreira Torres, Luis André L Barbas. Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses. Toxicology and applied pharmacology. 2018 12; 360(?):193-200. doi: 10.1016/j.taap.2018.10.008. [PMID: 30296455]
  • Edilene Gadelha de Oliveira, Aline Marquez Cardoso, Karina Paese, Karine Coradini, Clarissa Vasconcelos de Oliveira, Adriana Raffin Pohlmann, Mauro Schneider Oliveira, Sílvia Stanisçuaski Guterres, Ruy Carlos Ruver Beck. Reconstituted spray-dried phenytoin-loaded nanocapsules improve the in vivo phenytoin anticonvulsant effect and the survival time in mice. International journal of pharmaceutics. 2018 Nov; 551(1-2):121-132. doi: 10.1016/j.ijpharm.2018.09.023. [PMID: 30218826]
  • Ziyaur Rahman, Sathish Dharani, Sogra F Barakh Ali, Hamideh Afrooz, Indra K Reddy, Mansoor A Khan. Effect of processing parameters and controlled environment storage on the disproportionation and dissolution of extended-release capsule of phenytoin sodium. International journal of pharmaceutics. 2018 Oct; 550(1-2):290-299. doi: 10.1016/j.ijpharm.2018.07.042. [PMID: 30031866]
  • Brady S Moffett, Mindl M Weingarten, Lindsay R Schmees, Marianne Galati, Jennifer Erklauer, James J Riviello. Fosphenytoin Population Pharmacokinetics in the Acutely Ill Pediatric Population. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2018 08; 19(8):748-754. doi: 10.1097/pcc.0000000000001627. [PMID: 29927880]
  • Yuta Ohno, Takashi Niwa, Keita Hirai, Keiko Suzuki, Yuto Yamada, Yuichi Hayashi, Hideki Hayashi, Akio Suzuki, Yoshinori Itoh. Time-Dependent Decline in Serum Phenytoin Concentration With Heightened Convulsive Seizure Risk by Prolonged Administration of Fosphenytoin in Japanese: A Retrospective Study. Therapeutic drug monitoring. 2018 08; 40(4):507-511. doi: 10.1097/ftd.0000000000000521. [PMID: 29683874]
  • Julius Höhne, Karl-Michael Schebesch, Christian Ott, Alexander Brawanski, Max Lange. The risk of hypotension and seizures in patients receiving prophylactic anti-epileptic drugs for supratentorial craniotomy. Journal of neurosurgical sciences. 2018 Aug; 62(4):418-422. doi: 10.23736/s0390-5616.16.03826-1. [PMID: 27854111]
  • Kristine Hole, Birgit M Wollmann, Camilla Nguyen, Tore Haslemo, Espen Molden. Comparison of CYP3A4-Inducing Capacity of Enzyme-Inducing Antiepileptic Drugs Using 4β-Hydroxycholesterol as Biomarker. Therapeutic drug monitoring. 2018 08; 40(4):463-468. doi: 10.1097/ftd.0000000000000518. [PMID: 29649093]
  • Sapan Kumar Behera, Saibal Das, Alphienes Stanley Xavier, Sandhiya Selvarajan. DRESS syndrome: a detailed insight. Hospital practice (1995). 2018 Aug; 46(3):152-162. doi: 10.1080/21548331.2018.1451205. [PMID: 29519170]
  • Ashley B Prusakov, Anup D Patel, Justin W Cole. Impact of Obesity on Fosphenytoin Volume of Distribution in Pediatric Patients. Journal of child neurology. 2018 07; 33(8):534-536. doi: 10.1177/0883073818770801. [PMID: 29714095]
  • Fei Gao, Ying Gao, Fangling Meng, Chunmei Yang, Jiangfeng Fu, Yajun Li. The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus. Basic & clinical pharmacology & toxicology. 2018 Jul; 123(1):14-20. doi: 10.1111/bcpt.12973. [PMID: 29380527]
  • Abdul Sami Shaikh, Yi Li, Lili Cao, Ruichen Guo. Analysis of phenytoin drug concentration for evaluation of clinical response, uncontrolled seizures and toxicity. Pakistan journal of pharmaceutical sciences. 2018 Jul; 31(4(Special)):1697-1700. doi: . [PMID: 30203765]
  • Seyed Mohammad Reza Javadi, Mamak Hashemi, Younes Mohammadi, Alireza MamMohammadi, Ali Sharifi, Hamid Reza Makarchian. Synergistic effect of honey and Nigella sativa on wound healing in rats. Acta cirurgica brasileira. 2018 Jun; 33(6):518-523. doi: 10.1590/s0102-865020180060000006. [PMID: 30020313]
  • Tiantian Wang, Shiyang Dong, Xiaodong Chen, Kun Qian, Huayu Wang, Hexiu Quan, Zhongli Zhang, Yueming Zuo, Liping Huang, Dongxun Li, Ming Yang, Shilin Yang, Yi Jin, Zengtao Wang. Design, synthesis, biological evaluation, homology modeling and docking studies of (E)-3-(benzo[d][1,3]dioxol-5-ylmethylene) pyrrolidin-2-one derivatives as potent anticonvulsant agents. Bioorganic & medicinal chemistry letters. 2018 05; 28(8):1324-1329. doi: 10.1016/j.bmcl.2018.03.015. [PMID: 29548572]
  • Shakila Thangaratinam, Nadine Marlin, Sian Newton, Annalise Weckesser, Manny Bagary, Lynette Greenhill, Rachel Rikunenko, Maria D'Amico, Ewelina Rogozińska, Andrew Kelso, Kelly Hard, Jamie Coleman, Ngawai Moss, Tracy Roberts, Lee Middleton, Julie Dodds, Angela Pullen, Sandra Eldridge, Alexander Pirie, Elaine Denny, Doug McCorry, Khalid S Khan. AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies. Health technology assessment (Winchester, England). 2018 05; 22(23):1-152. doi: 10.3310/hta22230. [PMID: 29737274]
  • Matías N Baldo, Emmanuel Angeli, Natalia C Gareis, Gabriel A Hunzicker, Marcelo C Murguía, Hugo H Ortega, Gustavo J Hein. Liquid chromatography tandem-mass spectrometry (LC-MS/MS) and dried blood spot sampling applied to pharmacokinetics studies in animals: Correlation of classic and block design. Laboratory animals. 2018 Apr; 52(2):125-134. doi: 10.1177/0023677217734235. [PMID: 29058998]
  • Jana Tchekalarova, Keylla da Conceição Machado, Antonio Luiz Gomes Júnior, Ana Amélia de Carvalho Melo Cavalcante, Albena Momchilova, Rumyana Tzoneva. Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice. Seizure. 2018 Apr; 57(?):22-26. doi: 10.1016/j.seizure.2018.03.009. [PMID: 29547827]