L-Homocystine (BioDeep_00000027627)
Main id: BioDeep_00000001370
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019
代谢物信息卡片
2-Amino-4-{[(3S)-3-amino-3-carboxypropyl]disulphanyl}butanoic acid
化学式: C8H16N2O4S2 (268.0551)
中文名称: L-高胱氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CSSCCC(C(=O)O)N)C(C(=O)O)N
InChI: InChI=1S/C8H16N2O4S2/c9-5(7(11)12)1-3-15-16-4-2-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6-/m0/s1
描述信息
Homocystine is the oxidized form of homocysteine. Homocystine is a dipeptide consisting of two homocysteine molecules joined by a disulfide bond. Homocysteine is a sulfur-containing amino acid that arises during methionine metabolism. Homocystine occurs only transiently before being reduced to homocysteine and converted to the harmless cystathionine via a vitamin B6-dependent enzyme. Homocystine and homocysteine-cysteine mixed disulfides account for >98\\\% of total homocysteine in plasma from healthy individuals (PMID 11592966). Homocystine has been shown to stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells, thereby inducing a vascular cell type-specific oxidative stress. This vascular stress is associated with atherothrombotic cardiovascular disease (PMID: 14980706). High levels of homocysteine (and homocysteine) can be found in individuals suffering from homocystinura due to cystathionine synthase deficiency (PMID: 4685596)
Homocystine is the double-bonded form of homocysteine, but it occurs only transiently before being converted to the harmless cystathionine via a vitamin B6-dependent enzyme.
L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
同义名列表
13 个代谢物同义名
2-Amino-4-{[(3S)-3-amino-3-carboxypropyl]disulphanyl}butanoic acid; 2-amino-4-{[(3S)-3-amino-3-carboxypropyl]disulfanyl}butanoic acid; (2S)-2-amino-4-[(3-amino-3-carboxypropyl)disulfanyl]butanoic acid; 2-Amino-4-{[(3S)-3-amino-3-carboxypropyl]disulphanyl}butanoate; 2-Amino-4-{[(3S)-3-amino-3-carboxypropyl]disulfanyl}butanoate; [S-(R*,r*)]-4,4-dithiobis-2-amino-butanoic acid; [S-(R*,r*)]-4,4-dithiobis-2-amino-butanoate; 4,4-Dithiobis-2-amino-L-butyric acid; 4,4-Dithiobis(2-aminobutyric acid); 4,4-Dithiobis-2-amino-L-butyrate; L-Homocystine; L-Homocystine; L-Homocystine
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:141698
- ChEBI: CHEBI:89698
- KEGG: C01817
- PubChem: 439579
- PubChem: 69382
- HMDB: HMDB0000676
- Wikipedia: Homocystine
- foodb: FDB022176
- chemspider: 62590
- CAS: 626-72-2
- PubChem: 4941
- 3DMET: B01502
- NIKKAJI: J5.770C
- medchemexpress: HY-W011690
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-159
- KNApSAcK: 141698
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Aihua Zhang, Hui Sun, Ying Han, Ye Yuan, Ping Wang, Gaochen Song, Xiaoxia Yuan, Miao Zhang, Ning Xie, Xijun Wang. Exploratory urinary metabolic biomarkers and pathways using UPLC-Q-TOF-HDMS coupled with pattern recognition approach.
The Analyst.
2012 Sep; 137(18):4200-8. doi:
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Journal of medicine and life.
2012 Feb; 5(1):68-73. doi:
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PloS one.
2012; 7(2):e30975. doi:
10.1371/journal.pone.0030975. [PMID: 22383985] - Soo-Jung Lee, Myung-Hee Kang, Hyesun Min. Folic acid supplementation reduces oxidative stress and hepatic toxicity in rats treated chronically with ethanol.
Nutrition research and practice.
2011 Dec; 5(6):520-6. doi:
10.4162/nrp.2011.5.6.520. [PMID: 22259676] - György Jermendy, Tamás Horváth, Levente Littvay, Rita Steinbach, Adám L Jermendy, Adám D Tárnoki, Dávid L Tárnoki, Júlia Métneki, János Osztovits. Effect of genetic and environmental influences on cardiometabolic risk factors: a twin study.
Cardiovascular diabetology.
2011 Nov; 10(?):96. doi:
10.1186/1475-2840-10-96. [PMID: 22050728] - Franziska Marti, Peter Vollenweider, Pedro-Manuel Marques-Vidal, Vincent Mooser, Gérard Waeber, Fred Paccaud, Murielle Bochud. Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study.
BMC public health.
2011 Sep; 11(?):733. doi:
10.1186/1471-2458-11-733. [PMID: 21943240] - Veronica E Ohrvik, Cornelia M Witthoft. Human folate bioavailability.
Nutrients.
2011 04; 3(4):475-90. doi:
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PloS one.
2011 Mar; 6(3):e17706. doi:
10.1371/journal.pone.0017706. [PMID: 21423696] - Vincenzo Jacomella, Monika Wasila, Marc Husmann, Gabriela Gitzelmann, Thomas Meier, Beatrice Amann-Vesti. Plasma Homocysteine is Not Related to the Severity of Microangiopathy in Secondary Raynaud Phenomenon.
The open rheumatology journal.
2011; 5(?):64-8. doi:
10.2174/1874312901105010064. [PMID: 22216066] - Ahmad Mirdamadi, Hamid Farzamnia, Pooyan Varzandeh, Naser Almasi, Mahfar Arasteh. Association between serum homocysteine concentration with coronary artery disease in Iranian patients.
ARYA atherosclerosis.
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ARYA atherosclerosis.
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Clinical ophthalmology (Auckland, N.Z.).
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BMJ (Clinical research ed.).
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International journal of molecular sciences.
2010 Oct; 11(10):3988-98. doi:
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International journal of molecular sciences.
2010 Sep; 11(10):3696-704. doi:
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Yonsei medical journal.
2010 Jul; 51(4):526-33. doi:
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Journal of cardiovascular disease research.
2010 Jul; 1(3):152-7. doi:
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Neuropsychiatric disease and treatment.
2010 May; 6(?):159-95. doi:
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Archives of medical science : AMS.
2010 Apr; 6(2):168-75. doi:
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Journal of Korean medical science.
2010 Apr; 25(4):509-16. doi:
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The Journal of pediatrics.
2010 Feb; 156(2):237-41. doi:
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BMC medical genetics.
2010 Jan; 11(?):6. doi:
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PPAR research.
2010; 2010(?):806538. doi:
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PloS one.
2009 Oct; 4(10):e7540. doi:
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Nutrition & metabolism.
2009 Oct; 6(?):39. doi:
10.1186/1743-7075-6-39. [PMID: 19804640] - Radek Bukowski, Fergal D Malone, Flint T Porter, David A Nyberg, Christine H Comstock, Gary D V Hankins, Keith Eddleman, Susan J Gross, Lorraine Dugoff, Sabrina D Craigo, Ilan E Timor-Tritsch, Stephen R Carr, Honor M Wolfe, Mary E D'Alton. Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study.
PLoS medicine.
2009 May; 6(5):e1000061. doi:
10.1371/journal.pmed.1000061. [PMID: 19434228] - M N Ansari, G K Nigam, Uma Bhandari. Effect of folic Acid on hematological changes in methionine-induced hyperhomocysteinemia in rats.
Indian journal of pharmaceutical sciences.
2009 May; 71(3):270-5. doi:
10.4103/0250-474x.56025. [PMID: 20490293] - Markus Herrmann, Andrea Tami, Britt Wildemann, Martin Wolny, Alexandra Wagner, Heike Schorr, Omid Taban-Shomal, Natalia Umanskaya, Steffen Ross, Patric Garcia, Ulrich Hübner, Wolfgang Herrmann. Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone.
Bone.
2009 Mar; 44(3):467-75. doi:
10.1016/j.bone.2008.10.051. [PMID: 19056526] - Wouter de Ruijter, Rudi G J Westendorp, Willem J J Assendelft, Wendy P J den Elzen, Anton J M de Craen, Saskia le Cessie, Jacobijn Gussekloo. Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study.
BMJ (Clinical research ed.).
2009 Jan; 338(?):a3083. doi:
10.1136/bmj.a3083. [PMID: 19131384] - Hyesun Min. Effects of dietary supplementation of high-dose folic acid on biomarkers of methylating reaction in vitamin B(12)-deficient rats.
Nutrition research and practice.
2009; 3(2):122-7. doi:
10.4162/nrp.2009.3.2.122. [PMID: 20016712] - Sultan Durmus Aydogdu, Birgul Kirel, Turgay Coskun, Suna Kose. Prevalence of cystinuria among elementary schoolchildren in Eskisehir, Turkey.
Scandinavian journal of urology and nephrology.
2009; 43(2):138-41. doi:
10.1080/00365590802625060. [PMID: 19096983] - Amir Ghorbanihaghjo, Alireza Javadzadeh, Hassan Argani, Nariman Nezami, Nadereh Rashtchizadeh, Mandana Rafeey, Mohammad Rohbaninoubar, Babak Rahimi-Ardabili. Lipoprotein(a), homocysteine, and retinal arteriosclerosis.
Molecular vision.
2008 Sep; 14(?):1692-7. doi:
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Diabetes.
2008 Jul; 57(7):1966-70. doi:
10.2337/db08-0009. [PMID: 18390793] - Marcello Ciaccio, Giulia Bivona, Chiara Bellia. Therapeutical approach to plasma homocysteine and cardiovascular risk reduction.
Therapeutics and clinical risk management.
2008 Feb; 4(1):219-24. doi:
10.2147/tcrm.s1807. [PMID: 18728711] - C Lee Elmore, Rowena G Matthews. The many flavors of hyperhomocyst(e)inemia: insights from transgenic and inhibitor-based mouse models of disrupted one-carbon metabolism.
Antioxidants & redox signaling.
2007 Nov; 9(11):1911-21. doi:
10.1089/ars.2007.1795. [PMID: 17696766] - H Yokote, A Shiraishi, S Shintani, T Shiigai. Acute multiple brain infarction in large-artery atherosclerosis is associated with hyperhomocyst(e)inemia.
Acta neurologica Scandinavica.
2007 Oct; 116(4):243-7. doi:
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Diabetes care.
2007 Aug; 30(8):2122-7. doi:
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Molecular genetics and metabolism.
2007 May; 91(1):85-97. doi:
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Yonsei medical journal.
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Vascular health and risk management.
2007; 3(1):99-108. doi:
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Journal of biomedicine & biotechnology.
2007; 2007(1):80687. doi:
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Mediators of inflammation.
2007; 2007(?):15929. doi:
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BMC cardiovascular disorders.
2006 Sep; 6(?):38. doi:
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Thrombosis journal.
2006 Sep; 4(?):16. doi:
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Pediatrics.
2006 Jul; 118(1):242-53. doi:
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Lipids in health and disease.
2006 Jan; 5(?):1. doi:
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Nutrition & metabolism.
2006 Jan; 3(?):7. doi:
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Environmental health perspectives.
2005 Nov; 113(11):1615-21. doi:
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The Journal of clinical endocrinology and metabolism.
2005 Apr; 90(4):2175-8. doi:
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The British journal of nutrition.
2005 Mar; 93(3):353-60. doi:
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Current drug metabolism.
2005 Feb; 6(1):3-14. doi:
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Vascular medicine (London, England).
2005 Feb; 10(1):15-22. doi:
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Arthritis research & therapy.
2005; 7(6):R1404-11. doi:
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Current pharmaceutical design.
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Vascular health and risk management.
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Reproductive biology and endocrinology : RB&E.
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No to shinkei = Brain and nerve.
2004 Sep; 56(9):781-4. doi:
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Nutrition journal.
2004 May; 3(?):4. doi:
10.1186/1475-2891-3-4. [PMID: 15134582] - M A Williams, S E Sanchez, C Zhang, V Bazul. Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2004 May; 15(5):337-44. doi:
10.1080/14767050410001680037. [PMID: 15280126] - Tatsuya Tagawa, Yoshitoshi Urabe, Yoshikuni Kimura, Satoshi Suzuki, Hiroki Ono, Kotaro Takeda. Long-term treatment with probucol improves endothelial function in patients with coronary artery disease.
Hypertension research : official journal of the Japanese Society of Hypertension.
2004 May; 27(5):311-8. doi:
10.1291/hypres.27.311. [PMID: 15198477] - H H Kornhuber. [Prevention of dementia (including Alzheimer's disease)].
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).
2004 May; 66(5):346-51. doi:
10.1055/s-2004-812832. [PMID: 15141356] - Alexia Sophie Peña, Esko Wiltshire, Roger Gent, Craig Hirte, Jennifer Couper. Folic acid improves endothelial function in children and adolescents with type 1 diabetes.
The Journal of pediatrics.
2004 Apr; 144(4):500-4. doi:
10.1016/j.jpeds.2003.12.049. [PMID: 15069400] - Young Seoub Hong, Myeong Jin Lee, Kyeong Hee Kim, Sang Hwa Lee, Yong Hwan Lee, Byoung Gwon Kim, Baekgeun Jeong, Hyeong Ryeol Yoon, Hisahide Nishio, Joon Youn Kim. The C677 mutation in methylene tetrahydrofolate reductase gene: correlation with uric acid and cardiovascular risk factors in elderly Korean men.
Journal of Korean medical science.
2004 Apr; 19(2):209-13. doi:
10.3346/jkms.2004.19.2.209. [PMID: 15082892] - Stanley J Heydrick, Norbert Weiss, Shane R Thomas, Andre P Cap, David R Pimentel, Joseph Loscalzo, John F Keaney. L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells.
Free radical biology & medicine.
2004 Mar; 36(5):632-40. doi:
10.1016/j.freeradbiomed.2003.12.001. [PMID: 14980706] - Ming Zhang, Christine M Pfeiffer. Comparing the ESA HPLC total homocysteine assay with electrochemical detection to the CDC in-house HPLC assay with fluorescence detection.
Clinica chimica acta; international journal of clinical chemistry.
2004 Feb; 340(1-2):195-200. doi:
10.1016/j.cccn.2003.10.020. [PMID: 14734212] - Markus C Stühlinger, Roberta K Oka, Eric E Graf, Isabella Schmölzer, Barbara M Upson, Om Kapoor, Andrzej Szuba, M Rene Malinow, Thomas C Wascher, Otmar Pachinger, John P Cooke. Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine.
Circulation.
2003 Aug; 108(8):933-8. doi:
10.1161/01.cir.0000085067.55901.89. [PMID: 12912818] - Richard Gillum. Distribution of serum total homocysteine and its association with diabetes and cardiovascular risk factors of the insulin resistance syndrome in Mexican American men: the Third National Health and Nutrition Examination Survey.
Nutrition journal.
2003 Aug; 2(?):6. doi:
10.1186/1475-2891-2-6. [PMID: 12952548] - Ji Zhou, Jan Møller, Merel Ritskes-Hoitinga, Mogen L Larsen, Richard C Austin, Erling Falk. Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice.
Atherosclerosis.
2003 Jun; 168(2):255-62. doi:
10.1016/s0021-9150(03)00138-2. [PMID: 12801608] - Peter J Kelly, Vivian E Shih, J Philip Kistler, Megan Barron, Hang Lee, Roseann Mandell, Karen L Furie. Low vitamin B6 but not homocyst(e)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification.
Stroke.
2003 Jun; 34(6):e51-4. doi:
10.1161/01.str.0000071109.23410.ab. [PMID: 12738890] - Roberto Accinni, Jonica Campolo, Marina Parolini, Renata De Maria, Raffaele Caruso, Andrea Maiorana, Cino Galluzzo, Silvia Bartesaghi, Davide Melotti, Oberdan Parodi. Newborn screening of homocystinuria: quantitative analysis of total homocyst(e)ine on dried blood spot by liquid chromatography with fluorimetric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Mar; 785(2):219-26. doi:
10.1016/s1570-0232(02)00852-8. [PMID: 12554134] - Karsten Sydow, Edzard Schwedhelm, Naoshi Arakawa, Stefanie M Bode-Böger, Dimitrios Tsikas, Burkhard Hornig, Jürgen C Frölich, Rainer H Böger. ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.
Cardiovascular research.
2003 Jan; 57(1):244-52. doi:
10.1016/s0008-6363(02)00617-x. [PMID: 12504835] - Non Eleri Thomas, Julien S Baker, Bruce Davies. Established and recently identified coronary heart disease risk factors in young people: the influence of physical activity and physical fitness.
Sports medicine (Auckland, N.Z.).
2003; 33(9):633-50. doi:
10.2165/00007256-200333090-00001. [PMID: 12846588] - Inimioara Mihaela Cojocaru, Valentina Uscatescu, Camelia Muşuroi, Mihaela Botezat, Alexandra Oprişan, Alina Druţă. Study of total homocyst(e)ine levels in type 2 diabetic patients with silent brain infarction.
Romanian journal of internal medicine = Revue roumaine de medecine interne.
2003; 41(4):417-31. doi:
NULL. [PMID: 15526524] - Andrea Irvin-Jones. Lowering plasma homocyst(e)ine may affect atherosclerotic disease.
The Nurse practitioner.
2002 Oct; 27(10):52-4. doi:
10.1097/00006205-200210000-00019. [PMID: 12394589] - Muh-Han Shen, Nain-Feng Chu, Der-Min Wu, Jin-Biou Chang. Plasma homocyst(e)ine, folate and vitamin B(12) levels among school children in Taiwan: The Taipei Children Heart Study.
Clinical biochemistry.
2002 Sep; 35(6):495-8. doi:
10.1016/s0009-9120(02)00344-2. [PMID: 12413612] - Agostino Virdis, Lorenzo Ghiadoni, Guido Salvetti, Daniele Versari, Stefano Taddei, Antonio Salvett. Hyperhomocyst(e)inemia: is this a novel risk factor in hypertension?.
Journal of nephrology.
2002 Jul; 15(4):414-21. doi:
NULL. [PMID: 12243373] - Esko J Wiltshire, Roger Gent, Craig Hirte, Alexia Pena, David W Thomas, Jennifer J Couper. Endothelial dysfunction relates to folate status in children and adolescents with type 1 diabetes.
Diabetes.
2002 Jul; 51(7):2282-6. doi:
10.2337/diabetes.51.7.2282. [PMID: 12086961] - Martin Weger, Olaf Stanger, Hannes Deutschmann, Werner Temmel, Wilfried Renner, Otto Schmut, Franz Quehenberger, Jürgen Semmelrock, Anton Haas. Hyperhomocyst(e)inemia, but not methylenetetrahydrofolate reductase C677T mutation, as a risk factor in branch retinal vein occlusion.
Ophthalmology.
2002 Jun; 109(6):1105-9. doi:
10.1016/s0161-6420(02)01044-8. [PMID: 12045051] - Olaf H Stanger, Hans J Semmelrock, Peter Rehak, Beate Tiran, Andreas Meinitzer, Bruno Rigler, Andreas Tiran. Hyperhomocyst(e)inemia and Chlamydia pneumoniae IgG seropositivity in patients with coronary artery disease.
Atherosclerosis.
2002 May; 162(1):157-62. doi:
10.1016/s0021-9150(01)00686-4. [PMID: 11947909] - Pamela J Schreiner, Kenneth K Wu, M Rene Malinow, Valarie L Stinson, Moyses Szklo, F Javier Nieto, Gerardo Heiss. Hyperhomocyst(e)inemia and hemostatic factors: the atherosclerosis risk in communities study.
Annals of epidemiology.
2002 May; 12(4):228-36. doi:
10.1016/s1047-2797(01)00311-8. [PMID: 11988410] - Martin Weger, Olaf Stanger, Hannes Deutschmann, Werner Temmel, Wilfried Renner, Otto Schmut, Jürgen Semmelrock, Anton Haas. Hyperhomocyst(e)inemia and MTHFR C677T genotypes in patients with central retinal vein occlusion.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.
2002 Apr; 240(4):286-90. doi:
10.1007/s00417-002-0431-9. [PMID: 11981642] - Virginia J Howard, Elizabeth G Sides, George C Newman, Stanley N Cohen, George Howard, M Rene Malinow, James F Toole. Changes in plasma homocyst(e)ine in the acute phase after stroke.
Stroke.
2002 Feb; 33(2):473-8. doi:
10.1161/hs0202.103069. [PMID: 11823655] - Amanda Miller, Vibhas Mujumdar, Lena Palmer, John D Bower, Suresh C Tyagi. Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats.
American journal of hypertension.
2002 Feb; 15(2 Pt 1):157-63. doi:
10.1016/s0895-7061(01)02286-5. [PMID: 11863251] - Haruki Shimizu, Yutaka Kiyohara, Isao Kato, Yumihiro Tanizaki, Hirofumi Ueno, Yasuhiro Kimura, Hiromitsu Iwamoto, Michiaki Kubo, Hisatomi Arima, Setsuro Ibayashi, Masatoshi Fujishima. Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction. The Hisayama study.
Cerebrovascular diseases (Basel, Switzerland).
2002; 13(1):9-15. doi:
10.1159/000047739. [PMID: 11810004] - Judith W Cook, M Rene Malinow, Gregory L Moneta, Lloyd M Taylor, Susan L Orloff. Neointimal hyperplasia in balloon-injured rat carotid arteries: the influence of hyperhomocysteinemia.
Journal of vascular surgery.
2002 Jan; 35(1):158-65. doi:
NULL. [PMID: 11802148] - Brahmajee K Nallamothu, A Mark Fendrick, Gilbert S Omenn. Homocyst(e)ine and coronary heart disease: pharmacoeconomic support for interventions to lower hyperhomocyst(e)inaemia.
PharmacoEconomics.
2002; 20(7):429-42. doi:
10.2165/00019053-200220070-00001. [PMID: 12093299] - J Møller, L Ahola, L Abrahamsson. Evaluation of the DPC IMMULITE 2000 assay for total homocysteine in plasma.
Scandinavian journal of clinical and laboratory investigation.
2002; 62(5):369-73. doi:
10.1080/00365510260296528. [PMID: 12387583] - M H Moghadasian, B M McManus, L B Nguyen, S Shefer, M Nadji, D V Godin, T J Green, J Hill, Y Yang, C H Scudamore, J J Frohlich. Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2001 Dec; 15(14):2623-30. doi:
10.1096/fj.01-0463com. [PMID: 11726538] - J H Yoo, S C Lee. Elevated levels of plasma homocyst(e)ine and asymmetric dimethylarginine in elderly patients with stroke.
Atherosclerosis.
2001 Oct; 158(2):425-30. doi:
10.1016/s0021-9150(01)00444-0. [PMID: 11583722] - K Kario, P B Duell, T Matsuo, T Sakata, H Kato, K Shimada, T Miyata. High plasma homocyst(e)ine levels in elderly Japanese patients are associated with increased cardiovascular disease risk independently from markers of coagulation activation and endothelial cell damage.
Atherosclerosis.
2001 Aug; 157(2):441-9. doi:
10.1016/s0021-9150(00)00738-3. [PMID: 11472745] - J I Sigit, M Hages, K A Brensing, U Frotscher, K Pietrzik, K von Bergmann, D Lütjohann. Total plasma homocysteine and related amino acids in end-stage renal disease (ESRD) patients measured by gas chromatography-mass spectrometry--comparison with the Abbott IMx homocysteine assay and the HPLC method.
Clinical chemistry and laboratory medicine.
2001 Aug; 39(8):681-90. doi:
10.1515/cclm.2001.112. [PMID: 11592433] - O Stanger, M Weger, W Renner, R Konetschny. Vascular dysfunction in hyperhomocyst(e)inemia. Implications for atherothrombotic disease.
Clinical chemistry and laboratory medicine.
2001 Aug; 39(8):725-33. doi:
10.1515/cclm.2001.121. [PMID: 11592442] - T Del Ser, R Barba, A S Herranz, V Seijas, C López-Manglano, J Domingo, M Pondal. Hyperhomocyst(e)inemia is a risk factor of secondary vascular events in stroke patients.
Cerebrovascular diseases (Basel, Switzerland).
2001 Aug; 12(2):91-8. doi:
10.1159/000047687. [PMID: 11490102] - M Weger, O Stanger, H Deutschmann, M Simon, W Renner, O Schmut, J Semmelrock, A Haas. Hyperhomocyst(e)inaemia, but not MTHFR C677T mutation, as a risk factor for non-arteritic ischaemic optic neuropathy.
The British journal of ophthalmology.
2001 Jul; 85(7):803-6. doi:
10.1136/bjo.85.7.803. [PMID: 11423453] - G Y Lip, E Edmunds, S C Martin, A F Jones, A D Blann, D G Beevers. A pilot study of homocyst(e)ine levels in essential hypertension: relationship to von Willebrand factor, an index of endothelial damage.
American journal of hypertension.
2001 Jul; 14(7 Pt 1):627-31. doi:
10.1016/s0895-7061(00)01321-2. [PMID: 11465645]
