Pirenperone (BioDeep_00000275617)

   


代谢物信息卡片


Pirenperone

化学式: C23H24FN3O2 (393.1852)
中文名称: 肾上腺素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(=O)N2C=CC=CC2=N1)CCN3CCC(CC3)C(=O)C4=CC=C(C=C4)F
InChI: InChI=1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
Pirenperone (R 47465) is a 5-HT2 serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity[1][2].

同义名列表

2 个代谢物同义名

Pirenperone; R 47465



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ADRA1A, ADRA2A, DDC, FMR1, POMC, RBMS3
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 1 DRD1
Nucleus 4 ADRA1A, DRD1, FMR1, RBMS3
cytosol 5 ADRA1A, DDC, FMR1, KCNN4, RBMS3
dendrite 7 DRD2, FMR1, GRM2, HTR1A, HTR1B, HTR2A, HTR2C
nucleoplasm 2 ADRA1A, FMR1
Cell membrane 16 ADRA1A, ADRA2A, ADRB3, DRD1, DRD2, FMR1, GRM2, GRM3, HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, KCNN4, OPRD1, SLC6A4
Cleavage furrow 1 HTR3A
ruffle membrane 1 KCNN4
Cell projection, axon 2 FMR1, HTR2A
Cell projection, growth cone 1 FMR1
Multi-pass membrane protein 15 ADRA1A, ADRA2A, ADRB3, DRD1, DRD2, GRM2, GRM3, HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, KCNN4, OPRD1, SLC6A4
Golgi apparatus membrane 1 DRD2
Synapse 7 DRD2, FMR1, GRM2, HTR1A, HTR2C, HTR3A, SLC6A4
dendritic shaft 1 HTR2A
glutamatergic synapse 6 ADRA2A, DRD1, DRD2, GRM2, GRM3, HTR2A
Golgi membrane 1 DRD2
growth cone 1 FMR1
neuronal cell body 3 ADRA2A, HTR2A, KCNN4
postsynapse 2 FMR1, HTR3A
presynaptic membrane 9 DRD1, DRD2, FMR1, GRM2, GRM3, HTR1B, HTR2A, OPRD1, SLC6A4
Presynapse 3 FMR1, HTR2A, SLC6A4
acrosomal vesicle 1 DRD2
plasma membrane 15 ADRA1A, ADRA2A, ADRB3, DRD1, DRD2, GRM2, GRM3, HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, KCNN4, OPRD1, SLC6A4
synaptic vesicle membrane 2 DRD2, OPRD1
Membrane 7 FMR1, GRM2, GRM3, HTR3A, KCNN4, OPRD1, SLC6A4
axon 6 CCK, DRD2, FMR1, GRM2, GRM3, HTR2A
basolateral plasma membrane 1 ADRA2A
caveola 2 ADRA1A, HTR2A
extracellular exosome 1 DDC
endoplasmic reticulum 1 HTR1B
extracellular space 2 CCK, POMC
perinuclear region of cytoplasm 1 FMR1
intracellular membrane-bounded organelle 1 ADRA1A
postsynaptic density 2 FMR1, GRM3
Secreted 2 CCK, POMC
extracellular region 2 CCK, POMC
ciliary membrane 2 DRD1, DRD2
Nucleus membrane 1 ADRA1A
nuclear membrane 1 ADRA1A
dendritic spine 4 DRD1, DRD2, FMR1, GRM3
perikaryon 2 DRD2, FMR1
cytoplasmic vesicle 1 HTR2A
nucleolus 1 FMR1
vesicle 1 KCNN4
growth cone filopodium 1 FMR1
postsynaptic membrane 8 DRD1, DRD2, FMR1, GRM2, GRM3, HTR2A, HTR3A, SLC6A4
presynaptic active zone membrane 1 ADRA2A
Cell projection, filopodium tip 1 FMR1
Cell projection, ruffle membrane 1 KCNN4
Cytoplasm, perinuclear region 1 FMR1
filopodium tip 1 FMR1
Membrane raft 1 SLC6A4
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 1 SLC6A4
GABA-ergic synapse 3 ADRA2A, DRD1, DRD2
Cell projection, dendritic spine 2 DRD1, FMR1
secretory granule 1 POMC
lateral plasma membrane 1 DRD2
Postsynaptic cell membrane 2 FMR1, HTR3A
receptor complex 2 ADRA2A, ADRB3
Cell projection, neuron projection 2 FMR1, SLC6A4
neuron projection 5 FMR1, HTR3A, KCNN4, OPRD1, SLC6A4
cilium 2 DRD1, DRD2
cell projection 1 FMR1
Chromosome 1 FMR1
cytoplasmic ribonucleoprotein granule 1 FMR1
Nucleus, nucleolus 1 FMR1
non-motile cilium 2 DRD1, DRD2
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
sperm flagellum 1 DRD2
Endomembrane system 1 SLC6A4
Membrane, caveola 2 ADRA1A, HTR2A
Chromosome, centromere 1 FMR1
cell body fiber 1 HTR2A
Cell projection, dendrite 5 DRD1, FMR1, GRM2, HTR1A, HTR2A
Cytoplasm, Stress granule 1 FMR1
cytoplasmic stress granule 1 FMR1
Presynaptic cell membrane 1 FMR1
voltage-gated potassium channel complex 1 KCNN4
secretory granule lumen 1 POMC
axon terminus 4 ADRA2A, DRD2, FMR1, OPRD1
endocytic vesicle 1 DRD2
postsynaptic density membrane 2 ADRA2A, OPRD1
neuronal dense core vesicle 1 OPRD1
chromosome, centromeric region 1 FMR1
neurofilament 1 HTR2A
calyx of Held 1 HTR1B
Cajal body 1 FMR1
ribonucleoprotein complex 2 FMR1, RBMS3
Synapse, synaptosome 1 FMR1
Cytoplasm, Cytoplasmic ribonucleoprotein granule 1 FMR1
dopaminergic synapse 2 ADRA2A, DRD2
intracellular non-membrane-bounded organelle 1 FMR1
chromocenter 1 FMR1
dendrite membrane 1 OPRD1
neuronal ribonucleoprotein granule 1 FMR1
Nucleus, Cajal body 1 FMR1
Cell projection, cilium membrane 1 DRD1
astrocyte projection 2 GRM2, GRM3
glial cell projection 1 FMR1
[Isoform 6]: Cytoplasm 1 FMR1
dendritic filopodium 1 FMR1
G protein-coupled receptor complex 2 DRD1, DRD2
G protein-coupled serotonin receptor complex 3 HTR1B, HTR2A, HTR2C
serotonergic synapse 2 HTR1B, SLC6A4
spine apparatus 1 OPRD1
[Isoform 9]: Cytoplasm 1 FMR1
[Isoform 10]: Nucleus 1 FMR1
[Isoform 11]: Nucleus 1 FMR1


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • J C Winter, D Timineri. The discriminative stimulus properties of EGb 761, an extract of Ginkgo biloba. Pharmacology, biochemistry, and behavior. 1999 Mar; 62(3):543-7. doi: 10.1016/s0091-3057(98)00190-7. [PMID: 10080249]
  • H Y Meltzer, M Simonovic, G A Gudelsky. Effects of pirenperone and ketanserin on rat prolactin secretion in vivo and in vitro. European journal of pharmacology. 1983 Aug; 92(1-2):83-9. doi: 10.1016/0014-2999(83)90111-5. [PMID: 6628538]