Ethionamide (BioDeep_00000002720)
Secondary id: BioDeep_00001867780
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
2-ethylpyridine-4-carbothioamide
化学式: C8H10N2S (166.0565)
中文名称: 乙硫异酰胺, 乙硫异烟胺
谱图信息:
最多检出来源 Homo sapiens(blood) 26.42%
Reviewed
Last reviewed on 2024-07-12.
Cite this Page
Ethionamide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/ethionamide (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000002720). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CCc(n1)cc(cc1)C(N)=S
InChI: InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)
描述信息
Ethionamide is only found in individuals that have used or taken this drug. It is a second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organism. Ethionamide, like prothionamide and pyrazinamide, is a nicotinic acid derivative related to isoniazid. It is thought that ethionamide undergoes intracellular modification and acts in a similar fashion to isoniazid. Isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. Specifically isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.
Ethionamide. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=536-33-4 (retrieved 2024-07-12) (CAS RN: 536-33-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic.
同义名列表
24 个代谢物同义名
2-ethylpyridine-4-carbothioamide; Wyeth brand OF ethionamide; 2-Ethyl-4-thiopyridylamide; Ethionamid prothionamid; Ethylisothiamide; ABBR eto; Ethionamidum; Ethioniamide; Ethyonomide; ethionamide; Trecator SC; Trecator-SC; Etionamida; Etionamide; Ethinamide; Etioniamid; Amidazine; Etionamid; Trecator; ETH; ETP; 2-Ethylthioisonicotinamide; Ethionamide; Ethionamide
数据库引用编号
35 个数据库交叉引用编号
- ChEBI: CHEBI:4885
- KEGG: C07665
- KEGGdrug: D00591
- PubChem: 2761171
- HMDB: HMDB0014747
- Metlin: METLIN2591
- DrugBank: DB00609
- ChEMBL: CHEMBL1441
- Wikipedia: Ethionamide
- MeSH: Ethionamide
- chemspider: 2041901
- CAS: 536-33-4
- MoNA: LU104503
- MoNA: LU104506
- MoNA: KO000719
- MoNA: LU104551
- MoNA: LU104505
- MoNA: LU104501
- MoNA: KO000720
- MoNA: KO000723
- MoNA: LU104552
- MoNA: LU104553
- MoNA: LU104555
- MoNA: LU104504
- MoNA: LU104554
- MoNA: LU104556
- MoNA: KO000721
- MoNA: KO000722
- MoNA: LU104502
- PMhub: MS000004604
- PDB-CCD: 1JA
- NIKKAJI: J2.066D
- medchemexpress: HY-B0276
- PubChem: 9867
- KNApSAcK: 4885
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(2)
- ethionamide activation:
H+ + NADPH + O2 + ethionamide S-oxide ⟶ (2-ethylpyridin-4-yl)(imino)methanesulfinate + H2O + NADP+ - ethionamide activation:
H+ + NADPH + O2 + ethionamide S-oxide ⟶ (2-ethylpyridin-4-yl)(imino)methanesulfinate + H2O + NADP+
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ronald Rodriguez, Nick Campbell-Kruger, Jesus Gonzalez Camba, John Berude, Rachel Fetterman, Sarah Stanley. MarR-Dependent Transcriptional Regulation of mmpSL5 Induces Ethionamide Resistance in Mycobacterium abscessus.
Antimicrobial agents and chemotherapy.
2023 Mar; ?(?):e0135022. doi:
10.1128/aac.01350-22. [PMID: 36988462] - Kyotaka Muta, Kosuke Saito, Yusuke Kemmochi, Taku Masuyama, Akio Kobayashi, Yoshiro Saito, Shoichiro Sugai. Phosphatidylcholine (18:0/20:4), a potential biomarker to predict ethionamide-induced hepatic steatosis in rats.
Journal of applied toxicology : JAT.
2022 09; 42(9):1533-1547. doi:
10.1002/jat.4324. [PMID: 35315511] - Pradeep Kumar Anand, Arbind Kumar, Amrit Saini, Jagdeep Kaur. Mutation in Eth A protein of Mycobacterium tuberculosis conferred drug tolerance against enthinoamide in Mycobacterium smegmatis mc2155.
Computational biology and chemistry.
2022 Jun; 98(?):107677. doi:
10.1016/j.compbiolchem.2022.107677. [PMID: 35397466] - Xiaocui Wu, Guangkun Tan, Wei Sha, Haican Liu, Jinghui Yang, Yinjuan Guo, Xin Shen, Zheyuan Wu, Hongbo Shen, Fangyou Yu. Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures.
Microbiology spectrum.
2022 04; 10(2):e0251621. doi:
10.1128/spectrum.02516-21. [PMID: 35311541] - Maxwell T Chirehwa, Richard Court, Mariana de Kock, Lubbe Wiesner, Nihal de Vries, Joseph Harding, Tawanda Gumbo, Gary Maartens, Rob Warren, Paolo Denti, Helen McIlleron. Effect of Isoniazid Intake on Ethionamide Pharmacokinetics and Target Attainment in Multidrug-Resistant Tuberculosis Patients.
Antimicrobial agents and chemotherapy.
2021 09; 65(10):e0027821. doi:
10.1128/aac.00278-21. [PMID: 34310215] - Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue.
Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1. [PMID: 32808185] - Chaitra Ravi, Preeti Dabadghao. Treatment of Multi-drug Resistant Tuberculosis Causing Tubulopathy - Gitelman-like Syndrome.
Indian pediatrics.
2019 11; 56(11):976-977. doi:
. [PMID: 31729333] - Rajeev Ranjan, Ashish Srivastava, Reena Bharti, Trisha Roy, Sonia Verma, Lipika Ray, Amit Misra. Preclinical Development of Inhalable d-Cycloserine and Ethionamide To Overcome Pharmacokinetic Interaction and Enhance Efficacy against Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy.
2019 06; 63(6):. doi:
10.1128/aac.00099-19. [PMID: 30962335] - Agibothu Kupparam Hemanth Kumar, Alok Kumar, Thiruvengadam Kannan, Rakesh Bhatia, Dipti Agarwal, Santosh Kumar, Rajeshwar Dayal, Sheo Pratap Singh, Geetha Ramachandran. Pharmacokinetics of Second-Line Antituberculosis Drugs in Children with Multidrug-Resistant Tuberculosis in India.
Antimicrobial agents and chemotherapy.
2018 05; 62(5):. doi:
10.1128/aac.02410-17. [PMID: 29463539] - Lucila Garcia-Contreras, Danielle J Padilla-Carlin, Jean Sung, Jarod VerBerkmoes, Pavan Muttil, Katharina Elbert, Charles Peloquin, David Edwards, Anthony Hickey. Pharmacokinetics of Ethionamide Delivered in Spray-Dried Microparticles to the Lungs of Guinea Pigs.
Journal of pharmaceutical sciences.
2017 01; 106(1):331-337. doi:
10.1016/j.xphs.2016.09.033. [PMID: 27842973] - Bruno Regis Lyrio Ferraz, Fernando Roberto Figueiredo Leite, Andréa Renata Malagutti. Simultaneous determination of ethionamide and pyrazinamide using poly(l-cysteine) film-modified glassy carbon electrode.
Talanta.
2016 07; 154(?):197-207. doi:
10.1016/j.talanta.2016.03.058. [PMID: 27154666] - Gouranga Santra, Rudrajit Paul, Avik Karak, Somnath Mukhopadhay. Gitelman-like Syndrome with Kanamycin Toxicity.
The Journal of the Association of Physicians of India.
2016 05; 64(5):90-92. doi:
. [PMID: 27735167] - S Thee, A J Garcia-Prats, P R Donald, A C Hesseling, H S Schaaf. A review of the use of ethionamide and prothionamide in childhood tuberculosis.
Tuberculosis (Edinburgh, Scotland).
2016 Mar; 97(?):126-36. doi:
10.1016/j.tube.2015.09.007. [PMID: 26586647] - Joan M Korth-Bradley, Philip Mayer, Debra Mansfield, Hal Tucker, David Wu. Comparative bioavailability study of single-dose film-coated and sugar-coated ethionamide tablets in healthy volunteers.
Clinical therapeutics.
2014 Jun; 36(6):982-7. doi:
10.1016/j.clinthera.2014.04.014. [PMID: 24832559] - Stellah G Mpagama, Norah Ndusilo, Suzanne Stroup, Happiness Kumburu, Charles A Peloquin, Jean Gratz, Eric R Houpt, Gibson S Kibiki, Scott K Heysell. Plasma drug activity in patients on treatment for multidrug-resistant tuberculosis.
Antimicrobial agents and chemotherapy.
2014; 58(2):782-8. doi:
10.1128/aac.01549-13. [PMID: 24247125] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Justyna Wojno, John-Paul Jukes, Hemza Ghadbane, Dawn Shepherd, Gurdyal S Besra, Vincenzo Cerundolo, Liam R Cox. Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production.
ACS chemical biology.
2012 May; 7(5):847-55. doi:
10.1021/cb2005017. [PMID: 22324848] - Anil K Jain, Ish K Dhammi, Prashant Modi, Jaswant Kumar, Ravi Sreenivasan, Namita Singh Saini. Tuberculosis spine: Therapeutically refractory disease.
Indian journal of orthopaedics.
2012 Mar; 46(2):171-8. doi:
10.4103/0019-5413.93685. [PMID: 22448055] - Umesha Katrahalli, Veerendra Kumar A Kalalbandi, Seetharamappa Jaldappagari. The effect of anti-tubercular drug, ethionamide on the secondary structure of serum albumins: a biophysical study.
Journal of pharmaceutical and biomedical analysis.
2012 Feb; 59(?):102-8. doi:
10.1016/j.jpba.2011.09.013. [PMID: 22055802] - O Awodele, E B Patrick, Esther Oluwatoyin Agbaje, A A Oremosu, S C Gbotolorun. Assessing the risk of birth defects associated with exposure to fixed-dose combined antituberculous agents during pregnancy in rats.
TheScientificWorldJournal.
2012; 2012(?):585094. doi:
10.1100/2012/585094. [PMID: 22629151] - Keith A Rodvold, Liz Yoo, Jomy M George. Penetration of anti-infective agents into pulmonary epithelial lining fluid: focus on antifungal, antitubercular and miscellaneous anti-infective agents.
Clinical pharmacokinetics.
2011 Nov; 50(11):689-704. doi:
10.2165/11592900-000000000-00000. [PMID: 21973267] - S Thee, H I Seifart, B Rosenkranz, A C Hesseling, K Magdorf, P R Donald, H S Schaaf. Pharmacokinetics of ethionamide in children.
Antimicrobial agents and chemotherapy.
2011 Oct; 55(10):4594-600. doi:
10.1128/aac.00379-11. [PMID: 21788468] - S Thee, E W Zöllner, M Willemse, A C Hesseling, K Magdorf, H S Schaaf. Abnormal thyroid function tests in children on ethionamide treatment.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2011 Sep; 15(9):1191-3, i. doi:
10.5588/ijtld.10.0707. [PMID: 21943844] - Abhijeet Y Deshpande, Sandip Gurav, Ravindra Punde, Vishal Zambre, Rahul Kulkarni, Sarvesh Pandey, Ashish Mungantiwar, Ramesh Mullangi. Development and validation of a highly sensitive LC-MS/MS method for simultaneous quantitation of ethionamide and ethionamide sulfoxide in human plasma: application to a human pharmacokinetic study.
Biomedical chromatography : BMC.
2011 Sep; 25(9):985-94. doi:
10.1002/bmc.1554. [PMID: 21268048] - Adriana L Andrade, Kenneth Melich, G Gregory Whatley, Sarah R Kirk, Jeffrey W Karpen. Cyclic nucleotide-gated channel block by hydrolysis-resistant tetracaine derivatives.
Journal of medicinal chemistry.
2011 Jul; 54(13):4904-12. doi:
10.1021/jm200495g. [PMID: 21634421] - Ehab A Abourashed, Ahmed M Galal, Atef M Shibl. Antimycobacterial activity of ferutinin alone and in combination with antitubercular drugs against a rapidly growing surrogate of Mycobacterium tuberculosis.
Natural product research.
2011 Jul; 25(12):1142-9. doi:
10.1080/14786419.2010.481623. [PMID: 21442547] - Ezekiel Green, Lawrence C Obi, Amidou Samie, Pascal O Bessong, Roland N Ndip. Characterization of n-Hexane sub-fraction of Bridelia micrantha (Berth) and its antimycobacterium activity.
BMC complementary and alternative medicine.
2011 Apr; 11(?):28. doi:
10.1186/1472-6882-11-28. [PMID: 21481267] - Dorothee Heemskerk, Jeremy Day, Tran Thi Hong Chau, Nguyen Huy Dung, Nguyen Thi Bich Yen, Nguyen Duc Bang, Laura Merson, Piero Olliaro, Thomas Pouplin, Maxine Caws, Marcel Wolbers, Jeremy Farrar. Intensified treatment with high dose rifampicin and levofloxacin compared to standard treatment for adult patients with tuberculous meningitis (TBM-IT): protocol for a randomized controlled trial.
Trials.
2011 Feb; 12(?):25. doi:
10.1186/1745-6215-12-25. [PMID: 21288325] - Deepak Almeida, Paul J Converse, Zahoor Ahmad, Kelly E Dooley, Eric L Nuermberger, Jacques H Grosset. Activities of rifampin, Rifapentine and clarithromycin alone and in combination against mycobacterium ulcerans disease in mice.
PLoS neglected tropical diseases.
2011 Jan; 5(1):e933. doi:
10.1371/journal.pntd.0000933. [PMID: 21245920] - Gaurav Kumar, Sadhna Sharma, Nusrat Shafiq, Promila Pandhi, Gopal Krishan Khuller, Samir Malhotra. Pharmacokinetics and tissue distribution studies of orally administered nanoparticles encapsulated ethionamide used as potential drug delivery system in management of multi-drug resistant tuberculosis.
Drug delivery.
2011 Jan; 18(1):65-73. doi:
10.3109/10717544.2010.509367. [PMID: 20735202] - Abdullah A Alangari, Fahad Al-Zamil, Abdulrahman Al-Mazrou, Saleh Al-Muhsen, Stéphanie Boisson-Dupuis, Sitalbanat Awadallah, Abdelmageed Kambal, Jean-Laurent Casanova. Treatment of disseminated mycobacterial infection with high-dose IFN-γ in a patient with IL-12Rβ1 deficiency.
Clinical & developmental immunology.
2011; 2011(?):691956. doi:
10.1155/2011/691956. [PMID: 21234109] - Sammy Al-Benna, Yechiel Shai, Frank Jacobsen, Lars Steinstraesser. Oncolytic activities of host defense peptides.
International journal of molecular sciences.
2011; 12(11):8027-51. doi:
10.3390/ijms12118027. [PMID: 22174648] - Marcos Abdo Arbex, Marília de Castro Lima Varella, Hélio Ribeiro de Siqueira, Fernando Augusto Fiúza de Mello. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs.
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia.
2010 Sep; 36(5):641-56. doi:
10.1590/s1806-37132010000500017. [PMID: 21085831] - Aner Gurvitz. The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2.
Molecular genetics and genomics : MGG.
2009 Oct; 282(4):407-16. doi:
10.1007/s00438-009-0474-2. [PMID: 19685079] - Somaya Zakaria Mansour, Hanan El-Kabany. Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats.
Chinese medicine.
2009 Jan; 4(?):2. doi:
10.1186/1749-8546-4-2. [PMID: 19183455] - Apoorva Bhatt, Alistair K Brown, Albel Singh, David E Minnikin, Gurdyal S Besra. Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones.
Chemistry & biology.
2008 Sep; 15(9):930-9. doi:
10.1016/j.chembiol.2008.07.007. [PMID: 18804030] - Marianna N Xanthopoulou, Sotiris K Hadjikakou, Nick Hadjiliadis, Elena R Milaeva, Julia A Gracheva, Vladimir Yu Tyurin, Nikolaos Kourkoumelis, Kostantinos C Christoforidis, Apostolos K Metsios, Spyros Karkabounas, Konstantinos Charalabopoulos. Biological studies of new organotin(IV) complexes of thioamide ligands.
European journal of medicinal chemistry.
2008 Feb; 43(2):327-35. doi:
10.1016/j.ejmech.2007.03.028. [PMID: 17509733] - Sharon L Kendall, Mike Withers, Catherine N Soffair, Nicole J Moreland, Sudagar Gurcha, Ben Sidders, Rosangela Frita, Annemieke Ten Bokum, Gurdyal S Besra, J Shaun Lott, Neil G Stoker. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis.
Molecular microbiology.
2007 Aug; 65(3):684-99. doi:
10.1111/j.1365-2958.2007.05827.x. [PMID: 17635188] - Roberto Colangeli, Danica Helb, Catherine Vilchèze, Manzour Hernando Hazbón, Chee-Gun Lee, Hassan Safi, Brendan Sayers, Irene Sardone, Marcus B Jones, Robert D Fleischmann, Scott N Peterson, William R Jacobs, David Alland. Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis.
PLoS pathogens.
2007 Jun; 3(6):e87. doi:
10.1371/journal.ppat.0030087. [PMID: 17590082] - Deborah-Ann Johnson, Kevin D Smith. The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein.
Biomedical chromatography : BMC.
2006 Jun; 20(6-7):551-60. doi:
10.1002/bmc.641. [PMID: 16779786] - Rubén Alvarez-Sánchez, Maja Divkovic, David Basketter, Camilla Pease, Maria Panico, Anne Dell, Howard Morris, Jean-Pierre Lepoittevin. Effect of glutathione on the covalent binding of the 13C-labeled skin sensitizer 5-chloro-2-methylisothiazol-3-one to human serum albumin: identification of adducts by nuclear magnetic resonance, matrix-assisted laser desorption/ionization mass spectrometry, and nanoelectrospray tandem mass spectrometry.
Chemical research in toxicology.
2004 Sep; 17(9):1280-8. doi:
10.1021/tx049935+. [PMID: 15377163] - Marco W Fraaije, Nanne M Kamerbeek, Annelies J Heidekamp, Riccardo Fortin, Dick B Janssen. The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase.
The Journal of biological chemistry.
2004 Jan; 279(5):3354-60. doi:
10.1074/jbc.m307770200. [PMID: 14610090] - D E David E Nix, R D Rodney D Adam, Barbara Auclair, T S Todd S Krueger, P G Paul G Godo, C A Charles A Peloquin. Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid.
Tuberculosis (Edinburgh, Scotland).
2004; 84(6):365-73. doi:
10.1016/j.tube.2004.04.001. [PMID: 15525560] - M I Walash, M E-S Metwally, A M El-Brashy, A A Abdelal. Kinetic spectrophotometric determination of some sulfur containing compounds in pharmaceutical preparations and human serum.
Farmaco (Societa chimica italiana : 1989).
2003 Dec; 58(12):1325-32. doi:
10.1016/s0014-827x(03)00167-8. [PMID: 14630247] - Oselys R Justo, Angela M Moraes. Incorporation of antibiotics in liposomes designed for tuberculosis therapy by inhalation.
Drug delivery.
2003 Jul; 10(3):201-7. doi:
10.1080/713840401. [PMID: 12944141] - Claude Guillonneau, Yves Charton, Yves-Michel Ginot, Marie-Victoire Fouquier-d'Hérouël, Marc Bertrand, Brian Lockhart, Pierre Lestage, Solo Goldstein. Synthesis and pharmacological evaluation of new 1,2-dithiolane based antioxidants.
European journal of medicinal chemistry.
2003 Jan; 38(1):1-11. doi:
10.1016/s0223-5234(02)01424-1. [PMID: 12593911] - Charles A Peloquin. Therapeutic drug monitoring in the treatment of tuberculosis.
Drugs.
2002; 62(15):2169-83. doi:
10.2165/00003495-200262150-00001. [PMID: 12381217] - M Zhu, R Namdar, J J Stambaugh, J R Starke, A E Bulpitt, S E Berning, C A Peloquin. Population pharmacokinetics of ethionamide in patients with tuberculosis.
Tuberculosis (Edinburgh, Scotland).
2002; 82(2-3):91-6. doi:
10.1054/tube.2002.0330. [PMID: 12356460] - C A Peloquin, M Zhu, R D Adam, M D Singleton, D E Nix. Pharmacokinetics of para-aminosalicylic acid granules under four dosing conditions.
The Annals of pharmacotherapy.
2001 Nov; 35(11):1332-8. doi:
10.1345/aph.1a088. [PMID: 11724078] - H Mizutani, M Horiba, J Shindoh, T Kimura, M Son, K Wakahara. [Two cases of multi-drug-resistant pulmonary tuberculosis with para-aminosalicylic acid (PAS)-induced hypothyroidism].
Kekkaku : [Tuberculosis].
2001 Oct; 76(10):667-72. doi:
. [PMID: 11712388] - M Zhu, D E Nix, R D Adam, J M Childs, C A Peloquin. Pharmacokinetics of cycloserine under fasting conditions and with high-fat meal, orange juice, and antacids.
Pharmacotherapy.
2001 Aug; 21(8):891-7. doi:
10.1592/phco.21.11.891.34524. [PMID: 11718495] - M C Gennaro, R Calvino, C Abrigo. Ion interaction reagent reversed-phase high-performance liquid chromatography determination of anti-tuberculosis drugs and metabolites in biological fluids.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Apr; 754(2):477-86. doi:
10.1016/s0378-4347(01)00037-8. [PMID: 11339291] - J E Conte, G Wang, E T Lin, E Zurlinden. High-performance liquid chromatographic-tandem mass spectrometric method for the determination of ethionamide in human plasma, bronchoalveolar lavage fluid and alveolar cells.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Apr; 753(2):343-53. doi:
10.1016/s0378-4347(00)00572-7. [PMID: 11334350] - B Auclair, D E Nix, R D Adam, G T James, C A Peloquin. Pharmacokinetics of ethionamide administered under fasting conditions or with orange juice, food, or antacids.
Antimicrobial agents and chemotherapy.
2001 Mar; 45(3):810-4. doi:
10.1128/aac.45.3.810-814.2001. [PMID: 11181366] - J E Conte, J A Golden, M McQuitty, J Kipps, E T Lin, E Zurlinden. Effects of AIDS and gender on steady-state plasma and intrapulmonary ethionamide concentrations.
Antimicrobial agents and chemotherapy.
2000 May; 44(5):1337-41. doi:
10.1128/aac.44.5.1337-1341.2000. [PMID: 10770772] - R S Malone, D N Fish, D M Spiegel, J M Childs, C A Peloquin. The effect of hemodialysis on cycloserine, ethionamide, para-aminosalicylate, and clofazimine.
Chest.
1999 Oct; 116(4):984-90. doi:
10.1378/chest.116.4.984. [PMID: 10531163] - P R Donald, J F Schoeman, L E Van Zyl, J N De Villiers, M Pretorius, P Springer. Intensive short course chemotherapy in the management of tuberculous meningitis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
1998 Sep; 2(9):704-11. doi:
NULL. [PMID: 9755923] - N Rastogi, V Labrousse, K S Goh. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages.
Current microbiology.
1996 Sep; 33(3):167-75. doi:
10.1007/s002849900095. [PMID: 8672093] - H I Seifart, P B Kruger, D P Parkin, P P van Jaarsveld, P R Donald. Therapeutic monitoring of antituberculosis drugs by direct in-line extraction on a high-performance liquid chromatography system.
Journal of chromatography.
1993 Sep; 619(2):285-90. doi:
10.1016/0378-4347(93)80118-n. [PMID: 8263100] - A Quémard, G Lanéelle, C Lacave. Mycolic acid synthesis: a target for ethionamide in mycobacteria?.
Antimicrobial agents and chemotherapy.
1992 Jun; 36(6):1316-21. doi:
10.1128/aac.36.6.1316. [PMID: 1416831] - C A Peloquin, G T James, E McCarthy. Improved high-performance liquid chromatographic assay for the determination of ethionamide in serum.
Journal of chromatography.
1991 Feb; 563(2):472-5. doi:
10.1016/0378-4347(91)80058-k. [PMID: 2056012] - H Iwainsky, B Wiesner, K Winsel. [Clinical pharmacology in optimization of therapy of lung diseases].
Zeitschrift fur Erkrankungen der Atmungsorgane.
1991; 177(1-2):40-9. doi:
. [PMID: 1808851] - C A Peloquin, G T James, E McCarthy, M Goble. Pharmacokinetic evaluation of ethionamide suppositories.
Pharmacotherapy.
1991; 11(5):359-63. doi:
NULL. [PMID: 1745621] - G P Becks, M C Eggo, G N Burrow. Organic iodine inhibits deoxyribonucleic acid synthesis and growth in FRTL-5 thyroid cells.
Endocrinology.
1988 Jul; 123(1):545-51. doi:
10.1210/endo-123-1-545. [PMID: 3383784] - C N Lee, L B Heifets. Determination of minimal inhibitory concentrations of antituberculosis drugs by radiometric and conventional methods.
The American review of respiratory disease.
1987 Aug; 136(2):349-52. doi:
10.1164/ajrccm/136.2.349. [PMID: 3619193] - P R Donald, J F Schoeman, A O'Kennedy. Hepatic toxicity during chemotherapy for severe tuberculosis meningitis.
American journal of diseases of children (1960).
1987 Jul; 141(7):741-3. doi:
10.1001/archpedi.1987.04460070043019. [PMID: 2884866] - P J Jenner, S E Smith. Plasma levels of ethionamide and prothionamide in a volunteer following intravenous and oral dosages.
Leprosy review.
1987 Mar; 58(1):31-7. doi:
10.5935/0305-7518.19870004. [PMID: 3600145] - Iu I Slivka. [Effect of ethionamide and isoniazid on lipid peroxidation and the condition of the liver].
Problemy tuberkuleza.
1987; ?(8):67-9. doi:
". [PMID: 3684996] - O Garraud, O Ribierre, M A Bach. A follow up of T-cell subsets and of anti-M. leprae antibody titer as measured by the FLA-ABS test in Melanesian leprosy patients under polychemotherapy.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
1986 Mar; 54(1):38-45. doi:
NULL. [PMID: 2940306] - J N Stanley, J M Pearson, G A Ellard. Ethionamide, prothionamide and thiacetazone self-administration. Studies of patient compliance using isoniazid-marked formulations.
Leprosy review.
1986 Mar; 57(1):9-18. doi:
10.5935/0305-7518.19860003. [PMID: 2422517] - G J Traiger, K P Vyas, R P Hanzlik. Effect of thiocarbonyl compounds on alpha-naphthylisothiocyanate-induced hepatotoxicity and the urinary excretion of [35S]alpha-naphthylisothiocyanate in the rat.
Toxicology and applied pharmacology.
1984 Mar; 72(3):504-12. doi:
10.1016/0041-008x(84)90127-3. [PMID: 6324415] - P J Jenner, G A Ellard, P J Gruer, V R Aber. A comparison of the blood levels and urinary excretion of ethionamide and prothionamide in man.
The Journal of antimicrobial chemotherapy.
1984 Mar; 13(3):267-77. doi:
10.1093/jac/13.3.267. [PMID: 6725176] - V S Svinchuk. [Determination of isoniazid, PAS and ethionamide in urine].
Problemy tuberkuleza.
1983 Apr; ?(4):64-6. doi:
NULL. [PMID: 6866976] - J H Peters, G R Gordon, J F Murray, V F Simmon. Mutagenic activity of antileprosy drugs and their derivatives.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
1983 Mar; 51(1):45-53. doi:
NULL. [PMID: 6683259] - P J Jenner, G A Ellard. High-performance liquid chromatographic determination of ethionamide and prothionamide in body fluids.
Journal of chromatography.
1981 Sep; 225(1):245-51. doi:
10.1016/s0378-4347(00)80269-8. [PMID: 7298753] - H Iwainsky, I Sesser, H Reutgen. [The use of mycobacteria in the estimation of the concentration of antibiotics, antimycotics and antituberculotics (author's transl)].
Zeitschrift fur Erkrankungen der Atmungsorgane.
1978 Jan; 151(3):256-62. doi:
NULL. [PMID: 105479] - R H Waring, M Armitage, S C Mitchell. Sulphoxidation in the neonatal guinea pig.
Biochemical Society transactions.
1978; 6(1):91-3. doi:
10.1042/bst0060091. [PMID: 640213] - N Buchanan, L A van der Walt. The binding of antituberculous drugs to normal and kwashiorkor serum.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
1977 Sep; 52(13):522-5. doi:
. [PMID: 918794] - S R Pattyn, M T Rollier, R Rollier, G Verdoolaeghe-Van Loo. [Sensitivity to dapsone, sulfamethoxypyridazine and ethionamide of mycobacterium leprae taken from patients treated by the drugs].
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
1975 Oct; 43(4):356-63. doi:
. [PMID: 776843] - O P Arkhipova. [Effect of tuberculosis infection and antibacterial preparations on thiamine metabolism].
Voprosy meditsinskoi khimii.
1975 Sep; 21(5):485-9. doi:
NULL. [PMID: 1216765] - H H Hussey. Editorial: Gynecomastia.
JAMA.
1974 Jun; 228(11):1423. doi:
10.1001/jama.228.11.1423b. [PMID: 4406626] - R M Ehrlich, J K Lattimer. Genitourinary tuberculosis.
Surgery annual.
1974; 6(?):439-57. doi:
NULL. [PMID: 4610836] - B Devulder, G Lelievre, P Capier, A Tacquet. [Letter: Acute kidney failure due to rifampicin].
La Nouvelle presse medicale.
1973 Nov; 2(40):2691. doi:
NULL. [PMID: 4760681] - B Inouye, N Yoshimura, T Wachi. [Experimental studies on the mechanism of fatty liver formation induced by ethionamide. V. Liver and serum total cholesterol in ethionamide-administered rats].
Kekkaku : [Tuberculosis].
1973 Mar; 48(3):71-4. doi:
NULL. [PMID: 4721388] - D J Girling. Hong Kong Treatment Services-Royal Postgraduate Medical School-British Medical Research Council Co-operative study of rifampicin plus ethambutol in daily and intermittent regimens. Clinical observations on adverse reactions.
Scandinavian journal of respiratory diseases. Supplementum.
1973; 84(?):119-24. doi:
NULL. [PMID: 4522064] - V A Stepanenko. [Renal function in patients with minor forms of pulmonary tuberculosis in the course of treatment with 2d series drugs].
Vrachebnoe delo.
1972 Aug; 8(?):97-8. doi:
NULL. [PMID: 5073195] - J Pütter. [Determination of prothionamide and ethionamide and their sulfoxides in blood plasma].
Arzneimittel-Forschung.
1972 Jun; 22(6):1027-31. doi:
NULL. [PMID: 4262015] - D I Evans, B Attock. Folate deficiency in pulmonary tuberculosis: relationship to treatment and to serum vitamin A and beta-carotene.
Tubercle.
1971 Dec; 52(4):288-94. doi:
10.1016/0041-3879(71)90005-5. [PMID: 5143924] - J S Shronts, T K Rynearson, E Wolinsky. Rifampin alone and combined with other drugs in Mycobacterium kansasii and Mycobacterium intracellulare infections of mice.
The American review of respiratory disease.
1971 Nov; 104(5):728-41. doi:
10.1164/arrd.1971.104.5.728. [PMID: 5125181] - A Bieder, P Brunel. [Application of rapid polarography with overimposed alternating current to the study of urinary elimination of ethionamide and prothionamide metabolites in humans].
Annales pharmaceutiques francaises.
1971 Sep; 29(9):461-75. doi:
NULL. [PMID: 5129579] - R Kalich, H Eckert. [Experimental studies on the effect of ethionamide therapy on fertility and on the progeny of the white mouse].
Zeitschrift fur Erkrankungen der Atmungsorgane mit Folia bronchologica.
1971; 135(2):195-204. doi:
NULL. [PMID: 5004152] - M Grunert, H Iwainsky. [Pharmacokinetics and biotransformation of ethioniamide. II. Quantitative determination of ethioniamide, sulfoxide and methyl-ethioniamide in biologic materials].
Zeitschrift fur Erkrankungen der Atmungsorgane mit Folia bronchologica.
1971; 134(2):219-25. doi:
NULL. [PMID: 5206955] - M Grunert, H Iwainsky. [Pharmacokinetics and biotransformation of ethioniamide. 3. Behavior or ethioniamide in the macroorganism].
Zeitschrift fur Erkrankungen der Atmungsorgane mit Folia bronchologica.
1971; 134(2):227-33. doi:
NULL. [PMID: 5206956] - B Inoue, T Wachi. [Experimental studies on the mechanism of fatty liver formation induced by ethionamide. 3. Fatty acid composition of ethionamide-induced fatty liver and epididymal adipose tissue, and serum free fatty acid in ethionamide-administered rat].
Kekkaku : [Tuberculosis].
1970 Jul; 45(7):207-11. doi:
NULL. [PMID: 5449508] - A M Harnanansingh, L Eidus. Micro method for the determination of ethionamide in serum.
Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology.
1970 May; 3(2):128-31. doi:
NULL. [PMID: 5425954] - Z Rajtar-Leontiew. [Effect of isoniazid on pyridoxine (vitamin B6) metabolism in children. Experimental study].
Annales de pediatrie.
1970 Feb; 17(2):150-63. doi:
NULL. [PMID: 5513157] - K D Stottmeier, C L Woodley, G P Kubica. New approach for the evaluation of antimycobacterial drug combinations in vitro (the laboratory model man).
Applied microbiology.
1969 Sep; 18(3):399-403. doi:
10.1128/am.18.3.399-403.1969. [PMID: 5198127] - G Bleandonu, J Boye. [Neuropsychiatric incidences in antitubercular treatment consisting of isoniazid or isoniazid and ethionamide (8 cases)].
Annales medico-psychologiques.
1969 Jul; 127(2):201-26. doi:
NULL. [PMID: 4254305] - H Tiitinen. Isoniazid and ethionamide serum levels and inactivation in Finnish subjects.
Scandinavian journal of respiratory diseases.
1969; 50(2):110-24. doi:
NULL. [PMID: 5195839]
